| 1. |
- Fang, Shuhong, et al.
(författare)
-
Spatiotemporal distribution and isomer profiles of perfluoroalkyl acids in airborne particulate matter in Chengdu City, China
- 2019
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 689, s. 1235-1243
-
Tidskriftsartikel (refereegranskat)abstract
- Airborne particulate matter (APM) was collected in four seasons at five different areas of the city of Chengdu, China to study the spatial and seasonal contamination pattern of perfluoroalkyl acids (PFAAs). The results showed that Sigma PFAA concentrations in Downtown Chengdu (mean value: 297 +/- 238 pg/m(3)) were higher than concentrations in suburban areas. The highest concentrations of PFAAs occurred during spring (97.5-709 pg/L; arithmetic mean concentration: 297 +/- 191 pg/L) while the lowest concentration occurred during autumn (9.27-105 pg/L; arithmetic mean concentration 41.1 +/- 24.8 pg/L). Perfluorooctanoic acid (PFOA) was the main PFAA quantified during winter, summer and autumn, and perfluorononanoic acid (PFNA) was the predominant PFAA in spring. Relative humidity (RH) and average daily precipitation (PRE) showed significant negative correlations with PFAA concentrations in winter and summer, suggesting that they played an important role in controlling PFAA concentrations in APM. The linear structural isomer of PFOA (n-PFOA) was the most abundant isomer in APM in Chengdu, with the average proportion of 85.6% +/- 6.13%, higher than the proportion in ECF PFOA commercial products (74.3-77.6%). However, the consistent fingerprint of branched PFOA in the APM implies that ECF PFOA makes a significant contribution to the PFOA in APM. PEELS in the APM collected throughout the year had a mean proportion of 54.0 +/- 8.81% of n-PFOS. This proportion of n-PFOS is lower than commercial ECF products (62.9-78.2%), suggesting an additional proportion of branched PFOS isomers in APM in Chengdu.
|
|
| 2. |
- Liu, Yanna, et al.
(författare)
-
Nontarget Mass Spectrometry Reveals New Perfluoroalkyl Substances in Fish from the Yangtze River and Tangxun Lake, China
- 2018
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 52:10, s. 5830-5840
-
Tidskriftsartikel (refereegranskat)abstract
- Nontarget high-resolution mass spectrometry (Nt-HRMS) has been proven useful for the identification of unknown poly- and perfluoroalkyl substances (PFASs) in commercial products and water, but applications to biological samples are limited. China is the major PFAS-manufacturing nation; thus, here, we adapted our Nt-HRMS methods to fish collected from the Yangtze River and Tangxun Lake to discover potentially bioaccumulative PFASs in aquatic organisms destined for human consumption. In addition to traditional PFASs, over 330 other fluorinated analytes belonging to 10 classes of PFASs were detected among the pooled fish livers, including 6 sulfonate classes, 2 amine classes, 1 carboxylate class, and 1 N-heterocycle class. One class was detected in samples from both locations, 8 classes were detected exclusively in Tangxun Lake fish, and 1 class was detected exclusively in Yangtze River fish, 10 km downstream of a fluorochemical manufacturing site where we first reported these substances in wastewater 3 years ago. Overall, 4 of the PFAS classes (>165 analytes) are reported for the first time here. Wider monitoring and toxicological testing should be a priority for understanding the health risks posed to people and wildlife exposed to these substances.
|
|
| 3. |
- Morris, David L, et al.
(författare)
-
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
- 2016
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:8
-
Tidskriftsartikel (refereegranskat)abstract
- Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
|
|
