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| 2. |
- Andersson, Martin, et al.
(författare)
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Dose management in conventional nuclear medicine imaging and PET
- 2016
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Ingår i: Clinical and Translational Imaging. - : Springer Science and Business Media LLC. - 2281-5872 .- 2281-7565. ; 4:1, s. 21-30
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Forskningsöversikt (refereegranskat)abstract
- This review of the basic concepts of dose management in conventional nuclear medicine imaging and positron emission tomography focuses on methods for dose assessment, difficulties with image quality evaluation, need for clear image quality criteria and observer performance studies, studies on representative groups of patients contra individual patients, clinically applicable methods for dose reduction, including the use of diagnostic reference levels. The dose management in nuclear imaging requires more attention and there is a need for better contribution of new technology for individual patient dose management as well as for education and training of the multidisciplinary teams of nuclear medicine physicians, technologists and medical physicists, responsible for the investigations.
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| 3. |
- Bäck, Anna-Karin, 1971-, et al.
(författare)
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Timing of diuretics in diuresis renography
- 2022
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Ingår i: Clinical and translational imaging. - : Springer. - 2281-5872 .- 2281-7565. ; 10, s. 37-43
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Forskningsöversikt (refereegranskat)abstract
- Purpose: The aim of this systematic literature review was to obtain an overview of when to administer the diuretics in relation to the radiopharmaceutical during a diuresis renography.Methods: A systematic literature search was performed in three different databases (Embase, PubMed/Medline and Cochrane Library) together with an information specialist. The review question was: when should diuretics be administered in relation to the radiopharmaceutical in a diuresis renography? Studies of adults were included together with guidelines published in collaboration with an organization.Results: Seventeen articles and four guidelines were retrieved in the literature search. The F - 15 method (diuretics administered 15 min before the radiopharmaceutical) was the one that was studied and described most and was compared with other time points for diuretic administration. The retrieved articles and guidelines report of advantages with different time points for diuretics. Both F - 15 and F + 0 are reported to clarify washout in equivocal cases compared to F + 20.Conclusion: No consensus could be found for a preferred time point of diuretics administration during a diuresis renography.
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| 7. |
- Schou, M, et al.
(författare)
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PET microdosing of CNS drugs
- 2017
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Ingår i: CLINICAL AND TRANSLATIONAL IMAGING. - : Springer Science and Business Media LLC. - 2281-5872 .- 2281-7565. ; 5:3, s. 291-298
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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| 9. |
- van der Doef, Thalia F., et al.
(författare)
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Assessing brain immune activation in psychiatric disorders : clinical and preclinical PET imaging studies of the 18-kDa translocator protein
- 2015
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Ingår i: CLINICAL AND TRANSLATIONAL IMAGING. - : Springer Nature. - 2281-5872 .- 2281-7565. ; 3:6, s. 449-460
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Forskningsöversikt (refereegranskat)abstract
- Accumulating evidence from different lines of research suggests an involvement of the immune system in the pathophysiology of several psychiatric disorders. During recent years, a series of positron emission tomography (PET) studies have been published using radioligands for the translocator protein (TSPO) to study microglia activation in schizophrenia, bipolar I disorder, major depression, autism spectrum disorder, and drug abuse. The results have been somewhat conflicting, which could be due to differences both in patient sample characteristics and in PET methods. In particular, further work is needed to address both methodological and biological sources of variability in TSPO levels, a process in which the use of animal models and small animal PET systems can be a valuable tool. Given this development, PET studies of immune activation have the potential to further increase our understanding of disease mechanisms in psychiatric disorders, which is a requisite in the search for new treatment approaches. Furthermore, molecular imaging could become an important clinical tool for identifying specific subgroups of patients or disease stages that would benefit from treatment targeting the immune system.
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| 10. |
- Wade, Ryckie G., et al.
(författare)
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Diffusion tensor imaging of the roots of the brachial plexus : a systematic review and meta-analysis of normative values
- 2020
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Ingår i: Clinical and Transational Imaging. - : Springer. - 2281-5872 .- 2281-7565. ; 8, s. 419-431
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Diffusion tensor magnetic resonance imaging (DTI) characterises tissue microstructure and provides proxy measures of myelination, axon diameter, fibre density and organisation. This may be valuable in the assessment of the roots of the brachial plexus in health and disease. Therefore, there is a need to define the normal DTI values.Methods: The literature was systematically searched for studies of asymptomatic adults who underwent DTI of the brachial plexus. Participant characteristics, scanning protocols, and measurements of the fractional anisotropy (FA) and mean diffusivity (MD) of each spinal root were extracted by two independent review authors. Generalised linear modelling was used to estimate the effect of experimental conditions on the FA and MD. Meta-analysis of root-level estimates was performed using Cohen’s method with random effects.Results: Nine articles, describing 316 adults (1:1 male:female) of mean age 35 years (SD 6) were included. Increments of ten diffusion sensitising gradient directions reduced the mean FA by 0.01 (95% CI 0.01, 0.03). Each year of life reduced the mean MD by 0.03 × 10–3 mm2/s (95% CI 0.01, 0.04). At 3-T, the pooled mean FA of the roots was 0.36 (95% CI 0.34, 0.38; I2 98%). The pooled mean MD of the roots was 1.51 × 10–3 mm2/s (95% CI 1.45, 1.56; I2 99%).Conclusions: The FA and MD of the roots of the brachial plexus vary according to experimental conditions and participant factors. We provide summary estimates of the normative values in different conditions which may be valuable to researchers and clinicians alike.
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| 11. |
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| 12. |
- Yang, CT, et al.
(författare)
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PET probes for imaging pancreatic islet cells
- 2017
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Ingår i: CLINICAL AND TRANSLATIONAL IMAGING. - : Springer Science and Business Media LLC. - 2281-5872 .- 2281-7565. ; 5:6, s. 507-523
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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