| 1. |
- Tinetti, Giovanna, et al.
(författare)
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The EChO science case
- 2015
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 40:2-3, s. 329-391
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Tidskriftsartikel (refereegranskat)abstract
- The discovery of almost two thousand exoplanets has revealed an unexpectedly diverse planet population. We see gas giants in few-day orbits, whole multi-planet systems within the orbit of Mercury, and new populations of planets with masses between that of the Earth and Neptune-all unknown in the Solar System. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? How do planetary systems work and what causes the exceptional diversity observed as compared to the Solar System? The EChO (Exoplanet Characterisation Observatory) space mission was conceived to take up the challenge to explain this diversity in terms of formation, evolution, internal structure and planet and atmospheric composition. This requires in-depth spectroscopic knowledge of the atmospheres of a large and well-defined planet sample for which precise physical, chemical and dynamical information can be obtained. In order to fulfil this ambitious scientific program, EChO was designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large, diverse and well-defined planet sample within its 4-year mission lifetime. The transit and eclipse spectroscopy method, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allows us to measure atmospheric signals from the planet at levels of at least 10(-4) relative to the star. This can only be achieved in conjunction with a carefully designed stable payload and satellite platform. It is also necessary to provide broad instantaneous wavelength coverage to detect as many molecular species as possible, to probe the thermal structure of the planetary atmospheres and to correct for the contaminating effects of the stellar photosphere. This requires wavelength coverage of at least 0.55 to 11 mu m with a goal of covering from 0.4 to 16 mu m. Only modest spectral resolving power is needed, with R similar to 300 for wavelengths less than 5 mu m and R similar to 30 for wavelengths greater than this. The transit spectroscopy technique means that no spatial resolution is required. A telescope collecting area of about 1 m(2) is sufficiently large to achieve the necessary spectro-photometric precision: for the Phase A study a 1.13 m(2) telescope, diffraction limited at 3 mu m has been adopted. Placing the satellite at L2 provides a cold and stable thermal environment as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. EChO has been conceived to achieve a single goal: exoplanet spectroscopy. The spectral coverage and signal-to-noise to be achieved by EChO, thanks to its high stability and dedicated design, would be a game changer by allowing atmospheric composition to be measured with unparalleled exactness: at least a factor 10 more precise and a factor 10 to 1000 more accurate than current observations. This would enable the detection of molecular abundances three orders of magnitude lower than currently possible and a fourfold increase from the handful of molecules detected to date. Combining these data with estimates of planetary bulk compositions from accurate measurements of their radii and masses would allow degeneracies associated with planetary interior modelling to be broken, giving unique insight into the interior structure and elemental abundances of these alien worlds. EChO would allow scientists to study exoplanets both as a population and as individuals. The mission can target super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300-3000 K) of F to M-type host stars. The EChO core science would be delivered by a three-tier survey. The EChO Chemical Census: This is a broad survey of a few-hundred exoplanets, which allows us to explore the spectroscopic and chemical diversity of the exoplanet population as a whole. The EChO Origin: This is a deep survey of a subsample of tens of exoplanets for which significantly higher signal to noise and spectral resolution spectra can be obtained to explain the origin of the exoplanet diversity (such as formation mechanisms, chemical processes, atmospheric escape). The EChO Rosetta Stones: This is an ultra-high accuracy survey targeting a subsample of select exoplanets. These will be the bright "benchmark" cases for which a large number of measurements would be taken to explore temporal variations, and to obtain two and three dimensional spatial information on the atmospheric conditions through eclipse-mapping techniques. If EChO were launched today, the exoplanets currently observed are sufficient to provide a large and diverse sample. The Chemical Census survey would consist of > 160 exoplanets with a range of planetary sizes, temperatures, orbital parameters and stellar host properties. Additionally, over the next 10 years, several new ground- and space-based transit photometric surveys and missions will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets.
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| 2. |
- Kalman, L. V., et al.
(författare)
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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting
- 2016
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Ingår i: Clinical Pharmacology and Therapeutics. - : WILEY-BLACKWELL. - 0009-9236 .- 1532-6535. ; 99:2, s. 172-185
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Tidskriftsartikel (refereegranskat)abstract
- This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward.
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| 3. |
- Wesson, R., et al.
(författare)
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Herschel-SPIRE FTS spectroscopy of the carbon-rich objects AFGL 2688, AFGL 618, and NGC 7027
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L144-
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Tidskriftsartikel (refereegranskat)abstract
- We present far-infrared and submillimetre spectra of three carbon-rich evolved objects, AFGL 2688, AFGL 618 and NGC 7027. The spectra were obtained with the SPIRE Fourier-transform spectrometer on board the Herschel Space Observatory, and cover wavelengths from 195-670 mu m, a region of the electromagnetic spectrum hitherto difficult to study in detail. The far infrared spectra of these objects are rich and complex, and we measure over 150 lines in each object. Lines due to 18 different species are detected. We determine physical conditions from observations of the rotational lines of several molecules, and present initial large velocity gradient models for AFGL 618. We detect water in AFGL 2688 for the first time, and confirm its presence in AFGL 618 in both ortho and para forms. In addition, we report the detection of the J = 1-0 line of CH+ in NGC 7027.
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| 4. |
- Bulut, N., et al.
(författare)
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Gas phase Elemental abundances in Molecular cloudS (GEMS): III. Unlocking the CS chemistry: The CS+O reaction
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 646
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Tidskriftsartikel (refereegranskat)abstract
- Context. Carbon monosulphide (CS) is among the most abundant gas-phase S-bearing molecules in cold dark molecular clouds. It is easily observable with several transitions in the millimeter wavelength range, and has been widely used as a tracer of the gas density in the interstellar medium in our Galaxy and external galaxies. However, chemical models fail to account for the observed CS abundances when assuming the cosmic value for the elemental abundance of sulfur. Aims. The CS+O → CO + S reaction has been proposed as a relevant CS destruction mechanism at low temperatures, and could explain the discrepancy between models and observations. Its reaction rate has been experimentally measured at temperatures of 150-400 K, but the extrapolation to lower temperatures is doubtful. Our goal is to calculate the CS+O reaction rate at temperatures <150 K which are prevailing in the interstellar medium. Methods. We performed ab initio calculations to obtain the three lowest potential energy surfaces (PES) of the CS+O system. These PESs are used to study the reaction dynamics, using several methods (classical, quantum, and semiclassical) to eventually calculate the CS + O thermal reaction rates. In order to check the accuracy of our calculations, we compare the results of our theoretical calculations for T ~ 150-400 K with those obtained in the laboratory. Results. Our detailed theoretical study on the CS+O reaction, which is in agreement with the experimental data obtained at 150-400 K, demonstrates the reliability of our approach. After a careful analysis at lower temperatures, we find that the rate constant at 10 K is negligible, below 10-15 cm s-1, which is consistent with the extrapolation of experimental data using the Arrhenius expression. Conclusions. We use the updated chemical network to model the sulfur chemistry in Taurus Molecular Cloud 1 (TMC 1) based on molecular abundances determined from Gas phase Elemental abundances in Molecular CloudS (GEMS) project observations. In our model, we take into account the expected decrease of the cosmic ray ionization rate, ζH2, along the cloud. The abundance of CS is still overestimated when assuming the cosmic value for the sulfur abundance.
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| 5. |
- Cernicharo, J., et al.
(författare)
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Detection of anhydrous hydrochloric acid, HCl, in IRC+10216 with the Herschel SPIRE and PACS spectrometers Detection of HCI in IRC+10216
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L136-
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Tidskriftsartikel (refereegranskat)abstract
- We report on the detection of anhydrous hydrochloric acid (hydrogen chlorine, HCl) in the carbon-rich star IRC+10216 using the spectroscopic facilities onboard the Herschel satellite. Lines from J = 1-0 up to J = 7-6 have been detected. From the observed intensities, we conclude that HCl is produced in the innermost layers of the circumstellar envelope with an abundance relative to H-2 of 5 x 10(-8) and extends until the molecules reach its photodissociation zone. Upper limits to the column densities of AlH, MgH, CaH, CuH, KH, NaH, FeH, and other diatomic hydrides have also been obtained.
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| 6. |
- Decin, L., et al.
(författare)
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Silicon in the dust formation zone of IRC+10216
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L143-
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Tidskriftsartikel (refereegranskat)abstract
- The interstellar medium is enriched primarily by matter ejected from evolved low and intermediate mass stars. The outflows from these stars create a circumstellar envelope in which a rich gas-phase and dust-nucleation chemistry takes place. We observed the nearest carbon-rich evolved star, IRC + 10216, using the PACS (55-210 mu m) and SPIRE (194-672 mu m) spectrometers on board Herschel. We find several tens of lines from SiS and SiO, including lines from the v = 1 vibrational level. For SiS these transitions range up to J = 124-123, corresponding to energies around 6700 K, while the highest detectable transition is J = 90-89 for SiO, which corresponds to an energy around 8400 K. Both species trace the dust formation zone of IRC + 10216, and the broad energy ranges involved in their detected transitions permit us to derive the physical properties of the gas and the particular zone in which each species has been formed. This allows us to check the accuracy of chemical thermodynamical equilibrium models and the suggested depletion of SiS and SiO due to accretion onto dust grains.
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| 7. |
- Decin, L., et al.
(författare)
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Warm water vapour in the sooty outflow from a luminous carbon star
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 467:7311, s. 64-67
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Tidskriftsartikel (refereegranskat)abstract
- The detection(1) of circumstellar water vapour around the ageing carbon star IRC + 10216 challenged the current understanding of chemistry in old stars, because water was predicted(2) to be almost absent in carbon-rich stars. Several explanations for the water were postulated, including the vaporization of icy bodies (comets or dwarf planets) in orbit around the star(1), grain surface reactions(3), and photochemistry in the outer circumstellar envelope(4). With a single water line detected so far from this one carbon-rich evolved star, it is difficult to discriminate between the different mechanisms proposed. Here we report the detection of dozens of water vapour lines in the far-infrared and sub-millimetre spectrum of IRC + 10216 using the Herschel satellite(5). This includes some high-excitation lines with energies corresponding to similar to 1,000 K, which can be explained only if water is present in the warm inner sooty region of the envelope. A plausible explanation for the warm water appears to be the penetration of ultraviolet photons deep into a clumpy circumstellar envelope. This mechanism also triggers the formation of other molecules, such as ammonia, whose observed abundances(6) are much higher than hitherto predicted(7).
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| 8. |
- Royer, P., et al.
(författare)
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PACS and SPIRE spectroscopy of the red supergiant VY CMa
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L145-
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Tidskriftsartikel (refereegranskat)abstract
- With a luminosity > 10(5) L-circle dot and a mass-loss rate of similar to 2 x 10(-4) M-circle dot yr(-1), the red supergiant VY CMa truly is a spectacular object. Because of its extreme evolutionary state, it could explode as supernova any time. Studying its circumstellar material, into which the supernova blast will run, provides interesting constraints on supernova explosions and on the rich chemistry taking place in such complex circumstellar envelopes. We have obtained spectroscopy of VY CMa over the full wavelength range offered by the PACS and SPIRE instruments of Herschel, i.e. 55-672 micron. The observations show the spectral fingerprints of more than 900 spectral lines, of which more than half belong to water. In total, we have identified 13 different molecules and some of their isotopologues. A first analysis shows that water is abundantly present, with an ortho-to-para ratio as low as similar to 1.3:1, and that chemical non-equilibrium processes determine the abundance fractions in the inner envelope.
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| 9. |
- Cernicharo, J., et al.
(författare)
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A high-resolution line survey of IRC+10216 with Herschel/HIFI First results: Detection of warm silicon dicarbide (SiC2)
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 521:1, s. Article Number: L8-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first results of a high-spectral-resolution survey of the carbon-rich evolved star IRC+10216 that was carried out with the HIFI spectrometer onboard Herschel. This survey covers all HIFI bands, with a spectral range from 488 to 1901 GHz. In this letter we focus on the band-1b spectrum, in a spectral range 554.5-636.5 GHz, where we identified 130 spectral features with intensities above 0.03 K and a signal-to-noise ratio >5. Detected lines arise from HCN, SiO, SiS, CS, CO, metal-bearing species and, surprisingly, silicon dicarbide (SiC2). We identified 55 SiC2 transitions involving energy levels between 300 and 900 K. By analysing these rotational lines, we conclude that SiC2 is produced in the inner dust formation zone, with an abundance of similar to 2 x 10(-7) relative to molecular hydrogen. These SiC2 lines have been observed for the first time in space and have been used to derive an SiC2 rotational temperature of similar to 204 K and a source-averaged column density of similar to 6.4 x 10(15) cm(-2). Furthermore, the high quality of the HIFI data set was used to improve the spectroscopic rotational constants of SiC2.
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| 10. |
- Cernicharo, J., et al.
(författare)
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Discovery of time variation of the intensity of molecular lines in IRC+10216 in the submillimeter and far-infrared domains
- 2014
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 796:1
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Tidskriftsartikel (refereegranskat)abstract
- We report on the discovery of strong intensity variations in the high rotational lines of abundant molecular species toward the archetypical circumstellar envelope of IRC+10216. The observations have been carried out with the Heterodyne Instrument for the Far-Infrared (HIFI) instrument on board Herschel and with the IRAM30 m telescope. They cover several observing periods spreading over three years. The line intensity variations for molecules produced in the external layers of the envelope most likely result from time variations in the infrared pumping rates. We analyze the main implications this discovery has on the interpretation of molecular line emission in the envelopes of Mira-type stars. Radiative transfer calculations must take into account both the time variability of infrared pumping and the possible variation of the dust and gas temperatures with stellar phase in order to reproduce the observation of molecular lines at different epochs. The effect of gas temperature variations with stellar phase could be particularly important for lines produced in the innermost regions of the envelope. Each layer of the circumstellar envelope sees the stellar light radiation with a different lag time (phase). Our results show that this effect must be included in the models. The submillimeter and far infrared lines of asymptotic giant branch stars can no longer be considered as safe intensity calibrators.
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| 11. |
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| 12. |
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| 13. |
- Wakelam, V., et al.
(författare)
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Reaction Networks for Interstellar Chemical Modelling : Improvements and Challenges
- 2010
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Ingår i: Space Science Reviews. - : Springer Science and Business Media LLC. - 0038-6308 .- 1572-9672. ; 156:04-jan, s. 13-72
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Forskningsöversikt (refereegranskat)abstract
- We survey the current situation regarding chemical modelling of the synthesis of molecules in the interstellar medium. The present state of knowledge concerning the rate coefficients and their uncertainties for the major gas-phase processes-ion-neutral reactions, neutral-neutral reactions, radiative association, and dissociative recombination-is reviewed. Emphasis is placed on those key reactions that have been identified, by sensitivity analyses, as 'crucial' in determining the predicted abundances of the species observed in the interstellar medium. These sensitivity analyses have been carried out for gas-phase models of three representative, molecule-rich, astronomical sources: the cold dense molecular clouds TMC-1 and L134N, and the expanding circumstellar envelope IRC +10216. Our review has led to the proposal of new values and uncertainties for the rate coefficients of many of the key reactions. The impact of these new data on the predicted abundances in TMC-1 and L134N is reported. Interstellar dust particles also influence the observed abundances of molecules in the interstellar medium. Their role is included in gas-grain, as distinct from gas-phase only, models. We review the methods for incorporating both accretion onto, and reactions on, the surfaces of grains in such models, as well as describing some recent experimental efforts to simulate and examine relevant processes in the laboratory. These efforts include experiments on the surface-catalyzed recombination of hydrogen atoms, on chemical processing on and in the ices that are known to exist on the surface of interstellar grains, and on desorption processes, which may enable species formed on grains to return to the gas-phase.
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| 14. |
- Caudle, Kelly E, et al.
(författare)
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Incorporation of Pharmacogenomics into Routine Clinical Practice : the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process
- 2014
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Ingår i: Current drug metabolism. - : Bentham Science Publishers Ltd.. - 1389-2002 .- 1875-5453. ; 15:2, s. 209-217
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Tidskriftsartikel (refereegranskat)abstract
- The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.
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| 15. |
- Cernicharo, J., et al.
(författare)
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Discovery of the first Ca-bearing molecule in space: CaNC
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 627
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Tidskriftsartikel (refereegranskat)abstract
- We report on the detection of calcium isocyanide, CaNC, in the carbon-rich evolved star IRC + 10216. We derived a column density for this species of (2 +/- 0.5) x 10(11) cm(-2). Based on the observed line profiles and the modelling of its emission through the envelope, the molecule has to be produced in the intermediate and outer layers of the circumstellar envelope where other metal-isocyanides have previously been found in this source. The abundance ratio of CaNC relative to MgNC and FeCN is congruent to 1/60 and congruent to 1, respectively. We searched for the species CaF, CaCl, CaC, CaCCH, and CaCH3 for which accurate frequency predictions are available. Only upper limits have been obtained for these molecules.
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| 16. |
- Cernicharo, J., et al.
(författare)
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Discovery of two new magnesium-bearing species in IRC+10216: MgC3N and MgC4H
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 630
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Tidskriftsartikel (refereegranskat)abstract
- We report on the detection of two series of harmonically related doublets in IRC +10216. From the observed frequencies, the rotational constant of the first series is B = 1380.888 MHz and that of the second series is B = 1381.512 MHz. The two series correspond to two species with a (2)Sigma electronic ground state. After considering all possible candidates, and based on quantum chemical calculations, the first series is assigned to MgC3N and the second to MgC4H. For the latter species, optical spectroscopy measurements support its identification. Unlike diatomic metal-containing molecules, the line profiles of the two new molecules indicate that they are formed in the outer layers of the envelope, as occurs for MgNC and other polyatomic metal-cyanides. We also confirm the detection of MgCCH that was previously reported from the observation of two doublets. The relative abundance of MgC3N with respect to MgNC is close to one while that of MgC4H relative to MgCCH is about ten. The synthesis of these magnesium cyanides and acetylides in IRC +10216 can be explained in terms of a two-step process initiated by the radiative association of Mg+ with large cyanopolyynes and polyynes followed by the dissociative recombination of the ionic complexes.
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| 17. |
- Fonfria, J. P., et al.
(författare)
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Gas infall and possible circumstellar rotation in R Leonis
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622
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Tidskriftsartikel (refereegranskat)abstract
- We present new interferometer molecular observations of R Leo taken at 1.2 mm with the Atacama Large Millimeter Array with an angular resolution up to similar or equal to 0.'' 026. These observations permitted us to resolve the innermost envelope of this star, which revealed a complex structure that involves extended continuum emission and molecular emission showing a non-radial gas velocity distribution. This molecular emission displays prominent red-shifted absorptions located immediately in front of the star, which are typical footprints of material infall. This emission also shows lateral gas motions compatible with a torus-like structure.
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| 18. |
- Lombaert, Robin, 1986, et al.
(författare)
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Constraints on the H2O formation mechanism in the wind of carbon-rich AGB stars
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 588
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Tidskriftsartikel (refereegranskat)abstract
- Context. The recent detection of warm H2O vapor emission from the outflows of carbon-rich asymptotic giant branch (AGB) stars challenges the current understanding of circumstellar chemistry. Two mechanisms have been invoked to explain warm H2O vapor formation. In the first, periodic shocks passing through the medium immediately above the stellar surface lead to H2O formation. In the second, penetration of ultraviolet interstellar radiation through a clumpy circumstellar medium leads to the formation of H2O molecules in the intermediate wind. Aims. We aim to determine the properties of H2O emission for a sample of 18 carbon-rich AGB stars and subsequently constrain which of the above mechanisms provides the most likely warm H2O formation pathway. Methods. Using far-infrared spectra taken with the PACS instrument onboard the Herschel telescope, we combined two methods to identify H2O emission trends and interpreted these in terms of theoretically expected patterns in the H2O abundance. Through the use of line-strength ratios, we analyzed the correlation between the strength of H2O emission and the mass-loss rate of the objects, as well as the radial dependence of the H2O abundance in the circumstellar outflow per individual source. We computed a model grid to account for radiative-transfer effects in the line strengths. Results. We detect warm H2O emission close to or inside the wind acceleration zone of all sample stars, irrespective of their stellar or circumstellar properties. The predicted H2O abundances in carbon-rich environments are in the range of 10(-6) up to 10(-4) for Miras and semiregular-a objects, and cluster around 10 6 for semiregular-b objects. These predictions are up to three orders of magnitude greater than what is predicted by state-of-the-art chemical models. We find a negative correlation between the H2O/CO line-strength ratio and gas mass-loss rate for. M-g > 5 x 10(7) M-circle dot yr(-1), regardless of the upper-level energy of the relevant transitions. This implies that the H2O formation mechanism becomes less efficient with increasing wind density. The negative correlation breaks down for the sources of lowest mass-loss rate, the semiregular-b objects. Conclusions. Observational constraints suggest that pulsationally induced shocks play an important role in warm H2O formation in carbon-rich AGB stars, although photodissociation by interstellar UV photons may still contribute. Both mechanisms fail in predicting the high H2O abundances we infer in Miras and semiregular-a sources, while our results for the semiregular-b objects are inconclusive.
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| 19. |
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| 20. |
- Pardo, J. R., et al.
(författare)
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Detection of vibrationally excited HC7N and HC9N in IRC+10216
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 640
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Tidskriftsartikel (refereegranskat)abstract
- Observations of IRC +10216 with the Yebes 40 m telescope between 31 and 50 GHz have revealed more than 150 unidentified lines. Some of them can be grouped into a new series of 26 doublets, harmonically related with integer quantum numbers ranging from J(up)=54 to 80. The separation of the doublets increases systematically with J, that is to say, as expected for a linear species in one of its bending modes. The rotational parameters resulting from the fit to these data are B=290.8844 +/- 0.0004 MHz, D=0.88 +/- 0.04 Hz, and q=0.1463 +/- 0.0001 MHz. The rotational constant is very close to that of the ground state of HC9N. Our ab initio calculations show an excellent agreement between these parameters and those predicted for the lowest energy vibrationally excited state, nu (19)=1, of HC9N. This is the first detection, and complete characterization in space, of vibrationally excited HC9N. An energy of 41.5 cm(-1) is estimated for the nu (19) state. In addition, 17 doublets of HC7N in the nu (15)=1 state, for which laboratory spectroscopy is available, were detected for the first time in IRC +10216. Several doublets of HC5N in its nu (11)=1 state were also observed. The column density ratio between the ground and the lowest excited vibrational states are approximate to 127, 9.5, and 1.5 for HC5N, HC7N, and HC9N, respectively. We find that these lowest-lying vibrational states are most probably populated via infrared pumping to vibrationally excited states lying at approximate to 600 cm(-1). The lowest vibrationally excited states thus need to be taken into account to precisely determine absolute abundances and abundance ratios for long carbon chains. The abundance ratios N(HC5N)/N(HC7N) and N(HC7N)/N(HC9N) are 2.4 and 7.7, respectively.
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| 21. |
- Velilla Prieto, Luis, 1981, et al.
(författare)
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Circumstellar chemistry of Si-C bearing molecules in the C-rich AGB star IRC+10216
- 2018
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 14, s. 535-537
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Konferensbidrag (refereegranskat)abstract
- Silicon carbide together with amorphous carbon are the main components of dust grains in the atmospheres of C-rich AGB stars. Small gaseous Si-C bearing molecules (such as SiC, SiCSi, and SiC2) are efficiently formed close to the stellar photosphere. They likely condense onto dust seeds owing to their highly refractory nature at the lower temperatures (i.e., below about 2500 K) in the dust growth zone which extends a few stellar radii from the photosphere. Beyond this region, the abundances of Si-C bearing molecules are expected to decrease until they are eventually reformed in the outer shells of the circumstellar envelope, owing to the interaction between the gas and the interstellar UV radiation field. Our goal is to understand the time-dependent chemical evolution of Si-C bond carriers probed by molecular spectral line emission in the circumstellar envelope of IRC+10216 at millimeter wavelengths.
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| 22. |
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| 23. |
- Krause, Gesche, et al.
(författare)
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A revolution without people? Closing the people-policy gap in aquaculture development
- 2015
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Ingår i: Aquaculture. - : Elsevier BV. - 0044-8486 .- 1873-5622. ; 447, s. 44-55
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Forskningsöversikt (refereegranskat)abstract
- Failure of the blue revolutionis a global risk. The international problem is that there is a gap in knowledge exchange between the aquaculture industry, policy makers trying to support aquaculture development and people who depend on aquaculture for a job and/or food source. Thus, governments and international organizations promoting aquaculture as the solution to improving food security, nutrition and income are failing to optimise production of natural aquatic resources. We identify a people-policy gap, and suggest that this is an understudied constraint, which needs to be overcome before worldwide food security can be achieved from aquatic environments. We argue that this gap leads to uneven distribution of benefits, a disconnection between benefits and local needs, and detrimental effects on human health and food security, all of which can have negative repercussions on human communities and ecosystems. In order to address this need, we present an analytical framework to guide context specific, policy-relevant assessments of the social, economic and ecological dimensions of aquaculture on a case-by-case basis. The framework is designed to make best use of existing data and scientific tools for decision-making. In conclusion, we argue for: equal consideration of ecological, social and economic issues in aquaculture policy-making; pre-emptive identification of likely social impacts; integration of people-and context-specific social framing conditions into planning and policy review; addressing the social disconnection between global consumption and production; and, encouragement of creative combinations of theories and methods to assess and interpret the social dimensions of aquaculture in multiple contexts.
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| 24. |
- Massalkhi, S., et al.
(författare)
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The abundance of S- and Si-bearing molecules in O-rich circumstellar envelopes of AGB stars
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 641
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We aim to determine the abundances of SiO, CS, SiS, SO, and SO2 in a large sample of oxygen-rich asymptotic giant branch (AGB) envelopes covering a wide range of mass loss rates to investigate the potential role that these molecules could play in the formation of dust in these environments.Methods. We surveyed a sample of 30 oxygen-rich AGB stars in the lambda 2 mm band using the IRAM 30m telescope. We performed excitation and radiative transfer calculations based on the large velocity gradient method to model the observed lines of the molecules and to derive their fractional abundances in the observed envelopes.Results. We detected SiO in all 30 targeted envelopes, as well as CS, SiS, SO, and SO2 in 18, 13, 26, and 19 sources, respectively. Remarkably, SiS is not detected in any envelope with a mass loss rate below 10(-6)M(circle dot) yr(-1), whereas it is detected in all envelopes with mass loss rates above that threshold. From a comparison with a previous, similar study on C-rich sources, it becomes evident that the fractional abundances of CS and SiS show a marked differentiation between C-rich and O-rich sources, being two orders of magnitude and one order of magnitude more abundant in C-rich sources, respectively, while the fractional abundance of SiO turns out to be insensitive to the C/O ratio. The abundance of SiO in O-rich envelopes behaves similarly to C-rich sources, that is, the denser the envelope the lower its abundance. A similar trend, albeit less clear than for SiO, is observed for SO in O-rich sources.Conclusions. The marked dependence of CS and SiS abundances on the C/O ratio indicates that these two molecules form more efficiently in C- than O-rich envelopes. The decline in the abundance of SiO with increasing envelope density and the tentative one for SO indicate that SiO and possibly SO act as gas-phase precursors of dust in circumstellar envelopes around O-rich AGB stars.
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| 25. |
- Rosenblad, Carl, et al.
(författare)
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Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease
- 2019
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Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; , s. 2402-2416
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Tidskriftsartikel (refereegranskat)abstract
- Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson's disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive swings in striatal dopamine caused by intermittent oral delivery, can be avoided by delivering l-DOPA in a more continuous manner. Local gene delivery of the l-DOPA synthesizing enzymes, tyrosine hydroxylase and guanosine-tri-phosphate-cyclohydrolase-1, offers a new approach to a more refined dopaminergic therapy where l-DOPA is delivered continuously at the site where it is needed i.e. the striatum. In this study we have explored the therapeutic efficacy of adeno-associated viral vector-mediated l-DOPA delivery to the putamen in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys, the standard non-human primate model of Parkinson's disease. Viral vector delivery of the two enzymes, tyrosine hydroxylase and guanosine-5'-tri-phosphate-cyclohydrolase-1, bilaterally into the dopamine-depleted putamen, induced a significant, dose-dependent improvement of motor behaviour up to a level identical to that obtained with the optimal dose of peripheral l-DOPA. Importantly, this improvement in motor function was obtained without any adverse dyskinetic effects. These results provide proof-of-principle for continuous vector-mediated l-DOPA synthesis as a novel therapeutic strategy for Parkinson's disease. The constant, local supply of l-DOPA obtained with this approach holds promise as an efficient one-time treatment that can provide long-lasting clinical improvement and at the same time prevent the appearance of motor fluctuations and dyskinetic side effects associated with standard oral dopaminergic medication.
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