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- Frisen, J, et al.
(författare)
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Nerve growth factor induces process formation in meningeal cells : Implications for scar formation in the injured CNS
- 1998
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Ingår i: Journal of Neuroscience. - Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden. Karolinska Inst, Dept Cell & Mol Biol, Med Nobel Inst, S-17177 Stockholm, Sweden. Biomed Ctr, Dept Dev Neurosci, S-75123 Uppsala, Sweden. McGill Univ, Montreal Neurol Inst, Brain Tumor Res Ctr, Montreal, PQ H3A 2B4, Canada. : SOC NEUROSCIENCE. - 0270-6474 .- 1529-2401. ; 18, s. 5714-
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Tidskriftsartikel (refereegranskat)abstract
- Nerve growth factor (NGF) induces the differentiation and supports the survival of subpopulations of neurons in the PNS and CNS. Here we report that meningeal cells in the pia mater express immunoreactivity and mRNA for both known NGF receptors, the low-affinity receptor p75 and the tyrosine kinase receptor trkA. NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro. NGF does not stimulate proliferation of primary meningeal cells but induces process outgrowth. p75- and trkA-immunoreactive meningeal cells with long processes, resembling NGF-treated cells in vitro, are abundant in the scar tissue that forms at spinal cord lesions in rat and cat. These data suggest that NGF, which is expressed at increased levels in the brain and spinal cord after lesions, may be involved in scar formation in the injured CNS.
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