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Search: WFRF:(de Witte T)

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  • Bellenguez, C, et al. (author)
  • New insights into the genetic etiology of Alzheimer's disease and related dementias
  • 2022
  • In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
  • Journal article (peer-reviewed)abstract
    • Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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  • Edgecock, T. R., et al. (author)
  • High intensity neutrino oscillation facilities in Europe
  • 2013
  • In: Physical Review Special Topics - Accelerators and Beams. - : American Physical Society. - 1098-4402. ; 16:2, s. 021002-
  • Journal article (peer-reviewed)abstract
    • The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Frejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of mu(+) and mu(-) beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He-6 and Ne-18, also stored in a ring. The far detector is also the MEMPHYS detector in the Frejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.
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  • Result 1-10 of 178
Type of publication
journal article (129)
conference paper (49)
Type of content
peer-reviewed (124)
other academic/artistic (54)
Author/Editor
de Witte, T (83)
Hellstrom-Lindberg, ... (40)
Bowen, D (35)
Fenaux, P (34)
Symeonidis, A (34)
Cermak, J (34)
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Smith, A (33)
Germing, U (33)
Niederwieser, D (32)
Malcovati, L (31)
Stauder, R (30)
De Witte, H (29)
Gahrton, G (28)
Warr, N. (27)
Iacobelli, S (27)
Sanz, G (26)
Morris, C (21)
Reiter, P. (21)
Tatic, A (21)
van Biezen, A (20)
Seidlitz, M. (19)
Madry, K (19)
Kroger, N (18)
Gaffney, L. P. (18)
Garderet, L (18)
Holm, MS (18)
Pakarinen, J. (17)
de Swart, L (17)
Droste, J (16)
Savic, A. (16)
Langemeijer, S (16)
Mittelman, M (16)
Volin, L (15)
Wenander, F. (15)
Zielinska, M (14)
Ljungman, P (14)
van Marrewijk, C (14)
Konki, J. (13)
Hess, H. (13)
Van Duppen, P. (13)
Wrzosek-Lipska, K (13)
Huyse, M. (12)
Scheck, M. (12)
Gratwohl, A (12)
Voulot, D. (12)
Siebeck, B. (12)
Blazhev, A. (11)
Michallet, M (11)
Milone, G (11)
Rosiak, D. (11)
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University
Karolinska Institutet (126)
Lund University (43)
Uppsala University (21)
Umeå University (8)
Chalmers University of Technology (8)
University of Gothenburg (7)
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Royal Institute of Technology (4)
Stockholm University (3)
Linköping University (1)
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Language
English (177)
German (1)
Research subject (UKÄ/SCB)
Natural sciences (37)
Medical and Health Sciences (33)
Engineering and Technology (2)
Humanities (1)

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