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| 2. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 3. |
- Dumoulin, Mireille, et al.
(författare)
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A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
- 2003
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 424:6950, s. 783-8
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidogenic variant, D67H. Our structural studies reveal that the epitope includes neither the site of mutation nor most residues in the region of the protein structure that is destabilized by the mutation. Instead, the binding of the antibody fragment achieves its effect by restoring the structural cooperativity characteristic of the wild-type protein. This appears to occur at least in part through the transmission of long-range conformational effects to the interface between the two structural domains of the protein. Thus, reducing the ability of an amyloidogenic protein to form partly unfolded species can be an effective method of preventing its aggregation, suggesting approaches to the rational design of therapeutic agents directed against protein deposition diseases.
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| 5. |
- Mohammed, Abbas, et al.
(författare)
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Application of Novel Signal Processing Algorithms for the Detection and Minimization of Skywave Interfering Signals in Loran Receivers
- 2011
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Ingår i: Applied Signal and Image Processing. - Hershey : IGI Global. - 9781609604776 ; , s. 28-44
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Bokkapitel (refereegranskat)abstract
- Skywave interference commonly affects Loran receivers’ performance. Traditional skywave rejectionmethods that use fixed, worst-case, sample timing are far from optimal. This chapter reports on novel signal processing techniques for measuring in real-time the delay and strength of the varying skywave components of a Loran signal relative to the groundwave pulse. The merits and limitations of these techniques will be discussed. Their effectiveness will be assessed by theoretical analysis, computer simulations under a range of realistic conditions, and by testing using off-air signals. A prototype Loran system employing the proposed techniques is also presented. This work establishes a basis on which to design a Loran receiver capable of adjusting its sampling point adaptively to the optimal value in a constantly-changing skywave environment. Such receivers promise to improve significantly the accuracy and reliability of positioning under adverse operational conditions.
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| 8. |
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| 9. |
- Mohammed, Abbas, et al.
(författare)
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High Resolution Techniques for Loran-C Skywave Delay Estimation
- 1999
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Ingår i: Electronics Letters. - 0013-5194 .- 1350-911X. ; 35:18, s. 1516-1517
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Tidskriftsartikel (refereegranskat)abstract
- Two high-resolution estimation techniques are applied to the problem of estimating the delays of the skywave components of signals input to Loran-C receivers. Their performance is evaluated and compared with that of a Fourier-based spectral-division technique. Simulation results show that the high-resolution algorithms improve the accuracy of the estimates significantly and estimate the skywave delay successfully in situations in which the Fourier-based method fails.
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| 10. |
- Mohammed, Abbas, et al.
(författare)
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IFFT Technique for Skywave Detection in Loran-C Receivers
- 2001
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Ingår i: Electronics Letters. - 0013-5194 .- 1350-911X. ; 37:6, s. 398-400
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Tidskriftsartikel (refereegranskat)abstract
- An inverse fast Fourier transform (IFFT) technique is presented for isolating groundwave are and skyware components of Loran-C signals in receivers under conditions of very low signal-to-noise ratio. It includes the first example of the measurement of the skywave delays of off-air signals made using this method.
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