| 1. |
- Diaz, Sandra, et al.
(författare)
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Hyperpolarized (3)He apparent diffusion coefficient MRI of the lung: Reproducibility and volume dependency in healthy volunteers and patients with emphysema.
- 2008
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Ingår i: Journal of Magnetic Resonance Imaging. - : Wiley. - 1522-2586 .- 1053-1807. ; 27, s. 763-770
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) (3)He gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and examine the reproducibility and volume dependency. MATERIALS AND METHODS: A total of eight healthy volunteers and 16 patients with emphysema were examined after inhalation of HP (3)He gas mixed with nitrogen (N(2)) during breathhold starting from functional residual capacity (FRC) in supine position. Coronal diffusion-sensitized MR images were acquired. Each subject was imaged on three separate days over a seven-day period and received two different volumes (6% and 15% of total lung capacity [TLC]) of HP (3)He each day. ADC maps and histograms were calculated. The mean and standard deviation (SD) of the ADC at different days and volumes were compared. RESULTS: The reproducibility of the mean ADC and SD over several days was good in both healthy volunteers and patients (SD range of 0.003-0.013 cm(2)/second and 0.001-0.009 cm(2)/second at 6% and 15% of TLC for healthy volunteers, and a SD range of 0.001-0.041 cm(2)/second and 0.001-0.011 cm(2)/second, respectively, for patients). A minor but significant increase in mean ADC with increased inhaled gas volume was observed in both groups. CONCLUSION: Mean ADC and SD of HP (3)He MRI is reproducible and discriminates well between healthy controls and patients with emphysema at the higher gas volume. This method is robust and may be useful to gain new insights into the pathophysiology and course of emphysema. J. Magn. Reson. Imaging 2008. (c) 2008 Wiley-Liss, Inc.
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| 2. |
- Diaz, Sandra, et al.
(författare)
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Validity of apparent diffusion coefficient hyperpolarized He-3-MRI using MSCT and pulmonary function tests as references
- 2009
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Ingår i: European Journal of Radiology. - : Elsevier BV. - 1872-7727 .- 0720-048X. ; 71:2, s. 257-263
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To compare apparent diffusion coefficient (ADC) measurements from hyperpolarized (HP) helium (He-3)-magnetic resonance imaging (MRI) with quantitative data from multislice Computed Tomography (CT) (MSCT) of the whole lungs and pulmonary function tests (PFT). Materials and methods: Twenty-seven subjects, 22 with established emphysema and 5 with preclinical emphysema defined by PFT criteria, were examined with Hp He-3-MRI and MSCT. Mean age was 55 (+/- 12) years, 18 female and 9 male. Mean ADC from He-3-MRI was compared with emphysema index (EI), 15th percentile and mean lung density (MLD) values from MSCT. Both mean ADC and MSCT data were compared to PFT, especially percent of predicted diffusing capacity of carbon monoxide (%predicted DLCO), using Pearson's correlation test. Results: Mean ADC and standard deviation values were 0.392 +/- 0.119 cm(2)/s for the established emphysema group and 0.216 +/- 0.046 for the pre-clinical emphysema group. MSCT values for the established emphysema group and pre-clinical emphysema group were: EI (%) 11 +/- 12 and 0.4 +/- 0.6, respectively; 15th percentile (Hounsfield Units (HU)), -956 +/- 25 and -933 +/- 13, respectively and MLD (HU) -877 +/- 20 and -863 +/- 15, respectively. Correlations between mean ADC and El and 15th percentile were both r=0.90 and for MLD r=0.59. There was higher correlation between mean ADC and %predicted DLCO (r=0.90) than between El and %predicted DLCO (r=0.76). Conclusion: Hp He-3-MRI correlates well with density measurements from MSCT and agrees better than MSCT with %predicted DLCO which is the PFT most related to emphysema. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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| 3. |
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| 4. |
- Beniczky, Sandor, et al.
(författare)
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Source localization of rhythmic ictal EEG activity: A study of diagnostic accuracy following STARD criteria
- 2013
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Ingår i: Epilepsia. - : Wiley. - 0013-9580. ; 54:10, s. 1743-1752
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Tidskriftsartikel (refereegranskat)abstract
- PurposeAlthough precise identification of the seizure-onset zone is an essential element of presurgical evaluation, source localization of ictal electroencephalography (EEG) signals has received little attention. The aim of our study was to estimate the accuracy of source localization of rhythmic ictal EEG activity using a distributed source model. MethodsSource localization of rhythmic ictal scalp EEG activity was performed in 42 consecutive cases fulfilling inclusion criteria. The study was designed according to recommendations for studies on diagnostic accuracy (STARD). The initial ictal EEG signals were selected using a standardized method, based on frequency analysis and voltage distribution of the ictal activity. A distributed source modellocal autoregressive average (LAURA)was used for the source localization. Sensitivity, specificity, and measurement of agreement (kappa) were determined based on the reference standardthe consensus conclusion of the multidisciplinary epilepsy surgery team. Predictive values were calculated from the surgical outcome of the operated patients. To estimate the clinical value of the ictal source analysis, we compared the likelihood ratios of concordant and discordant results. Source localization was performed blinded to the clinical data, and before the surgical decision. Key FindingsReference standard was available for 33 patients. The ictal source localization had a sensitivity of 70% and a specificity of 76%. The mean measurement of agreement (kappa) was 0.61, corresponding to substantial agreement (95% confidence interval (CI) 0.38-0.84). Twenty patients underwent resective surgery. The positive predictive value (PPV) for seizure freedom was 92% and the negative predictive value (NPV) was 43%. The likelihood ratio was nine times higher for the concordant results, as compared with the discordant ones. SignificanceSource localization of rhythmic ictal activity using a distributed source model (LAURA) for the ictal EEG signals selected with a standardized method is feasible in clinical practice and has a good diagnostic accuracy. Our findings encourage clinical neurophysiologists assessing ictal EEGs to include this method in their armamentarium.
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| 5. |
- Diaz, Sandra, et al.
(författare)
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Progression of Emphysema in a 12-month Hyperpolarized (3)He-MRI Study Lacunarity Analysis Provided a More Sensitive Measure than Standard ADC Analysis(1).
- 2009
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Ingår i: Academic Radiology. - : Elsevier BV. - 1878-4046 .- 1076-6332. ; 16:6, s. 700-707
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE AND OBJECTIVES: Inhaled hyperpolarized (3)He magnetic resonance (MR) imaging has been used to measure alveolar size in patients with emphysema. The aim of this study was to test the hypothesis that (3)He MR images could be used to develop a biomarker of emphysema progression. MATERIALS AND METHODS: Twelve healthy controls and 18 patients with emphysema (eight current smokers, 10 ex-smokers) were imaged at baseline and 6 and 12 months. An additional nine subjects with alpha-1 antitrypsin deficiency (four with emphysema, six without symptoms) were also imaged at baseline and at 6 months. Each subject was imaged at two lung volumes: functional residual capacity (FRC) and FRC plus 15% of total lung capacity. Means and standard deviations of apparent diffusion coefficients (ADCs) were calculated from coronal images of the entire lung and correlated with pulmonary function test results. The lacunarity hypothesis was tested and calculated from the data using a range of 2x2 x 2 to 6x6 x 6 voxels, and the average was calculated. RESULTS: There was no change in the mean ADC at either lung volume in any subject over the 6- or 12-month period. FRC and residual volume increased over the 12 months, suggesting air trapping. The lacunarity of images collected at FRC increased at 6 and 12 months in smokers only (P=.063 and P=.023, respectively). CONCLUSIONS: The mean ADC calculated from MR images of the lungs with helium was not sufficiently sensitive to detect changes over a 12-month period. However, lacunarity captured more of the spatial information in the images and detected emphysema progress in the smokers.
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| 6. |
- Golman, Klaes, et al.
(författare)
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Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.
- 2008
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 59:5, s. 1005-1013
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Tidskriftsartikel (refereegranskat)abstract
- Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-(13)C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008. (c) 2008 Wiley-Liss, Inc.
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| 7. |
- Krite Svanberg, Emilie, et al.
(författare)
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Physiological influence of basic perturbations assessed by non-invasive optical techniques in humans
- 2011
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Ingår i: Applied Physiology, Nutrition and Metabolism. - : Canadian Science Publishing. - 1715-5320 .- 1715-5312. ; 36:6, s. 946-957
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Tidskriftsartikel (refereegranskat)abstract
- New non-invasive techniques enabling frequent or continuous assessments of various pathophysiological conditions might be used to improve in-hospital outcome by enabling earlier and more reliable bedside detection of medical deterioration. In this preclinical study, three modern non-invasive optical techniques, laser Doppler imaging (LDI), near-infrared spectroscopy (NIRS), and tissue viability imaging (TVI), were all evaluated with respect to the influence of basic physiological perturbations (including local changes in arm positioning, skin temperature, and regional blood flow conditions) on quasi simultaneously obtained values of skin perfusion, muscle tissue oxygenation (StO2), and skin blood volume, recorded in eighteen healthy volunteers. Skin perfusion measured by LDI responded prominently to changes in positioning of the arm, whereas muscle StO2 measured by NIRS did not change significantly. Total haemoglobin count (HbT) measured by NIRS and blood volume estimated by TVI both increased significantly on lowering of the limb. On local cooling, the perfusion and blood volume were both found to increase considerably, while StO2 and HbT did not change. Local heating induced a more than 10-fold increase in skin perfusion and a small increase in blood volume. On progressive venoarterial occlusion, the perfusion, StO2, HbT, and blood volume values decreased, after transient increases in HbT and blood volume before full arterial occlusion occurred, and all values approached the baseline level on release of the occlusion with a slight overshoot of the StO2. The results obtained have potential bearing on future utilization of these non-invasive techniques in the management of severely injured and (or) critically ill patients.
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| 8. |
- Steding Ehrenborg, Katarina, et al.
(författare)
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Left ventricular AV-plane displacement is preserved with lifelong endurance training and is the main determinant of maximal cardiac output.
- 2015
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Ingår i: Journal of Physiology. - 1469-7793. ; 593:23, s. 5157-5166
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Tidskriftsartikel (refereegranskat)abstract
- Age-related decline in cardiac function can be prevented or postponed by lifelong endurance training. However, effects of normal ageing as well as of lifelong endurance exercise on longitudinal and radial contribution to stroke volume are unknown. The aim of this study was to determine resting longitudinal and radial pumping in elderly athletes, sedentary elderly and young sedentary subjects. Furthermore, we aimed to investigate determinants of maximal cardiac output in elderly.
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| 9. |
- Tiderius, Carl Johan, et al.
(författare)
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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): intra- and interobserver variability in standardized drawing of regions of interest.
- 2004
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Ingår i: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 45:6, s. 628-634
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To establish the reproducibility of a standardized region of interest (ROI) drawing procedure in delayed gadolinium‐enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). Material and Methods: A large ROI in lateral and medial femoral weight‐bearing cartilage was drawn in images of 12 healthy male volunteers by 6 investigators with different skills in MRI. The procedure was done twice, with a 1‐week interval. Calculated T1‐values were evaluated for intra‐ and interobserver variability. Results: The mean interobserver variability for both compartments ranged between 1.3% and 2.3% for the 6 different investigators without correlation to their experience in MRI. Post‐contrast intra‐observer variability was low in both the lateral and the medial femoral cartilage, 2.6% and 1.5%, respectively. The larger variability in lateral than in medial cartilage was related to slightly longer and thinner ROIs. Conclusion: Intra‐observer variability and interobserver variability are both low when a large standardized ROI is used in dGEMRIC. The experience of the investigator does not affect the variability, which further supports a clinical applicability of the method.
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| 10. |
- Åkeson, Per, et al.
(författare)
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Brain lesion contrast in MR imaging. Dependence on field strength and concentration of gadodiamide injection in patients and phantoms
- 1997
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Ingår i: Acta Radiologica. - 1600-0455. ; 38:1, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To compare the contrast effects of gadodiamide injection at 0.3 and at 1.5 T, at different concentrations in phantoms, and to correlate the results to clinical doses used for examining brain lesions. MATERIAL AND METHODS: Gel phantoms with T1 and T2 corresponding to brain gray matter were doped with different concentrations of gadodiamide injection and examined with T1-weighted sequences. Two different sets of phantoms were used, one for 0.3 T and one for 1.5 T. To express contrast, a quotient (RATIOphantom) between signals in each tube with gadodiamide injection and in the one without it was calculated. A corresponding quotient (RATIOpatient) between signals in brain metastases and in gray matter was calculated in 16 patients examined at 0.3 T (0.1 and 0.3 mmol Gd/kg b.w.) and in 5 patients examined at 1.5 T (0.1 mmol Gd/kg b.w.). RESULTS: Maximum RATIOphantom and RATIOpatient were more than 50% higher at 1.5 T than at 0.3 T at equal concentrations using heavily T1-weighted sequences. The use of SE TR/TE 600/30 instead of 400/25 reduced the contrast effect 15-45% depending on concentration. Comparing RATIOpatient to RATIOphantom suggests that the maximum T1 effect of Gd contrast media occurs at higher doses than in current clinical use, as at 0.1 mmol/kg b.w. we achieved 38% (0.3 T) and 56% (1.5 T) of the maximum phantoms. At 0.3 mmol/kg b.w. we achieved 63% (0.3 T) of the theoretical maximum. CONCLUSION: The contrast effect of Gd contrast media is higher at 1.5 T than at 0.3 T. Higher doses than presently used might prove useful especially at lower field strengths where the contrast effect of Gd is less pronounced. Heavy T1-weighting is also important.
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| 11. |
- Åkeson, Per, et al.
(författare)
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Brain metastases--comparison of gadodiamide injection-enhanced MR imaging at standard and high dose, contrast-enhanced CT and non-contrast-enhanced MR imaging
- 1995
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Ingår i: Acta Radiologica. - 1600-0455. ; 36:3, s. 300-306
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to compare the abilities of contrast-enhanced CT, non-contrast-enhanced MR imaging and contrast-enhanced MR imaging using standard (0.1 mmol/kg b.w.) and high (0.3 mmol/kg b.w.) doses of Gadodiamide injection to detect brain metastases (i.e. blood-brain barrier damage). Sixteen patients with at least 2 metastases found by CT were evaluated by MR imaging using non-contrast-enhanced spin-echo, T1-weighted, T2-weighted sequences, and contrast-enhanced spin-echo T1-weighted sequences at 2 dose levels. Gadodiamide injection was first given at the dose of 0.1 mmol/kg b.w. After imaging, another 0.2 mmol/kg b.w. was given, yielding a cumulative dose of 0.3 mmol/kg b.w. No contrast media-related adverse events were recorded. The images were evaluated openly by one and blindly by 2 investigators and the number of metastases, size, delineation (open study) and diagnostic certainty (blind study) of each individual metastasis noted. High-dose MR imaging showed significantly more and smaller metastases than any other examination, and gave a higher diagnostic certainty. All high-dose images were superior to those with the standard dose MR imaging when compared blindly in pairs. We conclude that spin-echo MR imaging with a high dose of Gadodiamide injection is an efficient way to improve the detection of brain metastases, in particular of small ones.
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| 12. |
- Åkeson, Per, et al.
(författare)
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Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA
- 1995
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Ingår i: Neuroradiology. - 1432-1920. ; 37:3, s. 229-233
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Tidskriftsartikel (refereegranskat)abstract
- Gadodiamide injection, a new nonionic, MRI contrast medium, was compared with the ionic agent gadolinium (Gd)-DTPA at 0.1 mmol/kg body weight in a double-blind, randomised trial in 60 patients, 30 receiving each substance, with known or suspected lesions of the central nervous system. The patients were closely questioned about adverse events. In the Gadodiamide injection group, four patients reported six adverse advents, three of which were judged to be related to the contrast medium. In the Gd-DTPA group, two patients each reported one adverse event, both of which had an uncertain relation to the contrast medium. All events were mild and no medical treatment was needed. No significant change in neurological findings, blood pressure, pulse rate or blood parameters were noted in any patient. Both contrast media were effective; no difference in overall efficacy or safety was observed.
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| 13. |
- Åkeson, Per
(författare)
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Gadodiamide injection for Enhancement of MRI in the CNS. Applications, dose, field and time dependence.
- 1996
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aims of the study The aims of this study using Gadodiamide injection were to investigate: · Whether Gadodiamide injection was comparable to Gd-DTPA for the enhancement of CNS lesions. · The contrast effect at different field strengths. · The effective time-window for the enhancement of blood-brain barrier damage. · The relations between the concentration of contrast agent and enhancement in phantoms, and to correlate the results to doses given to patients. · The use of a higher dose in two important clinical problems; the detection of metastases in the brain, and the evaluation of patients with failed back surgery syndrome (patients with recurrent pain after surgery for lumbar disc herniation). Results and conclusions · Gadodiamide injection was comparable to Gd-DTPA with regard to both safety and diagnostic efficacy in the CNS. · The contrast effect of Gadolinium contrast agents is higher at 1.5 T than at 0.3 T both in phantoms and patients with a maximum ratio (signal lesion / signal grey matter) more than 50% higher at 1.5T. · To achieve high contrast effect, heavily T1-weighted images are also important at both field strengths, as prolonging the repetition time from 400 ms to 600 ms reduced the ratio by 15-45% depending on concentration. · The effective time-window for imaging of blood-brain barrier damage is between 2-5 and 25-30 minutes after injection and several scans can be performed without loss of enhancement. · To provide maximum detectability of blood-brain-barrier-damage in patients with brain lesions, higher doses of Gd contrast media should be useful, as the doses used clinically today do not utilize the maximum contrast effect, either at high or low field strength. However, higher doses are more important at low field strengths because the contrast effect is lower than at high field strengths. · High-dose (0.3 mmol/kg b.w.) contrast-enhanced T1-weighted spin-echo MRI with Gadodiamide injection allowed detection of significantly (p<<0.01) more and smaller metastases than standard-dose (0.1 mmol/kg b.w.) MRI at 0.3 T. High-dose contrast-enhanced MRI with Gadodiamide injection is an efficient way to improve the detection of brain metastases. This should also be true for blood-brain barrier disruptions of other causes. · High-dose (0.3 mmol/kg b.w.) contrast-enhanced T1-weighted spin-echo MRI at 0.3T did not increase the diagnostic information in patients with recurrent pain after surgery for lumbar disc herniation compared to standard-dose (0.1 mmol/kg b.w.) MRI. The high dose images were considered more informative than the standard dose images when compared in pairs but gave no additional or different diagnostic information when evaluated separately.
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| 14. |
- Åkeson, Per, et al.
(författare)
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Radiological investigation of neurofibromatosis type 2
- 1994
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Ingår i: Neuroradiology. - 1432-1920. ; 36:2, s. 107-110
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Tidskriftsartikel (refereegranskat)abstract
- The radiological findings in six patients fulfilling the criteria of neurofibromatosis type 2 (NF2) were reviewed. Subtle cutaneous lesions were found in three. All patients had bilateral acoustic schwannomas; two had small acoustic tumours and normal hearing. In these patients the presenting symptoms were caused by multiple intracranial meningiomas and spinal neurofibromas, respectively, whereas the remaining four patients presented with hearing loss. Two patients had other cranial nerve tumours. Three patients had rapidly growing multiple intracranial meningiomas; two had multiple spinal neurofibromas and one a spinal meningioma. NF2 is a rare disease with few cutaneous but frequent, typical radiological findings in the central nervous system. The presenting symptom is most commonly hearing loss due to acoustic schwannomas, although symptoms emanating from other intracranial or tumours are not uncommon. The discovery of multiple meningiomas or multiple spinal neurofibromas without cutaneous lesions should initiate a search for acoustic schwannomas even when the patient has normal hearing.
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| 15. |
- Åkeson, Per, et al.
(författare)
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Time-dependency in brain lesion enhancement with gadodiamide injection
- 1997
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Ingår i: Acta Radiologica. - 1600-0455. ; 38:1, s. 19-24
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To determine the effective time window for MR imaging of tumors with blood-brain barrier (BBB) damage after injection of Gd-containing contrast media. MATERIAL AND METHODS: Eleven patients with 15 brain lesions (metastasis, glioma, abscess) were studied with a T1-weighted spin-echo sequence repeated over periods of up to 43 min after contrast injection. A quotient was calculated between the signals in the lesion and in the gray matter, and plotted against time. RESULTS: All lesions reached 70% of the maximum RATIO within 3.5 min. After 25 min 12 out of 15 lesions showed persistent enhancement within 15% of the maximal RATIO. CONCLUSION: The peak enhancement of BBB damage occurs around 3.5 min after injection. The effect does not change during the next 25 min. Scanning should not be started until 2-5 min after injection of the contrast medium, and there is no advantage in waiting longer as no major increase (or decline) of contrast can be expected.
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| 16. |
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| 17. |
- Åkesson, Michael, et al.
(författare)
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Thoracic magnetic resonance venography using Gadofosveset in patients with venous pathology-A comparative study of image quality and inter-rater variability
- 2017
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Ingår i: Phlebology. - : SAGE Publications. - 1758-1125. ; 32:7, s. 453-458
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: High-quality non-invasive imaging of the deep venous system in the thorax is challenging, but nevertheless required for diagnosis of vascular pathology as well as for patient selection and preoperative planning for endovascular procedures.PURPOSE: To compare the diagnostic quality of Gadofosveset-enhanced thoracic magnetic resonance venography, seven consecutive patients with suspected or known disease affecting the central thoracic veins were compared to seven consecutive magnetic resonance venography using conventional gadolinium-based contrast agents.MATERIALS AND METHODS: Diagnostic capability, defined as the ability to assess vessel patency and pathologic conditions, for the major thoracic deep venous segments was assessed by two-independent readers. Both reviewers rated the overall subjective image quality on a four-graded scale, and inter-rater variability was analyzed using unweighted and weighted Cohen's kappa values.RESULTS: Diagnostic capability was generally considerably higher in the Gadofosveset group for all examined vessel segments. The overall images quality rating was significantly higher for the Gadofosveset group with a mean rating of 2.9 and 2.7 for the two-independent readers, compared to 1.2 and 1.0 for the control croup. Inter-rater variability showed less variability for the Gadofosveset group with a quadratic-weighted Cohen's Kappa value of 0.58 compared to 0.36 for the control group.CONCLUSION: Our results show that Gadofosveset-enhanced magnetic resonance venography of the central thoracic veins is a reliable technique in clinical routine practice that results in diagnostic images, superior to conventional gadolinium-based contrast medium.
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| 18. |
- Öhlund, Inger, 1954-, et al.
(författare)
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Vitamin D status and cardiometabolic risk markers in young Swedish children : A double-blind randomized clinical trial comparing different doses of vitamin D supplements
- 2020
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 111:4, s. 779-786
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Tidskriftsartikel (refereegranskat)abstract
- Background: Observational studies have linked low vitamin D status to unfavorable cardiometabolic risk markers, but double-blinded vitamin D intervention studies in children are scarce. Objectives: The aim was to evaluate the effect of different doses of a vitamin D supplement on cardiometabolic risk markers in young healthy Swedish children with fair and dark skin. Methods: Cardiometabolic risk markers were analyzed as secondary outcomes of a double-blind, randomized, milk-based vitamin D intervention trial conducted during late fall and winter in 2 areas of Sweden (latitude 63°N and 55°N, respectively) in both fair- and dark-skinned 5- to 7-y-old children. During the 3-mo intervention, 206 children were randomly assigned to a daily milk-based vitamin D3 supplement of either 10 or 25 μg or placebo (2 μg; only at 55°N). Anthropometric measures, blood pressure, serum 25-hydroxyvitamin D [25(OH)D], total cholesterol, HDL cholesterol, apoA-I, apoB, and C-reactive protein (CRP) were analyzed and non-HDL cholesterol calculated at baseline and after the intervention. Results: At baseline, serum 25(OH)D was negatively associated with systolic and diastolic blood pressure (β = -0.194; 95% CI: -0.153, -0.013; and β = -0.187; 95% CI: -0.150, -0.011, respectively). At follow-up, there was no statistically significant difference in any of the cardiometabolic markers between groups. Conclusions: We could not confirm any effect of vitamin D supplementation on serum lipids, blood pressure, or CRP in healthy 5- to 7-y-old children.
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