| 1. |
- Andersson, Siv GE, et al.
(författare)
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The genome sequence of Rickettsia prowazekii and the origin of mitochondria
- 1998
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 396:6707, s. 133-140
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Tidskriftsartikel (refereegranskat)abstract
- We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. This genome contains 834 protein-coding genes. The functional profiles of these genes show similarities to those of mitochondrial genes: no genes required for anaerobic glycolysis are found in either R. prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in R. prowazekii. In effect, ATP production in Rickettsia is the same as that in mitochondria. Many genes involved in the biosynthesis and regulation of biosynthesis of amino acids and nucleosides in free-living bacteria are absent from R. prowazekii and mitochondria. Such genes seem to have been replaced by homologues in the nuclear (host) genome. The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. Such non-coding sequences may be degraded remnants of 'neutralized' genes that await elimination from the genome. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far.
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| 2. |
- ANDERSSON, SGE, et al.
(författare)
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UNUSUAL ORGANIZATION OF THE RIBOSOMAL-RNA GENES IN RICKETTSIA-PROWAZEKII
- 1995
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Ingår i: JOURNAL OF BACTERIOLOGY. - : AMER SOC MICROBIOLOGY. ; 177:14
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We describe here the organization of the rRNA genes in Rickettsia prowazekii. In this organism, the 23S and the 5S rRNA genes are tightly linked to each other, whereas the 16S rRNA gene is separated from this cluster. The 23S-5S unit is preceded by the me
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| 3. |
- Zomorodipour, A, et al.
(författare)
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Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis
- 1999
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Ingår i: FEBS LETTERS. - : ELSEVIER SCIENCE BV. - 0014-5793. ; 452:1-2, s. 11-15
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Transitions to obligate intracellular parasitism have occurred at numerous times in the evolutionary past, The genome sequences of two obligate intracellular parasites, Rickettsia prowazekii and Chlamydia trachomatis, were published fast year. A comparati
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