| 1. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 2. |
- Abbott, Max, et al.
(författare)
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Cadre conceptuel du jeu préjudiciable: Une collaboration internationale, troisième édition
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Si le jeu est souvent considéré comme un divertissement ou un loisir, pour certaines personnes, qu’il s’agisse de familles ou d’individus, voire de la société en général, il peut avoir des répercussions graves. Depuis des décennies, les effets préjudiciables du jeu font l’objet d’études visant à comprendre les distinctions entre la pratique du jeu et le parcours de vie des problèmes liés au jeu. Le présent ouvrage élabore un cadre conceptuel complet et pertinent au niveau international du « jeu préjudiciable » qui identifie les préjudices au-delà d’une vue basée sur les symptômes et aborde une série de facteurs liés aux risques pour la population, de même qu’aux effets sur la communauté et la société. Les facteurs répertoriés dans le cadre représentent des éléments majeurs liés au jeu et sont tantôt spécifiques (environnement de jeu, exposition, types et ressources), tantôt généraux (culturels, sociétaux, psychologiques et biologiques). Le Cadre a été créé par une équipe internationale de spécialistes interdisciplinaires dans le but de faciliter la compréhension du jeu préjudiciable. Il reflète l’état des connaissances liées aux facteurs d’influence du jeu préjudiciable et a pour but secondaire de servir de guide au développement de programmes de recherche futurs et à l’éducation des personnes chargées de prendre des décisions en matière de jeu préjudiciable. Situé à Guelph, en Ontario (Canada), l’organisme Gambling Research Exchange Ontario ou GREO, anciennement Ontario Problem Gambling Research Centre (OPGRC) a facilité l’élaboration du présent Cadre conceptuel sur le jeu préjudiciable et demeurera responsable d’assurer la mise à jour de celui-ci.
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| 3. |
- Abbott, Max, et al.
(författare)
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Conceptual Framework of Harmful Gambling: An International Collaboration
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- While seen by many as a form of leisure and recreation, gambling can have serious repercussions for individuals, families, and society as a whole. The harmful effects of gambling have been studied for decades to attempt to understand individual differences in gambling engagement and the life- course of gamblingrelated problems. In this publication, we present a comprehensive, internationally relevant conceptual framework of “harmful gambling” that moves beyond a symptoms-based view of harm and addresses a broad set of factors related to population risk, community and societal effects. Interactive factors represented in the framework represent major themes in gambling that range from specific (gambling environment, exposure, types, and resources) to general (cultural, social, psychological, and biological). This framework has been created by international and interdisciplinary experts from a variety of stakeholder perspectives - including researchers, treatment providers, operators, policy makers, and individuals and their families - to facilitate an understanding of harmful gambling. It not only reflects the state of knowledge as it relates to factors influencing harmful gambling, but also acts to guide the development of future research programs and educate policy makers on issues related to harmful gambling. The Ontario Problem Gambling Research Centre (Guelph, Ontario, Canada) has facilitated the development of the Conceptual Framework of Harmful Gambling and is committed to updating it over time.
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| 4. |
- Abbott, Max, et al.
(författare)
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Conceptual Framework of Harmful Gambling: An International Collaboration (Revised Edition)
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Although it is seen by many as a form of leisure and recreation, gambling can have serious repercussions for individuals, families, and society as a whole. The harmful effects of gambling have been studied for decades in an attempt to understand individual differences in gambling engagement and the life-course of gambling-related problems. In this publication, we present a comprehensive, internationally relevant conceptual framework of “harmful gambling” that moves beyond a symptoms-based view of harm and addresses a broad set of factors related to population risk, community and societal effects. Interactive factors depicted in the framework represent major themes in gambling that range from specific (gambling environment, exposure, types, and resources) to general (cultural, social, psychological, and biological). The framework has been created by international interdisciplinary experts and stakeholders— including researchers, treatment providers, operators, policy makers, as well as individuals and their families—in order to facilitate an understanding of harmful gambling. It reflects the state of knowledge related to factors influencing harmful gambling; and serves a secondary purpose as a guide for the development of future research programs and education of policy makers on issues related to harmful gambling. Gambling Research Exchange Ontario (GREO) (formerly the Ontario Problem Gambling Research Centre (OPGRC) located in Guelph, Ontario, Canada) has facilitated the development of the Conceptual Framework of Harmful Gambling and will retain responsibility for keeping it up-to-date.
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| 5. |
- Abbott, Max, et al.
(författare)
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Conceptual framework of harmful gambling: An international collaboration, Third Edition
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Although it is seen by many as a form of leisure and recreation, gambling can have serious repercussions for individuals, families, and society as a whole. The harmful effects of gambling have been studied for decades in an attempt to understand individual differences in gambling engagement and the life-course of gambling-related problems. In this publication, we present a comprehensive, internationally relevant conceptual framework of “harmful gambling” that moves beyond a symptoms-based view of harm and addresses a broad set of factors related to population risk, community, and societal effects. Factors included in the framework represent major topics relating to gambling that range from specific (gambling environment, exposure, types, and resources) to general (cultural, social, psychological, and biological). The framework has been created by international, interdisciplinary experts in order to facilitate an understanding of harmful gambling. It reflects the state of knowledge related to factors influencing harmful gambling, and serves a secondary purpose as a guide for the development of future research programs and to educate policy makers on issues related to harmful gambling. Gambling Research Exchange Ontario (GREO) (formerly the Ontario Problem Gambling Research Centre (OPGRC) located in Guelph, Ontario, Canada) has facilitated the development of the Conceptual Framework of Harmful Gambling and retains responsibility for keeping it up-to-date.
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| 6. |
- Ding, Li, et al.
(författare)
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Somatic mutations affect key pathways in lung adenocarcinoma
- 2008
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 455:7216, s. 1069-1075
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Tidskriftsartikel (refereegranskat)abstract
- Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
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| 7. |
- Hilbrecht, Margo, et al.
(författare)
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The Conceptual Framework of Harmful Gambling: A revised framework for understanding gambling harm
- 2020
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Ingår i: Journal of Behavioral Addictions. - : Akademiai Kiado Zrt.. - 2063-5303 .- 2062-5871. ; 9:2, s. 190-205
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: The Conceptual Framework of Harmful Gambling moves beyond a symptoms-based view of harm and addresses a broad set of factors related to the risks and effects of gambling harmfully at the individual, family, and community levels. Coauthored by international research experts and informed by multiple stakeholders, Gambling Research Exchange (GREO) facilitated the framework development in 2013 and retains responsibility for regular updates and mobilization. This review article presents information about the revised version of the Conceptual Framework of Harmful Gambling completed in late 2018. Methods: We describe eight interrelated factors depicted in the framework that represent major themes in gambling ranging from the specific (gambling environment, exposure, gambling types, and treatment resources) to the general (cultural, social, psychological, and biological influences). After outlining the framework development and collaborative process, we highlight new topics for the recent update that reflect changes in the gambling landscape and prominent discourses in the scientific community. Some of these topics include social and economic impacts of gambling, and a new model of understanding gambling related harm. Discussion and conclusions: We address the relevance of the CFHG to the gambling and behavioral addictions research community. Harm-based frameworks have been undertaken in other areas of addiction that can both inform and be informed by a model dedicated to harmful gambling. Further, the framework brings a multi-disciplinary perspective to bear on antecedents and factors that co-occur with harmful gambling.
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| 8. |
- Li, Jing, et al.
(författare)
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Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce
- 2022
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Ingår i: Carbohydrate Research. - : Elsevier BV. - 0008-6215 .- 1873-426X. ; 521
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Tidskriftsartikel (refereegranskat)abstract
- Polygonatum odoratum is a perennial rhizomatous medicinal plant and different plant parts have been used in the treatment of various ailments. Herein, we have investigated the structural compositions of rhizome, leaf, and stem cell walls. We found 30–44% of polysaccharides in these wall preparations were cyclohexanediaminetetraacetic acid (CDTA) extractable, the proportion of heteromannans (HMs) in the rhizome is nearly three-fold compared to that of the leave and stem. The pectic polysaccharides of the rhizome are also structurally more diverse, with arabinans and type I and type II arabinogalactans being richest as shown by linkage study of the sodium carbonate (Na2CO3) extract. In addition, the 2-linked Araf was rhizome-specific, suggesting the cell walls in the rhizome had adapted to a more complex structure compared to that of the leaf and stem. Water-soluble polysaccharide fractions were also investigated, high proportion of Man as in 4-linked Manp indicated high proportion of HMs. The 21.4 kDa pectic polysaccharides and HMs derived from rhizome cell walls induced specific immune response in mice macrophage cells producing IL-1α and hematopoietic growth factors GM-CSF and G-CSF in vitro.
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