| 1. |
|
|
| 2. |
- Cochius-den Otter, S, et al.
(author)
-
The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia
- 2019
-
In: BMJ open. - : BMJ. - 2044-6055. ; 9:11, s. e032122-
-
Journal article (peer-reviewed)abstract
- Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on ‘trial and error’. Inhaled nitric oxide (iNO) is often the drug of first choice. However, iNO does not seem to improve mortality. Intravenous sildenafil has reduced mortality in newborns with PH without CDH, but prospective data in CDH patients are lacking.Methods and analysisIn an open label, multicentre, international randomised controlled trial in Europe, Canada and Australia, 330 newborns with CDH and PH are recruited over a 4-year period (2018–2022). Patients are randomised for intravenous sildenafil or iNO. Sildenafil is given in a loading dose of 0.4 mg/kg in 3 hours; followed by continuous infusion of 1.6 mg/kg/day, iNO is dosed at 20 ppm. Primary outcome is absence of PH on day 14 without pulmonary vasodilator therapy and/or absence of death within the first 28 days of life. Secondary outcome measures include clinical and echocardiographic markers of PH in the first year of life. We hypothesise that sildenafil gives a 25% reduction in the primary outcome from 68% to 48% on day 14, for which a sample size of 330 patients is needed. An intention-to-treat analysis will be performed. A p-value (two-sided) <0.05 is considered significant in all analyses.Ethics and disseminationEthics approval has been granted by the ethics committee in Rotterdam (MEC-2017-324) and the central Committee on Research Involving Human Subjects (NL60229.078.17) in the Netherlands. The principles of the Declaration of Helsinki, the Medical Research Involving Human Subjects Act and the national rules and regulations on personal data protection will be used. Parental informed consent will be obtained.Trial registration numberNTR6982; Pre-results.
|
|
| 3. |
|
|
| 4. |
- Allaire, C., et al.
(author)
-
Beam test measurements of Low Gain Avalanche Detector single pads and arrays for the ATLAS High Granularity Timing Detector
- 2018
-
In: Journal of Instrumentation. - : Institute of Physics (IOP). - 1748-0221. ; 13
-
Journal article (peer-reviewed)abstract
- For the high luminosity upgrade of the LHC at CERN, ATLAS is considering the addition of a High Granularity Timing Detector (HGTD) in front of the end cap and forward calorimeters at vertical bar z vertical bar = 3:5 m and covering the region 2:4 < vertical bar eta vertical bar < 4 to help reducing the effect of pile-up. The chosen sensors are arrays of 50 mu m thin Low Gain Avalanche Detectors (LGAD). This paper presents results on single LGAD sensors with a surface area of 1.3 x 1.3 mm(2) and arrays with 2 x 2 pads with a surface area of 2 x 2 mm(2) or 3 x 3 mm(2) each and different implant doses of the p(+) multiplication layer. They are obtained from data collected during a beam test campaign in autumn 2016 with a pion beam of 120 GeV energy at the CERN SPS. In addition to several quantities measured inclusively for each pad, the gain, efficiency and time resolution have been estimated as a function of the position of the incident particle inside the pad by using a beam telescope with a position resolution of few mu m. Different methods to measure the time resolution are compared, yielding consistent results. The sensors with a surface area of 1.3 x 1.3 mm(2) have a time resolution of about 40 ps for a gain of 20 and of about 27 ps for a gain of 50 and fulfil the HGTD requirements. Larger sensors have, as expected, a degraded time resolution. All sensors show very good efficiency and time resolution uniformity.
|
|
| 5. |
- Asghar, Rizwan
(author)
-
Flexible Interleaving Sub–systems for FEC in Baseband Processors
- 2010
-
Doctoral thesis (other academic/artistic)abstract
- Interleaving is always used in combination with an error control coding. It spreads the burst noise, and changes the burst noise to white noise so that the noise induced bit errors can be corrected. With the advancement of communication systems and substantial increase in bandwidth requirements, use of coding for forward error correction (FEC) has become an integral part in the modern communication systems. Dividing the FEC sub-systems in two categories i.e. channel coding/de-coding and interleaving/de-interleaving, the later appears to be more varying in permutation functions, block sizes and throughput requirements. The interleaving/de-interleaving consumes more silicon due to the silicon cost of the permutation tables used in conventional LUT based approaches. For multi-standard support devices the silicon cost of the permutation tables can grow much higher resulting in an un-efficient solution. Therefore, the hardware re-use among different interleaver modules to support multimode processing platform is of significance.The broadness of the interleaving algorithms gives rise to many challenges when considering a true multimode interleaver implementation. The main challenges include real-time low latency computation for different permutation functions, managing wide range of interleaving block sizes, higher throughput, low cost, fast and dynamic reconfiguration for different standards, and introducing parallelism where ever necessary.It is difficult to merge all currently used interleavers to a singlearchitecture because of different algorithms and throughputs; however, thefact that multimode coverage does not require multiple interleavers to workat the same time, provides opportunities to use hardware multiplexing. The multimode functionality is then achieved by fast switching between differentstandards. We used the algorithmic level transformations such as 2-Dtransformation, and realization of recursive computations, which appear to bethe key to bring different interleaving functions to the same level. In general,the work focuses on function level hardware re-use, but it also utilizesclassical data-path level optimizations for efficient hardware multiplexingamong different standards.The research has resulted in multiple flexible architectures supporting multiple standards. These architectures target both channel interleaving and turbo-code interleaving. The presented architectures can support both types of communication systems i.e. single-stream and multi-stream systems. Introducing the algorithmic level transformations and then applying hardware re-use methodology has resulted in lower silicon cost while supporting sufficient throughput. According to the database searching in March 2010, we have the first multimode interleaver core covering WLAN (802.11a/b/g and 802.11n), WiMAX (802.16e), 3GPP-WCDMA, 3GPP-LTE, and DVB-T/H on a single architecture with minimum silicon cost. The research also provides the support for parallel interleaver address generation using different architectures. It provides the algorithmic modifications and architectures to generate up to 8 addresses in parallel and handle the memory conflicts on-the-fly.One of the vital requirements for multimode operation is the fast switching between different standards, which is supported by the presented architectures with minimal cycle cost overheads. Fast switching between different standards gives luxury to the baseband processor to re-configure theinterleaver architecture on-the-fly and re-use the same hardware for another standard. Lower silicon cost, maximum flexibility and fast switchability among multiple standards during run time make the proposed research a good choice for the radio baseband processing platforms.
|
|
| 6. |
- Cavallaro, Sara, et al.
(author)
-
Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy : Correlation and Heterogeneity in Their Molecular and Biophysical Features
- 2021
-
In: Small. - : Wiley. - 1613-6810 .- 1613-6829. ; 17:14
-
Journal article (peer-reviewed)abstract
- Being a key player in intercellular communications, nanoscale extracellular vesicles (EVs) offer unique opportunities for both diagnostics and therapeutics. However, their cellular origin and functional identity remain elusive due to the high heterogeneity in their molecular and physical features. Here, for the first time, multiple EV parameters involving membrane protein composition, size and mechanical properties on single small EVs (sEVs) are simultaneously studied by combined fluorescence and atomic force microscopy. Furthermore, their correlation and heterogeneity in different cellular sources are investigated. The study, performed on sEVs derived from human embryonic kidney 293, cord blood mesenchymal stromal and human acute monocytic leukemia cell lines, identifies both common and cell line-specific sEV subpopulations bearing distinct distributions of the common tetraspanins (CD9, CD63, and CD81) and biophysical properties. Although the tetraspanin abundances of individual sEVs are independent of their sizes, the expression levels of CD9 and CD63 are strongly correlated. A sEV population co-expressing all the three tetraspanins in relatively high abundance, however, having average diameters of <100 nm and relatively low Young moduli, is also found in all cell lines. Such a multiparametric approach is expected to provide new insights regarding EV biology and functions, potentially deciphering unsolved questions in this field.
|
|
| 7. |
|
|
| 8. |
- Ghetti, R, et al.
(author)
-
Characterization of nuclear sources via two-neutron intensity interferometry
- 1999
-
In: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 660:1, s. 20-40
-
Journal article (peer-reviewed)abstract
- The neutron energy spectrum and the two-neutron correlation function have been measured for the E/A = 45 MeV Ni + Al reaction in order to assess the space-time characteristics of the neutron emitting source. When comparing the data to a statistical model,
|
|
| 9. |
- Ghetti, R., et al.
(author)
-
Influence of multiple sources on the two-neutron correlation function in Ni-induced, intermediate energy, heavy ion reactions
- 2001
-
In: Physical Review C. Nuclear Physics. - : American Physical Society. - 0556-2813 .- 1089-490X. ; 64:1
-
Journal article (peer-reviewed)abstract
- The strength of the neutron-neutron correlation function from the E=45AMeV58Ni+27Al, natNi, and 197Au reactions depends on the neutron parallel velocity. This indicates the presence of multiple sources of neutron emission. We find these sources consistent with a dissipative, binary reaction mechanism as it is described by, e.g., Boltzmann-Uehling-Uhlenbeck calculations.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Haschka, J, et al.
(author)
-
Identification of circulating microRNA patterns in patients in psoriasis and psoriatic arthritis
- 2023
-
In: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 62:10, s. 3448-3458
-
Journal article (peer-reviewed)abstract
- ObjectivemiRNAs are small non-coding RNAs that control gene expression. Specific intra- and extracellular miRNA signatures have been identified in various diseases. Whether certain miRNA signatures are associated with psoriasis (PsO) and PsA is currently unknown. We aimed to search for circulating miRNA signatures associated with PsO and PsA patients.MethodsExpression of miRNAs was analysed by reverse transcription quantitative real-time PCR (RT-qPCR) in the serum of PsA, PsO patients and healthy controls. Demographic and disease-specific characteristics and imaging data from hand MRI were recorded. In the discovery phase, 192 miRNA assays were analysed in 48 samples (PsA, PsO, controls: each N = 16). For validation, 17 selected miRNAs were measured in the total population.ResultsA total of 141 patients and controls were analysed (51 PsA, 40 PsO, 50 controls). In the discovery phase 51 miRNAs in PsO and 64 miRNAs in PsA were down- or upregulated compared with controls, with 33 miRNAs being changed in both (adj. P < 0.05). The 17 top candidates from discovery were assessed in the validation phase, 9 of them discriminated PsA and PsO from controls [area under the curve (AUC) ≥0.70, all P < 0.05]. Four miRNAs (miR-19b-3p, miR-21-5p, miR-92a-3p and let-7b-5p) were significantly differently regulated between PsO and PsA. A combination of these miRNAs increased the AUC to 0.92 in multivariate regression model to discriminate PsO and PsA.ConclusionmiRNA signatures in PsA and PsO patients differ from controls. Nine miRNAs were differentially regulated in PsA and PsO patients, five of them previously reported to be involved in bone and cartilage metabolism, indicating an intimate association of psoriatic inflammation and bone/cartilage changes.
|
|
| 13. |
- Helldin, L., et al.
(author)
-
A functional comparison of patients with schizophrenia between the North and South of Europe
- 2012
-
In: European psychiatry. - : Cambridge University Press (CUP). - 0924-9338 .- 1778-3585. ; 27:6, s. 442-444
-
Journal article (peer-reviewed)abstract
- Introduction: The main objective of this study was to compare clinical and functional outcomes of patients with schizophrenia in Italy and Sweden with a special focus on daily functioning performance and real life milestones. Also, to study if outcome is to be regarded as a consequence of premorbid function, the level of symptom control and functional capacity or if other influences, such as cultural differences, must parallel be considered. Method: Ninety-five patients from three centres, Milan and Naples in Italy and Trollhattan in Sweden were investigated. The Positive and Negative Syndrome Scale and the UCSD Performance-Based Skills Assessment - Brief version were used together with patients' school history and their status of accommodation and occupation. Results: Patients in Trollhattan were more likely to live independently and patients in Naples to have a work or take part in education. Differences in symptoms and the performance test were present but subtle. Discussion: Differences in real life milestones were not explained by corresponding differences in symptoms, premorbid function or the performance-based test. It is therefore not appropriate only to present functional outcome as an expression of how successful treatment has been. (C) 2011 Elsevier Masson SAS. All rights reserved.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Urrata, M, et al.
(author)
-
Neutron-neutron Intensity Interferometry in E/A = 45 MeV 58Ni + 27Al, 58Ni and 197Au Reactions
- 2000
-
In: Physical Review C. Nuclear Physics. - : American Institute of Physics (AIP). - 0556-2813 .- 1089-490X. ; 62
-
Journal article (peer-reviewed)abstract
- Small angle neutron-neutron correlations have been measured for the E/A=45 MeV 58Ni+27Al, natNi, and 197Au reactions. Two-neutron correlation functions, both integrated and gated on the total momentum of the neutron pair, have been constructed. In order to explain these data, a fraction of fast "dynamical" emission is needed in addition to slower evaporative emission. The overall emission time scale is shorter for the symmetric system, indicating that the dynamical component is stronger in this case.
|
|
