| 1. |
- Liang, Jianxin, et al.
(författare)
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Mechanistic study of transcription factor Sox18 during heart development
- 2024
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Ingår i: General and Comparative Endocrinology. - : Elsevier BV. - 0016-6480 .- 1095-6840. ; 350
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Tidskriftsartikel (refereegranskat)abstract
- Heart development is a delicate and complex process regulated by coordination of various signaling pathways. In this study, we investigated the role of sox18 in heart development by modulating Wnt/β-Catenin signaling pathways. Our spatiotemporal expression analysis revealed that sox18 is mainly expressed in the heart, branchial arch, pharyngeal arch, spinal cord, and intersegmental vessels at the tailbud stage of Xenopus tropicalis embryo. Overexpression of sox18 in the X. tropicalis embryos causes heart edema, while loss-of-function of sox18 can change the signal of developmental heart marker gata4 at different stages, suggesting that sox18 plays an essential role in the development of the heart. Knockdown of SOX18 in human umbilical vein endothelial cells suggests a link between Sox18 and β-CATENIN, a key regulator of the Wnt signaling pathway. Sox18 negatively regulates islet1 and tbx3, the downstream factors of Wnt/β-Catenin signaling, during the linear heart tube formation and the heart looping stage. Taken together, our findings highlight the crucial role of Sox18 in the development of the heart via inhibiting Wnt/β-Catenin signaling.
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| 2. |
- Zixin, Guo, et al.
(författare)
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The effects of three profiles on the mechanical properties and grain size of self-piercing riveting joints using ultrasonic welding
- 2023
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Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer Science+Business Media B.V.. - 0268-3768 .- 1433-3015. ; 129:11-12, s. 4869-4882
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Tidskriftsartikel (refereegranskat)abstract
- Ultrasonic welding has become a key joining approach in batteries and energy vehicles. This work reports the optimization in static property and stability of self-piercing riveting joints which is becoming the most versatile way to join microstructures. Tool heads of three different knurling profiles (e.g., A, B, and C) are used to perform ultrasonic composite with riveting. Based on tensile-shear tests, SEM, EDS, XRD, and Vickers microhardness analysis were conducted to investigate the comparative study of the fracture morphology, element distribution, phase structure, and hardness. The results indicated that all three types of knurling generate solid phase welding at the sheet joints. Thus, it improved the forming quality and mechanical properties of self-piercing riveting joints. The C-shaped welding tool head has advantageous effect on optimizing the mechanical properties of joints. Further, it enhanced the average peak load by 25.6%, the average failure displacement by 31.1%, and the average energy absorption by 88.8%. The microscopic results showed that a large amount of oxides are precipitated at the edge of welding joints when the B-shape knurling tool is used. The distribution of the hardness value of joints horizontal line is “M” shape. Besides, the coarse grains in the joint area and the interplanar space increase significantly after ultrasonic welding which softens the sheet. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
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| 3. |
- Huo, Xiaole, et al.
(författare)
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Effect of ultrasonic vibration on static properties of 5A06 aluminum alloy self-piercing riveting joints
- 2023
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Ingår i: Cailiao Kexue yu Gongyi/Material Science and Technology. - : Harbin Institute of Technology. - 1005-0299. ; 31:2, s. 44-49
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Tidskriftsartikel (refereegranskat)abstract
- Self-piercing riveting process is a new connection technology with excellent performance, green, and high efficiency. It can realize the connection of the similar, different, and multi-layer light alloy sheet materials and is widely used in new energy vehicles and other fields. Furthermore, it is becoming one of the critical technologies for achieving a lightweight body. However, because the self-piercing riveting joint is a typical tight connection component, fretting damage is prone to occur under the action of alternating stress or vibration, resulting in premature joint fatigue failure. This paper uses 5A06 aluminum alloy sheet material to carry out self-piercing riveting and ultrasonic self-piercing riveting composite connection tests under different ultrasonic welding tool heads. Based on the tensile-shear and electron microscope tests, the effect of ultrasonic vibration on the static properties of 5A06 aluminum alloy self-piercing riveted joints was studied. The results show that: ultrasonic vibration can effectively improve the static properties of self-piercing riveted joints; the ultrasonic metal welding will form a solid phase of welding between the sheets during the composite self-piercing riveting, which is the fundamental reason for improving the mechanical properties of the combined joint; the area of ultrasonic metal welding joints affects the mechanical properties of self-piercing riveted joints; the degree of ultrasonic solid-phase welding is higher when the welding area is more extensive; ultrasonic welding will increase the temperature of the rivet, which will affect the stability of the joints to a certain extent. © 2023 Harbin Institute of Technology. All rights reserved.
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| 4. |
- Lin, Sen, et al.
(författare)
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Non-destructive monitoring of forming quality of self-piercing riveting via a lightweight deep learning
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Self-piercing riveting (SPR) has been widely used in automobile body jointing. However, the riveting process is prone to various forming quality failures, such as empty riveting, repeated riveting, substrate cracking, and other riveting defects. This paper combines deep learning algorithms to achieve non-contact monitoring of SPR forming quality. And a lightweight convolutional neural network with higher accuracy and less computational effort is designed. The ablation and comparative experiments results show that the lightweight convolutional neural network proposed in this paper achieves improved accuracy and reduced computational complexity. Compared with the original algorithm, the algorithm's accuracy in this paper is increased by 4.5[Formula: see text], and the recall is increased by 1.4[Formula: see text]. In addition, the amount of redundant parameters is reduced by 86.5[Formula: see text], and the amount of computation is reduced by 47.33[Formula: see text]. This method can effectively overcome the limitations of low efficiency, high work intensity, and easy leakage of manual visual inspection methods and provide a more efficient solution for monitoring the quality of SPR forming quality. © 2023. The Author(s).
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| 5. |
- Zhao, Lun, et al.
(författare)
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Performance analysis of similar and dissimilar self-piercing riveted joints in aluminum alloys
- 2023
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Ingår i: Composites and Advanced Materials. - : Sage Publications. - 2634-9833. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- In this work, similar (2A12) and dissimilar (6061) aluminum alloy sheets are validly joined using self-piercing rivet process. A quasi-static experiment is proposed to investigate the mechanical behaviors, failures mode, and mechanism of the different joints. Moreover, a method based on deep learning algorithm is anticipated to detect the appearance defects of the SPR welded joints. The results indicated that 2A12 joints of similar sheets contained the advantageous static strength and 6061 similar sheet joints had superior anti-vibration performance conducts. The joints with 6061-2A12 sheets introduced the most decent and comprehensive mechanical properties. The main failure mode of 2A12 similar sheet joints was substrate fracture. The performance of the substrate affects the failure mode of the joint and the plasticity of the substrate is better. When the time comes, the failure mode is mostly pull-off failure. Poor plasticity of the substrate can easily lead to substrate breakage. The reason for joint pull-off and button fall-off failure is that there is large plastic deformation in the lower plate of the joint and the mechanical internal locking structure is damaged. 2A12 substrate breakage belongs to a composite fracture that combines intergranular fracture and microvoid aggregation type fracture. The area of the 6061 substrate near the edge of the sample is shear fracture and the area near the center of the sample thickness is dominated by microvoid aggregation type normal fracture. The effectiveness of the method was verified by conducting a series of experiments and the detection accuracy of the method can reach about 90%. The detection speed was as high as 50 frames per second (FPS), which can effectively solve the problem that the rivet quality was difficult to monitor.
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