| 1. |
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| 2. |
- Wall, Helena, et al.
(författare)
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Kläckning i kycklingstallet
- 2015
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Ingår i: Fjäderfä. - 0015-3338. ; , s. 16-18
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 3. |
- Carlsson, Malin, et al.
(författare)
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An evaluation of registered nurses’ experiences of person-centered care and competence after participating in a course in digital competence in care
- 2022
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Ingår i: BMC Nursing. - : Springer Science and Business Media LLC. - 1472-6955. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundHealth care’s rapid transition from in-person visits to more digital care meetings has challenged nurses to find new, sustainable ways of using digital technology.MethodsThe aim was to describe registered nurses’(RN) experiences with person-centred care (PCC) and competence after participating in a course in Digital Competence in Care (DCC). In this study, a qualitative descriptive design was used, and 16 individual interviews were carried out with RNs. Data were analysed using qualitative content analysis. The COREQ checklist was used in this study.ResultsThe results were presented in four categories: being open to change and new ways of working with patients; struggling to handle requirements; developing new ways of working and focusing on patients despite the distance.ConclusionsThe DCC course helped develop RNs' skills and practice of PCC in digital care meetings. Training in digital care theory increased RNs' competence and facilitated the creation of new knowledge. The RNs' professional role was strengthened by participating in the changing of work routines. Digital care meetings were shown to be distance bridging and complementary to physical care meetings contributing to PCC. The increased availability of health care via digital means has affected the consumption of care and tailored education needs for RNs must be met by nursing education programs. Digital care is accessible, efficient and enables care regardless of geographical conditions, its innovative development needs to be based on science and experience and RNs are key personnel in this process.
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| 4. |
- Alm, Malin, et al.
(författare)
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Corticosterone metabolites in laying hen droppings-Effects of fiber enrichment, genotype, and daily variations
- 2014
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Ingår i: Poultry Science. - : Elsevier BV. - 0032-5791 .- 1525-3171. ; 93, s. 2615-2621
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Tidskriftsartikel (refereegranskat)abstract
- There is growing interest and concern for animal welfare in commercial poultry production. To evaluate stress and welfare in an objective and noninvasive way, fecal corticosterone metabolites (FCM) in droppings can be analyzed. However, the influence of diet, genotype, and daily variations in FCM and production of droppings in laying hens has been poorly investigated. This study examined the effect of insoluble fiber by adding 3% ground straw pellets to the feed to Lohmann Selected Leghorn (LSL) and Lohmann Brown (LB) hens housed in furnished cages between 20 and 40 wk of age. In total, 960 hens were included in the study. Droppings were collected 4 times per day for 3 consecutive days and analyzed by corticosterone immunoassay. Biological validation confirmed the ability of the assay to detect changes in FCM levels. Inclusion of straw pellets in the feed increased FCM concentration in both hen genotypes and increased excretion rate of FCM in LB hens. The LB hens also produced greater amounts of droppings than LSL hens. Both FCM levels and production of droppings varied during the day, although no distinct diurnal rhythm was found. These findings demonstrate that when using FCM to evaluate stress and welfare in laying hens, many factors (e.g., diet, genotype used, and so on) need to be taken into account to allow accurate interpretation of the results. In addition, under certain conditions, excretion rate of FCM might be more appropriate to use compared with FCM concentration.
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| 5. |
- Alm, Malin, et al.
(författare)
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Mussel shells as an environment enrichment and calcium source for floor-housed laying hens
- 2017
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Ingår i: Journal of Applied Poultry Research. - : Elsevier BV. - 1056-6171 .- 1537-0437. ; 26, s. 159-167
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Tidskriftsartikel (refereegranskat)abstract
- Feather pecking is still a behavioral problem in laying hen flocks, resulting in impaired welfare and economic losses. Environment enrichment, e.g., providing access to litter, to increase foraging behavior in laying hens has been shown to decrease feather pecking. This study investigated the effect of spreading crushed mussel shells (particle size 10 to 20 mm) in the litter area as an environment enrichment and source of calcium for layers receiving a commercial feed and for layers given a feed with 40% less calcium. These treatments were compared with a control involving hens given the commercial feed, but no mussel shells in the litter. The study included 900 Dekalb White layers housed in a single-tier floor system during a production cycle (20 to 72 wk of age). The mussel shells were consumed to a lower extent than predicted, resulting in calcium deficiency in hens fed the low-calcium diet. This in turn was evident as increased degree of keel bone deviations and lower eggshell breaking strength. Daily addition of crushed mussel shells to the litter for laying hens on a balanced or calcium-deficient diets did not generate any positive effects on bird feather cover, eggshell quality, production performance, or fearfulness. Hence, with the particle size of mussel shells used in this study, there was no indication of improved welfare due to environment enrichment.
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| 6. |
- Alm, Malin, et al.
(författare)
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Short term deprivation of the litter area after transfer to the layer facility - effects on welfare and production in pullets
- 2013
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Ingår i: World's Poultry Science Journal. - 0043-9339. ; , s. 38-38
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In order to enable hens to find feed and water and to reduce the number of floor-laid eggs in floor systems, producers sometimes exclude pullets from the litter area for some time when they are moved into the production system. This could have negative consequences since litter is an important resource for layers and the procedure is not allowed in Sweden. The aim of the present study was to investigate how bird welfare and production are affected by deprivation of access to litter and space at introduction of pullets to the laying facility. The study comprised 600 floor reared Bovans Robust layers obtained at 16 weeks of age (wks) and housed in 6 groups of 100 in a single-tier floor laying system. Three groups had full access to the litter area during the whole study (OPEN) and three groups were excluded from the litter during the first two weeks (CLOSED) and then received full access throughout the rest of the study. The experiment will run a full production cycle (75 wks) and figures presented below show the results obtained until 51 wks as it is still in progress. Feather cover (6-24 points), pecking wounds, cleanliness, foot condition and keel bone deviations (all 1-4 points) were assessed by integument scoring at 40 wks. Fearfulness was assessed by testing novel object (NO) and tonic immobility (TI). Based on group means, the data were analyzed by analysis of variance (ANOVA) using the MIXED procedure of the statistical system (SAS 9.2). The feather cover score was higher in treatment CLOSED (17.9 points) compared to OPEN (12.3 points) (P=0.019). No difference was found between treatments in any of the other integument score parameters. Fearfulness was higher in groups in the OPEN treatment as compared to CLOSED, indicated by less approaches in the NO test (21.5 vs 48.0) (P<0.001) and longer duration of TI (11.3 min vs 6.4 min) (P=0.018). Rate of lay, number of mislaid eggs, proportion of cracked or dirty eggs and mortality were recorded regularly but no significant differences between treatments were shown. Thus, excluding hens from the litter area during the first two weeks in this type of production system did not decrease the number of floor laid eggs, but had a positive impact on feather cover and resulted in less fearful birds. Additional welfare parameters will be analyzed later on which may explain these results further.
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| 7. |
- Alm, Malin, et al.
(författare)
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Welfare and performance in layers following temporary exclusion from the litter area on introduction to the layer facility
- 2015
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Ingår i: Poultry Science. - : Elsevier BV. - 0032-5791 .- 1525-3171. ; 94, s. 565-573
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Tidskriftsartikel (refereegranskat)abstract
- When introduced to the laying facility, pullets are sometimes temporarily excluded from the litter area in order to help them locate food and water, and to prevent floor-laid eggs. This procedure is not permitted in Sweden, because it involves denying access to both litter and space, which may have a negative effect on bird welfare. The present study investigated how the welfare and performance of layers were affected by this temporary exclusion on introduction of hens to the laying facility. The study included 600 floor-reared Dekalb White layers obtained at 16wk age and housed in 6 groups of 100 in a conventional single-tier floor-laying system. Birds were either given full access to the litter area during the whole study or were excluded from the litter area during the first 2 wk after transfer to the laying facility. From 18 to 72 wk age, birds in both treatments had full access to the litter area. Excluding birds from the litter area for 2wk resulted in better feather cover and reduced fearfulness, according to novel object and tonic immobility tests. Furthermore, birds initially excluded from the litter area produced eggs with a lower proportion of shell irregularities than birds with full access to the litter area throughout. No difference was found in corticosterone metabolites in droppings rate of lay, mortality, or proportion of floor-laid eggs. In conclusion, none of the parameters studied indicated that the welfare of laying hens was compromised by temporary exclusion from the litter area on introduction to the laying facility. In fact, some of the data suggested that bird welfare had improved.
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| 8. |
- Alm, Malin
(författare)
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Welfare indicators in laying hens
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There is a growing concern regarding the welfare of laying hens worldwide and there are both ethical and economic reasons for improving their welfare. Although several different welfare indicators are used today, their ability to accurately reflect welfare status is sometimes questioned. This thesis sought to increase knowledge regarding a number of these welfare indicators by investigating whether and to what extent they were affected when layers were exposed to different stressors. Three different commercial laying hen genotypes were used and birds were challenged by being excluded either from their nests in furnished cages or from the litter area in a single-tier floor system. Excluding birds from their nests resulted in an increased stress response that was detectable in corticosterone metabolites in droppings, corticosterone concentration in egg yolk, heterophil to lymphocyte ratio and egg shell irregularities. Excluding birds from the litter area during the first two weeks in the laying facility resulted in differences in feather cover, approaches towards a novel object, tonic immobility duration and egg shell irregularities measured later in the laying period. Interestingly, according to the welfare indicators used, birds previously excluded from the litter area, and consequently deprived of litter and available area, had better welfare than non-excluded birds. In addition, levels of corticosterone metabolites in droppings were influenced by factors such as diet, genotype, bird age, cage tier, droppings mass, time of day and the kind of assay used. The results showed that several, but not all, indicators were able to detect different stress responses, suggesting that they are more or less appropriate to use depending on the situation prevailing. Many factors influenced the results obtained and there were few and inconsistent correlations, displaying a complex relationship between indicators. Overall, this indicates that welfare assessment should preferably be based on results from several indicators and that careful interpretation of the results is required before stating firm conclusions regarding laying hen welfare.
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| 9. |
- Alm, Malin, et al.
(författare)
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Welfare indicators in laying hens in relation to nest exclusion
- 2016
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Ingår i: Poultry Science. - : Elsevier BV. - 0032-5791 .- 1525-3171. ; 95, s. 1238-1247
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Tidskriftsartikel (refereegranskat)abstract
- Consumer concerns about the welfare of laying hens are increasing, leading to increased interest in identifying reliable ways to assess welfare. The present study evaluated invasive and non-invasive welfare indicators in relation to a stressful challenge. The study included 126 Lohmann Selected Leghorn hens housed in furnished cages. Welfare indicators were measured between 61 and 70 wk of age in birds excluded from their nests for 5 consecutive d and control birds that had continuous access to nests. Baseline recordings were carried out in both groups prior to and post exclusion period. The assessed indicators were: corticosterone metabolites in droppings (FCM), corticosterone concentration in yolk, corticosterone concentration in plasma, irregularities of eggshells, heterophil to lymphocyte (H:L) ratio, tonic immobility duration, and feather cover. Behavioral observations showed that the birds had a clear preference for using the secluded nest sites, confirming that they were likely to perceive nest exclusion as an undesirable experience. Further, elevated levels of FCM in droppings, yolk corticosterone concentrations, H:L ratios and irregular eggshells were detected in both nest deprived and control birds during the exclusion. This suggests that these indicators were able to detect an increased stress response arising from nest deprivation, and it is hypothesized that the stress spread to birds in adjacent cages with access to nests. There was a positive and consistent correlation between FCM in droppings and eggshell irregularities, also supporting the use of eggshell irregularities as a potential non-invasive welfare indicator. However, the pattern of the stress response varied between indicators and correlations were generally few and inconsistent, highlighting the complexity of the relationship among welfare indicators.
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| 10. |
- Alm, Rikard, et al.
(författare)
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Organ culture: a new model for vascular endothelium dysfunction.
- 2002
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Ingår i: BMC Cardiovascular Disorders. - 1471-2261. ; 2:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction. METHODS: The isometric tension was recorded in isolated segments of the rat mesenteric artery branch, before and after organ culture for 20 h. Vasodilatation was expressed as % of preconstriction with U46619. The acetylcholine (ACh) induced nitric oxide (NO) mediated dilatation was studied in the presence of 10 &mgr;M indomethacin, 50 nM charybdotoxin and 1 &mgr;M apamin. Endothelium-derived hyperpolarising factor (EDHF) was studied in the presence of 0.1 mM L-NOARG and indomethacin. Prostaglandins were studied in the presence of L-NOARG, charybdotoxin and apamin. RESULTS: The ACh-induced NO and prostaglandin-mediated dilatations decreased significantly during organ culture (NO: 84% in control and 36% in cultured; prostaglandins: 48% in control and 16% in cultured). Notably, the total ACh-dilatation was not changed. This might be explained by the finding that EDHF alone stimulated a full dilatation even after organ culture (83% in control and 80% in cultured). EDHF may thereby compensate for the loss in NO and prostaglandin-mediated dilatation. Dilatations induced by forskolin or sodium nitroprusside did not change after organ culture, indicating intact smooth muscle cell function. CONCLUSIONS: Organ culture induces a loss in NO and prostaglandin-mediated dilatation, which is compensated for by EDHF. This shift in mediator profile resembles that in endothelium dysfunction. Organ culture provides an easily accessible model where the molecular changes that take place, when endothelium dysfunction is developed, can be examined over time.
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| 11. |
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| 12. |
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| 13. |
- Grann, Martin, et al.
(författare)
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Methodological development : structured outcome assessment and community risk monitoring (SORM)
- 2005
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Ingår i: International Journal of Law and Psychiatry. - : Elsevier BV. - 0160-2527 .- 1873-6386. ; 28:4, s. 442-456
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes an effort to develop a clinical tool for the continuous monitoring of risk for violence in forensic mental health clients who have left their institutions and who are dwelling in the community on a conditional release basis. The model is called Structured Outcome Assessment and Community Risk Monitoring (SORM). The SORM consists of 30 dynamic factors and each factor in SORM is assessed in two ways: The current absence, presence or partial och intermittent presence of the factors, which is an actuarial (systematized and 'objective') assessment. Secondly, the risk effect, i.e. whether the presence/absence of factors currently increases, decreases or is perceived as unrelated to violence risk, is a clinical (or impressionistic) assessment. Thus, the factors considered via the SORM can be coded as risk factors or protective factors (or as factors unimportant to risk of violence) depending on circumstances that apply in the individual case. Further, the SORM has a built-in module for gathering idiographical information about risk-affecting contextual factors. The use of the SORM and its potential as a risk monitoring instrument is illustrated via preliminary data and case vignettes from an ongoing multicenter project. In this research project, patients leaving any of the 9 participating forensic hospitals in Sweden is assessed at release on a variety of static background factors, and the SORM is then administered every 30 days for 2 years.
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| 14. |
- Hellzén, Ove, 1954-, et al.
(författare)
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Primary Healthcare Nurses’ Views on Digital Healthcare Communication and Continuity of Care : A Deductive and Inductive Content Analysis
- 2022
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Ingår i: Nursing Reports. - : MDPI AG. - 2039-439X .- 2039-4403. ; 12:4, s. 945-957
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Tidskriftsartikel (refereegranskat)abstract
- Primary healthcare in the Western world faces significant functional challenges, resulting in the implementation of digital communication tools. Nurses are key professionals in primary care and focusing on the impact of digital communication and continuity of care in primary care organisations is important. This qualitative descriptive study explores digital communication and continuity of care from primary healthcare nurses’ perspective. Data from individual semi-structured interviews with 12 nurses were collected; deductive and inductive content analyses were performed. Three descriptive categories emerged from the deductive (digital communication as interpersonal, information, and management continuities) and inductive (‘digital care does not suit everyone’, ‘new technology is contextually intertwined with daily work’, and ‘patient-positive aspects of digital information’) phases. Additionally, a structural risk of obscuration of patients’ needs by the contextual conditions emerged. To ensure digital communication-aligned continuity of care, compatible information technology systems should be developed. Allowing nurses to provide high-quality care based on their own values would enhance person-centred patient care.
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| 15. |
- Jimenez, David Gomez, et al.
(författare)
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Subpopulations of organoid-forming cells have different motility
- 2020
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Ingår i: Applied Sciences (Switzerland). - : MDPI AG. - 2076-3417. ; 10:13
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Tidskriftsartikel (refereegranskat)abstract
- Cancer stem cells from oropharyngeal squamous cell carcinoma (OPSCC) have the ability to self-renew and differentiate into heterogeneous three-dimensional structures carrying features of tumor cells. Here, we describe a simple and label-free method for generating tumor organoids, and imaging them using live digital holographic microscopy (DHM) on the basis of the phase shift caused by light passing through the cells. We show early events of cell aggregation during tumor-organoid formation, and display their heterogeneity in terms of optical parameters up to an optical volume of 105 μm3. Lastly, by sorting OPSCC epithelial cells, we demonstrate that CD44+ cells displayed greater motility and tumor-forming capacity than those of CD44- cells. These results were in line with previous reports highlighting increased invasive and tumorigenic potential in tumor cells expressing high levels of CD44. Our method provides insight into the formation of tumor organoids, and could be used to assess stemness-associated biomarkers and drug screenings on the basis of tumor organoids.
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| 16. |
- Johansson, Fredrik, et al.
(författare)
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Cell guidance by magnetic nanowires.
- 2010
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Ingår i: Experimental Cell Research. - : Elsevier BV. - 1090-2422 .- 0014-4827. ; 316, s. 688-694
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Tidskriftsartikel (refereegranskat)abstract
- The phenomenon of contact guidance on thin fibers has been known since the beginning of the 20th century when Harrison studied cells growing on fibers from spider's web. Since then many studies have been performed on structured surfaces and fibers. Here we present a new way to induce guidance of cells or cell processes using magnetic nanowires. We have manufactured magnetic Ni-nanowires (200 nm in diameter and 40 mum long) with a template-based electro-deposition method. Drops of a nanowire/ethanol suspension were placed on glass cover slips. The nanowires were aligned in an external magnetic field and adhered to the cover slips after evaporation of the ethanol. When the wires had adhered, the magnetic field was removed. L929 fibroblasts and dissociated dorsal root ganglia (DRG) neurons from mice were cultured on the nanowire-coated cover slips for 24 h and 72 h respectively. The fibroblasts were affected by the aligned nanowires and displayed contact guidance. Regenerated axons also displayed contact guidance on the wires. There were no overt signs of toxicity caused by Ni-wires. Aligned magnetic nanowires can be useful for lab-on-a-chip devices and medical nerve grafts.
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| 17. |
- Kjellander, Pia, et al.
(författare)
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Validating a common tick survey method : cloth-dragging and line transects
- 2021
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Ingår i: Experimental & applied acarology. - : Springer Science and Business Media LLC. - 0168-8162 .- 1572-9702. ; 83:1, s. 131-146
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Tidskriftsartikel (refereegranskat)abstract
- Cloth-dragging is the most widely-used method for collecting and counting ticks, but there are few studies of its reliability. By using cloth-dragging, we applied a replicated line transects survey method, in two areas in Sweden with different Ixodes ricinus tick-densities (low at Grimso and high at Bogesund) to evaluate developmental stage specific repeatability, agreement and precision in estimates of tick abundance. 'Repeatability' was expressed as the Intraclass Correlation Coefficient (ICC), 'agreement' with the Total Deviation Index (TDI) and 'precision' by the coefficient of variation (CV) for a given dragging distance. Repeatability (ICC) and agreement (TDI) were higher for the most abundant instar (nymphs) and in the area of higher abundance. At Bogesund tick counts were higher than at Grimso and so also repeatability, with fair to substantial ICC estimates between 0.22 and 0.75, and TDI ranged between 1 and 44.5 counts of difference (thus high to moderate agreement). At Grimso, ICC was poor to moderate and ranged between 0 and 0.59, whereas TDI remained low with estimates lower or equal to 1 count (thus high agreement). Despite a 100-fold lower abundance at Grimso, the same level of precision for nymphs could be achieved with a 70% increase of dragging effort. We conclude that the cloth-dragging technique is useful for surveying ticks' and primarily to estimate abundance of the nymphal stage, whereas it rarely will be recommended for larvae and adults.
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| 18. |
- Kjällman Alm, Annika, 1963-, et al.
(författare)
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Creating a Dementia-Friendly Community
- 2023
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Ingår i: World Academy of Science, Engineering and Technology.
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Konferensbidrag (refereegranskat)abstract
- The concept of dementia‐friendly communities focuses on the lived experience of people who have dementia and is most relevant to addressing their needs and the needs of those people who live with and provide support for them. The goal of communities becoming dementia‐friendly is for dementia to be normalized and recognized as a disabling condition. People with dementia find being connected to self, to others, and to the environment by meaningful activities as important. According to the concept underlying dementia-friendly communities, people with dementia or cognitive decline can continue to live in the community if their residential community has sufficiently strong social capital. The aim of this study is to explore staff and leaders’ experiences in implementing interventions to enhance a more inclusive dementia-friendly community. A municipality in northern Sweden with a population of approx. 100 000 inhabitants decided to create a dementia friendly municipality. As part of the initiative, a Centre for support was established. The Centre offered support for both individuals and groups, did home visits, and provided information about Dementia. Interviews were conducted with staff who had undergone training in a structured form of multidimensional support, the PER-model®, and worked at the Centre for support. The staff consisted of registered nurses, occupational therapists, and specialized nurses who had worked there for more than five years, and all had training in dementia. All interviews were audio-recorded and transcribed verbatim. The transcribed data were analyzed using qualitative content analysis. Results suggest that implementing the PER-model® of support for persons in the early stages of dementia and their next of kin added a much-needed form of support and perceived possibilities to enhance daily life in the early stages of dementia. The staff appreciated that the structure of PER-model® was evidenced based. They also realized that they never even considered that the person with dementia also needed support in the early stages but that they now had tools for that as well. Creating a dementia friendly municipality offering different kinds of support for all stages of dementia is a challenge. However, evidence-based tools and a broad spectrum of different types of support, whether individual or group, are needed to tailor to everyone’s needs. A conviction that all citizens are equal and should all be involved in the community is a strong motivator.
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| 19. |
- Kjällman Alm, Annika, 1963-, et al.
(författare)
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Sense of Involvement and Support in Persons with Cognitive Decline in Ordinary Dwelling
- 2023
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Ingår i: World Academy of Science, Engineering and Technology.
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Konferensbidrag (refereegranskat)abstract
- Worldwide, the number of people who are living with dementia is increasing because of an aging population, which leads to increased financial and social costs, including reduced quality of life for people with dementia and their care partners. Most people who have dementia reside in the community. Aging in place could be described as having the health and social supports and services you need to live safely and independently in your home or your society for as long as you wish and are able. People with dementia are not different than people without dementia where they want to remain at home, if possible, with a sense of familiarity and engagement in typical everyday activities. So how do persons with dementia or cognitive decline see their possibilities to be socially involved and experience support? The aim of this study was to explore persons with cognitive decline's sense of involvement and support living in the ordinary dwelling. The study was approved by the Ethical Review Authority in Sweden prior to the interviews. Interviews were conducted with 20 persons living at home, either alone or in a relationship. The persons had perceived cognitive decline; some were under investigation or already had a diagnose of early dementia. Thematic analysis was used to identify, analyze, and report patterns within the data. Researchers extracted three main themes through participants’ interviews: a) Importance of social involvement with family and friends. b) Hindrances for social involvement. c) Struggling mentally with a new life situation. Results found that going to activity centers, staying involved, and meeting friends and family enhanced the sense of involvement and support. There were also hindrances to a sense of involvement and support as they struggled with the diagnose and the changes in daily life, such as physical problems, mental problems, or economic issues. The mental struggle of accepting the cognitive decline and the changes in daily life it brought was also an issue for some of the participants. A multidimensional support should be provided by the community to enable persons with cognitive decline to stay involved in family and community in the comfort of their own homes.
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| 20. |
- Lagerqvist, Nina, et al.
(författare)
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Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus
- 2016
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Ingår i: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 54:5, s. 1335-1339
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Tidskriftsartikel (refereegranskat)abstract
- Rodent-borne hantaviruses cause two severe acute diseases: hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and hantavirus pulmonary syndrome (HPS; also called hantavirus cardiopulmonary syndrome [HCPS]) in the Americas. Puumala virus (PUUV) is the most common causative agent of HFRS in Europe. Current routine diagnostic methods are based on serological analyses and can yield inconclusive results. Hantavirus-infected patients are viremic during the early phase of disease; therefore, detection of viral RNA genomes can be a valuable complement to existing serological methods. However, the high genomic sequence diversity of PUUV has hampered the development of molecular diagnostics, and currently no real-time reverse transcription- quantitative (RT)-PCR assay is available for routine diagnosis of HFRS. Here, we present a novel PUUV RT-PCR assay. The assay was validated for routine diagnosis of HFRS on samples collected in Sweden during the winter season from 2013 to 2014. The assay allowed detection of PUUV RNA in 98.7% of confirmed clinical HFRS samples collected within 8 days after symptomatic onset. In summary, this study shows that real-time RT-PCR can be a reliable alternative to serological tests during the early phase of HFRS.
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| 21. |
- Larsson Gerdin, Anna, et al.
(författare)
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Encountering patients in their homes : A qualitative study of home care nurses’ experiences
- 2023
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Ingår i: Nordic journal of nursing research. - : SAGE Publications. - 2057-1585 .- 2057-1593. ; 43:1
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Tidskriftsartikel (refereegranskat)abstract
- Many ill people want to be cared for at home, and home care nurses face an infinite number of encounters when providing that service. Despite the rising prominence of home care organizations worldwide, little research has been conducted on the encounters between home care nurses and patients and how encounters influence the nursing care provided. The aim of the present study was to describe home care nurses’ experiences of encounters with patients in their homes. In total, 11 home care nurses were selected through purposive sampling. The data consisted of individual interviews, which were analyzed through qualitative content analysis, and reported using COREQ reporting guidelines. The results were based on two categories describing the importance of adapting to each patient's needs and collaborating with the person being cared for. Implementing the findings could enable nurses to care for the patients without reducing them to recipients of objectified care.
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| 22. |
- Larsson Gerdin, Anna, et al.
(författare)
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Older persons' experiences of care encounters in their home : A multiple-case study
- 2024
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 33:6, s. 2287-2297
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Tidskriftsartikel (refereegranskat)abstract
- AimTo explore and describe older persons' unique experiences of care encounters with home care nurses in a real-life context.BackgroundThe increasing number of older persons in society contributes to increases in age-related impairments compromising their quality of life. Future care consists of “hospitals at home” where care encounters occur in a person's private domain, partly becoming a clinical workplace. Scant research has focused on how older persons experience care encounters with home care nurses and needs to be highlighted.DesignMultiple-case study.MethodsThe cases relied on replication logic and five purposive sampled older persons were interviewed. Data were analysed using qualitative content analysis and differences within and between cases were explored and findings across the cases were replicated.FindingsThe cross-analysis emerged in three categories: “Nursing routine rules the care encounters”, “Lack of knowledge and information” and “Dependency on support from others”.ConclusionsOur research has found that older persons face challenges while receiving home care, including limited engagement in their care and the need for enhanced support. Implementing person-centred care in homes poses ethical challenges that require careful consideration. Home care nurses should prioritise understanding each patient individually, recognising them beyond their patient role, which necessitates more thorough and time-sensitive care encounters.Reporting MethodFindings were reported using COREQ guidelines.Patient or Public ContributionPatients were interviewed and contributed with data for this study.Implications for the Profession and Patient CareThis study emphasises the need to prioritise individualised care in home settings and listen to the voices of older individuals to enhance quality.
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| 23. |
- Malmberg, Erik, et al.
(författare)
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Minimal residual disease assessed with deep sequencing of NPM1 mutations predicts relapse after allogeneic stem cell transplant in AML
- 2019
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 60:2, s. 409-417
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Tidskriftsartikel (refereegranskat)abstract
- Mutations in NPM1 can be used for minimal residual disease (MRD) analysis in acute myeloid leukemia (AML). We here applied a newly introduced method, deep sequencing, allowing for simultaneous analysis of all recurrent NPM1 insertions and thus constituting an attractive alternative to multiple PCRs for the clinical laboratory. We retrospectively used deep sequencing for measurement of MRD pre- and post-allogeneic hematopoietic stem cell transplantation (alloHCT). For 29 patients in morphological remission at the time of alloHCT, the effect of deep sequencing MRD on outcome was assessed. MRD positivity was defined as variant allele frequency ≥0.02%. Post-transplant MRD status was significantly and independently associated with clinical outcome; 3-year relapse-free survival 20% vs 85% (p <.001), HR 45 (95% CI 2–1260), and overall survival 20% vs 89% (p <.001), HR 49 (95% CI 2–1253). Thus, the new methodology deep sequencing is an applicable and predictive tool for MRD assessment in AML.
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| 24. |
- Radon, Anita, et al.
(författare)
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Asymmetrical Relationships in Online Payment Solutions
- 2016
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Dahlberg et al. (2008:165) in their paper proposed a definition for mobile payments as "payments for goods, services, and bills with a mobile device by taking advantage of wireless and other communication technologies", this in order to clarify the concept of mobile payments in particular, that had been subject to different interpretations. In this paper mobile payments are not specifically distinguished from other types of payments that occur online.After Dahlberg et als review (2008) several other literature reviews about mobile payments have been written. Such as Slade et al. (2013), de Albuquerque et al. (2014) and Dennehy and Sammon (2015) but the literature on relationships between payment provider and customer in an online context is quite scares.Asymmetrical relationships have been identified in the context of online payment solutions. Providers are turning more to service and debating how to offer better service and how to keep the customer as a customer for longer and how the customer can benefit more from the payment provider. The question of when a customer is converted into an actual customer arises. Some claiming it is when the transaction is completed, others that it is long after payment has been made. In light of this it is hard to see how the role online payment providers can expand but also how it will change when moving into a cashless society. The aim of this paper is to view online payment solutions in light of the relationships payment providers wish to establish and strengthen with their customer.Data has been generated through two focus groups, an online questionnaire and individual interviews. The in depth focus groups (2 with 5 participants in each) were analyzed and key areas were identified and a questionnaire was developed and distributed to customers of a provider of payment solutions (394 responses were gathered). After the questionnaire was analyzed and conclusions drawn, areas that needed to be further explored in-depth were identified. These areas were further explored through individual interviews. The methodology is characterized by using both qualitative and quantitative approaches to generate data.The results of the empirical material shows a desire, on the part of the provider of the payment solution to prolong the relationship but also that the customer has no wish to have a relationship with the provider or in some cases, doesn’t even view the provider as a partner/brand/etc. but merely as a means to and end or a facilitator of receiving a good or a service.This study is a comprehensive empirical framework on customer insight into online payments and issues connected to purchase as well as payment and potential relationships with payment solutions providers.ReferencesDahlberg, T., Mallat, N., Ondrus, J., Zmijewska, A., 2008b. Past, present and future of mobile payments research: {A} literature review. Electronic Commerce Research and Applications 7 (2), 165–181.de Albuquerque, J. P., Diniz, E. H., Cernev, A. K., 2014. Mobile payments: A scoping study of the literature and issues for future research. Information Development, 1–27.Dennehy, D., Sammon, D., 2015. Trends in mobile payments research: A literature review. Journal of Innovation Management 3 (1), 49–61.Slade, E. L., Williams, M. D., Dwivedi, Y. K., 2013. Mobile payment adoption: Classification and review of the extant literature. The Marketing Review 13 (2), 167–190
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| 25. |
- Radon, Anita, et al.
(författare)
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What happens when retail meets research? : Special session
- 2016
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- special session InformationWe are witnessing the beginning of a seismic shift in retail due to digitalization. However, what is meant by digitalization is less clear. Sometimes it is understood as means for automatization and sometimes it is regarded as equal to e-commerce. Sometimes digitalization is considered being both automatization and e-commerce trough new technology. In recent years there has been an increase in Internet and mobile devise usage within the retail sector and e-commerce is growing, encompassing both large and small retailers. Digital tools such as, new applications are developing rapidly in order to search for information about products based on price, health, environmental and ethical considerations, and also to facilitate payments. Also the fixed store settings are changing due to digitalization and at an overall level; digitalization will lead to existing business models being reviewed, challenged and ultimately changed. More specifically, digitalization has consequences for all parts of the physical stores including customer interface, knowledge creation, sustainability performance and logistics. As with all major shifts, digitalization comprises both opportunities and challenges for retail firms and employees, and these needs to be empirically studied and systematically analysed. The Swedish Institute for Innovative Retailing at University of Borås is a research centre with the aim of identifying and analysing emerging trends that digitalization brings for the retail industry.
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