| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Cossarizza, A., et al.
(författare)
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
- 2019
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 49:10, s. 1457-1973
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Tidskriftsartikel (refereegranskat)abstract
- These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
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| 5. |
- Kuschmierz, Paul, et al.
(författare)
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European first-year university students accept evolution but lack substantial knowledge about it : A standardized European cross-country assessment
- 2021
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Ingår i: Evolution. - : BioMed Central (BMC). - 1936-6426 .- 1936-6434. ; 14:1, s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- Background: Investigations of evolution knowledge and acceptance and their relation are central to evolution education research. Ambiguous results in this field of study demonstrate a variety of measuring issues, for instance differently theorized constructs, or a lack of standardized methods, especially for cross-country comparisons. In particular, meaningful comparisons across European countries, with their varying cultural backgrounds and education systems, are rare, often include only few countries, and lack standardization. To address these deficits, we conducted a standardized European survey, on 9200 first-year university students in 26 European countries utilizing a validated, comprehensive questionnaire, the “Evolution Education Questionnaire”, to assess evolution acceptance and knowledge, as well as influencing factors on evolution acceptance. Results: We found that, despite European countries’ different cultural backgrounds and education systems, European first-year university students generally accept evolution. At the same time, they lack substantial knowledge about it, even if they are enrolled in a biology-related study program. Additionally, we developed a multilevel-model that determines religious faith as the main influencing factor in accepting evolution. According to our model, knowledge about evolution and interest in biological topics also increase acceptance of evolution, but to a much lesser extent than religious faith. The effect of age and sex, as well as the country’s affiliation, students’ denomination, and whether or not a student is enrolled in a biology-related university program, is negligible. Conclusions: Our findings indicate that, despite all their differences, most of the European education systems for upper secondary education lead to acceptance of evolution at least in university students. It appears that, at least in this sample, the differences in knowledge between countries reflect neither the extent to which school curricula cover evolutionary biology nor the percentage of biology-related students in the country samples. Future studies should investigate the role of different European school curricula, identify particularly problematic or underrepresented evolutionary concepts in biology education, and analyze the role of religious faith when teaching evolution.
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| 6. |
- Cvetkovic, Vladimir, et al.
(författare)
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Parameter and model sensitivities for colloid-facilitated radionuclide transport on the field scale
- 2004
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Ingår i: Water resources research. - : American Geophysical Union (AGU). - 0043-1397 .- 1944-7973. ; 40:6
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the potential effects of inorganic colloids on radionuclide transport in groundwater using generic sensitivity studies and an example based on the alluvial aquifer near Yucca Mountain, Nevada. Our emphasis is on kinetically controlled sorption of radionuclides on mobile and immobile colloids. Three kinetic sorption models are considered for the sensitivity analysis: bilinear, Langmuir, and linear. Plutonium is assumed to be injected into the Yucca Mountain alluvial aquifer at a constant rate and follows a random stream tube to a monitoring boundary. The linear sorption model provides a reasonable upper bound on colloid-facilitated plutonium transport for the site-specific conditions. In the absence of colloid filtration and retardation, colloids enhance the plutonium discharge by a large factor over the situation without colloids. Exchange of plutonium between solution and reversibly attached colloids makes colloid retardation relatively ineffective at reducing colloid-facilitated transport except when the retardation factor is large. Irreversible removal of colloids (filtration) is more effective than retardation at reducing colloid-facilitated transport. For fixed filtration rate the degree of attenuation depends sensitively and nonmonotonically on the rate of plutonium desorption from colloids. These results emphasize the need for accurate measurements of rates of desorption from colloids as well as in situ studies of filtration of naturally occurring colloids.
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| 7. |
- Painter, S., et al.
(författare)
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Significance of kinetics for sorption on inorganic colloids : Modeling and experiment interpretation issues
- 2002
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 36:24, s. 5369-5375
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Tidskriftsartikel (refereegranskat)abstract
- A two-site kinetic model for solute sorption on inorganic colloids is developed. The model quantifies linear first-order sorption on two types of sites (fast and slow) characterized by two pairs of rates (forward and reverse). We use the model to explore data requirements for long-term predictive calculations of colloid-facilitated transport and to evaluate laboratory kinetic sorption data of Lu et al.. Five batch sorption data sets are considered with plutonium as the tracer and montmorillonite, hematite, silica, and smectite as colloids. Using asymptotic results applicable on the time stale of limited duration experiments, a robust estimation procedure is developed for the fast-site partitioning coefficient K-c and the slow forward rate alpha. The estimated range of K-c is 1.1-76 L/g, and the range for a is 0.0017-0.02 1/h. The fast reverse rate k(r) is estimated in the range 0.012-0.1 1/h. Comparison of one-site and two-site sorption interpretations reveals the difficulty in, discriminating between the two models for montmorillonite and to a lesser extent for hematite. For silica and smectite, the two-site model clearly provides a better representation of the data as compared with a single site model. Kinetic data for silica are available for different colloid concentrations (0.2 g/L and 1 g/L). For the range of experimental conditions considered, a. appears to be independent of colloid concentration.
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| 11. |
- Cvetkovic, M, et al.
(författare)
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International survey of neuromonitoring and neurodevelopmental outcome in children and adults supported on extracorporeal membrane oxygenation in Europe
- 2023
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Ingår i: Perfusion. - : SAGE Publications. - 1477-111X .- 0267-6591. ; 38:2, s. 245-260
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Tidskriftsartikel (refereegranskat)abstract
- Adverse neurological events during extracorporeal membrane oxygenation (ECMO) are common and may be associated with devastating consequences. Close monitoring, early identification and prompt intervention can mitigate early and late neurological morbidity. Neuromonitoring and neurocognitive/neurodevelopmental follow-up are critically important to optimize outcomes in both adults and children. Objective: To assess current practice of neuromonitoring during ECMO and neurocognitive/neurodevelopmental follow-up after ECMO across Europe and to inform the development of neuromonitoring and follow-up guidelines. Methods: The EuroELSO Neurological Monitoring and Outcome Working Group conducted an electronic, web-based, multi-institutional, multinational survey in Europe. Results: Of the 211 European ECMO centres (including non-ELSO centres) identified and approached in 23 countries, 133 (63%) responded. Of these, 43% reported routine neuromonitoring during ECMO for all patients, 35% indicated selective use, and 22% practiced bedside clinical examination alone. The reported neuromonitoring modalities were NIRS ( n = 88, 66.2%), electroencephalography ( n = 52, 39.1%), transcranial Doppler ( n = 38, 28.5%) and brain injury biomarkers ( n = 33, 24.8%). Paediatric centres (67%) reported using cranial ultrasound, though the frequency of monitoring varied widely. Before hospital discharge following ECMO, 50 (37.6%) reported routine neurological assessment and 22 (16.5%) routinely performed neuroimaging with more paediatric centres offering neurological assessment (65%) as compared to adult centres (20%). Only 15 (11.2%) had a structured longitudinal follow-up pathway (defined followup at regular intervals), while 99 (74.4%) had no follow-up programme. The majority ( n = 96, 72.2%) agreed that there should be a longitudinal structured follow-up for ECMO survivors. Conclusions: This survey demonstrated significant variability in the use of different neuromonitoring modalities during and after ECMO. The perceived importance of neuromonitoring and follow-up was noted to be very high with agreement for a longitudinal structured follow-up programme, particularly in paediatric patients. Scientific society endorsed guidelines and minimum standards should be developed to inform local protocols.
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| 12. |
- Cvetkovic, Vladimir D.
(författare)
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On the significance of hydrodynamic control for radionuclide retention in fractured porous media
- 2004
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Ingår i: Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-Systems — Fundamentals, Modelling, Experiments and Applications. - : Elsevier. ; , s. 507-511
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Bokkapitel (refereegranskat)abstract
- It is demonstrated that the approximate means of quantifying hydrodynamic control of retention is reasonably accurate for low values of the transport resistance on the 100m and 1000m scales; for high values, the approximate expression may significantly underestimate retention. Our results emphasize the need for further development of practical methodologies for quantifying statistical distributions of transport resistance by effectively combining field measurements, numerical simulations and theoretical/analytical considerations.
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| 13. |
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| 14. |
- Mörtberg, Ulla, et al.
(författare)
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Integrating ecosystem services in urban energy trajectories
- 2015
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Ingår i: Biwaes 2015 9Th Biennial International Workshop Advances In Energy Studies. - : Verlag der Technischen Universität Graz. - 9783851253931 - 9783851253955 ; , s. 89-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Changes in urban development trajectories towards renewable energy sources and compact, energy- efficient urban agglomerations will have major impacts on ecosystem services, which cities are dependent on but tend to overlook. Such ecosystem services can be provisioning, regulating and cultural ecosystem services, around which competition over land and water resources will increase with energy system shifts. Much of the land and water use conflicts can be foreseen to take place within urbanising regions, which simultaneously is the living environment of a major part of the human population today. In order to inform critical policy decisions, integrated assessment of urban energy system options and ecosystem services is necessary. For this purpose, the model integration platform Land Evolution and impact Assessment Model (LEAM) is built and empowered with models representing urban form, energy supply and use, transportation, and ecological processes and services, all related to the land and water use evolution. These types of analyses of interacting sub- systems require an advanced model integration platform, yet open for learning and for further development, with high visualisation capacity. Case studies are performed for the cities of Stockholm, Chicago and Shanghai, where urbanisation scenarios are under development. In the case study LEAMStockholm, scenarios for urban compaction and urban sprawl with different energy and water system solutions are being developed, in order to explore the sustainability of urban policy options. This will enable integrated policy assessment of complex urban systems, with the goal to increase their sustainability.
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| 15. |
- Painter, S., et al.
(författare)
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Effect of heterogeneity on radionuclide retardation in the alluvial aquifer near Yucca Mountain, Nevada
- 2001
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Ingår i: Ground Water. - : Wiley. - 0017-467X .- 1745-6584. ; 39:3, s. 326-338
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Tidskriftsartikel (refereegranskat)abstract
- The U.S. Department of Energy is currently studying Yucca Mountain, Nevada, as a potential site for a geological high-level waste repository. In the current conceptual models of radionuclide transport at Yucca Mountain, part of the transport path to pumping locations would be through an alluvial aquifer, Interactions with minerals in the alluvium are expected to retard the downstream migration of radionuclides, thereby delaying arrival times and reducing ground water concentrations. We evaluate the effectiveness of the alluvial aquifer as a transport barrier using the stochastic Lagrangian framework. A transport model is developed to account for physical and chemical heterogeneities and rate-limited mass transfer between mobile and immobile zones. The latter process is caused by small-scale heterogeneity and is thought to control the macroscopic-scale retardation in some field experiments. A geostatistical model for the spatially varying sorption parameters is developed from a site-specific database created from hydrochemical measurements and a calibrated modeling approach (Turner and Pabalan 1999). Transport of neptunium is considered as an example. The results are sensitive to the rate of transfer between mobile and immobile zones, and to spatial variability in the hydraulic conductivity. Chemical heterogeneity has only a small effect, as does correlation between hydraulic conductivity and the neptunium distribution coefficient. These results illustrate how general sensitivities can be explored with modest effort within the Lagrangian framework. Such studies complement and guide the application of more detailed numerical simulations.
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| 16. |
- Stevanovic, D., et al.
(författare)
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ESSENCE-Q: Slavic language versions for developmental screening in young children
- 2018
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Ingår i: Neuropsychiatric Disease and Treatment. - : Informa UK Limited. - 1178-2021. ; 14, s. 2141-2148
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations- Questionnaire (ESSENCE-Q) was developed as a brief screener to identify children with developmental concerns who might have neurodevelopmental disorders (NDDs). This study aimed to translate the ESSENCE -Q into south Slavic languages, namely, Bosnian, Bulgarian, Croatian, Macedonian, Montenegrin, Serbian, and Slovenian, and to evaluate its psychometric properties for screening purposes in clinical settings. Patients and methods: In the study, the ESSENCE-Q was completed for 251 "typically developing" children and 200 children with 1 or more diagnosed NDDs, all aged 1-6 years. Internal consistency and construct validity were tested first, followed by generating receiver operating characteristic curves and the area under the curve. Optimal cutoff values were then explored. Results: The Cronbach's alpha coefficients were 0.91, 0.88, and 0.86 for ESSENCE-Q parent-completed form, and the telephone and direct interview forms administered by trained nurse or specialist, respectively. The 3 versions produced area under the curve values (95% confidence interval): 0.96 (0.93-0.99), 0.91 (0.86-0.95), and 0.91 (0.86.-0.97), respectively. An optimal cutoff for ESSENCE-Q parent-completed form was found to be >= 3 points, while for the telephone and direct interviews, it was >= 5 points. Conclusion: We found adequate measurement properties of the south Slavic languages versions of the ESSENCE-Q as a screener for NDDs in clinical settings. This study provided additional data supporting sound psychometric properties of the ESSENCE-Q.
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| 17. |
- Wei, Jieqiang, et al.
(författare)
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Steady-state analysis of a human-social behavior model : A neural-cognition perspective
- 2019
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Ingår i: Proceedings of the American Control Conference. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538679265 ; , s. 199-204
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Konferensbidrag (refereegranskat)abstract
- We consider an extension of the Rescorla-Wagner model which bridges the gap between conditioning and learning on a neural-cognitive, individual psychological level, and the social population level. In this model, the interaction among individuals is captured by a Markov process. The resulting human-social behavior model is a recurrent iterated function system which behaves differently from the classical Rescorla-Wagner model due to randomness. A sufficient condition for the convergence of the forward process starting with arbitrary initial distribution is provided. Furthermore, the ergodicity properties of the internal states of agents in the proposed model are studied.
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