| 1. |
- Nonnecke, E. B., et al.
(författare)
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Human intelectin-1 (ITLN1) genetic variation and intestinal expression
- 2021
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also known as omentin) with susceptibility to Crohn's disease (CD); however, analysis of possible functional significance of SNPs at this locus is lacking. Using the Ensembl database, pairwise linkage disequilibrium (LD) analyses indicated that several disease-associated SNPs at the ITLN1 locus, including SNPs in CD244 and Ly9, were in LD. The alleles comprising the risk haplotype are the major alleles in European (67%), but minor alleles in African superpopulations. Neither ITLN1 mRNA nor protein abundance in intestinal tissue, which we confirm as goblet-cell derived, was altered in the CD samples overall nor when samples were analyzed according to genotype. Moreover, the missense variant V109D does not influence ITLN1 glycan binding to the glycan beta -D-galactofuranose or protein-protein oligomerization. Taken together, our data are an important step in defining the role(s) of the CD-risk haplotype by determining that risk is unlikely to be due to changes in ITLN1 carbohydrate recognition, protein oligomerization, or expression levels in intestinal mucosa. Our findings suggest that the relationship between the genomic data and disease arises from changes in CD244 or Ly9 biology, differences in ITLN1 expression in other tissues, or an alteration in ITLN1 interaction with other proteins.
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| 2. |
- De La Motte, L., et al.
(författare)
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Is EVAR a durable solution? Indications for reinterventions
- 2018
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Ingår i: Journal of Cardiovascular Surgery. - 0021-9509. ; 59:2, s. 201-212
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCION: Indications for reinterventions after endovascular aneurysm repair (EVAR), as well as their occurrence in number and time, are important to establish in order to optimize patient selection, postprocedure surveillance and also to guide improvements in endograft designs. The aim of this report was to present an overview of current data on reinterventions after elective EVAR. EVIDENCE ACQUISITION: Qualitative review of studies reporting on reinterventions after elective EVAR, identified by a systematic literature search in MEDLINE, EMBASEand the Cochrane Library for publications from 2010 to 13th of November 2017. EVIDENCESYNTHESIS: Twenty-Three studies reporting on 83,307 patients met the inclusion criteria. Index procedures were performed between 1996-2014. There was wide heterogeneity in reporting standards. Type Iendoleaks were reported in 0.6%-13% and type IIIendoleaks in 0.9-2.1% with a significant improvement for newer devices. Migration rates varied between 0-4%. Endoleak type II was the most common indication for re-intervention ranging from 14-25.3% although the majority resolved without intervention. Rupture rates ranged from 0-5.4% and carried a high mortality (60-67%). Ruptures occurred at any time after the index procedure. Limb ischemia rates were reported at 0.4-11.9% with re-intervention rates between 0.06-11.9%. Wound related complications and related re-interventions were the indication in 0.5-14% and 0.3-6.5%, respectively. Endograft infection carried a high risk of mortality and was described in 0.3-3.6%, often related to graft-enteric fistula and the majority had an open explantation of the endograft. CONCLUSIONS: This review showed that the rates of complications and techniques for reintervention developed over time with a tendency towards better outcomes considering the aneurysm related indications. Significant factors that led to subsequent secondary interventions were migration, rupture, infections and type Iand IIendoleaks. Patients treated with earlier generation endografts are still alive and need continued surveillance to detect these severe complications before they lead to rupture. © 2018 Edizioni Minerva Medica.
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| 3. |
- de la Motte, L, et al.
(författare)
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Effect of preoperative radiotherapy for rectal cancer on spermatogenesis
- 2021
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Ingår i: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 108:7, s. 750-753
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Tidskriftsartikel (refereegranskat)abstract
- In this study, preoperative radiotherapy for rectal cancer was found to result in a dose-dependent impairment of spermatogenesis and Sertoli cell function, reflected both by decreased sperm count and characteristic changes in hormonal response, with signs of partial recovery between 12 and 24 months after surgery. Decreased semen volume was also observed, indicating ejaculatory tract dysfunction, that seemed to be longer-lasting and not related to testicular dose. This threatens fertility in men treated for rectal cancer, and suggests that pretreatment cryopreservation and anticonception after treatment should be discussed individually.
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| 4. |
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| 5. |
- De La Motte, S. A., et al.
(författare)
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Measurements of SU(3) f symmetry breaking in B meson decay constants
- 2022
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- We present updates from QCDSF/UKQCD/CSSM on the SU(3) f breaking in B meson decay constants. The b-quarks are generated with an anisotropic clover-improved action, and are tuned to match properties of the physical B and B∗ mesons. Configurations are generated with m = 1/3(2ml + ms) kept constant to control symmetry breaking effects. Various sources of systematic uncertainty will be discussed, including those from continuum extrapolations and extrapolations to the physical point. We also present new efforts to calculate fB and fBs using weighted averages across multiple time fitting regions. The use of an automated weighted averaging technique over multiple fitting ranges allows for timely tuning of the b-quark and reduces the impact of systematic errors from fitting range biases in calculations of fB and fBs.
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