| 1. |
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| 2. |
- Azimi, Alireza, et al.
(författare)
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Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
- 2018
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Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 14:3
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Tidskriftsartikel (refereegranskat)abstract
- Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy-resistant melanomas. Unfortunately, our data show that this combination elicits a heterogeneous response in a panel of melanoma cell lines including PDX-derived models. We sought to understand the mechanisms underlying the differential responses and suggest a patient stratification strategy. Thermal proteome profiling (TPP) identified the protein targets of XL888 in a pair of sensitive and unresponsive cell lines. Unbiased proteomics and phosphoproteomics analyses identified CDK2 as a driver of resistance to both BRAF and Hsp90 inhibitors and its expression is regulated by the transcription factor MITF upon XL888 treatment. The CDK2 inhibitor, dinaciclib, attenuated resistance to both classes of inhibitors and combinations thereof. Notably, we found that MITF expression correlates with CDK2 upregulation in patients; thus, dinaciclib would warrant consideration for treatment of patients unresponsive to BRAF-MEK and/or Hsp90 inhibitors and/or harboring MITF amplification/overexpression.
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| 3. |
- Barroso da Silva, Fernando Luis, et al.
(författare)
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Effect of Charge Regulation and Ion-Dipole Interactions on the Selectivity of Protein-Nanoparticle Binding
- 2014
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:14, s. 4078-4083
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the role of different mesoscopic interactions (Coulomb, charge regulation, and ion-dipole "surface patch" effects) on the binding of bovine serum albumin (BSA) and beta-lactoglobulin (BLG) to a cationic gold nanoparticle (TTMA+). The results demonstrate that the charge-regulation mechanism plays a vital role for selectivity of protein-nanoparticle complexation at low salt concentration. At slightly higher ionic strengths, charge-dipole effects are the dominating driving force. Thus, very small variations in salt concentration strongly influence the origin of complexation.
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| 4. |
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| 5. |
- Boström, Adrian Desai E., et al.
(författare)
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Accelerated epigenetic aging in women with emotionally unstable personality disorder and a history of suicide attempts
- 2023
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Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Emotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge – a state-of-the-art epigenetic age (EA) estimator – strongly predicts mortality risk and physiological dysregulation. Herein, we utilize the GrimAge algorithm to investigate whether women with EUPD and a history of recent suicide attempts exhibit EA acceleration (EAA) in comparison to healthy controls. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from 97 EUPD patients and 32 healthy controls. The control group was significantly older (p < 0.0001) and reported lesser exposure to violent behavior in both youth and adulthood (p < 0.0001). Groups were otherwise comparable regarding gender, BMI, or tobacco usage (p > 0.05). EA estimator DNAmGrimAge exceeded chronological age by 8.8 and 2.3 years in the EUPD and control group, respectively. Similarly, EAA marker AgeAccelGrim was substantially higher in EUPD subjects when compared to controls, in both univariate and multivariate analyzes (p < 0.00001). Tobacco usage conferred substantial within-group effects on the EA-chronological age difference, i.e., 10.74 years (SD = 4.19) compared to 6.00 years (SD = 3.10) in the non-user EUPD group (p < 0.00001). Notably, past alcohol and substance abuse, use of psychotropic medications, global assessment of functioning, self-reported exposure to violent behavior in youth and adulthood, later completed suicide (N = 8) and age at first suicide attempt did not predict EAA in the EUPD group (p > 0.05). These results underscore the importance of addressing medical health conditions along with low-cost preventative interventions aimed at improving somatic health outcomes in EUPD, such as efforts to support cessation of tobacco use. The independency of GrimAge to other EA algorithms in this group of severely impaired EUPD patients, suggest it may have unique characteristics to evaluate risk of adverse health outcomes in context of psychiatric disorders.
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| 6. |
- Boström, Adrian Desai E., et al.
(författare)
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HPA-axis dysregulation is not associated with accelerated epigenetic aging in patients with hypersexual disorder
- 2022
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Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 141
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundHypersexual disorder (HD) - a nonparaphilic sexual desire disorder with impulsivity component - was evaluated for inclusion as a diagnosis in the DSM-5 and the diagnosis compulsive sexual behavior disorder is included as an impulse control disorder in the ICD-11. Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity is believed to affect cellular senescence and has been implicated in HD. No previous study investigated HD or HPA-axis dysregulation in relation to measures of epigenetic age (EA) acceleration.MethodsThis study reports on a case-control study set-up from a well-characterized cohort, contrasting EA predictors in relation to 60 HD patients and 33 healthy volunteers (HV) and 19 mixed HD/HV exhibiting dexamethasone suppression test (DST) non-suppression to 73 mixed HD/HV DST controls. The genome-wide methylation pattern was measured in whole blood from 94 subjects using the Illumina Infinium Methylation EPIC BeadChip and preprocessed according to specialized protocols suitable for epigenetic age estimation. The online DNAm Age Calculator (https://dnamage.genetics.ucla.edu/) was implemented to retrieve various EA predictors, which were compared between the in-silico generated subgroups.ResultsQuality control analyses indicated strong correlations between the EA measure DNA methylation GrimAge (DNAm GrimAge – the EA clock most reliably associated with mortality risk) and chronological age in all sub-groups. The study was adequately powered to detect differences of 2.5 and 3.0 years in DNAm GrimAge minus age in relation to both HD and HPA-axis dysregulation, respectively. Baseline DNAm GrimAge exceeded chronological age by 2.8 years on average across all samples. No EA acceleration marker was associated with HD or DST suppression status (p > 0.05).ConclusionEA acceleration markers shown to be strongly predictive of physiological dysregulation and mortality-risk, are not related to HD or DST non-suppression status (measured after 0.5 mg dexamethasone). The independency of HPA-axis dysregulation to EA acceleration does not support the biological relevance of this dosage-regimen when applied to patients with HD. These findings do not support the notion of accelerated cellular senescence in HD. Studies stratifying DST non-suppressors according to established dosage-regimens in somatic settings are needed to fully elucidate the putative contribution of HPA-axis dysregulation to EA.
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| 7. |
- Boström, Adrian Desai E., et al.
(författare)
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Regional clozapine, ECT and lithium usage inversely associated with excess suicide rates in male adolescents
- 2023
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Advanced psychiatric treatments remain uncertain in preventing suicide among adolescents. Across the 21 Swedish regions, using nationwide registers between 2016-2020, we found negative correlation between adolescent excess suicide mortality (AESM) and regional frequencies of clozapine, ECT, and lithium (CEL) usage among adolescents (β = -0.613, p = 0.0003, 95% CI: -0.338, -0.889) and males (β = -0.404, p = 0.009, 95% CI: -0.130, -0.678). No correlation was found among females (p = 0.197). Highest CEL usage among male adolescents was seen in regions with lowest quartile (Q1) AESM (W = 74, p = 0.012). Regional CEL treatment frequency in 15-19-year-olds was related to lower AESM in males, reflecting potential treatment efficacy, treatment compliance or better-quality mental health care. Suicide prevention may benefit from early recognition and CEL treatment for severe mental illness in male adolescents. The results indicate association but further research, using independent samples and both prospective and observational methodologies, is needed to confirm causality.
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| 8. |
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| 9. |
- Boström, Mathias, et al.
(författare)
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Atmospheric water droplets can catalyse atom pair break-up via surface-induced resonance repulsion
- 2013
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Ingår i: Europhysics letters. - : IOP Publishing. - 0295-5075 .- 1286-4854. ; 101:4, s. 43002-
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Tidskriftsartikel (refereegranskat)abstract
- We present the theory for a retarded resonance interaction between two identical atoms near a dielectric surface. In free space the resonance interaction between isotropically excited atom pairs is attractive at all atom-atom separations. We illustrate numerically how this interaction between oxygen, sulphur, hydrogen, or nitrogen atom pairs may turn repulsive near water droplets. The results provide evidence of a mechanism causing excited state atom pair breakage to occur in the atmosphere near water droplets.
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| 10. |
- Boström, Mathias, et al.
(författare)
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Atomic resonance interaction in dielectric media
- 2004
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 69:5 B, s. 054701-1
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Tidskriftsartikel (refereegranskat)abstract
- The retarded resonance interaction in dielectric media between a ground state atom and an excited atom were investigated. The whole system was represented by a superposition of states:symmetric and antisymmetric with respect to interchange of atoms. While the antisymmetric state can be long lived, the asymmetric state is likely to decay into two ground state atoms. The retarded limit large deviations were demonstrated.
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| 11. |
- Boström, Mathias, et al.
(författare)
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Casimir attractive-repulsive transition in MEMS
- 2012
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Ingår i: European Physical Journal B. - : Springer Science and Business Media LLC. - 1434-6028 .- 1434-6036. ; 85:11, s. 377-
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Tidskriftsartikel (refereegranskat)abstract
- Unwanted stiction in micro-and nanomechanical (NEMS/MEMS) systems due to dispersion (van der Waals, or Casimir) forces is a significant hurdle in the fabrication of systems with moving parts on these length scales. Introducing a suitably dielectric liquid in the interspace between bodies has previously been demonstrated to render dispersion forces repulsive, or even to switch sign as a function of separation. Making use of recently available permittivity data calculated by us we show that such a remarkable nonmonotonic Casimir force, changing from attractive to repulsive as separation increases, can in fact be observed in systems where constituent materials are in standard NEMS/MEMS use requiring no special or exotic materials. No such nonmonotonic behaviour has been measured to date. We calculate the force between a silica sphere and a flat surface of either zinc oxide or hafnia, two materials which are among the most prominent for practical microelectrical and microoptical devices. Our results explicate the need for highly accurate permittivity functions of the materials involved for frequencies from optical to far-infrared frequencies. A careful analysis of the Casimir interaction is presented, and we show how the change in the sign of the interaction can be understood as a result of multiple crossings of the dielectric functions of the three media involved in a given set-up.
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| 12. |
- Boström, Mathias, et al.
(författare)
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Casimir force between atomically thin gold films
- 2013
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Ingår i: European Physical Journal B. - : Springer Science and Business Media LLC. - 1434-6028 .- 1434-6036. ; 86:2, s. 43-
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Tidskriftsartikel (refereegranskat)abstract
- We have used density functional theory to calculate the anisotropic dielectric functions for ultrathin gold sheets (composed of 1, 3, 6, and 15 atomic layers). Such films are important components in nano-electromechanical systems. When using correct dielectric functions rather than bulk gold dielectric functions we predict an enhanced attractive Casimir-Lifshitz force (at most around 20%) between two atomically thin gold sheets. For thicker sheets the dielectric properties and the corresponding Casimir forces approach those of gold half-spaces. The magnitude of the corrections that we predict should, within the today's level of accuracy in Casimir force measurements, be clearly detectable.
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| 13. |
- Boström, Mathias, et al.
(författare)
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Casimir-Lifshitz interaction between ZnO and SiO2 nanorods in bromobenzene turns repulsive at intermediate separations due to retardation effects
- 2012
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 85:4, s. 044702-
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Tidskriftsartikel (refereegranskat)abstract
- We consider the interaction between a ZnO nanorod and a SiO2 nanorod in bromobenzene. Using optical data for the interacting objects and ambient we calculate the force (from short-range attractive van der Waals force to intermediate-range repulsive Casimir-Lifshitz force to long-range entropically driven attraction). The nonretarded van der Waals interaction is attractive at all separations. We demonstrate a retardation-driven repulsion at intermediate separations. At short separations (in the nonretarded limit) and at large separations (in the classical limit) the interaction is attractive. These effects can be understood from an analysis of multiple crossings of the dielectric functions of the three media as functions of imaginary frequencies.
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| 14. |
- Boström, Mathias, et al.
(författare)
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Comment on "Calculation of the Casimir force between imperfectly conducting plates"
- 2000
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 61:4
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In a recent paper [Phys. Rev. A 59, R3149 (1999)] Lamoreaux reported calculations of the Casimir force. The experimentally found permittivity was used in the calculations. Large deviations were found between numerically evaluated forces and forces derived from a series expanded plasma model. We would like to comment on a few results presented in this work. First, we claim that important features of the imaginary component of the permittivity of copper, presented in Fig. 1(a) are due to the interpolation procedure and are not caused by physical phenomena. These features influence the calculated permittivity for imaginary frequencies, which is the quantity used to calculate the Casimir attraction. Second, we discuss the extrapolation procedure used for low frequencies. The results depend substantially on how this extrapolation is performed.
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| 15. |
- Boström, Mathias, et al.
(författare)
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Contributions from dispersion and born self-free energies to the solvation energies of salt solutions
- 2004
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 108:33, s. 12593-12595
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Tidskriftsartikel (refereegranskat)abstract
- That the Born theory provides an accurate means of calculating solvation energies of ions in water has been demonstrated by Rashin and Honig (Rashin, A. A., Honig, B. J. Phys. Chem. 1985, 89, 5588). They could fit the experimental solvation energies of a number of salts nicely by a simple increase of 7% in the expected radii of all ions. However, as we demonstrate herein, there is an important previously ignored contribution due to the ionic dispersion self-free energy. The ionic parameters necessary to estimate the different contributions to solvation energy are the ionic radii, the ionic polarizabilities, and the ionization potentials. Whereas the polarizabilities and ionization potentials of a number of salts have recently been derived ab initio (in both vacuum and water), the appropriate choices of radii are less well-known. We pursue two different approaches to assign the ionic radii. In the first approach, we find that an increase of all expected radii by 23% gives reasonable agreement between theory and experiment (to within 6%). In the second approach, we increased the expected radii of six ions separately (10-30%) to obtain a best fit for the nine salts investigated. In this second approach, the deviations between theory and experiment were less than 0.1%. The essential point is that a proper theory must include contributions from both electrostatic (Born) and electrodynamic (dispersion) self-free energies.
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| 19. |
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| 20. |
- Boström, Mathias, et al.
(författare)
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Dispersion self-free energies and interaction free energies of finite-sized ions in salt solutions
- 2004
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Ingår i: Langmuir. - 0743-7463 .- 1520-5827. ; 20:18, s. 7569-7574
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Tidskriftsartikel (refereegranskat)abstract
- The role for many-body dipolar (dispersion) potentials in ion-solvent and ion-solvent-interface interactions is explored. Such many-body potentials, accessible in principle from measured dielectric data, are necessary in accounting for Hofmeister specific ion effects. Dispersion self-energy is the quantum electrodynamic analogue of the Born electrostatic self-energy of an ion. We here describe calculations of dispersion self-free energies of four different anions (OH-, Cl-, Br-, and I-) that take finite ion size into account. Three different examples of self-free energy calculations are presented. These are the self-free energy of transfer of an ion to bulk solution, which influences solubility, the dispersion potential acting between one ion and an air-water interface (important for surface tension calculations), and the dispersion potential acting between two ions (relevant to activity coefficient calculations). To illustrate the importance of dispersion self-free energies, we compare the Born and dispersion contributions to the free energy of ion transfer from water to air (oil). We have also calculated the change in interfacial tension with added salt for air (oil)-water interfaces. A new model is used that includes dispersion potentials acting on the ions near the interface, image potentials, and ions of finite size that are allowed to spill over the solution-air interface. It is shown that interfacial free energies require a knowledge of solvent profiles at the interface.
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| 21. |
- Boström, Mathias, 1970-, et al.
(författare)
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Dissolved gases
- 2005
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Ingår i: Water encyklopedia. - Hoboken, New Jersey : Wiley. - 9780471736875 - 0471736872 ; , s. 450-452
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Leading experts in water-related fields have come together to make Water Encyclopedia a one-stop, comprehensive reference about the world s most important natural resource. It covers designated topics in a clear concise and authoritative manner. The treatment is practical in orientation, keeping in mind the needs of the users. Theory is included only where required for an understanding of the topic.
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| 22. |
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| 23. |
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| 24. |
- Boström, Mathias, et al.
(författare)
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Enlarged molecules from excited atoms in nanochannels
- 2012
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 86:1, s. 014701-
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Tidskriftsartikel (refereegranskat)abstract
- The resonance interaction that takes place in planar nanochannels between pairs of excited-state atoms is explored. We consider interactions in channels of silica, zinc oxide, and gold. The nanosized channels induce a dramatically different interaction from that in free space. Illustrative calculations for two lithium and cesium atoms demonstrate that there is a short-range repulsion followed by long-range attraction. The binding energy is strongest near the surfaces. The size of the enlarged molecule is biggest at the center of the cavity and increases with channel width. Since the interaction is generic, we predict that enlarged molecules are formed in porous structures, and that the molecule size depends on the size of the nanochannels.
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| 25. |
- Boström, Mathias, et al.
(författare)
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Entropy of the Casimir effect between real metal plates
- 2004
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Ingår i: Physica A. - : Elsevier BV. - 0378-4371 .- 1873-2119. ; 339:01-Feb, s. 53-59
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Tidskriftsartikel (refereegranskat)abstract
- We first derive the zero-and-finite-temperature dispersion-forces in terms of changes in the energy of the electromagnetic normal modes of the system. We then use this to evaluate the entropy of the electromagnetic normal modes for the "Casimir system" consisting of two metal plates. We demonstrate that this entropy obeys the Nernst heat theorem. (C) 2004 Elsevier B.V. All rights reserved.
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