| 1. |
- Bergqvist, Joakim, et al.
(författare)
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Detection and Isolation of Sindbis Virus from Mosquitoes Captured During an Outbreak in Sweden, 2013
- 2015
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Ingår i: Vector Borne and Zoonotic Diseases. - : Mary Ann Liebert Inc. - 1530-3667 .- 1557-7759. ; 15:2, s. 133-140
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Tidskriftsartikel (refereegranskat)abstract
- Mosquito-borne alphaviruses have the potential to cause large outbreaks throughout the world. Here we investigated the causative agent of an unexpected Sindbis virus (SINV) outbreak during August-September, 2013, in a previously nonendemic region of Sweden. Mosquitoes were collected using carbon dioxide-baited CDC traps at locations close to human cases. The mosquitoes were initially screened as large pools by SINV-specific quantitative RT-PCR, and the SINV-positive mosquitoes were species determined by single-nucleotide polymorphism (SNP) analysis, followed by sequencing the barcoding region of the cytochrome oxidase I gene. The proportion of the collected mosquitoes was determined by a metabarcoding strategy. By using novel strategies for PCR screening and genetic typing, a new SINV strain, Lovanger, was isolated from a pool of 1600 mosquitoes composed of Culex, Culiseta, and Aedes mosquitoes as determined by metabarcoding. The SINV-positive mosquito Culiseta morsitans was identified by SNP analysis and sequencing. After whole-genome sequencing and phylogenetic analysis, the SINV Lovanger isolate was shown to be most closely similar to recent Finnish SINV isolates. In conclusion, within a few weeks, we were able to detect and isolate a novel SINV strain and identify the mosquito vector during a sudden SINV outbreak.
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| 2. |
- Björck, M, et al.
(författare)
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Twenty years with the Swedvasc Registry.
- 2008
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Ingår i: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. - : Elsevier BV. - 1532-2165 .- 1078-5884. ; 35:2, s. 129-30
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Björnfot, Patrik, et al.
(författare)
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Non-technical users’ first encounters with a robotic telepresence technology : An empirical study of office workers
- 2018
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Ingår i: Paladyn - Journal of Behavioral Robotics. - : Walter de Gruyter. - 2080-9778 .- 2081-4836. ; 9:1, s. 307-322
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Tidskriftsartikel (refereegranskat)abstract
- Robotic telepresence technologies are becoming ever more usable and affordable, as well as increasingly available as consumer products. In the coming years, a significant number of people are likely to encounter the technology for the first time, and many, if not most, of them are going to be “non-technical” users, that is, people who do not have special technical knowledge and skills of IT-professionals. Therefore, understanding how nontechnical users are getting familiar with robotic telepresence technology, how they perceive the technology, learn to control it, and relate it to their everyday work practices, is a topical research issue. This paper reports an empirical study, in which eight non-technical users, office workers who were not IT-professionals, were introduced to robotic telepresence and provided with a practical experience of acting as pilots of a remotely controlled robot. In follow up interviews the participants were asked to reflect on potential uses of the technology in their professional activities. The participants could successfully acquire basic navigation skills and reached a high level of spatial presence, but experienced problems with developing a "new body image”. When reflecting on the potential of the technology for supporting their work, the participants envisioned a number of benefits associated with remote physical mobility. The impact of the technology on the quality of workrelated social interactions was expected to be generally positive but somewhat limited.
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| 4. |
- Burden, Håkan, 1976, et al.
(författare)
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An Evaluation of Post-processing Google Translations with Microsoft® Word
- 2012
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Ingår i: SLTC 2012 The Fourth Swedish Language Technology Conference. ; , s. 13-14
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Konferensbidrag (refereegranskat)abstract
- We decided to evaluate the performance of Google Translate and the possible improvements on grammatical fluency through post-processing the candidate translations by Microsoft Word.
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| 8. |
- Sah, Vasu R., et al.
(författare)
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Chemokine Analysis in Patients with Metastatic Uveal Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy and Checkpoint Immunotherapy
- 2023
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Ingår i: Cancer Research Communications. - : American Association For Cancer Research (AACR). - 2767-9764. ; 3:5, s. 884-895
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Patients with metastatic uveal melanoma have limited therapeutic options and high mortality rate so new treatment options are needed.Patients and Methods: We previously reported that patients treated with the PD-1 inhibitor pembrolizumab and the histone deacetylase inhibitor entinostat in the PEMDAC trial, experienced clinical benefits if their tu-mor originated from iris or was wildtype for BAP1 tumor suppressor gene. Here we present the 2-year follow-up of the patients in the PEMDAC trial and identify additional factors that correlate with response or survival.Results: Durable responses were observed in 4 patients, with additional 8 patients exhibiting a stable disease. The median overall survival was 13.7 months. Grade 3 adverse events were reported in 62% of the patients, but they were all manageable. No fatal toxicity was observed. Activity of thymidine kinase 1 in plasma was higher in patients with stable disease or who progressed on treatment, compared with those with partial response. Chemokines and cytokines were analyzed in plasma. Three chemokines were significantly different when comparing patients with and without response. One of the factors, CCL21, was higher in the plasma of respond-ing patients before treatment initiation but decreased in the same patients upon treatment. In tumors, CCL21 was expressed in areas resembling ter -tiar y lymphoid structures (TLS). High plasma levels of CCL21 and presence of TLS-like regions in the tumor correlated with longer survival.Conclusions: This study provides insight into durable responses in the PEMDAC trial, and describes dynamic changes of chemokines and cytokines in the blood of these patients.Significance: The most significant finding from the 2-year follow-up study of the PEMDAC trial was that high CCL21 levels in blood was associated with response and survival. CCL21 was also expressed in TLS-like regions and presence of these regions was associated with longer survival. These analyses of soluble and tumor markers can inform on predictive biomark-ers needing validation and become hypothesis generating for experimental research.
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| 9. |
- Svensson, Per, et al.
(författare)
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Gene array identification of Ipf1/Pdx1(-/-) regulated genes in pancreatic progenitor cells
- 2007
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Ingår i: BMC Developmental Biology. - : Springer Science and Business Media LLC. - 1471-213X. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Background: The homeodomain transcription factor IPF1/PDX1 exerts a dual role in the pancreas; Ipf1/Pdx1 global null mutants fail to develop a pancreas whereas conditional inactivation of Ipf1/Pdx1 in beta-cells leads to impaired beta-cell function and diabetes. Although several putative target genes have been linked to the beta-cell function of Ipf1/Pdx1, relatively little is known with respect to genes regulated by IPF1/PDX1 in early pancreatic progenitor cells. Results: Microarray analyses identified a total of III genes that were differentially expressed in e10.5 pancreatic buds of Ipf1/Pdx1(-/-) embryos. The expression of one of these, Spondin 1, which encodes an extracellular matrix protein, has not previously been described in the pancreas. Quantitative real-time RT-PCR analyses and immunohistochemical analyses also revealed that the expression of FgfR2IIIb, that encodes the receptor for FGF10, was down-regulated in Ipf1/Pdx1(-/-) pancreatic progenitor cells. Conclusion: This microarray analysis has identified a number of candidate genes that are differentially expressed in Ipf1/Pdx1(-/-) pancreatic buds. Several of the differentially expressed genes were known to be important for pancreatic progenitor cell proliferation and differentiation whereas others have not previously been associated with pancreatic development.
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| 11. |
- Taghavi, Hamidreza, 1981, et al.
(författare)
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A vibration investigation of a flat surface contact to skull bone for direct bone conduction transmission in sheep skulls in vivo.
- 2013
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Ingår i: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. - 1537-4505 .- 1531-7129. ; 34:4, s. 690-8
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Tidskriftsartikel (refereegranskat)abstract
- Hypothesis: Bone conduction implant (BCI) attached with a flat surface contact will offer efficient and linear vibration transmission over time. Background: Despite that percutaneous bone conduction devices (PBCD) are successful in treating patients with conductive hearing loss, there are some drawbacks related to the need of a permanent skin penetration. The BCI system is designed as an alternative to the PBCD because it leaves the skin intact. Methods: BCI dummy implants were installed in 3 sheep skulls in vivo to study the vibration transmission characteristics over time. Mechanical point impedances and vibration transfer response functions of the BCI implants were measured at the time of surgery and after a healing period of 8 months. Results: In 1 sheep both implants healed without complications. In the other 2 sheep, the implants were either partially loose or lost to follow up. In the sheep with stable implants, it was found by the resonance frequency shift of the mechanical point impedance that a firmer integration between the implant and bone tissue as seen in osseointegrated surfaces developed over time. It was also shown that the transcranial vibration transmission remains stable and linear. Providing bone chips in the contact between the implant and the bone did not enhance vibration transmission. The surgical procedure for installing the BCI dummy implants was uneventful. Conclusion: The mechanical point impedances and vibration transfer response functions indicate that the BCI implants integrate and that transmission conditions remain stable over time.
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| 12. |
- Tunberger, Pernilla, 1982-
(författare)
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Earning, caring, and the quest for sustainable societies : Toward stable evolution?
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis studies changing conditions for earning and caring in Italy and Sweden, two cases out of a population of European welfare states facing similar challenges and processes of labor market liberalization affecting conditions for earning, but also for caring. Focus is on how such processes of change affect individual living conditions for earning and caring, as well as on how societies change as a result of changing individual living conditions. The theoretical framework is grounded in feminist institutionalism and multiple equilibria theory, with focus on the interrelation of earning and caring and on how the interaction of formal and informal institutions demarcates and stratifies individual room for maneuver - but also on how such room for maneuver aggregates to affect the evolutionary path of societies. The thesis makes a point of analyzing links between macro and micro levels, in both directions, as a way to offer a fuller and more accurate analysis of how and why societies evolve. It argues that such an analysis requires introducing new analytical tools. To that purpose, the concepts of augmented work family reconciliation, care security, and earning-caring models are defined and identified as key tools for understanding effects on individual living conditions as well as why, and indeed how, societies evolve in the process. Three separate studies are undertaken on each case: one study that analyzes patterns of change in earning and caring over time; a type-case simulation of effects of labor market liberalization on conditions for earning and caring; and an interview study with couples with young children. Together, the three studies allow for an analysis of micro-macro dynamics that enables a new understanding of the two cases. The results highlight gaps in work family reconciliation in the Swedish earning-caring model that other frameworks miss, and how the Italian earning-caring model is rocked at its core as a result of changing conditions for earning. While each earning-caring model is a case in its own right, the analytical framework developed here can fruitfully be applied to the evolution of other cases as well.
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