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- Bernardi, Anna, et al.
(författare)
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Multivalent glycoconjugates as anti-pathogenic agents
- 2013
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Ingår i: Chemical Society Reviews. - : Royal Society of Chemistry (RSC). - 0306-0012 .- 1460-4744. ; 42:11, s. 4709-4727
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Forskningsöversikt (refereegranskat)abstract
- Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
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| 2. |
- Wang, Yu, et al.
(författare)
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Ethyl Thioglycolate Assisted Multifunctional Surface Modulation for Efficient and Stable Inverted Perovskite Solar Cells
- 2024
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Ingår i: Advanced Functional Materials. - : WILEY-V C H VERLAG GMBH. - 1616-301X .- 1616-3028.
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Tidskriftsartikel (refereegranskat)abstract
- As the core component of sandwich-like perovskite solar cells (PSCs), the quality of perovskite layer is a challenge for further progress in PSCs due to the unfavorable defects and uncontrollable crystallization. Here, a surface post-treatment strategy employing ethyl thioglycolate (ET) as ligand molecule is developed for property manipulation of perovskite films. ET can lower surface energy of perovskite facets and induces secondary growth of grains, giving films with higher crystallinity and lower defect density. Meanwhile, both carbonyl and sulfhydryl in ET can bind to the Pb2+, thus forming bidentate anchoring on the surface for defect passivation. Besides, the perovskite/ET/C60 interface presents improved charge transfer owing to the well-aligned energy levels. Consequently, the power-conversion-efficiency (PCE) is boosted to 22.42% and 23.56% (certified 23.29%) for the FA0.85Cs0.15Pb(I0.95Br0.05)3 and FA0.9MA0.05Cs0.05Pb(I0.95Br0.05)3 PSCs, respectively, and the FA0.85Cs0.15Pb(I0.95Br0.05)3-based PSC with a larger area (1.03 cm2) delivers a PCE of 20.01%. Importantly, ET demonstrates effective management of I2 and PbI2, thereby preventing accelerated degradation and lead leakage of devices. Thanks to the multiple effects of ET, the resulting devices exhibit significantly enhanced ambient stability over a course of 800 h, and a thermal stability of over 1500 h while maintaining 80.4% of its original efficiency. The efficient and stable inverted perovskite solar cells are developed by introducing ethyl thioglycolate for synergistic crystallization modulation, surface passivation and interfacial PbI2/I2 management. image
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