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1.	Campbell, PJ, et al. (författare) Pan-cancer analysis of whole genomes 2020 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82- Tidskriftsartikel (refereegranskat)abstract Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
2.	Reifarth, R., et al. (författare) Nuclear astrophysics with radioactive ions at FAIR 2016 Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1 Konferensbidrag (refereegranskat)abstract The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process beta-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.
3.	Romagnoni, A, et al. (författare) Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data 2019 Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 10351- Tidskriftsartikel (refereegranskat)abstract Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural networks (NN). The main score used to compare the methods was the Area Under the ROC Curve (AUC) statistics. The impact of quality control (QC), imputing and coding methods on LR results showed that QC methods and imputation of missing genotypes may artificially increase the scores. At the opposite, neither the patient/control ratio nor marker preselection or coding strategies significantly affected the results. LR methods, including Lasso, Ridge and ElasticNet provided similar results with a maximum AUC of 0.80. GBT methods like XGBoost, LightGBM and CatBoost, together with dense NN with one or more hidden layers, provided similar AUC values, suggesting limited epistatic effects in the genetic architecture of the trait. ML methods detected near all the genetic variants previously identified by GWAS among the best predictors plus additional predictors with lower effects. The robustness and complementarity of the different methods are also studied. Compared to LR, non-linear models such as GBT or NN may provide robust complementary approaches to identify and classify genetic markers.
4.	de Jong, S, et al. (författare) Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder 2018 Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163- Tidskriftsartikel (refereegranskat)abstract Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
5.	Lehr, C., et al. (författare) Unveiling the two-proton halo character of 17 Ne: Exclusive measurement of quasi-free proton-knockout reactions 2022 Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 827 Tidskriftsartikel (refereegranskat)abstract The proton drip-line nucleus 17Ne is investigated experimentally in order to determine its two-proton halo character. A fully exclusive measurement of the 17Ne(p,2p)16F→15⁎O+p quasi-free one-proton knockout reaction has been performed at GSI at around 500 MeV/nucleon beam energy. All particles resulting from the scattering process have been detected. The relevant reconstructed quantities are the angles of the two protons scattered in quasi-elastic kinematics, the decay of 16F into 15O (including γ decays from excited states) and a proton, as well as the 15O+p relative-energy spectrum and the 16F momentum distributions. The latter two quantities allow an independent and consistent determination of the fractions of l=0 and l=2 motion of the valence protons in 17Ne. With a resulting relatively small l=0 component of only around 35(3)%, it is concluded that 17Ne exhibits a rather modest halo character only. The quantitative agreement of the two values deduced from the energy spectrum and the momentum distributions supports the theoretical treatment of the calculation of momentum distributions after quasi-free knockout reactions at high energies by taking into account distortions based on the Glauber theory. Moreover, the experimental data allow the separation of valence-proton knockout and knockout from the 15O core. The latter process contributes with 11.8(3.1) mb around 40% to the total proton-knockout cross section of 30.3(2.3) mb, which explains previously reported contradicting conclusions derived from inclusive cross sections.
6.	Wamers, F., et al. (författare) Diverse mechanisms in proton knockout reactions from the Borromean nucleus Ne-17 2023 Ingår i: European Physical Journal A. - : Springer. - 1434-6001 .- 1434-601X. ; 59 Tidskriftsartikel (refereegranskat)abstract Nucleon knockout experiments using beryllium or carbon targets reveal a strong dependence of the quenching factors, i.e., the ratio (Rs) of theoretical to the experimental spectroscopic factors (C2S), on the proton-neutron asymmetry in the nucleus under study. However, this dependence is greatly reduced when a hydrogen target is used. To understand this phenomenon, exclusive H-1(Ne-17, 2p F-16) and inclusive C-12(Ne-17, 2p 1(6)F)X, 1(2)C(Ne-17, F-16)X as well as 1H(Ne-17,(16) F)X(X-denotes undetected reaction products) reactions with F-16 in the ground and excited states were anal- ysed. The longitudinal momentum distribution of F-16 and the correlations between the detached protons were studied. In the case of the carbon target, there is a significant deviation from the predictions of the eikonal model. The eikonal approximation was used to extract spectroscopic factor values (CS)-S-2. The experimental (CS)-S-2 value obtained with C target is markedly lower than that for H target. This is interpreted as rescattering due to simultaneous nucleon knockout from both reaction partners, Ne-17 and C-12.
7.	Wamers, F., et al. (författare) New insight into knockout reactions from the two-proton halo nucleus Ne 17 2024 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 109:5 Tidskriftsartikel (refereegranskat)abstract Background: The unexplained disagreement in the dependence of spectroscopic factors (C2Sexp) on the binding energy obtained by nucleon knockout using different targets is still a puzzle that needs to be addressed. Purpose: To find an explanation of this riddle through exclusive measurements using different targets. Method: The exclusive measurements were performed by using a Ne17 beam with an energy of 500 MeV/u incident on C and CH2 targets. Through the standard theoretical approach, C2Sexp were derived from the analysis of the experimental data on proton ejection from the proton halo in Ne17 as well as from its core O15. Result: For the C target, proton ejection from the proton halo gave C2Sexp about 37% smaller than for the H target. But when protons are ejected from the core of Ne17, C2Sexp are identical within statistical uncertainties. Conclusion: An explanation for the difference in C2Sexp could be the removal of both halo protons, a more important reaction pathway for the C target. The C2Sexp values obtained by analyzing the proton ejection from the core indicate that it is not affected by the interaction with the halo protons.
8.	Altstadt, S.G., et al. (författare) B-13,B-14(n,gamma) via Coulomb Dissociation for Nucleosynthesis towards the r-Process 2014 Ingår i: Nuclear Data Sheets. - : Elsevier BV. - 1095-9904 .- 0090-3752. ; 120, s. 197-200 Konferensbidrag (refereegranskat)abstract Radioactive beams of 14,15B produced by fragmentation of a primary 40Ar beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/R3B setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, 13,14B(n,γ), are presented.
9.	Atar, L., et al. (författare) Quasifree (p, 2p) Reactions on Oxygen Isotopes: Observation of Isospin Independence of the Reduced Single-Particle Strength 2018 Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 120:5 Tidskriftsartikel (refereegranskat)abstract Quasifree one-proton knockout reactions have been employed in inverse kinematics for a systematic study of the structure of stable and exotic oxygen isotopes at the R3B/LAND setup with incident beam energies in the range of 300-450 MeV/u. The oxygen isotopic chain offers a large variation of separation energies that allows for a quantitative understanding of single-particle strength with changing isospin asymmetry. Quasifree knockout reactions provide a complementary approach to intermediate-energy one-nucleon removal reactions. Inclusive cross sections for quasifree knockout reactions of the type OA(p,2p)NA-1 have been determined and compared to calculations based on the eikonal reaction theory. The reduction factors for the single-particle strength with respect to the independent-particle model were obtained and compared to state-of-the-art ab initio predictions. The results do not show any significant dependence on proton-neutron asymmetry.
10.	Boillos, J. M., et al. (författare) Isotopic cross sections of fragmentation residues produced by light projectiles on carbon near 2022 Ingår i: Physical Review C. - 2469-9993 .- 2469-9985. ; 105:1 Tidskriftsartikel (refereegranskat)abstract We measured 135 cross sections of residual nuclei produced in fragmentation reactions of C12, N14, and O13−16,20,22 projectiles impinging on a carbon target at kinetic energies of near 400A MeV, most of them for the first time, with the RB3/LAND setup at the GSI facility in Darmstadt (Germany). The use of this state-of-the-art experimental setup in combination with the inverse kinematics technique gave the full identification in atomic and mass numbers of fragmentation residues with a high precision. The cross sections of these residues were determined with uncertainties below 20% for most of the cases. These data are compared to other previous measurements with stable isotopes and are also used to benchmark different model calculations.
11.	Caesar, C., et al. (författare) Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26 2013 Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 88:3 Tidskriftsartikel (refereegranskat)abstract The very neutron-rich oxygen isotopes O-25 and O-26 are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from F-26 and F-27 at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of the decay into O-24 plus one or two neutrons, the O-25 ground-state energy and width are determined, and upper limits for the O-26 ground-state energy and lifetime are extracted. In addition, the results provide indications for an excited state in O-26 at around 4 MeV. The experimental findings are compared to theoretical shell-model calculations based on chiral two- and three-nucleon (3N) forces, including for the first time residual 3N forces, which are shown to be amplified as valence neutrons are added.
12.	Heine, M., et al. (författare) Determination of the neutron-capture rate of C-17 for r-process nucleosynthesis 2017 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 95:1, s. Article no 014613 - Tidskriftsartikel (refereegranskat)abstract With the (RB)-B-3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C-18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C-17 into the ground state of C-18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C-18. This allowed to derive the astrophysical cross section sigma(n gamma)*. accounting for the thermal population of C-17 target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures T-9
13.	Ribeiro, G., et al. (författare) Structure of Be-13 studied in proton knockout from B-14 2018 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 98:2 Tidskriftsartikel (refereegranskat)abstract The neutron-unbound isotope Be-13 has been studied in several experiments using different reactions, different projectile energies, and different experimental setups. There is, however, no real consensus in the interpretation of the data, in particular concerning the structure of the low-lying excited states. Gathering new experimental information, which may reveal the Be-13 structure, is a challenge, particularly in light of its bridging role between Be-12, where the N = 8 neutron shell breaks down, and the Borromean halo nucleus Be-14. The purpose of the present study is to investigate the role of bound excited states in the reaction product Be-12 after proton knockout from B-14, by measuring coincidences between Be-12, neutrons, and gamma rays originating from de-excitation of states fed by neutron decay of Be-13. The Be-13 isotopes were produced in proton knockout from a 400 MeV/nucleon B-14 beam impinging on a CH2 target. The Be-12-n relative-energy spectrum d sigma/dE(fn) was obtained from coincidences between Be-12(g.s.) and a neutron, and also as threefold coincidences by adding gamma rays, from the de-excitation of excited states in Be-12. Neutron decay from the first 5/2(+) state in Be-13 to the 2(+) state in Be-12 at 2.11 MeV is confirmed. An energy independence of the proton-knockout mechanism is found from a comparison with data taken with a 35 MeV/nucleon B-14 beam. A low-lying p-wave resonance in Be-13(1/2(-)) is confirmed by comparing proton- and neutron-knockout data from B-14 and Be-14.
14.	Röder, M., et al. (författare) Coulomb dissociation of 20,21 N 2016 Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 93:6 Tidskriftsartikel (refereegranskat)abstract Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 excitation functions and thermonuclear reaction rates have been determined. The N19(n,γ)N20 rate is up to a factor of 5 higher at T
15.	Thies, Ronja, 1987, et al. (författare) Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes 2016 Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 93:5 Tidskriftsartikel (refereegranskat)abstract Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neutron-rich nuclei, creating a need for models to describe also these reactions. Purpose: We want to extend the presently available data on fragmentation reactions towards the light exotic region on the nuclear chart. Furthermore, we want to improve the understanding of projectile fragmentation especially for unstable isotopes. Method: We have measured projectile fragments from C10,12-18 and B10-15 isotopes colliding with a carbon target. These measurements were all performed within one experiment, which gives rise to a very consistent data set. We compare our data to model calculations. Results: One-proton removal cross sections with different final neutron numbers (1pxn) for relativistic C10,12-18 and B10-15 isotopes impinging on a carbon target. Comparing model calculations to the data, we find that the epax code is not able to describe the data satisfactorily. Using abrabla07 on the other hand, we find that the average excitation energy per abraded nucleon needs to be decreased from 27 MeV to 8.1 MeV. With that decrease abrabla07 describes the data surprisingly well. Conclusions: Extending the available data towards light unstable nuclei with a consistent set of new data has allowed a systematic investigation of the role of the excitation energy induced in projectile fragmentation. Most striking is the apparent mass dependence of the average excitation energy per abraded nucleon. Nevertheless, this parameter, which has been related to final-state interactions, requires further study.
16.	Diaz Fernandez, Paloma, 1983, et al. (författare) Quasifree (p, pN) scattering of light neutron-rich nuclei near N=14 2018 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 97:2 Tidskriftsartikel (refereegranskat)abstract Background: For many years, quasifree scattering reactions in direct kinematics have been extensively used to study the structure of stable nuclei, demonstrating the potential of this approach. The (RB)-B-3 collaboration has performed a pilot experiment to study quasifree scattering reactions in inverse kinematics for a stable C-12 beam. The results from that experiment constitute the first quasifree scattering results in inverse and complete kinematics. This technique has lately been extended to exotic beams to investigate the evolution of shell structure, which has attracted much interest due to changes in shell structure if the number of protons or neutrons is varied. Purpose: In this work we investigate for the first time the quasifree scattering reactions (p, pn) and (p, 2p) simultaneously for the same projectile in inverse and complete kinematics for radioactive beams with the aim to study the evolution of single-particle properties from N = 14 to N = 15. Method: The structure of the projectiles O-23, O-22, and N-21 has been studied simultaneously via (p, pn) and (p, 2p) quasifree knockout reactions in complete inverse kinematics, allowing the investigation of proton and neutron structure at the same time. The experimental data were collected at the (RB)-B-3-LAND setup at GSI at beam energies of around 400 MeV/u. Two key observables have been studied to shed light on the structure of those nuclei: the inclusive cross sections and the corresponding momentum distributions. Conclusions: The knockout reactions (p, pn) and (p, 2p) with radioactive beams in inverse kinematics have provided important and complementary information for the study of shell evolution and structure. For the (p, pn) channels, indications of a change in the structure of these nuclei moving from N = 14 to N = 15 have been observed, i.e., from the 0d(5/2) shell to the 1s(1/2). This supports previous observations of a subshell closure at N = 14 for neutron-rich oxygen isotopes and its weakening for the nitrogen isotopes.
17.	Holl, M., et al. (författare) Quasi-free neutron and proton knockout reactions from light nuclei in a wide neutron-to-proton asymmetry range 2019 Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 795, s. 682-688 Tidskriftsartikel (refereegranskat)abstract The quasi-free scattering reactions 11C(p,2p) and 10,11,12C(p,pn) have been studied in inverse kinematics at beam energies of 300–400 MeV/u at the R3B-LAND setup. The outgoing proton-proton and proton-neutron pairs were detected in coincidence with the reaction fragments in kinematically complete measurements. The efficiency to detect these pairs has been obtained from GEANT4 simulations which were tested using the 12C(p,2p) and 12C(p,pn) reactions. Experimental cross sections and momentum distributions have been obtained and compared to DWIA calculations based on eikonal theory. The new results reported here are combined with previously published cross sections for quasi-free scattering from oxygen and nitrogen isotopes and together they enable a systematic study of the reduction of single-particle strength compared to predictions of the shell model over a wide neutron-to-proton asymmetry range. The combined reduction factors show a weak or no dependence on isospin asymmetry, in contrast to the strong dependency reported in nucleon-removal reactions induced by nuclear targets at lower energies. However, the reduction factors for (p,2p) are found to be 'significantly smaller than for (p,pn) reactions for all investigated nuclei.
18.	Revel, A., et al. (författare) Strong Neutron Pairing in core+4n Nuclei 2018 Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 120:15 Tidskriftsartikel (refereegranskat)abstract The emission of neutron pairs from the neutron-rich N=12 isotones C18 and O20 has been studied by high-energy nucleon knockout from N19 and O21 secondary beams, populating unbound states of the two isotones up to 15 MeV above their two-neutron emission thresholds. The analysis of triple fragment-n-n correlations shows that the decay N19(-1p)C18∗→C16+n+n is clearly dominated by direct pair emission. The two-neutron correlation strength, the largest ever observed, suggests the predominance of a C14 core surrounded by four valence neutrons arranged in strongly correlated pairs. On the other hand, a significant competition of a sequential branch is found in the decay O21(-1n)O20∗→O18+n+n, attributed to its formation through the knockout of a deeply bound neutron that breaks the O16 core and reduces the number of pairs.
19.	Syndikus, I., et al. (författare) Probing the Z = 6 spin-orbit shell gap with (p,2p) quasi-free scattering reactions 2020 Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 809 Tidskriftsartikel (refereegranskat)abstract The evolution of the traditional nuclear magic numbers away from the valley of stability is an active field of research. Experimental efforts focus on providing key spectroscopic information that will shed light into the structure of exotic nuclei and understanding the driving mechanism behind the shell evolution. In this work, we investigate the Z=6 spin-orbit shell gap towards the neutron dripline. To do so, we employed NA(p,2p)CA−1 quasi-free scattering reactions to measure the proton component of the 21+ state of 16,18,20C. The experimental findings support the notion of a moderate reduction of the proton 1p1/2−1p3/2 spin-orbit splitting, at variance to recent claims for a prevalent Z=6 magic number towards the neutron dripline.
20.	Vandebrouck, M., et al. (författare) Effective proton-neutron interaction near the drip line from unbound states in F-25,F-26 2017 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 96:5 Tidskriftsartikel (refereegranskat)abstract Background: Odd-odd nuclei, around doubly closed shells, have been extensively used to study proton-neutron interactions. However, the evolution of these interactions as a function of the binding energy, ultimately when nuclei become unbound, is poorly known. The F-26 nucleus, composed of a deeply bound pi 0d(5/2) proton and an unbound v0d(3/2) neutron on top of an O-24 core, is particularly adapted for this purpose. The coupling of this proton and neutron results in a J(pi) = 1(1)(+) - 4(1)(+) multiplet, whose energies must be determined to study the influence of the proximity of the continuum on the corresponding proton-neutron interaction. The J(pi) = 1(1)(+), 2(1)(+), 4(1)(+) bound states have been determined, and only a clear identification of the J(pi) = 3(1)(+) is missing. Purpose: We wish to complete the study of the J(pi) = 1(1)(+) - 4(1)(+) multiplet in F-26, by studying the energy and width of the J(pi) = 3(1)(+) unbound state. The method was first validated by the study of unbound states in F-25, for which resonances were already observed in a previous experiment. Method: Radioactive beams of Ne-26 and Ne-27, produced at about 440AMeV by the fragment separator at the GSI facility were used to populate unbound states in F-25 and F-26 via one-proton knockout reactions on a CH2 target, located at the object focal point of the (RB)-B-3/LAND setup. The detection of emitted. rays and neutrons, added to the reconstruction of the momentum vector of the A - 1 nuclei, allowed the determination of the energy of three unbound states in F-25 and two in F-26. Results: Based on its width and decay properties, the first unbound state in F-25, at the relative energy of 49(9) keV, is proposed to be a J(pi) = 1/ 2(-) arising from a p1/2 proton- hole state. In F-26, the first resonance at 323(33) keV is proposed to be the J(pi) = 3(1)(+) member of the J(pi) = 1(1)(+) - 4(1)(+) multiplet. Energies of observed states in F-25,F-26 have been compared to calculations using the independent-particle shell model, a phenomenological shell model, and the ab initio valence-space in-medium similarity renormalization group method. Conclusions: The deduced effective proton- neutron interaction is weakened by about 30-40% in comparison to the models, pointing to the need for implementing the role of the continuum in theoretical descriptions or to a wrong determination of the atomic mass of F-26.
21.	Bhattacharyya, A., et al. (författare) Neutron capture cross sections of light neutron-rich nuclei relevant for -process nucleosynthesis 2021 Ingår i: Physical Review C. - 2469-9993 .- 2469-9985. ; 104:4 Tidskriftsartikel (refereegranskat)abstract The measurements of neutron capture cross sections of neutron-rich nuclei are challenging but essential for understanding nucleosynthesis and stellar evolution processes in the explosive burning scenario. In the quest of -process abundances, according to the neutrino-driven-wind model, light neutron-rich unstable nuclei may play a significant role as seed nuclei that influence the abundance pattern. Hence, experimental data for neutron capture cross sections of neutron-rich nuclei are needed. Coulomb dissociation of radioactive ion beams at intermediate energy is a powerful indirect method for inferring capture cross section. As a test case for validation of the indirect method, the neutron capture cross section (, ) for was inferred from the Coulomb dissociation of at intermediate energy ( MeV). A comparison between different theoretical approaches and experimental results for the reaction is discussed. We report for the first time experimental reaction cross sections of , , , and . The reaction cross sections were inferred indirectly through Coulomb dissociation of , , and at incident projectile energies around 400-430 MeV using the FRS-LAND setup at GSI, Darmstadt. The neutron capture cross sections were obtained from the photoabsorption cross sections with the aid of the detailed balance theorem. The reaction rates for the neutron-rich Na, Mg, Al nuclei at typical -process temperatures were obtained from the measured () capture cross sections. The measured neutron capture reaction rates of the neutron-rich nuclei, , , and are significantly lower than those predicted by the Hauser-Feshbach decay model. A similar trend was observed earlier for and but in the case of the trend is opposite. The situation is more complicated when the ground state has a multi-particle-hole configuration. For , the measured cross section is about higher than the Hauser-Feshbach prediction.
22.	Chakraborty, S., et al. (författare) Ground-state configuration of neutron-rich Al-35 via Coulomb breakup 2017 Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 96:3, s. 1965- Tidskriftsartikel (refereegranskat)abstract The ground-state configuration of Al-35 has been studied via Coulomb dissociation (CD) using the LAND-FRS setup (GSI, Darmstadt) at a relativistic energy of similar to 403 MeV/nucleon. The measured inclusive differential CD cross section for Al-35, integrated up to 5.0 MeV relative energy between the Al-34 core and the neutron using a Pb target, is 78(13) mb. The exclusive measured CD cross section that populates various excited states of 34Al is 29(7) mb. The differential CD cross section of Al-35 -> Al-34 + n has been interpreted in the light of a direct breakup model, and it suggests that the possible ground-state spin and parity of Al-35 could be, tentatively, 1/2+ or 3/2(+) or 5/2(+). The valence neutrons, in the ground state of Al-35, may occupy a combination of either l = 3,0 or l = 1,2 orbitals coupled with the Al-34 core in the ground and isomeric state(s), respectively. This hints of a particle-hole configuration of the neutron across the magic shell gaps at N = 20,28 which suggests narrowing the magic shell gap. If the 5/2+ is the ground-state spin-parity of Al-35 as suggested in the literature, then the major ground-state configuration of Al-35 is a combination of Al-34(g. s.; 4(-)) circle times upsilon(p3/2) and Al-34(isomer; 1(+)) circle times upsilon(d3/2) states. The result from this experiment has been compared with that from a previous knockout measurement and a calculation using the SDPF-M interaction.
23.	Craddock, Nick, et al. (författare) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls 2010 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720 Tidskriftsartikel (refereegranskat)abstract Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
24.	Panin, V., et al. (författare) Quasi-free proton knockout from 12C on carbon target at 398 MeV/u 2019 Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 797 Tidskriftsartikel (refereegranskat)abstract The proton-removal mechanism of the 12C→11B reaction induced on a carbon target via elementary nucleon-nucleon scattering is investigated in exclusive triple-coincidence measurements. The observed two-nucleon angular correlations are found to be consistent with quasi-free scattering of a projectile-like proton off a target-like nucleon. Exclusive cross sections for one-step pp and pn interactions are determined as σpp=17.2(12) mb and σpn=18.2(18), respectively. The extracted quasi-free component amounts up to 58(4)% of the total proton-removal cross section. The results are compared to total proton-removal cross sections obtained from the experiment and eikonal reaction theory.
25.	Rahaman, A., et al. (författare) Coulomb breakup of neutron-rich Na-29,Na-30 isotopes near the island of inversion 2017 Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 44:4, s. 045101- Tidskriftsartikel (refereegranskat)abstract First results are reported on the ground state configurations of the neutron-rich Na-29,Na-30 isotopes, obtained via Coulomb dissociation (CD) measurements. The invariant mass spectra of these nuclei have been obtained through measurement of the four-momenta of all decay products after Coulomb excitation of those nuclei on a Pb-208 target at energies of 400-430 MeV/nucleon using the FRS-ALADIN-LAND setup at GSI, Darmstadt. Integrated inclusive CD cross-sections (CD) of 89 (7) mb and 167 (13) mb for one neutron removal from Na-29 and Na-30, respectively, have been extracted up to an excitation energy of 10 MeV. The major part of one neutron removal, CD cross-sections of those nuclei populate the core, in its ground state. A comparison with the direct breakup model, suggests the predominant occupation of the valence neutron in the ground state of Na-29 (3/2(+)) and Na-30 (2(+)) is the d-orbital with a small contribution from the s-orbital, which are coupled with the ground state of the core. One of the major components of the ground state configurations of these nuclei are Na-28(gs)(1(+)) circle times v(s,d) and Na-29(gs)(3/2(+)) circle times v(s,d), respectively. The ground state spin and parity of these nuclei obtained from this experiment are in agreement with earlier reported values. The spectroscopic factors for the valence neutron occupying the s and d orbitals for these nuclei in the ground state have been extracted and reported for the first time. A comparison of the experimental findings with shell model calculation using the MCSM suggests a lower limit of around 4.3 MeV of the sd-pf shell gap in Na-30.

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