| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 3. |
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| 5. |
- Dunham, I, et al.
(författare)
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The DNA sequence of human chromosome 22
- 1999
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Wachtmeister, Henrik
(författare)
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World oil supply and unconventional resources : Bottom-up perspectives on tight oil production
- 2018
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Oil is the world’s largest primary energy source. It dominates the transportation sector which underpins the world economy. Yet, oil is a nonrenewable resource, destined not to last forever. In the mid-2000s global conventional oil production stagnated, leading to rising oil prices and fears of permanent oil scarcity. These fears, together with the high prices, receded with the unforeseen emergence of a new supply source: tight oil.This licentiate thesis investigates unconventional tight oil production and its impacts on world oil supply in terms of resource availability and oil market dynamics, and in turn briefly discusses some possible wider economic, political and environmental implications of these impacts. The thesis is based on three papers. The first investigates the usefulness of bottom-up modelling by a retrospective study of past oil projections. The second looks at how unconventional tight oil production can be modelled on the well level using decline curve analysis. The third derives typical production parameters for conventional offshore oil fields, a growing segment of conventional production and a useful comparison to tight oil.The results show that tight oil production has increased resource availability significantly, as well as introduced a fast responding marginal supply source operating on market principles rather than political ones. The emergence of tight oil production has altered OPEC’s strategic options and led to a period of lower and less volatile oil prices. However, this condition of world oil supply can only last as long as the unconventional resource base allows, and, at the same time, total fossil fuel consumption will have to fall to limit climate change. It is concluded that this breathing space with lower oil prices could be used as an opportunity to develop and implement policy for an efficient managed decline of global oil use in order to achieve the dual goals of increased human economic welfare and limited climate change, and in the process preempt any future oil supply shortage. Unconventional tight oil production can both help and hinder in this endeavor. Accurate models and analyses of oil production dynamics and impacts are therefore crucial when maneuvering towards this preferred future.
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| 7. |
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| 8. |
- Bentley, MA, et al.
(författare)
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High-spin spectroscopy of natural and unnatural parity states in the mirror-pair V-45/Ti-45
- 2006
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 73:2: 024304
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in the proton-rich nucleus V-45 have been identified for the first time. A comprehensive gamma-ray decay scheme has been established following an experiment performed at the Vivitron accelerator at IReS Strasbourg by using the Euroball gamma-ray detector array coupled to the Neutron Wall and Euclides detector arrays. The natural (negative-) parity scheme is identified up to the f(7/2) band termination in addition to a positive-parity collective structure based on a d(3/2) particle-hole excitation. Comparison of this scheme with that of the mirror partner, Ti-45, has yielded detailed information on the variation of Coulomb energy as a function of excitation energy and angular momentum. This is the first time that such an analysis has been performed for a collective structure built on a cross-shell excitation. Comparison of the observed Coulomb energies with those predicted by large-scale shell-model calculations is presented. In this case, unusually, the calculations do not fare as well as for heavier nuclei in the shell. In addition, stark differences between the two nuclei are observed for the decay intensities of the parity-changing E1 decays that de-excite the positive-parity deformed bands.
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| 9. |
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| 10. |
- du Rietz, Rickard, et al.
(författare)
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Effective Charges in the fp Shell
- 2004
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Ingår i: Physical Review Letters. - 1079-7114. ; 93:22
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Tidskriftsartikel (refereegranskat)abstract
- Following the heavy-ion fusion-evaporation reaction S-32+Mg-24 at 95 MeV beam energy the lifetimes of analogue states in the T-z=+/-1/2 A=51 mirror nuclei Fe-51 and Mn-51 have been measured using the Cologne plunger device coupled to the GASP gamma-ray spectrometer. The deduced B(E2;27/2(-)-->23/2(-)) values afford a unique opportunity to probe isoscalar and isovector polarization charges and to derive effective proton and neutron charges, epsilon(p) and epsilon(n), in the fp shell. A comparison between the experimental results and several different large-scale shell-model calculations yields epsilon(p)similar to1.15e and epsilon(n)similar to0.80e.
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| 11. |
- du Rietz, Rickard, et al.
(författare)
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Investigation of High-spin States in 53Fe
- 2005
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 72:1
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Tidskriftsartikel (refereegranskat)abstract
- The fusion-evaporation reactions Si-28(S-32,1 alpha 2p1n)Fe-53 at 125 MeV and Mg-24(S-32,2p1n)Fe-53 at a 95-MeV beam energy were used to investigate excited states in Fe-53. The combination of the Gammasphere Ge detector array and ancillary devices led to the construction of an extensive level scheme comprising some 90 transitions connecting 40 states. The lifetime of the yrast 25/2(-) state and upper limits for the lifetimes of a number of additional states were determined using the Cologne plunger device coupled to the GASP gamma-ray spectrometer. The experimental results are compared to large-scale shell-model calculations using different sets of two-body matrix elements. In particular, predictions on electromagnetic decay properties such as lifetimes, branching ratios, and mixing ratios are studied in detail.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Kilpelainen, TO, et al.
(författare)
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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- 2019
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Ingår i: Nature communications. - London : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 376-
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Tidskriftsartikel (refereegranskat)abstract
- Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
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| 16. |
- Lenzi, SM, et al.
(författare)
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Coulomb energy differences in T=1 mirror rotational bands in Fe-50 and Cr-50 - art. no. 122501
- 2001
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 8712:12, s. 2501-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Gamma rays from the N = Z - 2 nucleus Fe-50 have been observed, establishing the rotational ground state band up to the state J(pi) = 11(+) at 6.994 MeV excitation energy. The experimental Coulomb energy differences, obtained by comparison with the isobar
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| 19. |
- Söderbergh, Bengt, 1975-
(författare)
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Production from Giant Gas Fields in Norway and Russia and Subsequent Implications for European Energy Security
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The International Energy Agency (IEA) expects total natural gas output in the EU to decrease from 216 billion cubic meters per year (bcm/year) in 2006 to 90 bcm/year in 2030. For the same period, EU demand for natural gas is forecast to increase rapidly. In 2006 demand for natural gas in the EU amounted to 532 bcm/year. By 2030, it is expected to reach 680 bcm/year. As a consequence, the widening gap between EU production and consumption requires a 90% increase of import volumes between 2006 and 2030. The main sources of imported gas for the EU are Russia and Norway. Between them they accounted for 62% of the EU’s gas imports in 2006. The objective of this thesis is to assess the potential future levels of gas supplies to the EU from its two main suppliers, Norway and Russia. Scenarios for future natural gas production potential for Norway and Russia have been modeled utilizing a bottom-up approach, building field-by-field, and individual modeling has been made for giant and semi- giant gas fields. In order to forecast the production profile for an individual giant natural gas field a Giant Gas Field Model (GGF-model) has been developed. The GGF-model has also been applied to production from an aggregate of fields, such as production from small fields and undiscovered resources. Energy security in the EU is heavily dependent on gas supplies from a relatively small number of giant gas fields. In Norway almost all production originates from 18 fields of which 9 can be considered as giant fields. In Russia 36 giant fields account for essentially all gas production. There is limited potential for increased gas exports from Norway to the EU, and all of the scenarios investigated show Norwegian gas production in decline by 2030. Norwegian pipeline gas exports to the EU may even be, by 2030, 20 bcm/year lower than today’s level. The maximum increase in exports of Russian gas supplies to the EU amount to only 45% by 2030. In real numbers this means a mere increase of about 70 bcm In addition, there are a number of potential downside factors for future Russian gas supplies to the European markets. Consequently, a 90% increase of import volumes to the EU by 2030 will be impossible to achieve. From a European energy security perspective the dependence of pipeline gas imports is not the only energy security problem to be in the limelight, the question of physical availability of overall gas supplies deserves serious attention as well. There is a lively discussion regarding the geopolitical implications of European dependence on imported gas from Russia. However, the results of this thesis suggest that when assessing the future gas demand of the EU it would be of equal importance to be concerned about diminishing availability of global gas supplies.
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| 20. |
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| 21. |
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| 22. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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