SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Zimmermann Andreas) "

Sökning: WFRF:(Zimmermann Andreas)

  • Resultat 1-10 av 67
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Beal, Jacob, et al. (författare)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
  •  
2.
  • Kalman, Janos L, et al. (författare)
  • Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.
  • 2019
  • Ingår i: Bipolar disorders. - : Wiley. - 1399-5618 .- 1398-5647. ; 21:1, s. 68-75
  • Tidskriftsartikel (refereegranskat)abstract
    • Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 67
Typ av publikation
tidskriftsartikel (62)
rapport (2)
bokkapitel (2)
konferensbidrag (1)
Typ av innehåll
refereegranskat (61)
övrigt vetenskapligt/konstnärligt (4)
populärvet., debatt m.m. (2)
Författare/redaktör
Chen, L (32)
Aad, G (32)
Abbott, B. (32)
Abdinov, O (32)
Zwalinski, L. (32)
Gregersen, K. (32)
visa fler...
Kalderon, C.W. (32)
Poettgen, R. (32)
Aben, R. (32)
Abreu, H. (32)
Abreu, R. (32)
Adye, T. (32)
Agatonovic-Jovin, T. (32)
Ahmadov, F. (32)
Aielli, G. (32)
Alberghi, G. L. (32)
Albert, J. (32)
Albrand, S. (32)
Aleksa, M. (32)
Aleksandrov, I. N. (32)
Alexander, G. (32)
Alexopoulos, T. (32)
Alhroob, M. (32)
Alimonti, G. (32)
Alio, L. (32)
Aloisio, A. (32)
Alonso, A. (32)
Alonso, F. (32)
Alpigiani, C. (32)
Altheimer, A. (32)
Alviggi, M. G. (32)
Amako, K. (32)
Amelung, C. (32)
Amidei, D. (32)
Amorim, A. (32)
Amoroso, S. (32)
Amram, N. (32)
Amundsen, G. (32)
Anastopoulos, C. (32)
Ancu, L. S. (32)
Andari, N. (32)
Andeen, T. (32)
Anders, G. (32)
Anderson, K. J. (32)
Andreazza, A. (32)
Andrei, V. (32)
Angelidakis, S. (32)
Anger, P. (32)
Angerami, A. (32)
Anghinolfi, F. (32)
visa färre...
Lärosäte
Lunds universitet (42)
Uppsala universitet (36)
Stockholms universitet (36)
Kungliga Tekniska Högskolan (32)
Göteborgs universitet (9)
Karolinska Institutet (5)
visa fler...
Umeå universitet (4)
Chalmers tekniska högskola (3)
Linnéuniversitetet (2)
Blekinge Tekniska Högskola (2)
Luleå tekniska universitet (1)
Örebro universitet (1)
Linköpings universitet (1)
Jönköping University (1)
Försvarshögskolan (1)
visa färre...
Språk
Engelska (65)
Svenska (1)
Tyska (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (47)
Medicin och hälsovetenskap (11)
Teknik (5)
Samhällsvetenskap (5)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy