| 1. |
- Chen, Jihong, et al.
(författare)
-
Analyzing the impact and evolution of ocean & coastal management : 30 years in retrospect
- 2023
-
Ingår i: Ocean and Coastal Management. - : Elsevier. - 0964-5691 .- 1873-524X. ; 242
-
Forskningsöversikt (refereegranskat)abstract
- Ocean & Coastal Management (OCMA) has significantly contributed to international ocean and coastal management, policy-making, governance, and other related research fields. This article highlights the contributions OCMA has made in these areas by summarizing the trends in 3782 articles published from 1992 to 2021. Using bibliometric and knowledge graph visualization analyses, this article systematically reviews the historical research contributions in each field and identifies emerging topics in recent years, such as the Blue Economy, shipping, and marine litter. OCMA has made a substantial positive impact on global ocean and coastal management by fostering collaboration among scholars and practitioners, advancing policy and regulatory development, enhancing management practices, increasing public awareness of environmental protection, and promoting sustainable development. In addition to its critical academic role in the field of ocean and coastal management, OCMA has also facilitated advancements in related research and practice (such as coastal erosion, litter, port management), ultimately contributing to the protection of global ocean and coastal ecosystems.
|
|
| 2. |
- Li, Jian, et al.
(författare)
-
A 3D extra-large-pore zeolite enabled by 1D-to-3D topotactic condensation of a chain silicate
- 2023
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 379:6629, s. 283-287
-
Tidskriftsartikel (refereegranskat)abstract
- Zeolites are microporous silicates with a large variety of applications as catalysts, adsorbents, and cation exchangers. Stable silica-based zeolites with increased porosity are in demand to allow adsorption and processing of large molecules but challenge our synthetic ability. We report a new, highly stable pure silica zeolite called ZEO-3, which has a multidimensional, interconnected system of extra-large pores open through windows made by 16 and 14 silicate tetrahedra, the least dense polymorph of silica known so far. This zeolite was formed by an unprecedented one-dimensional to three-dimensional (1D-to-3D) topotactic condensation of a chain silicate. With a specific surface area of more than 1000 square meters per gram, ZEO-3 showed a high performance for volatile organic compound abatement and recovery compared with other zeolites and metal-organic frameworks.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Coelho, Teresa, et al.
(författare)
-
A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis
- 2020
-
Ingår i: Orphanet Journal of Rare Diseases. - : BioMed Central (BMC). - 1750-1172. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Patisiran, an RNA interference therapeutic, has demonstrated robust reduction of wild-type and mutant transthyretin protein and was able to improve polyneuropathy and quality of life following 18 months of treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis.In this 24-month Phase II open-label extension study, we evaluated the effects of patisiran treatment (0.3 mg/kg intravenously every 3 weeks) on safety, serum transthyretin levels, and clinical parameters. Efficacy assessments included modified Neuropathy Impairment Score +7 (mNIS+7) and multiple disease-relevant measures. Cardiac assessments were performed in a pre-specified cardiac subgroup.Results: Twenty-seven patients entered this study, including 12 (44%) with ambulation difficulties due to their neuropathy and 11 (41%) who met criteria for the cardiac subgroup. During treatment, the majority of adverse events were mild/moderate in severity; there were no drug-related adverse events leading to treatment discontinuation. The most common drug-related adverse events were flushing and infusion-related reactions (22% each). Patisiran resulted in rapid, robust (similar to 82%), and sustained reduction of mean transthyretin levels over 24 months. A mean 6.95-point decrease (improvement) in mNIS+7 from baseline was observed at 24 months. Patisiran's impact on mNIS+7 was irrespective of concomitant tafamidis or diflunisal use, sex, or age. Clinical assessments of motor function, autonomic symptoms, disease stage, and quality of life remained stable over 24 months. No significant changes were observed for echocardiographic measures or cardiac biomarkers in the cardiac subgroup. Exploratory analyses demonstrated improvements in nerve-fiber density with corresponding reductions in amyloid burden observed in skin biopsies over 24 months.Conclusions: Long-term treatment with patisiran had an acceptable safety profile and was associated with halting/improvement of polyneuropathy progression in patients with hATTR amyloidosis.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Li, Ping, et al.
(författare)
-
Structures, protonation, and electrochemical properties of diiron dithiolate complexes containing pyridyl-phosphine ligands
- 2009
-
Ingår i: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; :11, s. 1919-1926
-
Tidskriftsartikel (refereegranskat)abstract
- Diiron complexes containing pyridyl-phosphine ligands, that is, (mu-pdt)[Fe-2(CO)(5)L] (pdt = S(CH2)(3)S, L = Ph2PCH2Py, 3a; Ph2PPy, 3b) and (mu-pdt)[Fe(CO)(2)(PMe3)][Fe(CO)(2)L] (L = Ph2PCH2Py, 4a; Ph2PPy, 4b) were prepared as model complexes of the [FeFe]-hydrogenase active site. Protonation of 3a and 3b by HOTf afforded the pyridyl-nitrogen protonated products [3aH(N)][OTf] and [3bH(N)][OTf], respectively. The molecular structures of 3a, 3b, 4a, 4b, as well as [3aH(N)][OTf] and [3bH(N)][OTf] were confirmed by X-ray diffraction studies, which show that the Ph2PCH2Py ligand occupies the basal position both in 3a and its protonated species [3aH(N)][OTf], while the Ph2PPy ligand prefers the apical position in 3b and [3bH(N)][OTf]. The double protonation process of complex 4b was monitored by in situ IR, H-1 and P-31 NMR spectroscopy at low temperature. The spectroscopic evidence indicates that the protonation of 4b occurs first at the Fe-Fe bond and then at the pyridyl-nitrogen atom. Cyclic voltammograms reveal that protonation of 3a and 3b results in a considerable decrease in the overpotential for electrocatalytic proton reduction in the presence of HOTf, while the efficiency is not influenced by protonation. The electrocatalytic efficiency of 4a for proton reduction in the presence of HOAc in CH3CN-H2O (50:1, v/v) is 5 times higher than that in pure CH3CN.
|
|
| 10. |
- Mayoral, Alvaro, et al.
(författare)
-
Direct Atomic-Level Imaging of Zeolites : Oxygen, Sodium in Na-LTA and Iron in Fe-MFI
- 2020
-
Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 59:44, s. 19510-19517
-
Tidskriftsartikel (refereegranskat)abstract
- Zeolites are becoming more versatile in their chemical functions through rational design of their frameworks. Therefore, direct imaging of all atoms at the atomic scale, basic units (Si, Al, and O), heteroatoms in the framework, and extra-framework cations, is needed. TEM provides local information at the atomic level, but the serious problem of electron-beam damage needs to be overcome. Herein, all framework atoms, including oxygen and most of the extra-framework Na cations, are successfully observed in one of the most electron-beam-sensitive and lowest framework density zeolites, Na-LTA. Zeolite performance, for instance in catalysis, is highly dependent on the location of incorporated heteroatoms. Fe single atomic sites in theMFIframework have been imaged for the first time. The approach presented here, combining image analysis, electron diffraction, and DFT calculations, can provide essential structural keys for tuning catalytically active sites at the atomic level.
|
|
| 11. |
|
|
| 12. |
- Solomon, Scott D., et al.
(författare)
-
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis : Analysis of the APOLLO Study
- 2019
-
Ingår i: Circulation. - : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 139:4, s. 431-443
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive, multisystem disease that presents with cardiomyopathy or polyneuropathy. The APOLLO study assessed the efficacy and tolerability of patisiran in patients with hATTR amyloidosis. The effects of patisiran on cardiac structure and function in a prespecified subpopulation of patients with evidence of cardiac amyloid involvement at baseline were assessed.Methods: APOLLO was an international, randomized, double-blind, placebo-controlled phase 3 trial in patients with hATTR amyloidosis. Patients were randomized 2:1 to receive 0.3 mg/kg patisiran or placebo via intravenous infusion once every 3 weeks for 18 months. The prespecified cardiac subpopulation comprised patients with a baseline left ventricular wall thickness 13 mm and no history of hypertension or aortic valve disease. Prespecified exploratory cardiac end points included mean left ventricular wall thickness, global longitudinal strain, and N-terminal prohormone of brain natriuretic peptide. Cardiac parameters in the overall APOLLO patient population were also evaluated. A composite end point of cardiac hospitalizations and all-cause mortality was assessed in a post hoc analysis.Results: In the cardiac subpopulation (n=126; 56% of total population), patisiran reduced mean left ventricular wall thickness (least-squares mean difference SEM: -0.90.4 mm, P=0.017), interventricular septal wall thickness, posterior wall thickness, and relative wall thickness at month 18 compared with placebo. Patisiran also led to increased end-diastolic volume (8.3 +/- 3.9 mL, P=0.036), decreased global longitudinal strain (-1.4 +/- 0.6%, P=0.015), and increased cardiac output (0.38 +/- 0.19 L/min, P=0.044) compared with placebo at month 18. Patisiran lowered N-terminal prohormone of brain natriuretic peptide at 9 and 18 months (at 18 months, ratio of fold-change patisiran/placebo 0.45, P<0.001). A consistent effect on N-terminal prohormone of brain natriuretic peptide at 18 months was observed in the overall APOLLO patient population (n=225). Median follow-up duration was 18.7 months. The exposure-adjusted rates of cardiac hospitalizations and all-cause death were 18.7 and 10.1 per 100 patient-years in the placebo and patisiran groups, respectively (Andersen-Gill hazard ratio, 0.54; 95% CI, 0.28-1.01).Conclusions: Patisiran decreased mean left ventricular wall thickness, global longitudinal strain, N-terminal prohormone of brain natriuretic peptide, and adverse cardiac outcomes compared with placebo at month 18, suggesting that patisiran may halt or reverse the progression of the cardiac manifestations of hATTR amyloidosis.
|
|
| 13. |
- Wang, Ning, et al.
(författare)
-
Preparation, Facile Deprotonation, and Rapid H/D Exchange of the mu-Hydride Diiron Model Complexes of the FeFe -Hydrogenase Containing a Pendant Amine in a Chelating Diphosphine Ligand
- 2009
-
Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 48:24, s. 11551-11558
-
Tidskriftsartikel (refereegranskat)abstract
- The CO-displacement of [(μ-pdt)Fe2(CO)6] with (Ph2PCH2)2N(n-Pr) in refluxing toluene gave an unsymmetrical chelating complex [(μ-pdt){Fe(CO)3}{Fe(CO)(κ2-Ph2PCH2N(n-Pr)CH2PPh2}] (1) as a major product, together with a small amount of the symmetrical intramolecular bridging complex [(μ-pdt){μ-Ph2PCH2N(n-Pr)CH2PPh2}{Fe(CO)2}2] (2) and the intermolecular bridging complex [{μ,κ1,κ1-Ph2PCH2N(n-Pr)CH2PPh2}{(μ-pdt)Fe2(CO)5}2] (3). In contrast, the reaction of [(μ-pdt)Fe2(CO)6] with (Ph2PCH2)2NR (R = n-Pr, Ph) afforded the intermolecular bridging isomers 3 and 4 in the presence of a CO-removing reagent Me3NO·2H2O in CH3CN at room temperature. The molecular structures of 1, 3, and 4, as well as the doubly protonated complex [1(HNHμ)](OTf)2] were determined by X-ray analyses. The protonation processes of 1 with HBF4·Et2O and HOTf were studied in different solvents. The presence of the Hμ···HN interaction in [1(HNHμ)]2+ was studied by relaxation time T1 and spin saturation transfer measurements. The μ-hydride of [1(Hμ)]+ and [1(HNHμ)]2+ undergo facile deprotonation with aniline and rapid H/D exchange with deuterons in solution. In contrast, neither deprotonation nor H/D exchange was detected for [(μ-H)(μ-pdt){Fe(CO)3}{Fe(CO)(κ2-dppp)}]+ ([5(Hμ)]+, dppp = Ph2PCH2CH2CH2PPh2) without internal base.
|
|
| 14. |
- Zhang, Jihong, et al.
(författare)
-
Pricing and Inventory Control Strategy for a Periodic-Review Energy Buy-Back System
- 2016
-
Ingår i: Journal of Systems Science and Complexity. - : Springer Science and Business Media LLC. - 1009-6124 .- 1559-7067. ; 29:4, s. 1018-1033
-
Forskningsöversikt (refereegranskat)abstract
- Along with the rapid development of economics and enhancement of industrialization, the power demand keeps rising and frequently creates mismatch between demand and supply in electricity. This provides miscellaneous energy buy-back programs with great opportunities. Such programs, when activated, offer certain amount of financial compensations to participants for reducing their energy consumption during peak time. They aim at encouraging participants to shift their electricity usage from peak to non-peak time, and thereby release the demand pressure during peak time. This paper considers a periodic-review joint pricing and inventory decision model under an energy buy-back program over finite planning horizons, in which the compensation levels, setup cost and additive random demand function are incorporated. The objective is to maximize a manufacturer's expected total profit. By using Veinott's conditions, it is shown that the manufacturer's optimal decision is a state dependent (s, S, P) policy under a peak market condition, or partly an (s, S, A, P) policy under the normal market condition.
|
|
