| 1. |
- Bergström, Gunnar, et al.
(författare)
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A comprehensive workplace intervention and its outcome with regard to lifestyle, health and sick leave : the AHA study
- 2008
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Ingår i: Work. - 1051-9815 .- 1875-9270. ; 31:2, s. 167-180
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Tidskriftsartikel (refereegranskat)abstract
- This study is a prospective multicentre cohort study entitled Work and Health in the Processing and Engineering Industries, the AHA Study (AHA is the Swedish abbreviation for the study). Four large workplaces in Sweden participated during the years from 2000 to 2003. The present report has two objectives: (1) to present a comprehensive occupational health intervention programme and (2) to evaluate this programme with a focus on lifestyle (smoking and exercise), health related quality of life (HRQoL) and sick leave. Interventions were provided on an individual and group level, including evidence-based methods for four health/focus areas (individual level) and a group intervention based on a survey-feedback methodology. The analyses in this report were exclusively employed at an organizational level. The proportion of smokers decreased at three companies and the course of the HRQoL was advantageous at two of the companies as compared to a gainfully employed reference group. A significant decrease in sick leave was revealed at one company, whereas a break in an ascending sick-leave trend appeared at a second company as compared to their respective corporate groups. This comprehensive workplace intervention programme appears to have had positive effects on smoking habits, HRQoL and sick leave.
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| 2. |
- Blom, Victoria, 1975-, et al.
(författare)
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Genetic susceptibility to burnout in a Swedish twin cohort
- 2012
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Ingår i: European Journal of Epidemiology. - : Springer. - 0393-2990 .- 1573-7284. ; 27:3, s. 225-231
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Tidskriftsartikel (refereegranskat)abstract
- Most previous studies of burnout have focused on work environmental stressors, while familial factors so far mainly have been overlooked. The aim of the study was to estimate the relative importance of genetic influences on burnout (measured with Pines Burnout Measure) in a sample of monozygotic (MZ) and dizygotic (DZ) Swedish twins. The study sample consisted of 20,286 individuals, born 1959–1986 from the Swedish twin registry who participated in the cross-sectional study of twin adults: genes and environment. Probandwise concordance rates (the risk for one twin to be affected given that his/her twin partner is affected by burnout) and within pair correlations were calculated for MZ and DZ same—and opposite sexed twin pairs. Heritability coefficients i.e. the proportion of the total variance attributable to genetic factors were calculated using standard biometrical model fitting procedures. The results showed that genetic factors explained 33% of the individual differences in burnout symptoms in women and men. Environmental factors explained a substantial part of the variation as well and are thus important to address in rehabilitation and prevention efforts to combat burnout.
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| 3. |
- Blom, Victoria, et al.
(författare)
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The Importance of Genetic and Shared Environmental Factors for the Associations between Job Demands, Control, Support and Burnout.
- 2013
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:9, s. e75387-
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Tidskriftsartikel (refereegranskat)abstract
- Within occupational health research, one of the most influential models is the Job Demands-Control-Support model. Numerous studies have applied the model to different domains, with both physical and psychological health outcomes, such as burnout. The twin design provides a unique and powerful research methodology for examining the effects of environmental risk factors on burnout while taking familial factors (genetic and shared environment) into account. The aim of the present study was to investigate the impact of familial factors on the associations of burnout with job demands, control and support. A total of 14 516 individuals from the Swedish Twin Registry, who were born between 1959 and 1986, and who participated in the Study of Twin Adults: Genes and Environment (STAGE) by responding to a web-based questionnaire in 2005, were included in the analyses. Of these, there were 5108 individuals in complete same-sex twin pairs. Co-twin control analyses were performed using linear mixed modeling, comparing between-pairs effects and within-pair effects, stratified also by zygosity and sex. The results indicate that familial factors are of importance in the association between support and burnout in both women and men, but not between job demands and burnout. There are also tendencies towards familial factors being involved in the association between control and burnout in men. These results offer increased understanding of the mechanisms involved in the associations between work stress and burnout.
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| 4. |
- Bodin Danielsson, Christina, et al.
(författare)
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Difference in satisfaction with office environment among employees in different office types
- 2009
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Ingår i: Journal of Architectural and Planning Research. - 0738-0895. ; 26:3, s. 241-257
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Tidskriftsartikel (refereegranskat)abstract
- Differences between office types may have an influence on the employees' satisfaction and psychological responses with respect to different aspects of the office environment. For this study, 469 employees rated their perceptions of and satisfaction with the office environments of seven different office types, which were classified as cell-office, shared-room office, small open-plan office, medium open-plan office, large open-plan office, flex-office, and combi-office. Three domains of environmental factors were analyzed: (1) ambient factors, (2) noise and privacy, and (3) design-related factors. Employee responses were evaluated using multivariate logistic and Poisson regression., Adjustments were made for potential confounders such as age, gender job rank, and line of business. Substantial differences between employees in different office types were found The analysis of frequencies in complaints within the three domains shows that noise and privacy is the domain that causes the most dissatisfaction among office employees. Cell-office employees are most satisfied with the physical environment overall, followed by those in flex-office. However the results for cell-office are not uniformly best, since they score low with regard to the social aspects of design-related factors and, in particular on support of affinity. The most dissatisfaction is reported in medium and large open-plan offices, where the complaints about noise and lack of privacy are especially negative. Architectural and functional features of the offices are discussed as the main explanatory factors for these results.
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| 5. |
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| 6. |
- Bodin Danielsson, Christina, et al.
(författare)
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Office-type in Relation to Health, Well-being and Job Satisfaction Among Employees
- 2008
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Ingår i: Environment and Behavior. - : SAGE Publications. - 0013-9165 .- 1552-390X. ; 40, s. 636-668
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Tidskriftsartikel (refereegranskat)abstract
- This article investigates the hypothesis that office type has an influence on workers’ health status and job satisfaction and 469 employees in seven different types, defined by their unique setup of architectural and functional features, have rated their health status and job satisfaction. Multivariate regression models were used for analysis of these outcomes, with adjustment for age, gender, job rank, and line of business. Both health status and job satisfaction differed between the seven office types. Lowest health status was found in medium-sized and small open plan offices. Best health was among employees in cell offices and flex offices. Workers in these types of offices and in shared room offices also rated the highest job satisfaction. Lowest job satisfaction was in combi offices, followed by medium-sized open plan offices. The differences between employees could possibly be ascribed to variations in architectural and functional features of the office types.
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| 7. |
- Bodin Danielsson, Christina, et al.
(författare)
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Office type in relation to health, well-being, and job satisfaction among employees : Erratum
- 2010
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Ingår i: Environment and Behavior. - : Sage Publications. - 0013-9165 .- 1552-390X. ; 42:6, s. 887-887
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Tidskriftsartikel (refereegranskat)abstract
- Reports an error in "Office type in relation to health, well-being, and job satisfaction among employees" by Christina Bodin Danielsson and Lennart Bodin (Environment and Behavior, 2008[Sep], Vol 40[5], 636-668). In the original article, a symbol was missing from Table 7 on p. 654. In that table, an open circle ("o") should have been present to show that the odds ratio indicated low risk for having poor quality of sleep among those who worked in the flex office. The corrected table is present in the erratum. (The following abstract of the original article appeared in record 2008-12036-003). This article investigates the hypothesis that office type has an influence on workers' health status and job satisfaction and 469 employees in seven different types, defined by their unique setup of architectural and functional features, have rated their health status and job satisfaction. Multivariate regression models were used for analysis of these outcomes, with adjustment for age, gender, job rank, and line of business. Both health status and job satisfaction differed between the seven office types. Lowest health status was found in medium-sized and small open plan offices. Best health was among employees in cell offices and flex offices. Workers in these types of offices and in shared room offices also rated the highest job satisfaction. Lowest job satisfaction was in combi offices, followed by medium-sized open plan offices. The differences between employees could possibly be ascribed to variations in architectural and functional features of the office types. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
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| 8. |
- Bodin Danielsson, Christina, 1969-
(författare)
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The Office - An Explorative Study : Architectural Design's Impact on Health, Job Satisfaction & Well-being
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This doctoral thesis examines the office environment’s influence on employees’ perception oftheir workplaces, their organizations and their job satisfaction, as well as their health and wellbeing.It is based on an empirical study of 491 office employees from twenty-six companies anddivisions in large companies. Seven office types, defined by their architectural and functionalfeatures, are represented in the study group: cell-office, shared-room office, small open planoffice, medium-sized open plan office, large open plan office, flex-office and combi-office. Theresearch has its basis in architecture, although an interdisciplinary approach using organizationaland management theory, environmental psychology, and social and stress medicine has beenemployed. Qualitative (Articles I & V) and quantitative methods(Articles II & IV) were used.The thesis also contains an explorative, review article. Thus it comprises all in all five articles.Article I is an analysis of the importance of architectural quality for employees´ perceptionand experience of the office using Lynch’s method (1960) developed to measure inhabitants’perception of architectural quality in cities. The study shows that in the office the experienceto a high degree is independent of both the scale of the office and office type; instead it isdetermined by the quality of the plan layout combined with the quality of other design features.It also shows Lynch’s method to be useful in foreseeing where the elements that reinforce‘imageability’ will most likely appear in an office environment.Article II investigates employees’ environmental satisfaction focusing on:1) ambient factors; 2) noise and privacy; and 3) design-related factors. The results, based onregression models with age, gender, job rank and line of business as additional covariates,show office type as a factor with a statistically significant impact on satisfaction with the officeenvironment. Employees in cell-offices are prominently most satisfied, followed by those inflex-offices, cell-offices rate low only on social aspects of design-related factors. A major findingis the internal differences between office types where employees share workspace and facilitieswith lowest satisfaction in medium-sized and large open plan offices.Article III is a review article that analyzes the employees’ office experiences in two ways:1) by framing the physical work environment’s influence on employees into the model oforganizational theorist Davis (1994); and 2) by categorizing the office experience into twogroups based on the nature of the experience and problems related to them. The results of theemperical study presented in Article II are the basis for the discussion in this article.Article IV examines employees’ health, well-being and job satisfaction. A multivariateanalysis applied to the study sample and equivalent to that of Article II shows significantly higherrisks for ill health and poor well-being in medium-sized and small open plan offices, comparedespecially with cell-office. In medium-sized open plan and combi-offices the employees evincethe lowest job satisfaction. The best chance for good health status and job satisfaction is in cellofficesand flex-offices.Article V examines the office architecture´s importance for employees’ perception of theirown workplaces and organizations based on the two key components of architecture—theaesthetical and functional dimensions. The results show that overall the employees had positiveexperiences of their office environments. These mainly concerned the aesthetical dimension,whereas the negative comments dealt with the functional dimension. The aesthetical dimensionappears not only to set the agenda for employees’ perception of the workplace and organizationas a whole, but also for the perception of the functional dimensions. The functional dimensionswere only in focus when the workstation and its proximate area were discussed.
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| 9. |
- Bodin Danielsson, Christina, et al.
(författare)
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The relation between office type and workplace conflict : A gender and noise perspective
- 2015
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Ingår i: Journal of Environmental Psychology. - : Elsevier BV. - 0272-4944 .- 1522-9610. ; 42, s. 161-171
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Tidskriftsartikel (refereegranskat)abstract
- This exploratory study aimed to investigate the impact of the office design on workplace conflicts, with a special attention to noise in the office. A gender perspective was applied. The sample consisted of 5229 employees from the Swedish Longitudinal Occupational Survey of Health 2010 (SLOSH), working in different office types. In the multivariate analysis office type was used as the explanatory variable with adjustments for age, supervisory position and labour market sector. Analysis stratified for gender was used. Among women a significant impact of office type per se on workplace conflicts was found, but not among men. For women several office types differed significantly from the cell-office with regard to prevalence of conflicts during the past two years, but for men only the combi-office differed from the cell-office. Noise had an impact on workplace conflicts, but is not the only explanatory factor since the effect of office type remained also after adjustment for noise in multivariate analyses. Other environmental factors inherent in the office type might thus explain the occurrence of conflicts.
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| 10. |
- Franzén, Lennart E., et al.
(författare)
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Characterization of colon carcinoma growth pattern by computerized morphometry : definition of a complexity index
- 2008
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Ingår i: International Journal of Molecular Medicine. - : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 22:4, s. 465-472
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Tidskriftsartikel (refereegranskat)abstract
- The invasive front of carcinomas may vary in complexity from smooth to highly complex when the front splits up into small cell clusters or even single cancer cells. The degree of complexity is usually estimated visually and semiquantitatively by a pathologist, although more objective methods based on computer-assisted image analysis are available. In this study, we compared the visual estimation of the irregularity of the tumour invasion front of colon carcinomas to different quantitative image analytical techniques and defined a complexity index for the invasive margin. Sections from 29 archived colon carcinomas were stained immunohistochemically for cytokeratin 8. Images of the tumour invasion front were read into a computer and thresholded so that the tumour tissue became black and the background white or so that the tumour front was outlined by a single pixel line. The invasive front was visually classified into four degrees of irregularity by a pathologist. The complexity of the front was then assessed using four different image analysis techniques, i.e. the estimation of fractal dimension, tumour front length, number of tumour cell clusters and lacunarity. Fractal dimension and tumour cell clusters together gave the best correlation to visual grading using a discriminant analysis. A cluster analysis and a tree diagram analysis were then performed and were found to be superior to visual estimation. The clusters represent different degrees of complexity and the result of the tree diagram analysis can be used to assign complexity indices to colon tumours. The fractal dimension separated tumours up to a certain level (1.5-1.6) of complexity. When the tumour front split up into small cell clusters, the counting of tumour cell clusters separated the cells over and above the fractal dimension. This new technique can be used to objectively and quantitatively describe the complexity of the invasive front of tumours.
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| 11. |
- Franzén, Lennart E, et al.
(författare)
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Semiquantitative evaluation overestimates the degree of steatosis in liver biopsies : a comparison to stereological point counting.
- 2005
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Ingår i: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 18:7, s. 912-916
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Tidskriftsartikel (refereegranskat)abstract
- The degree of steatosis in liver biopsies is usually assessed by a morphological semiquantitative approach in which the histopathologist uses a four-graded scale: 0-3 or none, slight, moderate and severe. Scores 1-3 are considered to correspond to fat deposition in <33, 33-66 and >66% of the hepatocytes. There is a considerable inter- and intra-individual variation in such scoring methods and a more standardized and quantitative approach is preferable. In the present study, we compare the semiquantitative technique with the stereological point counting method in the assessment of hepatic steatosis. A total of 75 archived liver needle biopsies were used. They were selected according to the original routine diagnosis of slight, moderate or severe steatosis. In all, 10 randomly selected images from each biopsy were digitized into a computer, a point grid lattice was superimposed and the number of hits on fat globules was counted. A pathologist scored the specimens in a four-graded scale as described above. The mean liver biopsy area (volume) with fat in hepatocytes was 2.2% for grade 1, 9.2% for grade 2 and 23.1% for grade 3. The kappa value for the semiquantitative estimates was 0.71 for the unweigthed kappa and 0.87 for weighted kappa. The intraclass correlation coefficient (ICC) was 0.99 for images counted twice and 0.95 when two sets of images were captured from the same biopsy. These ICCs indicate excellent agreement and above that of the semiquantitative estimates. In conclusion, the area/volume of fat content of the hepatocytes is greatly overemphasized in semiquantitative estimation. Furthermore, the point counting technique has a better reproducibility than visual evaluation and should be preferred in estimates of liver steatosis in scientific studies and in clinical contexts when the amount of steatosis is important for treatment and prognosis, such as liver transplantation.
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| 12. |
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| 13. |
- Hahn-Strömberg, Victoria, et al.
(författare)
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Disturbed expression of E-cadherin, beta-catenin and tight junction proteins in colon carcinoma is unrelated to growth pattern and genetic polymorphisms
- 2008
-
Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 116:4, s. 253-262
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Tidskriftsartikel (refereegranskat)abstract
- Adhesion proteins are responsible for the structural integrity of epithelial tissue and in tumors this integrity is often lost, resulting in a disorganization of the tissue. In the present study the complexity of the invasive front of colon carcinomas was correlated with cell adhesion protein expression and with polymorphisms in their genes. A complexity index was constructed from 32 colon carcinomas using computer-assisted morphometry estimating fractal dimension and tumor cell clusters followed by tree analysis. Immunohistochemical staining of beta-catenin, E-cadherin, occludin and claudin 2 was used for assessment of protein expression. Genetic screening of tissue from the tumor invasion front with laser microdissection was performed using SSCP and DNA sequencing. Adhesion protein distribution was significantly disturbed in most carcinomas. A single mutation in the gene of beta-catenin was found but there was no correlation between protein expression and genetic polymorphism. Nor was there any correlation between the complexity of the invasive border and protein distribution or genetic alterations. The results indicate that the complexity of colon carcinoma invasion is not dependent on genetic derangements in the genes of adhesion proteins or the protein distribution. Rather, aberrations in the function of other proteins related to the adhesive proteins could be responsible.
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| 14. |
- Hahn-Strömberg, Victoria, et al.
(författare)
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Tumor volume of colon carcinoma is related to the invasive pattern but not to the expression of cell adhesion proteins
- 2009
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Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley-Blackwell Publishing Inc.. - 0903-4641 .- 1600-0463. ; 117:3, s. 205-211
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Tidskriftsartikel (refereegranskat)abstract
- Tumor volume increases during growth and due to tumor progression various mutations appear that may cause phenotypic changes. The invasive pattern may thus be affected resulting in a more disorganized growth. This phenomenon might be due to mutations in the genome of the adhesion proteins, which are responsible for the structural integrity of epithelial tissue. Tumor volume was assessed in whole mount sections of 33 colon carcinomas using Cavalieri's principle. Images from the entire invasive border were captured and used for calculating the irregularity of the border (Complexity Index). The expression of the adhesion proteins E-cadherin, beta-catenin, Claudin 2 and Occludin was assessed after immunohistochemical staining of two randomly selected areas of the invasive front of the tumor. Statistical significance for differences in volume was obtained for tumor Complexity Index, tumor stage (pT) and lymph node status (pN). Expression of adhesion proteins was significantly perturbed in the tumors compared with normal mucosa but only infrequently correlated to tumor differentiation or invasive pattern. The results show that when tumor volume increases the invasive pattern becomes more irregular which is compatible with tumor progression. A direct contribution of adhesion protein derangement to this process appears to be insignificant.
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| 15. |
- Linton, Steven J., 1952-, et al.
(författare)
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Psychological factors related to health, back pain, and dysfunction
- 1994
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Ingår i: Journal of occupational rehabilitation. - : Springer. - 1053-0487 .- 1573-3688. ; 4:1, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Psychosocial variables may be important determinants of experienced back pain as well as dysfunction. This paper reports on differences on a battery of psychosocial variables between women, from the same work place, off work because of back pain, having only back pain (not off work), and those without back pain. The groups suffering pain had similar levels of pain intensity and frequency and the covariates of age and work load were used in MANCOVA analyses. The results showed significant overall differences on the Coping Strategies Questionnaire, Handicap Index, Duke Health Profile, as well as items concerning family support and the relation of pain to work. Several variables differed between the Healthy group on the one hand and the two groups suffering pain on the other hand. However, coping strategies and perceived health produced significant differences between all three groups in univariate analyses. Unlike other studies the Work APGAR produced no significant results. These data suggest that work status is not directly related to pain intensity, but rather to an interaction between psychosocial factors and the pain experience. Future research should delineate which variables may be used in screening.
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| 16. |
- Magnusson, Magnus, et al.
(författare)
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Predicting grey-sided vole occurrence in northern Sweden at multiple spatial scales
- 2013
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Ingår i: Ecology and Evolution. - Hoboken, USA : Wiley-Blackwell Publishing Inc.. - 2045-7758. ; 3:13, s. 4365-4376
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Tidskriftsartikel (refereegranskat)abstract
- Forestry is continually changing the habitats for many forest-dwelling species around the world. The grey-sided vole (Myodes rufocanus) has declined since the 1970s in forests of northern Sweden. Previous studies suggested that this might partly be caused by reduced focal forest patch size due to clear-cutting. Proximity and access to old pine forest and that microhabitats often contains stones have also been suggested previously but never been evaluated at multiple spatial scales. In a field study in 2010–2011 in northern Sweden, we investigated whether occurrence of grey-sided voles would be higher in (1) large focal patches of >60 years old forest, (2) in patches with high connectivity to sur- rounding patches, and (3) in patches in proximity to stone fields. We trapped animals in forest patches in two study areas (V€asterbotten and Norrbotten). At each trap station, we surveyed structural microhabitat characteristics. Land- scape-scale features were investigated using satellite-based forest data combined with geological maps. Unexpectedly, the vole was almost completely absent in Norrbotten. The trap sites in Norrbotten had a considerably lower amount of stone holes compared with sites with voles in V€asterbotten. We suggest this might help to explain the absence in Norrbotten. In V€asterbotten, the distance from forest patches with voles to stone fields was significantly shorter than from patches without voles. In addition, connectivity to surrounding patches and size of the focal forest patches was indeed related to the occurrence of grey-sided voles, with connectivity being the overall best predictor. Our results support previous findings on the importance of large forest patches, but also highlight the importance of connectivity for occurrence of grey-sided voles. The results further suggest that proximity to stone fields increase habitat quality of the forests for the vole and that the presence of stone fields enhances the voles’ ability to move between nearby forest patches through the matrix
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| 17. |
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| 18. |
- Svedberg, Pia, et al.
(författare)
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Genetic and environmental influences on the association between performance-based self-esteem and exhaustion : A study of the self-worth notion of burnout
- 2016
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Ingår i: Scandinavian Journal of Psychology. - : John Wiley & Sons. - 0036-5564 .- 1467-9450. ; 57:5, s. 419-426
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Tidskriftsartikel (refereegranskat)abstract
- In the self-worth model, burnout is considered to be a syndrome of performance-based self-esteem (PBSE) and experiences of exhaustion. Studies have shown that PBSE and burnout indices such as Pines' Burnout Measure (BM) are associated. Whether these variables have overlapping etiologies has however not been studied before. Genetic and environmental components of covariation between PBSE and exhaustion measured with Pines' BM were examined in a bivariate Cholesky model using data from 14,875 monozygotic and dizygotic Swedish twins. Fifty-two per cent of the phenotypic correlation (r = 0.41) between PBSE and Pines' BM was explained by genetics and 48% by environmental factors. The findings of the present study strengthen the assumption that PBSE should be considered in the burnout process as proposed by the self-worth conception of burnout. The present results extend our understanding of the link between this contingent self-esteem construct and exhaustion and provide additional information about the underlying mechanisms in terms of genetics and environment. This finding corroborates the assumed syndrome view on burnout, while it also suggests an altered view of how the syndrome emerges and how it can be alleviated.
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| 19. |
- Ahlsson, Anders J., et al.
(författare)
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Postoperative atrial fibrillation is not correlated to C-reactive protein
- 2007
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Ingår i: Annals of Thoracic Surgery. - : Elsevier BV. - 0003-4975 .- 1552-6259. ; 83:4, s. 1332-1337
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The peak incidence of postoperative atrial fibrillation (AF) occurs around the second postoperative day, a time at which serum inflammatory markers are elevated. The aim of this study was to investigate differences between patients with and without postoperative AF with special regard to C-reactive protein (CRP) serum levels. METHODS: The study cohort included all heart surgery patients who had sinus rhythm preoperatively, survived postoperative day 3, and were operated on between July 1, 2004, and June 30, 2005 (n = 524). Any episode of AF during the first 7 postoperative days defined the patient as belonging to the postoperative AF group. Creatine kinase-myocardial band (CK-MB) was measured at postoperative day 1, and CRP was measured preoperatively and at postoperative day 3. Risk factors for postoperative AF were determined using bivariate and multivariate regression analysis. RESULTS: Of 524 patients, 182 had at least one episode of AF (34.7%). Preoperative and postoperative CRP concentrations did not differ between the groups (postoperative CRP 175.4 +/- 64.4 versus 175.3 +/- 60.1 mg/L respectively, p = 0.99). Atrial fibrillation patients were significantly older (p < 0.001) and had higher CK-MB levels (33.6 +/- 53.1 microg/L versus 22.5 +/- 26.7 microg/L, respectively, p = 0.009). The odds ratio for postoperative AF with postoperative CK-MB greater than 70 microg/L was 3.5 (confidence interval: 1.4 to 8.6). CONCLUSIONS: Postoperative AF has no correlation to the inflammatory marker CRP in heart surgery patients. Ischemic myocardial injury might predispose for postoperative AF.
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| 20. |
- Ahlsson, Anders, 1962-, et al.
(författare)
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Patients with postoperative atrial fibrillation have a doubled cardiovascular mortality
- 2009
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Ingår i: Scandinavian cardiovascular journal : SCJ. - : Informa UK Limited. - 1651-2006 .- 1401-7431. ; 43:5, s. 330-336
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To investigate the impact of postoperative AF on late mortality and cause of death in CABG patients.DESIGN: All CABG patients without preoperative AF surgically treated between January 1, 1997 and June 30, 2000 were included (N = 1419). Altogether, 419 patients (29.5%) developed postoperative AF. After a median follow-up of 8.0 years, survival data were obtained, causes of death were compared and Cox proportional hazard analysis was used to determine predictors of late mortality.RESULTS: The total mortality was 140 deaths/419 patients (33.4%) in postoperative AF patients and 191 deaths/1 000 patients (19.1%) in patients without AF. Death due to cerebral ischemia (2.6% vs. 0.5%), myocardial infarction (7.4% vs. 3.0%), sudden death (2.6% vs. 0.9%), and heart failure (6.7% vs. 2.7%) was more common among postoperative AF patients. Postoperative AF was an age-independent risk indicator for late mortality with a hazard ratio (HR) of 1.56 (95% confidence interval 1.23-1.98).CONCLUSIONS: Postoperative AF is an age-independent risk factor for late mortality in CABG patients, explained by an increased risk of cardiovascular death.
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| 21. |
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| 22. |
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| 23. |
- Ahlsson, Anders, 1962-, et al.
(författare)
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Postoperative atrial fibrillation in patients undergoing aortocoronary bypass surgery carries an eightfold risk of future atrial fibrillation and a doubled cardiovascular mortality
- 2010
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Ingår i: European Journal of Cardio-Thoracic Surgery. - : Oxford University Press (OUP). - 1010-7940 .- 1873-734X. ; 37:6, s. 1353-1359
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: This article presents a study of postoperative atrial fibrillation (AF) and its long-term effects on mortality and heart rhythm.METHODS: The study cohort consisted of 571 patients with no history of AF who underwent primary aortocoronary bypass surgery from 1999 to 2000. Postoperative AF occurred in 165/571 patients (28.9%). After a median follow-up of 6 years, questionnaires were obtained from 91.6% of surviving patients and an electrocardiogram (ECG) from 88.6% of all patients. Data from hospitalisations due to arrhythmia or stroke during follow-up were analysed. The causes of death were obtained for deceased patients.RESULTS: In postoperative AF patients, 25.4% had atrial fibrillation at follow-up compared with 3.6% of patients with no AF at surgery (p<0.001). An episode of postoperative AF was the strongest independent risk factor for development of late AF, with an adjusted risk ratio of 8.31 (95% confidence interval (CI) 4.20-16.43). Mortality was 29.7% (49 deaths/165 patients) in the AF group and 14.8% (60 deaths/406 patients) in the non-AF group (p<0.001). Death due to cerebral ischaemia was more common in the postoperative AF group (4.2% vs 0.2%, p<0.001), as was death due to myocardial infarction (6.7% vs 3.0%, p=0.041). Postoperative AF was an age-independent risk factor for late mortality, with an adjusted hazard ratio of 1.57 (95% CI 1.05-2.34).CONCLUSIONS: Postoperative AF patients have an eightfold increased risk of developing AF in the future, and a doubled long-term cardiovascular mortality.
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| 24. |
- Alipour, Akbar, et al.
(författare)
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The transitional pattern of pain and disability, from perceived pain to sick leave : Experience from a longitudinal study
- 2013
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Ingår i: Journal of Back and Musculoskeletal Rehabilitation. - : IOS Press. - 1053-8127 .- 1878-6324. ; 26:4, s. 411-419
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate the prospective value of the transitional and dynamic patterns of pain disability over time on sick leave in chronic recurrent back/neck pain cases.Methods: The material used was based on a longitudinal study with three repeated measurements. The graded Chronic Pain Scale was used to assess levels of pain disability. The relationship between the transitional patterns of the pain disability score ( ten defined states of decrease, increase or no change, between two time points) and sick leave was analyzed for 909 chronic/recurrent cases in three different models using logistic regression. Results: Those with high level of pain disability have a more transitional pattern and their pain level changed during the time period studied. When adjusting for age, gender, education and previous sick leave, the final model indicated that the current level of pain disability was a risk factor in taking sick leave. The likelihood of sick leave was highest in the transition of pain into the highest levels of disability, independent of past disability level of pain. Earlier sick leave remained as an important predictor of sick leave.Conclusions: From a clinical and prognostic perspective the probability of sick leave will be different and can be predicted based on previous sick leave but not from former history of pain disability level or its transitional pattern.
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- Almroth, Henrik, et al.
(författare)
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Safety of flecainide for atrial fibrillation : the Swedish atrial fibrillation cohort study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background Little is known about the safety of flecainide in atrial fibrillation (AF). Whether current flecainide treatment practice in Sweden is associated with increased mortality compared to treatment with beta-blockers alone was investigated in patients with atrial fibrillation (AF).Methods and Results A total of 182,678 patients diagnosed with AF between 1 July 2005 and 31 December 2008 were identified through the Swedish National Hospital Discharge Register. These data were matched to data from the Prescribed Drug Register and information about death from the Total Population Register. The primary outcome was all cause mortality at the end of the study period, 1 Feb 2010. Flecainide was prescribed to 5381 patients (2.9%), and 64,918 patients (45.7%) received beta-blockers only. During follow-up, 2.8% and 30.8% of these patients died, respectively. After coarsened and exact matching, 2,178 patients (1.2% of total) on flecainide and beta-blockers had more similar baseline characteristics to 27,313 patients (15.3% of total) on beta-blockers only. In the main analysis, flecainide exposure was not associated with increased mortality (OR 0.27, 95% CI 0.21-0.36,P<0.001). In the matched flecainide population, 205 (9.4%) patients had underlying structural heart disease. Sixteen (28.6%) of the flecainide-exposed patients who died had structural heart disease. The patients who only received flecainide (n=264) had higher mortality rate than the patients who received flecainide and beta-blockers (6.8 versus 2.6%,P<0.001).Conclusions Flecainide is not associated with increased mortality in patients with AF compared to beta-blockers alone. Patients who die after receiving flecainide often have structural heart disease.
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