SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Darrow D.) "

Sökning: WFRF:(Darrow D.)

  • Resultat 1-23 av 23
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Joffrin, E., et al. (författare)
  • Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
  • 2019
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
  • Forskningsöversikt (refereegranskat)abstract
    • For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
  •  
2.
  • Bombarda, F., et al. (författare)
  • Runaway electron beam control
  • 2019
  • Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
  • Tidskriftsartikel (refereegranskat)
  •  
3.
  • Krasilnikov, A., et al. (författare)
  • Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
  • 2018
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
  •  
4.
  • 2018
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
  • Forskningsöversikt (refereegranskat)
  •  
5.
  • 2018
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
  • Tidskriftsartikel (refereegranskat)
  •  
6.
  • Romanelli, F, et al. (författare)
  • Overview of the JET results
  • 2011
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
  •  
7.
  • Abel, I, et al. (författare)
  • Overview of the JET results with the ITER-like wall
  • 2013
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
  • Tidskriftsartikel (refereegranskat)abstract
    • Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
  •  
8.
  • Kirk, A., et al. (författare)
  • Overview of recent physics results from MAST
  • 2017
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 57:10
  • Tidskriftsartikel (refereegranskat)abstract
    • New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp-up, models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge, detailed studies have revealed how filament characteristics are responsible for determining the near and far scrape off layer density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during edge localized modes (ELMs) and the number of filaments released determines the power profile at the divertor. Resonant magnetic perturbations can mitigate ELMs provided the edge peeling response is maximised and the core kink response minimised. The mitigation of intrinsic error fields with toroidal mode number n > 1 has been shown to be important for plasma performance.
  •  
9.
  • Chapman, I. T., et al. (författare)
  • Overview of MAST results
  • 2015
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
  • Tidskriftsartikel (refereegranskat)abstract
    • The Mega Ampere Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number n(RMP) = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating n(RMP) = 3 RMPs. n(RMP) = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with n(RMP) = 4 than n(RMP) = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with 'classical' fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved in solenoid-free start-up. A new proton detector has characterized escaping fusion products. Langmuir probes and a high-speed camera suggest filaments play a role in particle transport in the private flux region whilst coherence imaging has measured scrape-off layer (SOL) flows. BOUT++ simulations show that fluxes due to filaments are strongly dependent on resistivity and magnetic geometry of the SOL, with higher radial fluxes at higher resistivity. Finally, MAST Upgrade is due to begin operation in 2016 to support ITER preparation and importantly to operate with a Super-X divertor to test extended leg concepts for particle and power exhaust.
  •  
10.
  • Kiptily, V. G., et al. (författare)
  • Fast ion JET diagnostics : Confinement and losses
  • 2008
  • Ingår i: BURNING PLASMA DIAGNOSTICS. - : AIP. ; , s. 283-290
  • Konferensbidrag (refereegranskat)abstract
    • A study of magnetically confined fast ions in tokamaks plays an important role in burning plasma research. To reach ignition and steady burning of a reactor plasma an adequate confinement of energetic ions produced by NBI heating, accelerated with ICRF and born in fusion reactions is essential to provide efficient heating of the bulk plasma. Thus, investigation of the fast ion behaviour is an immediate task for present-day large machines, such as JET, in order to understand the main mechanisms of slowing down, redistribution and losses, and to develop optimal plasma scenarios. Today's JET has an enhanced suite of fast ion diagnostics both of confined and lost ions that enable to significantly contribute to this important area of research. Fast ion populations of p, d, t, 3He and 4He, made with ICRF, NBI, and fusion reactions have been investigated in experiments on JET with sophisticated diagnostics in conventional and shear-reversed plasmas, exploring a wide range of effects. This paper will introduce to the JET fast-ion diagnostic techniques and will give an overview of recent observations. A synergy of the unique diagnostic set was utilised in JET, and studies of the response of fast ions to MHD modes (e.g. tornado modes, sawtooth crashes), fast 3He-ions behaviour in shear-reversed plasmas are impressive examples of that. Some results on fast ion losses in JET experiments with various levels of the toroidal field ripple will be demonstrated.
  •  
11.
  • Kiptily, V. G., et al. (författare)
  • Recent progress in fast ion studies on JET
  • 2009
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 49:6
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents recent results on fast ion studies on JET. A set of diagnostics for both confined and lost fast ions was employed for investigating the response of fast ions to MHD modes and for studying their behaviour in plasmas with toroidal field ripple and in shear-reversed plasmas. A dependence of the losses on MHD mode amplitude was deduced from the experimental data. A study of various plasma scenarios has shown that a significant redistribution of the fast ions happens during changes in the profile of the safety factor from shear-reversed to monotonic. Significant changes in the losses of ICRH accelerated protons were found to be associated with L-H confinement transitions in plasmas. After an L-H transition, an abrupt decrease in the ICRH proton losses was observed. In plasmas with an internal transport barrier, the loss of ICRH accelerated ions was found to increase as the barrier forms. Further results concerning fast ion losses were obtained during JET experiments in which the magnitude of the TF ripple was varied. The ripple losses of fusion products appear similar to classical losses, and are in agreement with modelling.
  •  
12.
  •  
13.
  • Kiptily, V. G., et al. (författare)
  • Fusion Alpha-Particle Diagnostics for DT Experiments on the Joint European Torus
  • 2014
  • Ingår i: FUSION REACTOR DIAGNOSTICS. - : AIP Publishing LLC. ; , s. 87-92
  • Konferensbidrag (refereegranskat)abstract
    • JET equipped with ITER-like wall (a beryllium wall and a tungsten divertor) can provide auxiliary heating with power up to 35MW, producing a significant population of alpha-particles in DT operation. The direct measurements of alphas are very difficult and alpha-particle studies require a significant development of dedicated diagnostics. JET now has an excellent set of confined and lost fast particle diagnostics for measuring the alpha-particle source and its evolution in space and time, alpha-particle energy distribution, and alpha-particle losses. This paper describes how the above mentioned JET diagnostic systems could be used for alpha-particle measurements, and what options exist for keeping the essential alpha-particle diagnostics functioning well in the presence of intense DT neutron flux. Also, alpha-particle diagnostics for ITER are discussed.
  •  
14.
  • Cecconello, Marco, et al. (författare)
  • Energetic ion behaviour in MAST
  • 2015
  • Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 57:1, s. 014006-
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent studies of fast ion transport resulting from a range of instabilities, including n = 1 internal kink modes (fishbones and long-lived modes), toroidal Alfven eigenmodes and sawteeth have been carried out at MAST. Strong correlations were found between relative changes in magnetic edge coils signals, edge D alpha signal a fast ion D alpha system, a prototype collimated neutron flux monitor and a recently installed prototype charged fusion product detector array, indicating both redistribution and loss of fast ions. Preliminary interpretation of these observations with a suite of stability, modelling and interpretative codes is discussed.
  •  
15.
  • Fasoli, A., et al. (författare)
  • Chapter 5 : Physics of energetic ions
  • 2007
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 47:6, s. S264-S284
  • Forskningsöversikt (refereegranskat)abstract
    • This chapter reviews the progress accomplished since the redaction of the first ITER Physics Basis (1999 Nucl. Fusion 39 2137-664) in the field of energetic ion physics and its possible impact on burning plasma regimes. New schemes to create energetic ions simulating the fusion-produced alphas are introduced, accessing experimental conditions of direct relevance for burning plasmas, in terms of the Alfvenic Mach number and of the normalised pressure gradient of the energetic ions, though orbit characteristics and size cannot always match those of ITER. Based on the experimental and theoretical knowledge of the effects of the toroidal magnetic field ripple on direct fast ion losses, ferritic inserts in ITER are expected to provide a significant reduction of ripple alpha losses in reversed shear configurations. The nonlinear fast ion interaction with kink and tearing modes is qualitatively understood, but quantitative predictions are missing, particularly for the stabilisation of sawteeth by fast particles that can trigger neoclassical tearing modes. A large database on the linear stability properties of the modes interacting with energetic ions, such as the Alfven eigenmode has been constructed. Comparisons between theoretical predictions and experimental measurements of mode structures and drive/damping rates approach a satisfactory degree of consistency, though systematic measurements and theory comparisons of damping and drive of intermediate and high mode numbers, the most relevant for ITER, still need to be performed. The nonlinear behaviour of Alfven eigenmodes close to marginal stability is well characterized theoretically and experimentally, which gives the opportunity to extract some information on the particle phase space distribution from the measured instability spectral features. Much less data exists for strongly unstable scenarios, characterised by nonlinear dynamical processes leading to energetic ion redistribution and losses, and identified in nonlinear numerical simulations of Alfven eigenmodes and energetic particle modes. Comparisons with theoretical and numerical analyses are needed to assess the potential implications of these regimes on burning plasma scenarios, including in the presence of a large number of modes simultaneously driven unstable by the fast ions.
  •  
16.
  •  
17.
  • Kiptily, V. G., et al. (författare)
  • Fast ions in mode conversion heating (He-3)-H plasmas in JET
  • 2012
  • Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 54:7, s. 074010-
  • Tidskriftsartikel (refereegranskat)abstract
    • Fast ions were analysed in experiments focusing on fundamental He-3 minority and mode conversion (MC) in the ion cyclotron resonance range of frequencies (ICRF) in H plasmas and on second harmonic heating of He-3 ions at 2.65 T mimicking D-T plasma heating in ITER at half its nominal toroidal magnetic field. Gamma-ray spectrometry, neutral particle analysers and fast-ion loss diagnostics provided information on the generation of fast-ion populations and on the distribution of ICRH power among the species in various heating scenarios and for a large range of He-3 concentrations. In the scenario with the fundamental He-3 minority and MC wave heating at B-T(0) = 3.41 T and f approximate to 32 MHz, fast He-3 ions accelerated by ICRH in the MeV energy range were detected in discharges with low He-3 concentration. In the experiments with a He-3 concentration scan it was found that at a He-3 concentration of approximate to 2.2% the He-3 ion losses disappeared while a population of energetic D ions gradually built up due to a redistribution of the ICRH power between species on reaching the first MC regime. Under those conditions the ICRF-heated D beam ions effectively absorbed the wave power at their Doppler shifted resonance, which was close to the plasma centre. In discharges with second harmonic heating of He-3 ions at B-T(0) = 2.65 T and f approximate to 52 MHz, the confined energetic He-3 ions were found in the MeV energy range. There is some evidence that the D ions were also accelerated by ICRF. This paper also demonstrates that the synergy of the various fast ion diagnostics allows making a broad picture of the physics of the redistribution of the absorbed ICRH power in complicated heating scenarios of JET.
  •  
18.
  • Perez, R. V., et al. (författare)
  • Investigating fusion plasma instabilities in the Mega Amp Spherical Tokamak using mega electron volt proton emissions
  • 2014
  • Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 85:11, s. 11D701-
  • Tidskriftsartikel (refereegranskat)abstract
    • The proton detector (PD) measures 3 MeV proton yield distributions from deuterium-deuterium fusion reactions within the Mega Amp Spherical Tokamak (MAST). The PD's compact four-channel system of collimated and individually oriented silicon detectors probes different regions of the plasma, detecting protons (with gyro radii large enough to be unconfined) leaving the plasma on curved trajectories during neutral beam injection. From first PD data obtained during plasma operation in 2013, proton production rates (up to several hundred kHz and 1 ms time resolution) during sawtooth events were compared to the corresponding MAST neutron camera data. Fitted proton emission profiles in the poloidal plane demonstrate the capabilities of this new system.
  •  
19.
  • von Thun, C. Perez, et al. (författare)
  • MeV-range fast ion losses induced by fishbones on JET
  • 2010
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 50:8, s. 084009-
  • Tidskriftsartikel (refereegranskat)abstract
    • Energy and pitch angle resolved measurements of highly energetic (megaelectronvolt (MeV) range) suprathermal ions ejected from the plasma through interaction with fishbone oscillations are presented. The measurements are obtained with a 2D scintillator probe diagnostic installed on JET, which is designed to detect lost ions only above a certain energy threshold (E-min,E- D similar to 200 keV). In the case reported here the lost ions are identified as fast protons which had been accelerated to high energies by ICRF minority heating. The energy of the lost protons (similar to 0.5-4 MeV) is approximately one order of magnitude higher than the energy of the injected beam ions (maximum 130 keV) driving the fishbone. Losses arriving at the probe are enhanced by about a factor 10-20 with respect to MHD-quiescent levels, and are found to increase quadratically with the fishbone amplitude. Using a number of simplifying assumptions, numerical simulations have been performed which combine the HAGIS, MISHKA and SELFO codes (where the distribution function predicted by SELFO has been validated against neutral particle analyser measurements). The losses are found to originate from orbit stochastic diffusion of trapped protons near the plasma boundary or from counter-passing protons deep in the plasma core, which transit under the influence of the fishbone into an unconfined trapped orbit. The simulations show further that the losses are of non-resonant type. The simulated energy and pitch angle distribution of the losses, the temporal behaviour of the losses during a fishbone cycle and the scaling of the losses with the fishbone amplitude are compared with experiment. The simulation results are mostly in broad agreement with experiment, but some of the predictions could not be reconciled with experiment using this model.
  •  
20.
  • von Thun, C. Perez, et al. (författare)
  • Numerical simulation of fast ion loss detector measurements for fishbones on JET
  • 2011
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 51:5, s. 053003-
  • Tidskriftsartikel (refereegranskat)abstract
    • A synthetic diagnostic model for the simulation of energy and pitch angle resolved measurements of fast ion losses obtained by 2D scintillation-type detectors is presented and subsequently tested on a JET discharge with fishbones (previously documented in Perez von Thun et al 2010 Nucl. Fusion 50 084009). The simulated energy and pitch angle distributions at the detector are found to be in excellent agreement with the measurements. The simulations further suggest that nearly all the fast ion losses take place in the early growth phase of the fishbone cycle, and reach their maximum well ahead of the magnetic perturbation peak.
  •  
21.
  • Glicksberg, Benjamin S., et al. (författare)
  • Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits
  • 2019
  • Ingår i: BMC Medical Genomics. - : BMC. - 1755-8794. ; 12
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundGenetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and clinical data from 10,511 individuals in the Mount Sinai BioMe Biobank to identify genes with loss-of-function variants (LoFs) significantly associated with cardiovascular disease (CVD) traits, and used RNA-sequence data of seven metabolic and vascular tissues isolated from 600 CVD patients in the Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) study for validation. We also carried out in vitro functional studies of several candidate genes, and in vivo studies of one gene.ResultsWe identified LoFs in 433 genes significantly associated with at least one of 10 major CVD traits. Next, we used RNA-sequence data from the STARNET study to validate 115 of the 433 LoF harboring-genes in that their expression levels were concordantly associated with corresponding CVD traits. Together with the documented hepatic lipid-lowering gene, APOC3, the expression levels of six additional liver LoF-genes were positively associated with levels of plasma lipids in STARNET. Candidate LoF-genes were subjected to gene silencing in HepG2 cells with marked overall effects on cellular LDLR, levels of triglycerides and on secreted APOB100 and PCSK9. In addition, we identified novel LoFs in DGAT2 associated with lower plasma cholesterol and glucose levels in BioMe that were also confirmed in STARNET, and showed a selective DGAT2-inhibitor in C57BL/6 mice not only significantly lowered fasting glucose levels but also affected body weight.ConclusionIn sum, by integrating genetic and electronic medical record data, and leveraging one of the world's largest human RNA-sequence datasets (STARNET), we identified known and novel CVD-trait related genes that may serve as targets for CVD therapeutics and as such merit further investigation.
  •  
22.
  • Murari, A., et al. (författare)
  • JET new diagnostic capability on the route to ITER
  • 2007
  • Ingår i: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 82:14-maj, s. 1161-1166
  • Tidskriftsartikel (refereegranskat)abstract
    • The JET scientific programme is directed towards the development of ITER relevant scenarios. In support of this, significant effort has been made to develop diagnostics to better characterise the power deposition on the plasma facing components, to investigate in more detail the radiation losses particularly in the divertor region and to better detect Magneto Hydrodynamic Modes (MHD) instabilities and their effects on fast ion confinement. A new wide-angle infrared camera provides for the first time the opportunity to perform infrared thermography in the JET main chamber, even during fast events like ELMs and disruptions. A completely new bolometric system, with better spatial resolution particularly in the divertor, is now used to investigate the total radiation losses and their influence on the ELM behaviour. A new set of microwave waveguides has improved by 20 dB the signal to noise ratio of the JET X-mode reflectometers, that are now routinely used to detect MHD instabilities and in particular to localise the location of Alfven Eigenmodes. This improved diagnostic capability to monitor MHD instabilities is complemented by two new diagnostics to detect lost fast particles. Both the new scintillator probe and a poloidal array of Faraday cups have already shown clear correlations between MHD activity and ion losses at the edge.
  •  
23.
  • Murari, A., et al. (författare)
  • New developments in the diagnostics for the fusion products on JET in preparation for ITER, (invited)
  • 2010
  • Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 81:10, s. 10E136-
  • Tidskriftsartikel (refereegranskat)abstract
    • Notwithstanding the advances of the past decades, significant developments are still needed to satisfactorily diagnose "burning plasmas." D-T plasmas indeed require a series of additional measurements for the optimization and control of the configuration: the 14 MeV neutrons, the isotopic composition of the main plasma, the helium ash, and the redistribution and losses of the alpha particles. Moreover a burning plasma environment is in general much more hostile for diagnostics than purely deuterium plasmas. Therefore, in addition to the development and refinement of new measuring techniques, technological advances are also indispensable for the proper characterization of the next generation of devices. On JET an integrated program of diagnostic developments, for JET future and in preparation for ITER, has been pursued and many new results are now available. In the field of neutron detection, the neutron spectra are now routinely measured in the energy range of 1-18 MeV by a time of flight spectrometer and they have allowed studying the effects of rf heating on the fast ions. A new analysis method for the interpretation of the neutron cameras measurements has been refined and applied to the data of the last trace tritium campaign (TTE). With regard to technological upgrades, chemical vapor deposition diamond detectors have been qualified both as neutron counters and as neutron spectrometers, with a potential energy resolution of about one percent. The in situ calibration of the neutron diagnostics, in preparation for the operation with the ITER-like wall, is also promoting important technological developments. With regard to the fast particles, for the first time the temperature of the fast particle tails has been obtained with a new high purity Germanium detector measuring the gamma emission spectrum from the plasma. The effects of toroidal Alfven eigenmodes modes and various MHD instabilities on the confinement of the fast particles have been determined with a combination of gamma ray cameras, neutral particle analyzers, scintillator probe, and Faraday cups. From a more technological perspective, various neutron filters have been tested to allow measurement of the gamma ray emission also at high level of neutron yield.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-23 av 23

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy