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- Rosén von Rosenstein, Nils, 1706-1773
(författare)
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Theses medicæ, speciminis inauguralis loco, quas, ... præside rectore magnifico, ... Nicolao Rosén, S:æ R:æ M:tis archiatro, pro licentia, summos in medicina obtinendi honores, publico examini submittit S:æ R:æ M:tis stipendiarius, Johannes Bergstral, Christinæhafnia Vermelandus. In Auditoria Carolino Majori die XXVIII. Octob. MDCCXLVII. Horis ante et post meridiem solitis.
- 1747
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
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- Jansen, Willemijn J, et al.
(författare)
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- 2022
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 79:3, s. 228-243
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Tidskriftsartikel (refereegranskat)abstract
- One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
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- Amiri, Saeid, et al.
(författare)
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A statistical study of similarities and dissimilarities in results between districts used in Swedish crop variety trials
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The annual results of Swedish crop variety trials are presented in reports and on the internet for Sweden divided into seven regions (production areas) A-G covering southern Sweden. The yield results for test varieties are usually presented as ratios relative to the yield of a control variety. These ratios are presented per region, with the implicit assumption that differences in ratios may exist between regions. In this report, the division of agricultural districts into regions was investigated through cluster analyses. Districts that produced similar levels of yield or similar ratios were clustered into groups of similar districts. Cluster analyses were performed on regions, districts and soil types for spring barley, winter wheat and oats, based on a large data set of results from variety trials performed during the period 1997-2006. The study revealed that some regions, districts and soil types produce similar levels of yield or similar yield ratios. However, clusters of regions, districts or soil types that produce similar levels of yield do not always produce similar yield ratios
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- Forkman, Johannes, et al.
(författare)
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Effect of region on the uncertainty in crop variety trial programs with a reduced number of trials
- 2012
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Ingår i: Euphytica. - : Springer Science and Business Media LLC. - 0014-2336 .- 1573-5060. ; 186, s. 489-500
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Tidskriftsartikel (refereegranskat)abstract
- Results from crop variety trials may vary between geographical regions because of differences in climate and soil types. Results are usually presented at regional level. To evaluate the importance of the regions used in the Swedish variety trial programs, we examined which regions produced similar levels of yield and similar ratios in yield between cultivars; the amount by which variance could be reduced by division into regions or clusters of regions; and the amount of trials per region and year, replicates per trial, and trials per year required in order to fulfill specifications on the precision of results. Yield data from spring barley and winter wheat trials performed during 1997-2006 were studied using cluster analysis and variance component estimation. The objectives were (1) to discuss the effects of regions on precision when the number of trials has decreased; (2) to demonstrate the method; and (3) to report the results obtained. In spring barley, clusters of regions produced different levels of yield, but similar yield ratios between cultivars. In winter wheat, clusters of regions giving different yield ratios were identified. When the option of a single analysis was compared with that of region-wise analysis, the reduction in variance with the former, due to the larger number of trials, outweighed the reduction in variance with the latter due to decreased random interaction between trials and cultivars.
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- Forkman, Johannes, et al.
(författare)
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Konsekvenser av indelningar i områden för redovisning av försök i svensk sortprovning
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten jämförs alternativa regionala och jordartsbaserade indelningar av södra Sverige för redovisning av resultat från sortprovningen. Undersökningen görs för vårkorn, höstvete och havre. Rapporten diskuterar också hur många försök som behövs per år och region för att nå tillräcklig precision i resultaten. De slumpmässiga variationerna vid olika indelningar jämförs. Det visar sig att indelningar i regioner minskar variationskoefficienten med 0,15 procent¬enheter i vårkorn, 1,0 procentenheter i höstvete och 0,5 procentenheter i havre. Eftersom dessa tal inte är större, och eftersom det behövs ett stort antal försök per region för att ge nödvändig säkerhet i resultaten rekommenderas att inga regionindelningar görs. Av samma skäl rekommenderas inte heller jordartsbaserade indelningar av försöken. För höstvete skulle dock tre storregioner kunna användas
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- Schneppenheim, Reinhard, et al.
(författare)
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A common origin of the 4143insA ADAMTS13 mutation
- 2006
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 96:1, s. 3-6
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Tidskriftsartikel (refereegranskat)abstract
- Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease,ADAMTS 13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS 13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP. The 4143insA mutation is unusual with respect to its geographic concentration. Following the initial report from Germany in which the 4143insA mutation was detected in four apparently unrelated families, we have now identified this mutation in a further eleven patients from Norway, Sweden, Poland, Germany, the Czech Republic and Australia. Confirmation that the Australian patient is of German ancestry, together with the Northern and Central European origin of most of the other patients, suggests that the 4143insA mutation has a common genetic background.We established ADAMTS 13 haplotypes by analyzing 17 polymorphic intragenic markers.The haplotypes linked to 4143insA were identical in all informative families. Three novel candidate mutations, C347S, P67IL and RI060W, as well as the known mutation R507Q, were also identified during the course of the study.We conclude that 4143insA has a common genetic background and is frequent among patients with hereditary ADAMTS 13 deficiency in Northern and Central European countries.
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