| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Cossarizza, A., et al.
(författare)
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
- 2019
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 49:10, s. 1457-1973
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Tidskriftsartikel (refereegranskat)abstract
- These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
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| 5. |
- Kuschmierz, Paul, et al.
(författare)
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European first-year university students accept evolution but lack substantial knowledge about it : A standardized European cross-country assessment
- 2021
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Ingår i: Evolution. - : BioMed Central (BMC). - 1936-6426 .- 1936-6434. ; 14:1, s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- Background: Investigations of evolution knowledge and acceptance and their relation are central to evolution education research. Ambiguous results in this field of study demonstrate a variety of measuring issues, for instance differently theorized constructs, or a lack of standardized methods, especially for cross-country comparisons. In particular, meaningful comparisons across European countries, with their varying cultural backgrounds and education systems, are rare, often include only few countries, and lack standardization. To address these deficits, we conducted a standardized European survey, on 9200 first-year university students in 26 European countries utilizing a validated, comprehensive questionnaire, the “Evolution Education Questionnaire”, to assess evolution acceptance and knowledge, as well as influencing factors on evolution acceptance. Results: We found that, despite European countries’ different cultural backgrounds and education systems, European first-year university students generally accept evolution. At the same time, they lack substantial knowledge about it, even if they are enrolled in a biology-related study program. Additionally, we developed a multilevel-model that determines religious faith as the main influencing factor in accepting evolution. According to our model, knowledge about evolution and interest in biological topics also increase acceptance of evolution, but to a much lesser extent than religious faith. The effect of age and sex, as well as the country’s affiliation, students’ denomination, and whether or not a student is enrolled in a biology-related university program, is negligible. Conclusions: Our findings indicate that, despite all their differences, most of the European education systems for upper secondary education lead to acceptance of evolution at least in university students. It appears that, at least in this sample, the differences in knowledge between countries reflect neither the extent to which school curricula cover evolutionary biology nor the percentage of biology-related students in the country samples. Future studies should investigate the role of different European school curricula, identify particularly problematic or underrepresented evolutionary concepts in biology education, and analyze the role of religious faith when teaching evolution.
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| 6. |
- Cvetkovic, M, et al.
(författare)
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International survey of neuromonitoring and neurodevelopmental outcome in children and adults supported on extracorporeal membrane oxygenation in Europe
- 2023
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Ingår i: Perfusion. - : SAGE Publications. - 1477-111X .- 0267-6591. ; 38:2, s. 245-260
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Tidskriftsartikel (refereegranskat)abstract
- Adverse neurological events during extracorporeal membrane oxygenation (ECMO) are common and may be associated with devastating consequences. Close monitoring, early identification and prompt intervention can mitigate early and late neurological morbidity. Neuromonitoring and neurocognitive/neurodevelopmental follow-up are critically important to optimize outcomes in both adults and children. Objective: To assess current practice of neuromonitoring during ECMO and neurocognitive/neurodevelopmental follow-up after ECMO across Europe and to inform the development of neuromonitoring and follow-up guidelines. Methods: The EuroELSO Neurological Monitoring and Outcome Working Group conducted an electronic, web-based, multi-institutional, multinational survey in Europe. Results: Of the 211 European ECMO centres (including non-ELSO centres) identified and approached in 23 countries, 133 (63%) responded. Of these, 43% reported routine neuromonitoring during ECMO for all patients, 35% indicated selective use, and 22% practiced bedside clinical examination alone. The reported neuromonitoring modalities were NIRS ( n = 88, 66.2%), electroencephalography ( n = 52, 39.1%), transcranial Doppler ( n = 38, 28.5%) and brain injury biomarkers ( n = 33, 24.8%). Paediatric centres (67%) reported using cranial ultrasound, though the frequency of monitoring varied widely. Before hospital discharge following ECMO, 50 (37.6%) reported routine neurological assessment and 22 (16.5%) routinely performed neuroimaging with more paediatric centres offering neurological assessment (65%) as compared to adult centres (20%). Only 15 (11.2%) had a structured longitudinal follow-up pathway (defined followup at regular intervals), while 99 (74.4%) had no follow-up programme. The majority ( n = 96, 72.2%) agreed that there should be a longitudinal structured follow-up for ECMO survivors. Conclusions: This survey demonstrated significant variability in the use of different neuromonitoring modalities during and after ECMO. The perceived importance of neuromonitoring and follow-up was noted to be very high with agreement for a longitudinal structured follow-up programme, particularly in paediatric patients. Scientific society endorsed guidelines and minimum standards should be developed to inform local protocols.
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| 7. |
- Carruba, V., et al.
(författare)
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On the identification of the first two young asteroid families in g-type non-linear secular resonances
- 2024
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Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 528:1, s. 796-814
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Tidskriftsartikel (refereegranskat)abstract
- Linear secular resonances happen when there is a commensurability between the precession frequency of the pericenter, g, or longitude of the node, s, of an asteroid and a planet. Non-linear resonances are higher order combinations of these frequencies. Here, we studied the three most diffusive g-type non-linear secular resonances using Artificial Neural Networks. We identified a population of more than 2100 resonant objects in the g − 2g6 + g5 and g − 3g6 + 2g5 resonances. This allows the creation of a Convolutional Neural Network model for the g − 2g6 + g5 resonance, able to predict the status of several thousands of asteroids in seconds. We identified 12 new possible dynamical groups among the resonant population, including the 5507 and 170776 families, which have both estimated ages of less than 7 Myr. These are the two first-ever identified young families in resonant configurations of the investigated resonances, which allows for setting limits on their original ejection velocity field.
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| 9. |
- Destouni, Georgia, 1961-, et al.
(författare)
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Needs and means to advance science, policy and management understanding of the freshwater system : A synthesis report
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fragmented and inconsistent understanding of the freshwater system limits our ability to achieve water security and sustainability under the human-driven changes occurring in the Anthropocene. To advance system-level understanding of freshwater, gaps and inconsistencies in knowledge, data, representations and links of processes and subsystems need to be identified and bridged under consideration of the freshwater system as a continuous whole. Based on such identification, a freshwater system conceptualization is developed in this report, which emphasizes four essential, yet often neglected system aspects:i) Distinction of coastal divergent catchments.ii) Four main zones (surface, subsurface, coastal, observation) of different types of freshwater change.iii) Water pathways as system-coupling agents that link and partition water change among the four change zones.iv) Direct interactions with the anthroposphere as integral system pathways across the change zones.We explain and exemplify some key implications of these aspects, identifying in the process also distinct patterns of human-driven changes in large-scale water fluxes and nutrient loads.The present conceptualization provides a basis for common inter- and trans-disciplinary understanding and systematic characterization of the freshwater system function and its changes, and of approaches to their modeling and monitoring. This can be viewed and used as a unifying checklist that can advance science, policy and management of freshwater and related environmental changes across various scales and world regions.
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| 10. |
- Keimer, Alexander, et al.
(författare)
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Information Patterns in the Modeling and Design of Mobility Management Services
- 2018
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Ingår i: Proceedings of the IEEE. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9219 .- 1558-2256. ; 106:4, s. 554-576
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Tidskriftsartikel (refereegranskat)abstract
- The development of sustainable transportation infrastructure for people and goods, using new technology and business models, can prove beneficial or detrimental for mobility, depending on its design and use. The focus of this paper is on the increasing impact new mobility services have on traffic patterns and transportation efficiency in general. Over the last decade, the rise of the mobile internet and the usage of mobile devices have enabled ubiquitous traffic information. With the increased adoption of specific smartphone applications, the number of users of routing applications has become large enough to disrupt traffic flow patterns in a significant manner. Similarly, but at a slightly slower pace, novel services for freight transportation and city logistics improve the efficiency of goods transportation and change the use of road infrastructure. This paper provides a general four-layer framework for modeling these new trends. The main motivation behind the development is to provide a unifying formal system description that can at the same time encompass system physics (flow and motion of vehicles) as well as coordination strategies under various information and cooperation structures. To showcase the framework, we apply it to the specific challenge of modeling and analyzing the integration of routing applications in today's transportation systems. In this framework, at the lowest layer (flow dynamics), we distinguish routed users from nonrouted users. A distributed parameter model based on a nonlocal partial differential equation is introduced and analyzed. The second layer incorporates connected services (e.g., routing) and other applications used to optimize the local performance of the system. As inputs to those applications, we propose a third layer introducing the incentive design and global objectives, which are typically varying over the day depending on road and weather conditions, external events, etc. The high-level planning is handled on the fourth layer taking social long-term objectives into account. We illustrate the framework by considering its ability to model at two different levels. Specific to vehicular traffic, numerical examples enable us to demonstrate the links between the traffic network layer and the routing decision layer. With a second example on optimized freight transport, we then discuss the links between the cooperative control layer and the lower layers. The congestion pricing in Stockholm is used to illustrate how also the social planning layer can be incorporated in future mobility services.
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| 11. |
- Pan, Kaikai, et al.
(författare)
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Combined data integrity and availability attacks on state estimation in cyber-physical power grids
- 2016
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Ingår i: 2016 IEEE Int. Conf. Smart Grid Commun.. - : IEEE. ; , s. 271-277
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Konferensbidrag (refereegranskat)abstract
- © 2016 IEEE. This paper introduces combined data integrity and availability attacks to expand the attack scenarios against power system state estimation. The goal of the adversary, who uses the combined attack, is to perturb the state estimates while remaining hidden from the observer. We propose security metrics that quantify vulnerability of power grids to combined data attacks under single and multi-path routing communication models. In order to evaluate the proposed security metrics, we formulate them as mixed integer linear programming (MILP) problems. The relation between the security metrics of combined data attacks and pure data integrity attacks is analyzed, based on which we show that, when data availability and data integrity attacks have the same cost, the two metrics coincide. When data availability attacks have a lower cost than data integrity attacks, we show that a combined data attack could be executed with less attack resources compared to pure data integrity attacks. Furthermore, it is shown that combined data attacks would bypass integrity-focused mitigation schemes. These conclusions are supported by the results obtained on a power system model with and without a communication model with single or multi-path routing.
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| 14. |
- Stevanovic, D., et al.
(författare)
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ESSENCE-Q: Slavic language versions for developmental screening in young children
- 2018
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Ingår i: Neuropsychiatric Disease and Treatment. - : Informa UK Limited. - 1178-2021. ; 14, s. 2141-2148
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations- Questionnaire (ESSENCE-Q) was developed as a brief screener to identify children with developmental concerns who might have neurodevelopmental disorders (NDDs). This study aimed to translate the ESSENCE -Q into south Slavic languages, namely, Bosnian, Bulgarian, Croatian, Macedonian, Montenegrin, Serbian, and Slovenian, and to evaluate its psychometric properties for screening purposes in clinical settings. Patients and methods: In the study, the ESSENCE-Q was completed for 251 "typically developing" children and 200 children with 1 or more diagnosed NDDs, all aged 1-6 years. Internal consistency and construct validity were tested first, followed by generating receiver operating characteristic curves and the area under the curve. Optimal cutoff values were then explored. Results: The Cronbach's alpha coefficients were 0.91, 0.88, and 0.86 for ESSENCE-Q parent-completed form, and the telephone and direct interview forms administered by trained nurse or specialist, respectively. The 3 versions produced area under the curve values (95% confidence interval): 0.96 (0.93-0.99), 0.91 (0.86-0.95), and 0.91 (0.86.-0.97), respectively. An optimal cutoff for ESSENCE-Q parent-completed form was found to be >= 3 points, while for the telephone and direct interviews, it was >= 5 points. Conclusion: We found adequate measurement properties of the south Slavic languages versions of the ESSENCE-Q as a screener for NDDs in clinical settings. This study provided additional data supporting sound psychometric properties of the ESSENCE-Q.
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| 15. |
- Widestrand, H., et al.
(författare)
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Sorbing tracer experiments in a crystalline rock fracture at Aspo (Sweden) : 1. Experimental setup and microscale characterization of retention properties
- 2007
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Ingår i: Water resources research. - : American Geophysical Union (AGU). - 0043-1397 .- 1944-7973. ; 43:10
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Tidskriftsartikel (refereegranskat)abstract
- [ 1] Mineralogical and retardation properties of rock materials responsible for water-rock interaction in in situ migration experiments with sorbing radioactive tracers were studied in laboratory experiments. The porosity was studied by water saturation measurements and the PMMA method was used for detailed porosity characterization of heterogeneity distributions and porosity profiles toward the fracture surface. Mylonite and altered diorite sampled in the rim zone of the fracture and representative bulk rock types were investigated by batch sorption measurements with crushed materials and through-diffusion and in-diffusion experiments in intact rock pieces. Autoradiography was used for visualization of in-diffusion profiles of sorbing tracers. The use of detailed porosity information and quantitative data on heterogeneity in porosity is shown to significantly improve the interpretation and evaluation of laboratory-scale diffusion experiments. We show through the combined approach of detailed porosity characterization and laboratory sorption and diffusion investigations that we can distinguish retention properties of bulk rock and altered rock and provide qualitative and quantitative data of heterogeneous rock properties that expand the possibility for including relevant processes in the interpretation of the results of in situ tracer tests.
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