| 1. |
- Clyne, Naomi, et al.
(författare)
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Akut njurskada
- 2015. - 1:1
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Ingår i: Njursjukdom : Teori och Klinik - Teori och Klinik. - 9789144089256 ; , s. 245-263
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Bokkapitel (populärvet., debatt m.m.)
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| 2. |
- Clyne, Naomi, et al.
(författare)
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Att bli njursjuk och sköta sin behandling
- 2015. - 1.1
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Ingår i: Njursjukdom : Teori och klinik - Teori och klinik. - 9789144089256 ; , s. 379-382
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
- Clyne, Naomi, et al.
(författare)
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Fysisk träning
- 2015. - 1.1
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Ingår i: Njursjukdom : Teori och klinik - Teori och klinik. - 9789144089256 ; , s. 393-400
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
- Clyne, Naomi, et al.
(författare)
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Läkaren och vårdens organisation
- 2015. - 1.1
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Ingår i: Njursjukdom : Teori och klinik - Teori och klinik. - 9789144089256 ; , s. 369-378
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Bokkapitel (populärvet., debatt m.m.)
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| 5. |
- Clyne, Naomi, et al.
(författare)
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Preventiv nefrologi
- 2015. - 1:1
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Ingår i: Njursjukdom : Teori och klinik - Teori och klinik. - 9789144089256 ; , s. 363-368
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Bokkapitel (populärvet., debatt m.m.)
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| 6. |
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| 7. |
- Almquist, Martin, et al.
(författare)
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The treatment of renal hyperparathyroidism
- 2020
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Ingår i: Endocrine-Related Cancer. - 1351-0088. ; 27:1, s. 21-34
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Forskningsöversikt (refereegranskat)abstract
- Renal hyperparathyroidism (rHPT) is a complex and challenging disorder. It develops early in the course of renal failure and is associated with increased risks of fractures, cardiovascular disease and death. It is treated medically, but when medical therapy cannot control the hyperparathyroidism, surgical parathyroidectomy is an option. In this review, we summarize the pathophysiology, diagnosis, and medical treatment; we describe the effects of renal transplantation; and discuss the indications and strategies in parathyroidectomy for rHPT. Renal hyperparathyroidism develops early in renal failure, mainly as a consequence of lower levels of vitamin D, hypocalcemia, diminished excretion of phosphate and inability to activate vitamin D. Treatment consists of supplying vitamin D and reducing phosphate intake. In later stages calcimimetics might be added. RHPT refractory to medical treatment can be managed surgically with parathyroidectomy. Risks of surgery are small but not negligible. Parathyroidectomy should likely not be too radical, especially if the patient is a candidate for future renal transplantation. Subtotal or total parathyroidectomy with autotransplantation are recognized surgical options. Renal transplantation improves rHPT but does not cure it.
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| 8. |
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| 9. |
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| 10. |
- Clyne, Naomi
(författare)
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Caring for older people with chronic kidney disease-primum non nocere
- 2020
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; , s. 1-4
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Tidskriftsartikel (refereegranskat)
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| 11. |
- Clyne, Naomi, et al.
(författare)
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Exercise training in chronic kidney disease-effects, expectations and adherence
- 2021
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Ingår i: Clinical Kidney Journal. - : Oxford University Press (OUP). - 2048-8505 .- 2048-8513. ; 14:Suppl 2, s. 3-14
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Forskningsöversikt (refereegranskat)abstract
- There is increasing evidence showing the health benefits of physical activity, such as better survival and possibly even a slower decline in kidney function, in people with chronic kidney disease (CKD). There is convincing evidence that exercise training improves physical function measured as aerobic capacity, muscle endurance strength and balance at all ages and all stages of CKD. In fact, long-term adherence to well-designed and adequately monitored exercise training programmes is high. In general, patients express interest in exercise training and are motivated to improve their physical function and health. A growing number of nephrologists regard physical activity and exercise training as beneficial to patients with CKD. However, many feel that they do not have the knowledge to prescribe exercise training and suppose that patients are not interested. Patients state that support from healthcare professionals is crucial to motivate them to participate in exercise training programmes and overcome medical, physical and psychological barriers such as frailty, fatigue, anxiety and fear. Equally important is the provision of funding by healthcare providers to ensure adequate prescription and follow-up by trained exercise physiologists for this important non-pharmacological treatment.
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| 12. |
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| 13. |
- Clyne, Naomi, et al.
(författare)
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Njurar
- 2021. - 4:1
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Ingår i: Kliniska Färdigheter : Mötet mellan patient och läkare - Mötet mellan patient och läkare. - 9789144135885 ; , s. 115-126
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Bokkapitel (populärvet., debatt m.m.)
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| 14. |
- Clyne, Naomi, et al.
(författare)
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Njurmedicin
- 2022. - 1
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Ingår i: Konsultationspsykiatri: : Kliniska riktlinjer för konsultation-liaisonpsykiatri - Kliniska riktlinjer för konsultation-liaisonpsykiatri. - 9789177413455 ; , s. 120-122
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Bokkapitel (refereegranskat)
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| 15. |
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| 16. |
- Clyne, Naomi, et al.
(författare)
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Relationship between declining GFR and measures of cardiac and vascular autonomic neuropathy.
- 2015
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Ingår i: Nephrology. - : Wiley. - 1320-5358. ; 21:12, s. 1047-1055
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Tidskriftsartikel (refereegranskat)abstract
- Cardiac and vascular autonomic neuropathy contributes to increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to analyze the effects of a decline in GFR on heart rate variability (HRV) and nocturnal blood pressure dipping.
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| 17. |
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| 18. |
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| 19. |
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| 20. |
- Drueke, Tilman B., et al.
(författare)
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Normalization of hemoglobin level in patients with chronic kidney disease and anemia
- 2006
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Ingår i: New England Journal of Medicine. - 0028-4793. ; 355:20, s. 2071-2084
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Tidskriftsartikel (refereegranskat)abstract
- Background: Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established. Methods: We randomly assigned 603 patients with an estimated glomerular filtration rate (GFR) of 15.0 to 35.0 ml per minute per 1.73 m(sup 2) of body-surface area and mild-to-moderate anemia (hemoglobin level, 11.0 to 12.5 g per deciliter) to a target hemoglobin value in the normal range (13.0 to 15.0 g per deciliter, group 1) or the subnormal range (10.5 to 11.5 g per deciliter, group 2). Subcutaneous erythropoietin (epoetin beta) was initiated at randomization (group 1) or only after the hemoglobin level fell below 10.5 g per deciliter (group 2). The primary end point was a composite of eight cardiovascular events; secondary end points included left ventricular mass index, quality-of-life scores, and the progression of chronic kidney disease. Results: During the 3-year study, complete correction of anemia did not affect the likelihood of a first cardiovascular event (58 events in group 1 vs. 47 events in group 2; hazard ratio, 0.78; 95% confidence interval, 0.53 to 1.14; P=0.20). Left ventricular mass index remained stable in both groups. The mean estimated GFR was 24.9 ml per minute in group 1 and 24.2 ml per minute in group 2 at baseline and decreased by 3.6 and 3.1 ml per minute per year, respectively (P=0.40). Dialysis was required in more patients in group 1 than in group 2 (127 vs. 111, P=0.03). General health and physical function improved significantly (P=0.003 and P<0.001, respectively, in group 1, as compared with group 2). There was no significant difference in the combined incidence of adverse events between the two groups, but hypertensive episodes and headaches were more prevalent in group 1. Conclusions: In patients with chronic kidney disease, early complete correction of anemia does not reduce the risk of cardiovascular events.
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| 21. |
- Eckardt, Kai-Uwe, et al.
(författare)
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Left Ventricular Geometry Predicts Cardiovascular Outcomes Associated with Anemia Correction in CKD
- 2009
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Ingår i: Journal of the American Society of Nephrology. - 1046-6673. ; 20:12, s. 2651-2660
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Tidskriftsartikel (refereegranskat)abstract
- Partial correction of anemia in patients with chronic kidney disease (CKD) reduces left ventricular hypertrophy (LVH), which is a risk factor for cardiovascular (CV) morbidity, but complete correction of anemia does not improve CV outcomes. Whether LV geometry associates with CV events in patients who are treated to different hemoglobin (Hb) targets is unknown. One of the larger trials to study the effects of complete correction of anemia in stages 3 to 4 CKD was the Cardiovascular Risk Reduction by Early Anemia Treatment with Epoetin Beta (CREATE) trial. Here, we analyzed echocardiographic data from CREATE to determine the prevalence, dynamics, and prognostic implications of abnormal LV geometry in patients who were treated to different Hb targets. The prevalence of LVH at baseline was 47%, with eccentric LVH more frequent than concentric. During the study, LVH prevalence and mean left ventricular mass index did not change significantly, but LV geometry fluctuated considerably within 2 yr in both groups. CV event-free survival was significantly worse in the presence of concentric LVH and eccentric LVH compared with the absence of LVH (P = 0.0009 and P <= 0.0001, respectively). Treatment to the higher Hb target associated with reduced event-free survival in the subgroup with eccentric LVH at baseline (P = 0.034). In conclusion, LVH is common and associates with poor outcomes among patients with stages 3 to 4 CKD, although both progression and regression of abnormal LV geometry occur. Complete anemia correction may aggravate the adverse prognosis of eccentric LVH.
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| 22. |
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| 23. |
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| 24. |
- Hagren, Birger, 1951-, et al.
(författare)
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Maintenance haemodialysis: patients’ experiences of their life situation
- 2005
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 14:3, s. 294-300
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine how patients suffering from CKD on maintenance haemodialysis experience their life situation. The focus was on how treatment encroaches on time and space and how patients experience care. The rationale was that this knowledge is necessary to provide professional support that takes into consideration a person's whole life situation.The experiences of patients with chronic kidney disease (CKD) undergoing maintenance haemodialysis have been studied in many quantitative studies, which translate patients’ subjective experiences into objectively quantifiable data. However, there are few qualitative studies examining the experiences of these patients’ life situation and expressing their experiences within the context of a nursing and caregiver's perspective.Data were collected by interviews with 41 patients between the ages of 29 and 86 years who participated in the study. A content analysis was used to identify common themes that describe the patients’ experiences of their life situation.Three main themes were identified,‘not finding space for living’,‘feelings evoked in the care situation’ and,‘attempting to manage restricted life’. The first theme‘not finding space for living’ consisted of two sub-themes:‘struggling with time-consuming care’ and‘feeling that life is restricted’. The second theme‘feelings evoked in the care situation’ consisted of two sub-themes:‘sense of emotional distance’ and‘feeling vulnerable’.The patients in this study indirectly expressed an existential struggle, indicating that encroachment of time and space were important existential dimensions of CKD. The findings indicated that caregivers were not always aware of this inducing a sense of emotional distance and a sense of vulnerability in the patients.Caregivers in dialysis units have to consider haemodialysis patients’ experience of a sense of emotional distance in their relationship to caregivers. Nurses and doctors need to create routines within nursing practice to overcome this.
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