| 1. |
- Agostoni, Pierguseppe, et al.
(författare)
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Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan.
- 2019
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Ingår i: Cardiac failure review. - 2057-7540. ; 5:3, s. 155-161
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Tidskriftsartikel (refereegranskat)abstract
- Acute and advanced heart failure are associated with substantial adverse short- and longer-term prognosis. Both conditions necessitate complex treatment choices to restore haemodynamic stability and organ perfusion, relieve congestion, improve symptoms and allow the patient to leave the hospital and achieve an adequate quality of life. Among the available intravenous vasoactive therapies, inotropes constitute an option when an increase in cardiac contractility is needed to reverse a low output state. Within the inotrope category, levosimendan is well suited to the needs of both sets of patients since, in contrast to conventional adrenergic inotropes, it has not been linked in clinical trials or wider clinical usage with increased mortality risk and retains its efficacy in the presence of beta-adrenergic receptor blockade; it is further believed to possess beneficial renal effects. The overall haemodynamic profile and clinical tolerability of levosimendan, combined with its extended duration of action, have encouraged its intermittent use in patients with advanced heart failure. This paper summarises the key messages derived from a series of 12 tutorials held at the Heart Failure 2019 congress organised in Athens, Greece, by the Heart Failure Association of the European Society of Cardiology.
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| 2. |
- Sun, AY, et al.
(författare)
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Ethanol and oxidative stress
- 2001
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Ingår i: Alcoholism, clinical and experimental research. - : Wiley. - 0145-6008 .- 1530-0277. ; 25:55 Suppl ISBRA, s. 237S-243S
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Volf, Martin, et al.
(författare)
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Community structure of insect herbivores is driven by conservatism, escalation and divergence of defensive traits in Ficus
- 2018
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 21:1, s. 83-92
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Tidskriftsartikel (refereegranskat)abstract
- Escalation (macroevolutionary increase) or divergence (disparity between relatives) in trait values are two frequent outcomes of the plant-herbivore arms race. We studied the defences and caterpillars associated with 21 sympatric New Guinean figs. Herbivore generalists were concentrated on hosts with low protease and oxidative activity. The distribution of specialists correlated with phylogeny, protease and trichomes. Additionally, highly specialised Asota moths used alkaloid rich plants. The evolution of proteases was conserved, alkaloid diversity has escalated across the studied species, oxidative activity has escalated within one clade, and trichomes have diverged across the phylogeny. Herbivore specificity correlated with their response to host defences: escalating traits largely affected generalists and divergent traits specialists; but the effect of escalating traits on extreme specialists was positive. In turn, the evolution of defences in Ficus can be driven towards both escalation and divergence in individual traits, in combination providing protection against a broad spectrum of herbivores.
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| 4. |
- Zima, T, et al.
(författare)
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Modulation of oxidative stress by alcohol
- 2005
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Ingår i: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. - 0145-6008. ; 29:6, s. 1060-1065
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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