| 1. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Centeno, D, et al.
(författare)
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Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection
- 2024
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Ingår i: bioRxiv : the preprint server for biology. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are needed. We have profiled ascites as OC tumor microenvironments (TMs) to search for potential components that would exert growth suppression on OC cell cultures. Our investigations revealed that low levels of taurine, a non-proteogenic sulfonic amino acid, were present within OC ascites. Taurine supplementation, beyond levels found in ascites, induced growth suppression without causing cytotoxicity in multiple OC cell cultures, including patient-derived chemotherapy-resistant spheroid and organoid cultures. Suppression of proliferation by taurine was associated with the inhibition of glycolysis, mitochondrial function, and the activation of p21 and TIGAR, theTP53-dependent and independent tumor suppression regulatory pathways. Expression of p21 or TIGAR in various OC cells, in part, mimicked taurine-induced inhibition of OC cell proliferation. Our data support the potential therapeutic value of taurine supplementation in OC after chemotherapy.
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| 7. |
- Al-Rabiah, Abdulrahman A., et al.
(författare)
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Comparative Kinetic Analysis and Process Optimization for the Production of Dimethyl Ether via Methanol Dehydration over a γ-Alumina Catalyst
- 2022
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Ingår i: Chemical Engineering & Technology. - : Wiley. - 1521-4125 .- 0930-7516. ; 45:2, s. 319-328
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Tidskriftsartikel (refereegranskat)abstract
- Various kinetic models of methanol dehydration to dimethyl ether over a commercial γ-alumina catalyst were compared with a view to selecting the most appropriate model as a basis for process optimization. To achieve significant improvements in the conventional design, the Berčič-and-Levec kinetic model was employed and process intensification was applied to develop a more energy-efficient process, by enhancing the adiabatic reactor performance and maximizing the heat recovery from the highly exothermic reactor. The single-pass conversion of methanol was increased to 83 %, with an inlet temperature of 217 °C to the adiabatic reactor. Application of process intensification resulted in an improved flowsheet, which reduced the total energy requirements by 59.3 % and cut the CO2 emissions by 60.8 %.
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| 8. |
- Engels, E. B., et al.
(författare)
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The synthesized vectorcardiogram resembles the measured vectorcardiogram in patients with dyssynchronous heart failure
- 2015
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Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736 .- 1532-8430. ; 48:4, s. 586-592
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Tidskriftsartikel (refereegranskat)abstract
- Background: The use of vectorcardiography (VCG) has regained interest, however, original Frank-VCG equipment is rare. This study compares the measured VCGs with those synthesized from the 12-lead electrocardiogram (ECG) in patients with heart failure and conduction abnormalities, who are candidate for cardiac resynchronization therapy (CRT). Methods: In 92 CRT candidates, Frank-VCG and 12-lead ECG were recorded before CRT implantation. The ECG was converted to a VCG using the Kors method (Kors-VCG) and the two methods were compared using correlation and Bland-Altman analyses. Results: Variables calculated from the Frank- and Kors-VCG showed correlation coefficients between 0.77 and 0.90. There was a significant but small underestimation by the Kors-VCG method, relative bias ranging from -1.9%+/- 4.6% (QRS-T angle) to -9.4%+/- 20.8% (T area). Conclusion: The present study shows that it is justified to use Kors-VCG calculations for VCG analysis, which enables retrospective VCG analysis of previously recorded ECGs in studies related to CRT. (C) 2015 Elsevier Inc. All rights reserved.
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