| 1. |
- Niemi, MEK, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Jia, TY, et al.
(författare)
-
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
- 2021
-
Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:8, s. 3884-3895
-
Tidskriftsartikel (refereegranskat)abstract
- DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
|
|
| 7. |
|
|
| 8. |
- Aps, R., et al.
(författare)
-
Central Baltic Sea herring : effect of environmental trends and fishery management
- 2011
-
Ingår i: Ecosystems and Sustainable Development VIII. - Southampton : BioMed Central Ltd.. - 9781845645106 - 9781845645113 ; , s. 69-80
-
Konferensbidrag (refereegranskat)abstract
- Uncertainty is an endemic condition of the Baltic Sea herring (Clupea harengus membras, L) fishery management. It is a condition exacerbated by the fishing fleet overcapacity and consequent exploitation of the herring stock at a level believed to be unsustainable. Some sources of uncertainty are mainly related to biology and fishing technique: the unsolved problem of herring assessment and management units, the recruitment–environment relationship and the reduction in mean weights-at-age, uncertain ageing of fish, the problem of unaccounted fishing mortality caused by the fish selection through the trawl net. Fishing fleet overcapacity is believed to be behind of the regulatory overfishing when setting the Total Allowable Catches (TACs) higher than the scientific advice (decision overfishing) and tolerating the extensive underreporting of catches (implementation overfishing). Two scenarios for the Central Baltic Sea herring fishery management options are constructed and the Bayesian networks are used to represent and update uncertainties encountered in the process of the management related situation assessment. First scenario represents the current status of the fishery management resulting in fishing mortality (F) higher than FMSY – the fishing mortality that corresponds to the Maximum Sustainable Yield (MSY). The second scenario demonstrates the assumed potential impact of economic incentives (e.g.zoning, individual transferable quotas (ITQs), territorial use rights etc.) on the reduction of excessive fishing capacity and bringing actual fishing mortality closer to FMSY.
|
|
| 9. |
- Aps, R., et al.
(författare)
-
Fisheries management : from linear to collaborative science-policy interface
- 2011
-
Ingår i: Management of Natural Resources, Sustainable Development and Ecological Hazards III. - : WIT Press. - 9781845645328 - 1845645324 ; , s. 3-14
-
Konferensbidrag (refereegranskat)abstract
- The context of fisheries management, according to recent studies, tends to be complex, uncertain and controversial and it cannot be adequately addressed based on work done within the “linear” science-policy interface (SPI). It is believed that moving towards a more participatory and “collaborative” SPI model would favour implementation of more efficient economic incentives to reduce the fishing fleet capacity and bring the actual fishing mortality closer to the levels considered to be sustainable. Focusing the participatory research basically on fish biology and fish stock assessment seems to be too narrow while, on the other hand, it does not embrace many other important issues of contemporary fisheries management. It is suggested that further involvement of stakeholders into the full-scale bio-economic modelling based participatory research would contribute to better understanding of the dynamics of human natural interface concerned and, consequently, would improve the consensus between different interests.
|
|
| 10. |
- Holmgren, Noél M. A., et al.
(författare)
-
MSY oriented management of the Baltic Sea herring under regime shifts
- 2011
-
Ingår i: ICES report of the Baltic Fisheries Assessment working Group (WGBFAS). - Copenhagen : ICES. ; , s. 752-798
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The ecosystem of the baltic sea has undergone dramatic changes, perhaps a regime-shift, during the last four decades. The Baltic Sea Herring SSB has declined to a third and weight-at-age has halved due to plankton prey deficits. The management objective of the herring is currently in the transition to a cautionary maximum sustainable yield (MSY). We modelled the main basin Baltic Sea herring under the currernt regime, and analysed the effect of a ercovery of the cod stock and the food availability as they were in the early 1980s. We recommend a target F MSY of 0.16, but with a recovery of the cod, recommended target F MSY is is 0.10. A simultaneous increase in both cod and food availability is estimated to increase the yield with 40% at the target F MSY is 0.20. We present functions to calculate F MSY and estimate the expected yield depending on the abundance of cod and food-availability. A retrospective application of our functions indicates over-fishing in the 1990s and early 2000s, and a net loss in yields with a landing value of about E440 Millions.
|
|
| 11. |
- Kotta, Jonne, et al.
(författare)
-
Assessing the potential for sea-based macroalgae cultivation and its application for nutrient removal in the Baltic Sea
- 2022
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 839
-
Tidskriftsartikel (refereegranskat)abstract
- Marine eutrophication is a pervasive and growing threat to global sustainability. Macroalgal cultivation is a promising circular economy solution to achieve nutrient reduction and food security. However, the location of production hotspots is not well known. In this paper the production potential of macroalgae of high commercial value was predicted across the Baltic Sea region. In addition, the nutrient limitation within and adjacent to macroalgal farms was investigated to suggest optimal site-specific configuration of farms. The production potential of Saccharina latissima was largely driven by salinity and the highest production yields are expected in the westernmost Baltic Sea areas where salinity is >23. The direct and interactive effects of light availability, temperature, salinity and nutrient concentrations regulated the predicted changes in the production of Ulva intestinalis and Fucus vesiculosus. The western and southern Baltic Sea exhibited the highest farming potential for these species, with promising areas also in the eastern Baltic Sea. Macroalgal farming did not induce significant nutrient limitation. The expected spatial propagation of nutrient limitation caused by macroalgal farming was less than 100–250 m. Higher propagation distances were found in areas of low nutrient and low water exchange (e.g. offshore areas in the Baltic Proper) and smaller distances in areas of high nutrient and high water exchange (e.g. western Baltic Sea and Gulf of Riga). The generated maps provide the most sought-after input to support blue growth initiatives that foster the sustainable development of macroalgal cultivation and reduction of in situ nutrient loads in the Baltic Sea.
|
|
