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| 2. |
- de Rojas, I., et al.
(författare)
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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| 3. |
- Bouyoucef, S E, et al.
(författare)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
- Vicente-Serrano, S. M., et al.
(författare)
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Diverse relationships between forest growth and the Normalized Difference Vegetation Index at a global scale
- 2016
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Ingår i: Remote Sensing of Environment. - : Elsevier BV. - 0034-4257. ; 187, s. 14-29
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Tidskriftsartikel (refereegranskat)abstract
- This study compared the densest available database of tree-ring growth with the longest Normalized Difference Vegetation Index (NDVI) information available at the global scale to quantify the relationship between annual forest growth and the NDVI across different forest types and regions and to characterize the patterns of response of forest growth to NDVI values at different temporal scales. We found a general positive relationship between the inter-annual NDVI variability and the annual tree growth in most of the analyzed forests. Nevertheless, there were strong differences in the tree growth responses to NDVI, given that the annual tree-ring records in each forest responded in a different way to the magnitude, seasonality and accumulation period of the NDVI values. Thus, we found eight main patterns of tree-ring response to the NDVI, which were related to the forest type and climate conditions of each corresponding site. The identified patterns may be useful for determining early-warning signals of changes in forest growth over large areas based on remote sensing information.
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| 6. |
- Vicente-Serrano, S. M., et al.
(författare)
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The complex multi-sectoral impacts of drought : Evidence from a mountainous basin in the Central Spanish Pyrenees
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 769
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Tidskriftsartikel (refereegranskat)abstract
- We analyzed the impacts of drought severity on a variety of sectors in a topographically complex basin (the upper Aragón basin 2181 km2) in the Central Spanish Pyrenees. Using diverse data sources including meteorological and hydrological observations, remote sensing and tree rings, we analyze the possible hydrological implications of drought occurrence and severity on water availability in various sectors, including downstream impacts on irrigation water supply for crop production. Results suggest varying responses in forest activity, secondary growth, plant phenology, and crop yield to drought impacts. Specifically, meteorological droughts have distinct impacts downstream, mainly due to water partitioning between streamflow and irrigation channels that transport water to crop producing areas. This implies that drought severity can extend beyond the physical boundaries of the basin, with impacts on crop productivity. This complex response to drought impacts makes it difficult to develop objective basin-scale operational definitions for monitoring drought severity. Moreover, given the high spatial variability in responses to drought across sectors, it is difficult to establish reliable drought thresholds from indices that are relevant across all socio-economic sectors. The anthropogenic impacts (e.g. water regulation projects, ecosystem services, land cover and land use changes) pose further challenges to assessing the response of different systems to drought severity. This study stresses the need to consider the seasonality of drought impacts and appropriate drought time scales to adequately assess and understand their complexity.
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| 7. |
- Navarro-Serrano, F., et al.
(författare)
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Estimation of near-surface air temperature lapse rates over continental Spain and its mountain areas
- 2018
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418. ; 38:8, s. 3233-3249
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Tidskriftsartikel (refereegranskat)abstract
- Although the mean environmental lapse rate (MELR) value (a linear decrease of -6.5 degrees C/km) is the most widely used, near-surface (i.e., non-free atmosphere) air temperature lapse rates (NSLRs; measured at 1.5 m height) are variable in space and time because of their dependence on topography and meteorological conditions. In this study we conducted the first analysis of the spatial and temporal variability of NSLRs for continental Spain and their relationship to synoptic atmospheric circulation (circulation weather types [CWTs]), focusing on major mountain areas including the Pyrenees, Cantabrian, Central, Baetic, and Iberian ranges. The results showed that the NSLR varied markedly at spatial and seasonal scales and depended on the dominant atmospheric conditions. The median NSLR values were weaker (less negative) than the MELR for the mountain areas (Pyrenees -5.17 degrees C/km; Cantabrian range -5.22 degrees C/km; Central range -5.78 degrees C/km; Baetic range -4.83 degrees C/km; Iberian range -5.79 degrees C/km) and for the entire continental Spain (-5.28 degrees C/km). For the entire continental Spain the steepest NSLR values were found in April (-5.80 degrees C/km), May (-5.58 degrees C/km), and October (-5.54 degrees C/km) because of the dominance of northerly and westerly advections of cold air. The weakest NSLR values were found in July (-4.67 degrees C/km) and August (-4.78 degrees C/km) because of the inland heating, and in winter because of the occurrence of thermal inversions. As the use of the MELR involves the assumption of large errors, we propose 1 zonal, 12 monthly, 11 CWTs, and 132 hybrid monthly-CWTs NSLRs for each of the mountain ranges and for the entire continental Spain. More regional studies are urgently needed to accurately assess the NSLR as a function of atmospheric circulation conditions.
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| 8. |
- Vicente-Serrano, S. M., et al.
(författare)
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A comparison of temporal variability of observed and model-based pan evaporation over Uruguay (1973-2014)
- 2018
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418. ; 38:1, s. 337-350
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Tidskriftsartikel (refereegranskat)abstract
- This study analyses variability and trends of atmospheric evaporative demand (AED) across Uruguay in the past four decades. Changes were assessed using pan evaporation measurements from 10 meteorological stations and compared to PenPan model calculations, which is a physically based model that employs meteorological data as input. Results demonstrate a high agreement between the observed AED and those estimated from the PenPan model. Both observations and model estimations agree on a high interannual variability in AED, though being statistically insignificant (p>0.05) at seasonal and annual scales. Given that AED shows high sensitivity to changes in relative humidity and sunshine duration, as a surrogate of solar radiation, the lack of significant trends in the AED observations and estimations over Uruguay can be linked to the insignificant trend found for these climate variables for the period from 1973 to 2014. This is the first study that reports Pan evaporation trends for this part of the world, helping to infill gaps for mid-latitude Southern Hemisphere areas, which are poorly represented in Pan evaporation trends.
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| 9. |
- Dominguez-Castro, F., et al.
(författare)
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Mapping seasonal and annual extreme precipitation over the Peruvian Andes
- 2018
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418. ; 38:15, s. 5459-5475
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Tidskriftsartikel (refereegranskat)abstract
- Seasonal and annual extreme precipitation over the Peruvian Andes have been mapped for the first time. Maps were developed using the most complete, quality-controlled and homogenous daily precipitation records in Peru from 1973 to 2016. For each observed rain gauge series, we defined parameters as the de-clustered daily intensity, total precipitation duration, total magnitude and dry-spell length. Then, we fitted the seasonal and annual series of these variables to a Generalized-Pareto distribution using a peak-over-threshold approach. We estimated the distribution parameters and validated the performance of different thresholds to obtain the best estimation of precipitation probability. We also mapped the distribution parameters obtained for the different meteorological stations using the universal kriging algorithm, accounting for elevation and the distance to the Pacific Ocean as co-variables. The accuracy of the extreme precipitation maps for a period of 25 and 50 years were validated using a jack-knife approach. Some of the maps show strong uncertainty given the random spatial distribution of the variables as a consequence of the complex topography and climate of the region. Nevertheless, the maps show a useful general assessment of the spatial distribution of the precipitation hazard probability over the region, providing a good agreement with the estimations obtained in the meteorological stations for some variables and time periods analysed. Extreme precipitation maps over this high-complex terrain of Peru are of key importance for flood risk assessment, water resources management, crop yield, soil conservation and human settlements.
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| 10. |
- Vicente-Serrano, S. M., et al.
(författare)
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Increased Vegetation in Mountainous Headwaters Amplifies Water Stress During Dry Periods
- 2021
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Ingår i: Geophysical Research Letters. - 0094-8276. ; 48:18
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Tidskriftsartikel (refereegranskat)abstract
- The dynamics of blue and green water partitioning under vegetation and climate change, as well as their different interactions during wet and dry periods, are poorly understood in the literature. We analyzed the impact of vegetation changes on blue water generation in a central Spanish Pyrenees basin undergoing intense afforestation. We found that vegetation change is a key driver of large decreases in blue water availability. The effect of vegetation increase is amplified during dry years, and mainly during the dry season, with streamflow reductions of more than 50%. This pattern can be attributed primarily to increased plant water consumption. Our findings highlight the importance of vegetation changes in reinforcing the decrease in water resource availability. With aridity expected to rise in southern Europe over the next few decades, interactions between climate and land management practices appear to be amplifying future hydrological drought risk in the region.
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