| 1. |
- Kotronen, Anna, et al.
(författare)
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Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
- 2009
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Ingår i: European Journal of Endocrinology. - 1479-683X. ; 160:4, s. 593-602
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We investigated whether polymorph isms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver I, at content. Methods: Liver fat content was measured using proton magnetic resonance spectroscopy (H-1-MRS) in 302 Finns, in whom single nucleotide polymorphisms (SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4). acliponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2), and the three peroxisome proliferator-activated receptors (PPARA, PPARD, and PPARG) were analyzed. To validate our findings, SNPs significantly associated with liver fat content were Studied in two independent cohorts and related to surrogate markers of liver fat content. Results: In the Finnish subjects, polymorphisms in ACSL4 (rs7887981), ADIPOR2 (rs767870), and PPARG (rs3856806) were significantly associated with liver fat content measured with H-1-MRS after adjusting for age, gender, and BMI, Anthropometric and circulating parameters were comparable between genotypes. In the first validation cohort of similar to 600 Swedish men, ACSL4 rs7887981 was related to fasting insulin and triglyceride concentrations, and ADIPOR2 rs767870 to serum gamma glutamyltransfer concentrations after adjusting for BMI. The SNP in PPARG (rs3856806) was not significantly associated with any relevant metabolic parameter in this cohort. In the second validation cohort of similar to 3000 subjects from Western Finland, ADIPOR2 rs767870, but not ACSL4 rs7887981 was related to fasting triglyceride concentrations. Conclusions: Genetic variation, particularly in the ADIPOR2 gene, contributes to variation in hepatic fat accumulation in humans.
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| 2. |
- Abrahamson, Josefin, et al.
(författare)
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Adolescent elite skiers with and without cam morphology did change their hip joint range of motion with 2 years follow-up
- 2019
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Ingår i: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Science and Business Media LLC. - 0942-2056 .- 1433-7347. ; 27:10, s. 3149-3157
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To investigate how range of motion of the hips and the lumbar spine are affected by continued elite, alpine skiing in young subjects, with and without a magnetic resonance imaging verified cam morphology, in a 2-year follow-up study. The hypothesis is that skiers with cam morphology will show a decrease in hip joint range of motion as compared with skiers without cam, after a 2-year follow-up. Method: Thirty adolescent elite alpine skiers were examined at the baseline (mean age 17.3 ± 0.7 years) and after 2 years. All skiers were examined for the presence of cam morphology (α-angle > 55°) using magnetic resonance imaging at the baseline. Clinical examinations of range of motion in standing lumbar flexion and extension, supine hip flexion, internal rotation, FABER test and sitting internal rotation and external rotation were performed both at the baseline and after 2 years. Results: Skiers with and without cam morphology showed a significant decrease from baseline to follow-up in both hips for supine internal rotation (right: mean − 13.3° and − 10.9° [P < 0.001]; left: mean − 7.6° [P = 0.004] and − 7.9° [P = 0.02]), sitting internal rotation (right: mean − 9.6° and − 6.3° [P < 0.001]; left: mean − 7.6° [P = 0.02] and − 3.3° [P = 0.008]) and sitting external rotation (right: mean − 16.9° and − 11.4° and left: mean − 17.9° and − 14.5° [P < 0.001]) and were shown to have an increased left hip flexion (mean + 8.4° and + 4.6° [P = 0.004]). Skiers with cam were also shown to have an increased right hip flexion (mean + 6.4° [P = 0.037]). Differences were found between cam and no-cam skiers from baseline to follow-up in the sitting internal rotation in both hips (right: mean 3.25°, left: mean 4.27° [P < 0.001]), the right hip flexion (mean 6.02° [P = 0.045]) and lumbar flexion (mean − 1.21°, [P = 0.009]). Conclusion: Young, elite alpine skiers with cam morphology decreased their internal rotation in sitting position as compared with skiers without the cam morphology after 2 years of continued elite skiing. Level of evidence: II.
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| 3. |
- Abrahamson, Josefin, et al.
(författare)
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Hip pain and its correlation with cam morphology in young skiers-a minimum of 5 years follow-up
- 2020
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Ingår i: Journal of Orthopaedic Surgery and Research. - : Springer Science and Business Media LLC. - 1749-799X. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThere is conflicting evidence regarding the association between cam morphological changes and hip pain, and it remains unclear who with cam morphology will develop hip pain and who will not. This study aimed to investigate the correlation between cam morphology, hip pain, and activity level at a 5-year follow-up in young Alpine and Mogul skiers.MethodAll students (n = 76) at angstrom re Ski National Sports High School were invited and accepted participation in this prospective study at baseline. Magnetic resonance imaging (MRI) of both hips was conducted to evaluate the presence of cam morphology (alpha -angle >= 55 degrees) and its size alongside the reporting of hip pain, type, and frequency of training by the Back and hip questionnaire, at baseline. After 5 years, the skiers were invited to complete a shortened version of the same questionnaire.ResultsA total of 60 skiers (80%) completed the follow-up questionnaire, of which 53 had concomitant MRI data. Cam morphology was present in 25 skiers (47.2%, 39 hips). Hip pain at baseline and at follow-up was reported in 17 (28.3%) and 22 (36.7%) skiers, respectively. No correlations were found between the activity level, the frequency, and the size of cam morphology and hip pain, except for the right hip alpha -angle at 1 o'clock and hip pain in skiers with cam morphology at baseline (r(s) = 0.49; P = 0.03) and at follow-up (r(s) = 0.47; P = 0.04). A total of 73.3% skiers had retired, of which 48% reported this was due to injuries.ConclusionHip pain was not shown to be correlated, or had a low correlation, with activity level and the presence and size of cam morphology in young skiers on a 5-year follow-up. Based on these results, cam morphology or activity level did not affect hip pain to develop during 5 years of follow-up in young skiers. Furthermore, this study highlights that almost 75% of young elite skiers had retired from their elite career with almost 50% reporting that this was due to injuries sustained from skiing.
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| 4. |
- Amerstorfer, Eva Elisa, et al.
(författare)
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What do pediatric surgeons think about sexual issues in dealing with patients with anorectal malformations? The ARM-Net consortium members’ opinion
- 2019
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Ingår i: Pediatric Surgery International. - : Springer Science and Business Media LLC. - 0179-0358 .- 1437-9813. ; 35:9, s. 935-943
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Since pediatric surgeons aim to follow their patients with anorectal malformations (ARM) into adulthood the aim of this study was to investigate how pediatric surgeons deal with sexual issues related to ARM. Methods: In 2018, a questionnaire was developed by the working group “Follow-up and sexuality” of the ARM-Net consortium and sent to all consortium-linked pediatric surgeons from 31 European pediatric surgical centers. Obtained data were statistically analyzed. Results: Twenty-eight of 37 pediatric surgeons (18 males/10 females) answered the questionnaire. The majority of pediatric surgeons (82%) think they should talk about sexual issues with their patient. More than 50% of pediatric surgeons do not feel at all or only moderately confident discussing the topic of sexuality. Most pediatric surgeons require more support (96%) and wish to be trained in sexuality and sexual issues (78%) to feel confident towards their ARM-patients/parents. For optimal care, sexual issues with ARM-patients should be managed by a multidisciplinary team. Conclusions: Pediatric surgeons feel that sexuality is an important issue for their ARM-patients, which they are primarily responsible of but should be managed in concert with a multidisciplinary team. A training in sexuality is wished to feel more confident about this specific issue.
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| 5. |
- Aminoff, Anna
(författare)
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Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lipids including triglycerides, cholesterol, cholesterol esters and fatty acids are important sources for energy production, act as building blocks for intracellular compartments, are involved in numerous biological pathways and may act as signal molecules. Lipids are transported in blood as lipoproteins between organs, where they are immediately used in cellular processes or stored as cytosolic lipid droplets. The lipoprotein and intracellular lipid metabolism need to be under tight control to avoid adverse cellular events. Dyslipidaemia and ectopic lipid accumulation are associated with metabolic disorders such as obesity, insulin resistance, type 2 diabetes and a spectrum of cardiovascular diseases. Microsomal triglyceride transfer protein (MTTP) and perilipin 2 (PLIN2) are two main players in lipid metabolism. MTTP is crucial for the assembly of apolipoprotein B containing lipoproteins, which are mainly secreted by the liver as very low density lipoprotein, and the intestine as chylomicrons. PLIN2 is the main lipid droplet associated protein in non-adipose tissue and is important for the management of intracellular lipid droplets. This thesis investigates genetic variations in MTTP and PLIN2 and their relation to lipid metabolism and metabolic disorders. A common variant of MTTP, comprising two promoter polymorphisms (rs1800591G>T and rs1800804T>C), and a missense polymorphism (rs3816873/ Ile128Thr), results in decreased expression of MTTP and a less stable protein. The decreased expression, associated with the minor alleles, is mediated by allele-specific binding of nuclear factors to the rs1800804T>C polymorphism. As shown by association studies of cardiovascular diseases, and patients with suspected coronary artery disease undergoing extensively characterisation of their cardiac function, the minor allele of rs1800804T>C confers increased risk for cardiovascular diseases and negatively influences the cardiac function. Decreased cardiac MTTP may impair transport of surplus lipids from heart that may cause lipotoxicity and heart failure. Two patients suffering from Abetalipoproteinaemia were investigated and two novel mutations were identified. Abetalipoproteinaemia is a rare recessive monogenic disease caused by lack-of-function mutations in MTTP. The first proband is homozygous for a missense mutation in exon 13 of MTTP, p.Pro552Leu (NM_000253.2:c.1655C>T). Amino acid 552 is present in an α-helix domain predicted to bind to protein disulfide isomerase required for functional MTTP. There are three other missense mutations reported in exon 13 of MTTP that cause Abetalipoproteinaemia. The four missense mutations are associated with different severity of disease, and structural analysis of MTTP shows that the position of the mutations may reflect different functional domains of MTTP. The second proband was found to be homozygous for a duplication in the splice junction of intron 17, NM_000253.2:c.2342+2dup. The mother is a heterozygous carrier of this mutation, while no aberrations could be found in MTTP of the father. MTTP is located at 4q22-24, and analysis of microsatellite markers across the complete chromosome 4 showed that the proband has inherited two copies of chromosome 4 from only the mother, a condition called uniparental disomy. As a result of crossing over events, the interstitial region comprising MTTP, is inherited from only one of the mother’s chromosome 4, while the telomeric regions origins from both of the two maternal chromosomes. This explains why the proband is homozygous for the mutation while the mother is heterozygous. Genetic analysis of PLIN2 identified a missense polymorphism in exon 6, rs35568725 (Ser251Pro). The minor Pro251 allele is associated with decreased plasma triglyceride and very low density lipoprotein concentrations. Functional studies showed that the minor Pro251 allele disrupts an α-helix, is evolutionarily conserved, increases intracellular lipid accumulation and reduces lipolysis. This is the first time a genetic variant of PLIN2 has been shown to influence the lipid metabolism in humans. The Pro251 variant alters the function of PLIN2 and results in more stable lipid droplets, and appears to mediate an increased capacity to store intracellular lipids. The increased understanding of lipid metabolism in the past decade highlights that it is not the amount or concentration of lipid that is the most important issue for maintaining lipid homeostasis. In order to understand the underlying pathophysiology of metabolic disorders we need to address questions related to where, how and why different kinds of lipids are stored and used.
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| 6. |
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| 7. |
- Aminoff, Anna Swärd
(författare)
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Hip range of motion and the prevalence of cam morphology in young athletes - clinical and radiological studies
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Abstract Hip and groin pain is common among athletes and the active population, and one important cause for this is femoroacetabular impingement syndrome (FAIS). To meet the diagnosis of FAIS, a combination of radiological findings (cam and/or pincer morphology), hip pain and clinical findings (reduced hip joint range of motion (ROM) and/or positive anterior impingement test (FADIR)) needs to be present. To quantify a cam morphology, the α-angle is often measured, and a cam morphology is usually considered present with an α-angle of ≥55°. Factors that have been associated with the development of cam morphology are genetics, ethnicity and participation in high impact sports during the pubertal growth spurt. Why some individuals develop FAIS and others do not, in the presence of a cam morphology, is still unknown. Therefore, there are still many questions that need to be answered regarding the aetiology, prevalence, impacts of different types of sports and loads, and treatment of cam/pincer and FAIS. Cam-type FAIS has also been associated with early hip osteoarthritis, and therefore this thesis focuses on cam morphology of the hip. The overall aim of this thesis was to investigate the prevalence of cam morphology, hip ROM, hip pain and FAIS among young elite skiers and football players. Further, to investigate the relationship between hip ROM and cam, and hip range of motion and pelvic tilt (with and without cam morphology). Study 1 is a cross-sectional study, including 87 skiers and 27 non-athletes with a mean age of 17.7 (SD1.4) years, where the aim was to examine the relationship between the clinical examination of the hip and cam morphology. The study population was divided into cam- and no cam-groups depending on the -angle measured with MRI. The main findings showed that reduced hip joint internal rotation, hip flexion and a positive anterior impingement test were associated with MRI-verified cam. Study 2 is a cross-sectional study with the aim to investigate the effect of changes in pelvic tilt on hip ROM in individuals with and without cam. The same study population was included as in Study 1. The main finding was that dynamic changes in pelvic tilt significantly influenced hip ROM, independent of cam morphology. Study 3 is a cross-sectional study investigating the prevalence of cam morphology (-angle >55°) in a group of elite Mogul and Alpine skiers, compared with non-athletes and between the sexes. The same study population was included as in Study 1. The skiers had a significantly higher prevalence of cam compared with the non-athletes. A significant difference was also found between males and females, with males having a higher prevalence of cam. Study 4 is a cross-sectional study with the aim to investigate the difference in hip ROM, hip pain, cam morphology and FAIS in young athletes. One-hundred-and-thirty-five athletes (60 male soccer players, 40 male skiers and 35 female skiers) with a mean age of 17.7 (SD 1.2) years were included. Please find results in manuscript.
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| 8. |
- Aminoff, Anna Swärd, et al.
(författare)
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Young elite Alpine and Mogul skiers have a higher prevalence of cam morphology than non-athletes
- 2020
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Ingår i: Knee Surgery Sports Traumatology Arthroscopy. - : Springer Science and Business Media LLC. - 0942-2056 .- 1433-7347. ; 28:4, s. 1262-1269
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To investigate the prevalence of cam morphology in (1) a group of young elite Mogul and Alpine skiers compared with non-athletes and (2) between the sexes. Method The hip joints of 87 subjects [n = 61 young elite skiers (29 females and 32 males) and n = 26 non-athletes (17 females and 9 males)] were examined using MRI, for measurements of the presence of cam morphology (alpha-angle >= 55). Results The skiers had a significantly higher prevalence of cam morphology compared with the non-athletes (49% vs 19%, p = 0.009). A significant difference (p < 0.001) was also found between females and males, where 22% of the females and 61% of the males had cam morphology. Among the skiers, there was also a significant difference (p < 0.001) between the sexes, where 28% of the females and 68% of the males had cam morphology. This difference between the sexes was not found in the non-athletic group. No significant differences were found between Mogul and Alpine skiers. Conclusion Young male elite skiers have a higher prevalence of cam morphology of the hips compared with non-athletes.
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| 9. |
- Burström, Lage, et al.
(författare)
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Musculoskeletal symptoms and exposure to whole-body vibration among open-pit mine workers in the arctic
- 2017
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Ingår i: International Journal of Occupational Medicine and Environmental Health. - : Nofer Institute of Occupational Medicine. - 1232-1087 .- 1896-494X. ; 30:4, s. 553-564
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: This cross-sectional questionnaire study was carried out at 4 open-pit mines in Finland, Norway, Russia and Sweden as part of the MineHealth project. The aim has been to compare the prevalence of musculoskeletal symptoms between drivers of mining vehicles and non-drivers. Material and Methods: The mine workers were asked whether they had suffered from any musculoskeletal symptoms during the previous 12 months in specified body regions, and to grade the severity of these symptoms during the past month. They were also asked about their daily driving of mining vehicles. Results: The questionnaire was completed by 1323 workers (757 vehicle drivers) and the reported prevalence and severity of symptoms were highest for the lower back, followed by pain in the neck, shoulder and upper back. Drivers in the Nordic mines reported fewer symptoms than non-drivers, while for Russian mine workers the results were the opposite of that. The daily driving of mining vehicles had no significant association with the risk of symptoms. Female drivers indicated a higher prevalence of symptoms as compared to male drivers. Conclusions: The study provided only weak support for the hypothesis that drivers of vehicles reported a higher prevalence of musculoskeletal symptoms than non-vehicle drivers. There were marked differences in the prevalence of symptoms among workers in various enterprises, even though the nature of the job tasks was similar.
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| 10. |
- Hageman, Isabel C., et al.
(författare)
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A Quality Assessment of the ARM-Net Registry Design and Data Collection
- 2023
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Ingår i: Journal of Pediatric Surgery. - : Elsevier BV. - 0022-3468. ; 58:10, s. 1921-1928
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Tidskriftsartikel (refereegranskat)abstract
- Background: Registries are important in rare disease research. The Anorectal Malformation Network (ARM-Net) registry is a well-established European patient registry collecting demographic, clinical, and functional outcome data. We assessed the quality of this registry through review of the structure, data elements, collected data, and user experience. Material and methods: Design and data elements were assessed for completeness, consistency, usefulness, accuracy, validity, and comparability. An intra- and inter-user variability study was conducted through monitoring and re-registration of patients. User experience was assessed via a questionnaire on registration, design of registry, and satisfaction. Results: We evaluated 119 data elements, of which 107 were utilized and comprised 42 string and 65 numeric elements. A minority (37.0%) of the 2278 included records had complete data, though this improved to 83.5% when follow-up elements were excluded. Intra-observer variability demonstrated 11.7% incongruence, while inter-observer variability was 14.7%. Users were predominantly pediatric surgeons and typically registered patients within 11–30 min. Users did not experience any significant difficulties with data entry and were generally satisfied with the registry, but preferred more longitudinal data and patient-reported outcomes. Conclusions: The ARM-Net registry presents one of the largest ARM cohorts. Although its collected data are valuable, they are susceptible to error and user variability. Continuous evaluations are required to maintain relevant and high-quality data and to achieve long-term sustainability. With the recommendations resulting from this study, we call for rare disease patient registries to take example and aim to continuously improve their data quality to enhance the small, but impactful, field of rare disease research. Level of Evidence: V.
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| 11. |
- Hemilä, Jukka, et al.
(författare)
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Reverse supply chain relationship to circular economy
- 2016
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Ingår i: The Proceedings of 21st International Symposium on Logistics (ISL 2016). - Nottingham, UK : Centre for Concurrent Enterprise, Nottingham University Business School. - 9780853583172 ; , s. 217-223
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Konferensbidrag (refereegranskat)abstract
- Most of the focus in logistics and supply chain research has been on forward logistics, but the reverse supply chain (RSC) has been studied for more than a decade. Meanwhile, the Circular Economy (CE) has gathered a lot of attention in recent years from management sciences as well as companies offering a practical alternative to the current linear economic model. The purpose of this paper is to analyze the relationship of these two concepts of RSC and CE, especially in terms of value creation. The study also suggests how to develop a sustainable business model by following RSC and CE concepts. The paper indicates future research questions and hypotheses for these topics.
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| 12. |
- Johanna, Bragge, et al.
(författare)
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Unveiling the intellectual structure and evolution of external resource management research: Insights from a bibliometric study
- 2019
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Ingår i: Journal of Business Research. - : Elsevier BV. - 0148-2963. ; 97, s. 141-159
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Tidskriftsartikel (refereegranskat)abstract
- In the current hyper-competitive economy, it is increasingly important to understand how firms can and should access and leverage external resources, such as customer knowledge or supply-chain partners’ capabilities. In this paper, we report the results of bibliometric analyses on external resource management (ERM) research in nine representative journals, and elaborate the underlying patterns and dynamics in this relatively young research area. A total of 1290 articles ranging from year 2000 to 2015 were analyzed with text-mining and visualization methods. We found that the annual number of ERM publications is steadily increasing, and identified and described four distinct research clusters focusing on integration & operational effectiveness, innovation & value creation, inter-organizational relationships, and knowledge transfer & learning. The identification of research clusters and key works and authors in this multidisciplinary research field can assist future research in better positioning their studies and finding the key references across disciplinary silos.
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| 13. |
- Jussila, Kirsi, et al.
(författare)
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Thermal comfort sustained by cold protective clothing in Arctic open-pit mining : a thermal manikin and questionnaire study
- 2017
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Ingår i: Industrial Health. - : National Institute of Occupational Safety and Health. - 0019-8366 .- 1880-8026. ; 55:6, s. 537-548
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Tidskriftsartikel (refereegranskat)abstract
- Workers in the Arctic open-pit mines are exposed to harsh weather conditions. Employers are required to provide protective clothing for workers. This can be the outer layer, but sometimes also inner or middle layers are provided. This study aimed to determine how the Arctic open-pit miners protect themselves against cold and the sufficiency, and the selection criteria of the garments. Workers' cold experiences and the clothing in four Arctic open-pit mines in Finland, Sweden, Norway and Russia were evaluated by a questionnaire (n=1323). Basic thermal insulation (Icl) of the reported clothing was estimated (ISO 9920). The Icl of clothing from the mines were also measured by thermal manikin (standing/walking) in 0.3 and 4.0 m/s wind. The questionnaire showed that the Icl of the selected clothing was on average 1.2 and 1.5 clo in mild (-5 to +5°C) and dry cold (-20 to -10°C) conditions, respectively. The Icl of the clothing measured by thermal manikin was 1.9w2.3 clo. The results show that the Arctic open-pit miners' selected their clothing based on occupational (time outdoors), environmental (temperature, wind, moisture) and individual factors (cold sensitivity, general health). However, the selected clothing was not sufficient to prevent cooling completely at ambient temperatures below -10°C.
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| 14. |
- Lorentz, Harri, et al.
(författare)
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Acquisition of supply market intelligence – An information processing perspective
- 2020
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Ingår i: Journal of Purchasing and Supply Management. - : Elsevier BV. - 1478-4092. ; 26:5
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Tidskriftsartikel (refereegranskat)abstract
- The capability to develop and sustain superior knowledge of markets and supply chains, or supply market intelligence (SMI), is an important element in increasing the strategic relevance of purchasing and supply management (PSM). This study draws on information processing theory (IPT) to shed light on how firms acquire SMI. In particular, the study aims to identify the drivers and mechanisms of information processing in SMI acquisition and to explore how the two constructs are related. Our findings emerged from an abductive multiple case study including 22 SMI tasks in eight case companies operating in various manufacturing industries. We find that the drivers of information processing needs in SMI acquisition are related either to uncertainty or equivocality. Uncertainty describes a situation in which decision-makers may be ignorant of a variable's value while equivocality describes a situation in which they may be ignorant of the variable's existence. We identify four structural mechanisms and three information technology mechanisms for information processing in the SMI context. We also find that equivocality seems to trump uncertainty in determining the use of the identified SMI acquisition mechanisms. In addition to elaborating IPT in the SMI context and exploring the theoretical foundations of SMI, we offer practitioners a framework for supporting the design of SMI practices in procurement organisations.
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| 15. |
- Manninen, Kaisa, et al.
(författare)
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Do circular economy business models capture intended environmental value propositions?
- 2018
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 171, s. 413-422
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Tidskriftsartikel (refereegranskat)abstract
- The circular economy (CE) can be a driver for sustainability and CE can be promoted and supported by the creation of new and innovative business models, which embed CE principles into their value propositions throughout the value chains. This study focuses on the environmental value propositions of the CE business models. The term environmental value proposition refers here to an absolute value being a promise of environmental improvement, which a company provides to the environment by its impacts throughout the whole value chain. The aim of this study is to outline a framework for evaluating the environmental value propositions of CE business models. The framework consists of an environmental value propositions table (EVPT) and a step-by-step approach towards an evaluation process. The framework was tested in three CE business model cases. The outlined framework enables a better understanding of circular economy principles, combining them with the environmental value proposition. With the framework, companies can plan and design new CE business models or they can verify intended environmental benefits and analyse their contribution to sustainability. The biggest challenges, when applying the framework, were related to the estimation of environmental benefits gained from the environmental value propositions at the system level. In the future, intensive scientific work should concentrate on developing environmental assessment methods specifically for companies developing new CE business models.
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| 16. |
- Morandi, Anna, et al.
(författare)
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Urological Impact of Epididymo-orchitis in Patients with Anorectal Malformation : An ARM-Net Consortium Study
- 2022
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Ingår i: European Journal of Pediatric Surgery. - : Georg Thieme Verlag KG. - 0939-7248 .- 1439-359X. ; 32:6, s. 504-511
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Tidskriftsartikel (refereegranskat)abstract
- Introduction To investigate the current experience of the ARM-Net Consortium in the management of epididymo-orchitis (EO) in patients with anorectal malformations (ARMs), and to identify specific risk factors and the need for urological care involvement. Materials and Methods We retrospectively collected data of EO in patients with ARM between 2015 and 2019. Data on urological aspects, ARM type, surgical approach, associated anomalies, diagnosis, and treatment of EO were collected and analyzed. Results Twenty-nine patients were reported by 12 centers. Twenty-six patients with EO (90%) had ARM with a rectourinary fistula. Median age at first EO was 2 years (range: 15 days-27 years). Twenty patients (69%) experienced multiple EO, and 60% of recurrences were ipsilateral. Associated urological anomalies included vesicoureteral reflux (48%), urethral anomalies (41%), neurogenic bladder (41%), and ectopic vas (10%). A positive urine culture during EO was present in 69%. EO was treated with antibiotics (90%), limiting surgical exploration to 14%. Prevention of recurrences included surgery (bulking agents 15%, vasectomy 15%, and orchiectomy 5%) and antibiotic prophylaxis (20%). Conclusion Urologists may encounter patients with EO in ARM patients, frequently with positive urine culture. An appropriate urologic work-up for most ARM patients is necessary to identify and treat underlying risk factors. A practical scheme for the work-up is suggested for a close collaboration between pediatric surgeons and urologists.
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| 17. |
- Pihlajamaa, Matti, et al.
(författare)
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How to stimulate supplier innovation? Insights from a multiple case study
- 2019
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Ingår i: Journal of Purchasing and Supply Management. - : Elsevier BV. - 1478-4092. ; 25:3
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on the literature on supplier innovation, supplier development, and the relational view, we bring forward the concept of stimulation of supplier innovation, which refers to the buyer company's actions which aim to enhance its suppliers' innovativeness, guide its suppliers' innovation processes, and/or encourage its suppliers to share their innovations. Through four case studies about purchasing categories in three companies, we study how the stimulation focus is determined and what methods can be used for stimulating supplier innovation. We propose that stimulation comprises indirect and direct forms of knowledge-sharing and governance with an emphasis on indirect methods and suggest that the concept sheds light on the research gap on the push model of supplier innovation. We also elaborate the literature on supplier development and relational view in the context of supplier innovation.
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| 18. |
- Stjernbrandt, Albin, et al.
(författare)
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Neurosensory and vascular symptoms and clinical findings in the hands of Arctic open-pit miners in Sweden and Norway : a descriptive study
- 2023
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Ingår i: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 82:1
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Tidskriftsartikel (refereegranskat)abstract
- This cross-sectional study aimed to describe exposure to cold climate and hand-arm vibration (HAV) as well as neurosensory and vascular symptoms and clinical findings among open-pit Arctic miners. It was based on data from questionnaires and physical examinations, including 177 men and 75 women from two open-pit mines in Sweden and Norway (response rate 54%). Working outdoors or in an unheated building or machine for at least two hours per day was reported by 44% and HAV exposure of the same duration by 10%. Neurosensory symptoms (e.g. reduced perception of touch) in the hands were reported by 47% and Raynaud’s phenomenon by 14%. In brief conclusion, the study showed that Arctic miners were commonly exposed to both cold temperatures and HAV. They also reported a broad range of neurosensory and vascular symptoms in their hands and had abnormal clinical findings related to the symptoms. The results emphasise the need for additional preventive measures in this occupational setting.
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| 19. |
- Stjernbrandt, Albin, et al.
(författare)
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Raynaud's phenomenon in the feet of Arctic open-pit miners
- 2024
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Ingår i: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 83:1
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Tidskriftsartikel (refereegranskat)abstract
- The literature on Raynaud's phenomenon (RP) in the feet is scarce, especially in the occupational setting. The primary aim of our study was to investigate the occurrence of RP in the feet of miners. As part of the MineHealth project, written surveys and clinical examinations were completed by 260 Arctic open-pit miners working in northern Sweden and Norway (participation rate 53.6%). Data on RP were collected using standardised colour charts and questionnaire items. Clinical examination included assessing the perception of vibration and pain in both feet. There were eight women and three men who reported RP in the feet. Four also had RP in their hands but none acknowledged any first-degree relatives with the condition. Nine reported exposure to foot-transmitted vibration and one to hand-arm vibration. Seven showed signs of neurosensory injury in the feet. To conclude, the occurrence of RP in the feet of miners was 4.4%. Most cases with RP in the feet did not report the condition in the hands and were exposed to vibration transmitted directly to the feet. There were no reports of a hereditary component. Most cases with RP in the feet also had clinical findings suggestive of peripheral neuropathy in the feet.
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| 20. |
- Tanskanen, Kari, et al.
(författare)
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Towards evidence-based management of external resources: developing design propositions and future research avenues through research synthesis
- 2017
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Ingår i: Research Policy. - : Elsevier BV. - 0048-7333. ; 46:6, s. 1087-1105
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Tidskriftsartikel (refereegranskat)abstract
- The general question of how best to access and leverage resources that reside outside the boundaries of the focal firm has become increasingly important for companies during the last decennia, and scholars across management disciplines have responded with increasing research efforts. However, managers still seldom base their decisions on scientific evidence. Research on managing external resources is carried out in disciplinary silos and it is extremely difficult for managers to make sense of the vast amount of scientific studies. The success story of medicine as the first domain to widely adopt evidence-based practices has been an exemplar for other disciplines such as management to address the prevailing research-practice gap. Through a systematic review and synthesis of 601 articles in six academic journals representing three management disciplines we develop design propositions for supporting evidence-based management of external resources in firms. Our analysis reveals external resource management (ERM) research to be concentrated on six distinct, yet interrelated, themes. We adopt the CIMO-logic (Context, Intervention, Mechanism, Outcomes) for developing the set of design propositions within each of the research themes. A key scientific contribution is our identification of future research opportunities and directions to advance science in the field of ERM.
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| 21. |
- Thoreson, Olof, 1981, et al.
(författare)
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The one-year prevalence of nonspecific back pain in public primary health care establishments among 1.7 million people in western Sweden
- 2020
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Ingår i: Primary Health Care Research and Development. - : Cambridge University Press (CUP). - 1463-4236 .- 1477-1128. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The one-year prevalence of diagnosed nonspecific back pain in Sweden is not known. Thus, this observational register-based study aimed to evaluate this prevalence by using data from the Region Vastra Gotaland, inhabiting 1.7 million people. Methods: Data from 2014 to 2018 were extracted from the VEGA database register. This register holds all health data from the publicly funded health care establishments in Region Vastra Gotaland. Aggregated data are presented as the one-year prevalence of unique individuals diagnosed with nonspecific back pain (i.e., the ICD-10 code M54). Stratification by health care level, gender, age, and M54 sub-diagnoses were made. Findings: Between 2014 and 2018, the annual prevalence of diagnosed nonspecific back pain in public primary health care increased from 4.8% to 6.0% (26% increase, P < 0.001, CI 25-27%). In 2018, the one-year prevalence was 7.2% among women and 4.8% among men (50% difference, P = 0.001, CI 49-52%). The one-year prevalence increased by age, and the highest figure (11%) was seen in the age group of 80-84. Low back pain, M54.5, was the most common sub-diagnosis. The one-year prevalence was significantly higher (P < 0.001) among women in all the M54 sub-diagnoses. Conclusion: The one-year prevalence of diagnosed nonspecific back pain was 6% in public primary health care in 2018 and has increased since 2014. Women were diagnosed considerably more frequently than men. Publicly funded rehabilitation efforts, as well as actions focusing on the prevention of back pain, is probably money well spent.
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| 22. |
- Witwit, Wisam, et al.
(författare)
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No Significant Change in MRI Abnormalities or Back Pain Prevalence in the Thoraco-Lumbar Spine of Young Elite Skiers Over a 2-Year Follow-Up
- 2022
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Ingår i: Open Access Journal of Sports Medicine. - 1179-1543. ; 13, s. 69-76
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Tidskriftsartikel (refereegranskat)abstract
- Background: Young athletes are at increasing risk for spinal column injuries due to overloading the spine with excessive sports activities, with potential development of complications later in life.Purpose: The purpose of this 2-year follow-up study of young elite skiers and non-athletes was to investigate any potential change in the thoraco-lumbar findings on MIRI and to outline any change in back pain prevalence with continuing sporting activity and age. Study Design: Longitudinal cross-sectional study.Methods: MIRI of the thoraco-lumbar spine was performed on 30 skiers (mean age 20 years, female 43%) and 16 non-athletes (mean age 19, female 75%), available for the 2-year follow-up. The intervertebral discs were evaluated for signal, height, bulge/herniation, and additionally according to Pfirrmann classification, and the endplates were graded according to endplate defect score. Any of the following disc findings was defined as disc degenerative change: reduced signal, reduced height, bulge, or herniation. All participants answered a specific back pain questionnaire.Results: No significant difference in spinal column abnormalities, nor back pain, was found between baseline and 2-year follow-up in neither skiers nor controls. There was significantly higher prevalence of disc degenerative changes in skiers (73%) than in non-athletes (44%, p=0.05). Skiers (63%) had significantly more Pfirrmann grade >= 3 discs compared to non-athletes (25%) (p=0.03). There was no significant difference in number of endplates with score >= 4 between skiers and non-athletes (50% vs 38%, p=0.40) nor in lifetime prevalence of back pain between skiers (46%) and non-athletes (40%).Conclusion: There was no significant change over time of the spinal column MIRI abnormalities, nor back pain prevalence, during a 2-year follow-up of skiers and non-athletes. Young skiers had significantly higher prevalence of spine abnormalities compared with non-athletes. There was no significant difference of the back pain lifetime prevalence in skiers compared with non-athletes.
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