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| 2. |
- Carlini, V. P., et al.
(författare)
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Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats
- 2011
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Ingår i: Neuroscience. - : Elsevier BV. - 0306-4522 .- 1873-7544. ; 197, s. 145-152
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Tidskriftsartikel (refereegranskat)abstract
- A 13-amino acid peptide named neuronostatin (NST) encoded in the somatostatin pro-hormone has been recently reported. It is produced throughout the body, particularly in brain areas that have significant actions over the metabolic and autonomic regulation. The present study was performed in order to elucidate the functional role of NST on memory, anxiety-like behavior and food intake and the hippocampal participation in these effects. When the peptide was intra-hippocampally administered at 3.0 nmol/mu l, it impaired memory retention in both, object recognition and step-down test. Also, this dose blocked the hippocampal long-term potentiation (LTP) generation. When NST was intra-hippocampally administered at 0.3 nmol/mu l and 3.0 nmol/mu l, anxiolytic effects were observed. Also, the administration in the third ventricle at the higher dose (3.0 nmol/mu l) induced similar effects, and both doses reduced food intake. The main result of the present study is the relevance of the hippocampal formation in the behavioral effects induced by NST, and these effects could be associated to a reduced hippocampal synaptic plasticity.
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| 3. |
- Söder, Lennart, 1956-, et al.
(författare)
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Review of wind generation within adequacy calculations and capacity markets for different power systems
- 2020
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Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1364-0321. ; 119
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Tidskriftsartikel (refereegranskat)abstract
- The integration of renewable energy sources, including wind power, in the adequacy assessment of electricity generation capacity becomes increasingly important as renewable energy generation increases in volume and replaces conventional power plants. The contribution of wind power to cover the electricity demand is less certain than conventional power sources; therefore, the capacity value of wind power is smaller than that of conventional plants.This article presents an overview of the adequacy challenge, how wind power is handled in the regulation of capacity adequacy, and how wind power is treated in a selection of jurisdictions. The jurisdictions included in the overview are Sweden, Great Britain, France, Ireland, United States (PJM and ERCOT), Finland, Portugal, Spain, Norway, Denmark, Belgium, Germany, Italy and the Netherlands.
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| 4. |
- Carlini, V P, et al.
(författare)
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Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration
- 2008
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Ingår i: Neuroscience. - : Elsevier BV. - 0306-4522 .- 1873-7544. ; 153:4, s. 929-34
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Tidskriftsartikel (refereegranskat)abstract
- It has been demonstrated, in normal and aged rats and mice, that acute i.c.v. ghrelin (Ghr) administration increases memory retention. In order to evaluate if this treatment, restores memory retention in animals exhibiting impaired memory, in the present work we selected a chronic food restriction mouse model (since undernutrition prejudices higher nervous functions). We employed adult female mice with 28 days of 50% food restriction and evaluated: a) behavioral performance using novel object recognition test for memory, and plus maze for anxiety-like behavior, b) some morphometric parameters as body and hepatic weights and c) plasma Ghr levels. The animals with 50% food restriction showed an increase in plasma Ghr levels and a decrease in morphometric parameters and in the percentage of novel object recognition time. When the peptide was i.c.v. injected in food-restricted animals (0.03, 0.3 or 3.0 nmol/microl), memory increases in relation to food-restricted mice injected with vehicle, reaching a performance similar to controls.
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| 5. |
- Bilandi, R. N., et al.
(författare)
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A numerical and analytical way for double-stepped planing hull in regular wave
- 2019
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Ingår i: 8th International Conference on Computational Methods in Marine Engineering, MARINE 2019. - : International Center for Numerical Methods in Engineering. ; , s. 417-427
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Konferensbidrag (refereegranskat)abstract
- The paper presents a comparison analysis between numerical method and nonlinear mathematical model for the prediction of the vertical motions of a double stepped planing hull in regular wave. The numerical method is to Unsteady Reynolds Averaged Navier-Stokes (URANS) equations solution via moving mesh techniques (overset/chimera), performed at different model speeds, wavelengths, and wave heights using the commercial software Siemens PLM Star-CCM+. Instead, the analytical solution is obtained using nonlinear mathematical model. The presented non-linear mathematical model is developed using a combined approach based on 2D+T theory, momentum theory, and linear wake profile. Under such assumption, the double stepped planing hull is divided into three planing surfaces, and hydrodynamic forces acting on each planing surface is found by extension of simulation of symmetric water entry of two-dimensional wedge section bodies. Then, each sub-problem is solved by extending the mathematical simulation of wedge penetrating water. Final vertical force and pitching moment are found and substituted in motion equation. The mathematical model is able to compute heave and pitch motion in calm water and regular waves. Results of numerical method and novel 2D+T analytical method are compared against each other.
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| 6. |
- Di Caterino, F., et al.
(författare)
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A numerical way for a stepped planing hull design and optimization
- 2018
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Ingår i: Technology and Science for the Ships of the Future - Proceedings of NAV 2018. - : IOS Press. ; , s. 220-229
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Konferensbidrag (refereegranskat)abstract
- Stepped planing hulls enable the feasibility of running at a relatively low drag-lift ratio by means of achieving more optimal trim angle at high speeds than a similar non-stepped hull. Furthermore, stepped planing hulls ensure good dynamic stability and seakeeping qualities at high speeds. However, there is no precise method to analyze these hulls over the full range of operating speeds. For the above-mentioned reason, in this study, a CFD-based design was presented, starting from a non-stepped hull configuration, a multiple step solution was developed and an optimization of the unwetted aft body area behind the steps was performed. The goal of the optimization is the drag reduction and a dynamic stability. The CFD results were compared with the well-known empirical approach and a novel 2D+T analytical method.
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| 7. |
- Ghersi, Marisa Soledad, et al.
(författare)
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Ghrelin inhibited serotonin release from hippocampal slices
- 2011
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Ingår i: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 32:11, s. 2367-2371
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Tidskriftsartikel (refereegranskat)abstract
- Ghrelin (Ghr) is a peptide produced peripherally and centrally. It participates in the modulation of different biological processes. In our laboratory we have shown that (a) Ghr administration, either intracerebroventricular or directly into the hippocampus enhanced memory consolidation in a step down test in rats (b) the effect of Ghr upon memory decreases in animals pretreated with a serotonin (5-HT) reuptake inhibitor, Fluoxetine, suggesting that Ghr effects in the hippocampus could be related to the availability of 5-HT. It has been demonstrated that Ghr inhibits 5-HT release from rat hypothalamic synaptosomes. Taking in mint these evidences, we studied the release of radioactive 5-HT to the superfusion medium from hippocampal slices treated with two doses of Ghr (0.3 and 3 nm/mu l). Ghr inhibited significantly the 5-HT release in relation to those superfused with artificial cerebrospinal fluid (ACSF) (H = 9.48, df = 2, p <= 0.05). In another set of experiments. Ghr was infused into the CA1 area of hippocampus of the rats immediately after training in the step down test and the 5-HT release from slices was studied 24 h after Ghr injection showing that in this condition also the 5-HT release was inhibited (H = 11.72, df = 1, p < 0.05). In conclusion, results provide additional evidence about the neurobiological bases of Ghr action in hippocampus.
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