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Sökning: WFRF:(Zukunft S)

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  • Fisslthaler, B, et al. (författare)
  • Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis
  • 2019
  • Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 20:12
  • Tidskriftsartikel (refereegranskat)abstract
    • The AMP-activated protein kinase (AMPK) is an energy sensing kinase that is activated by a drop in cellular ATP levels. Although several studies have addressed the role of the AMPKα1 subunit in monocytes and macrophages, little is known about the α2 subunit. The aim of this study was to assess the consequences of AMPKα2 deletion on protein expression in monocytes/macrophages, as well as on atherogenesis. A proteomics approach was applied to bone marrow derived monocytes from wild-type mice versus mice specifically lacking AMPKα2 in myeloid cells (AMPKα2∆MC mice). This revealed differentially expressed proteins, including methyltransferases. Indeed, AMPKα2 deletion in macrophages increased the ratio of S-adenosyl methionine to S-adenosyl homocysteine and increased global DNA cytosine methylation. Also, methylation of the vascular endothelial growth factor and matrix metalloproteinase-9 (MMP9) genes was increased in macrophages from AMPKα2∆MC mice, and correlated with their decreased expression. To link these findings with an in vivo phenotype, AMPKα2∆MC mice were crossed onto the ApoE-/- background and fed a western diet. ApoExAMPKα2∆MC mice developed smaller atherosclerotic plaques than their ApoExα2fl/fl littermates, that contained fewer macrophages and less MMP9 than plaques from ApoExα2fl/fl littermates. These results indicate that the AMPKα2 subunit in myeloid cells influences DNA methylation and thus protein expression and contributes to the development of atherosclerotic plaques.
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3.
  • Magesacher, Thomas, et al. (författare)
  • On the Capacity of the Copper Cable Channel Using the Common Mode
  • 2002
  • Ingår i: IEEE Global Telecommunications Conference GLOBECOM '02.. - 0780376323 ; 2, s. 1269-1273
  • Konferensbidrag (refereegranskat)abstract
    • The common-mode (CM) signal in wireline transmission systems has proven to provide valuable information exploited for mitigating narrowband noise at the receive side. We focus on the case of broadband noise. Treating the CM signal as an additional receive signal, we investigate the capacity of the copper cable channel for different levels of coordination among the users. We introduce a channel model which includes the common-mode paths and derive a suitable form of the channel capacity formula. CM crosstalk measurement results, essential for evaluation of the channel capacity, are presented. Using the measurement data, exemplary results of capacity gain achievable by CM-aided data transmission over the copper cable are shown.
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