| 1. |
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| 2. |
- Abdellaoui, G., et al.
(författare)
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Meteor studies in the framework of the JEM-EUSO program
- 2017
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Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 143, s. 245-255
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Tidskriftsartikel (refereegranskat)abstract
- We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA.
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| 3. |
- Abdellaoui, G., et al.
(författare)
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First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
- 2018
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Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector.
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| 4. |
- Horwich, A, et al.
(författare)
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EAU–ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multi-stakeholder effort : under the auspices of the EAU and ESMO Guidelines Committees
- 2019
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Ingår i: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 30:11, s. 1697-1727
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach.
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| 5. |
- Elhai, M, et al.
(författare)
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Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
- 2019
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
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Tidskriftsartikel (refereegranskat)abstract
- To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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| 6. |
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| 8. |
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| 9. |
- Adriani, O., et al.
(författare)
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Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
- 2013
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Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
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Tidskriftsartikel (refereegranskat)abstract
- It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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| 10. |
- Bazilevskaya, G. A., et al.
(författare)
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Solar proton events at the end of the 23rd and start of the 24th solar cycle recorded in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 493-496
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA magnetic spectrometer was launched into a near-Earth orbit on board the Resurs-DK1 satellite in June 2006; in December 2006, it recorded the last strong solar high-energy particle event of the 23rd solar cycle. A deficit was thereafter observed in solar energetic particle events because of the lengthy solar activity minimum and the weak evolution of the next (24th) solar cycle. As a result, only a few solar events involving protons with energies of more than 100 MeV were recorded between 2010 and 1012. This work presents the preliminary results from measurements of charged particle fluxes in these events, recorded by the Pamela spectrometer.
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| 11. |
- Koldobskiy, S. A., et al.
(författare)
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Deuteron spectrum measurements under radiation belt with PAMELA instrument
- 2016
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Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 2345-2347
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Tidskriftsartikel (refereegranskat)abstract
- In this work the results of data analysis of the deuteron albedo radiation obtained in the PAMELA experiment are presented. PAMELA is an international space experiment carried out on board of the satellite Resurs DK-1. The high precision detectors allow to register and identify cosmic ray particles in a wide energy range. The albedo deuteron spectrum in the energy range 70 - 600 MeV/nucleon has been measured.
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| 12. |
- Koldobskiy, S. A., et al.
(författare)
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Study of deuteron spectra under radiation belt with PAMELA instrument
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- This paper presents the results of measurements of proton and deuteron fluxes of albedo radiation in the Earth vicinity, obtained in the PAMELA experiment. PAMELA is an international experiment meant to study cosmic rays. PAMELA is carried out on board the satellite Resurs-DK1. High-precision equipment of the experiment allows registration and identification of cosmic ray particles of different varieties in a wide energy range. The albedo deuteron spectrum and albedo deuteron-to-proton fluxes ratio in the energy range 70 - 600 MeV/nucleon at altitude of 350 - 600 km for different geomagnetic latitudes is presented.
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| 13. |
- Malakhov, V. V., et al.
(författare)
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Time variations of proton flux in Earth inner radiation belt during 23/24 solar cycles based on the PAMELA and the ARINA data.
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- The PAMELA and the ARINA experiments are carried out on the board of satellite RESURS-DK1 since 2006 up to now. Main goal of the PAMELA instrument is measurements of high energy antiparticles in cosmic rays while the ARINA instrument is intended studying high energy charged particle bursts in the magnetosphere. Both of these experiments have a possibility to study trapped particles in the inner radiation belt. Complex of these two instruments covers proton energy range from 30 MeV up to trapping limit (E= similar to 2 GeV). Continuous measurements with the PAMELA and the ARINA spectrometers include falling and rising phases of 23/24 solar cycles and maximum of 24th one. In this report we present temporal profiles of proton flux in the inner zone of the radiation belt (1.11 < L < 1.18, 0.18 < B < 0.22G). Dependence of proton fluxes on a magnitude of the solar activity was studied for various phases of 23/24 solar cycles. At that it was shown that proton fluxes at the solar minimum are several times greater than at the solar maximum.
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| 14. |
- Martucci, M., et al.
(författare)
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Analysis on H spectral shape during the early 2012 SEPs with the PAMELA experiment
- 2014
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 742, s. 158-161
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Tidskriftsartikel (refereegranskat)abstract
- The satellite-borne PAMELA experiment has been continuously collecting data since 2006. This apparatus is designed to study charged particles in the cosmic radiation. The combination of a permanent magnet, a silicon strip tracker and a silicon-tungsten imaging calorimeter, and the redundancy of instrumentation allow very precise studies on the physics of cosmic rays in a wide energy range and with high statistics. This makes PAMELA a very suitable instrument for Solar Energetic Particle (SEP) observations. Not only does it span the energy range between the ground-based neutron monitor data and the observations of SEPs from space, but PAMELA also carries out the first direct measurements of the composition for the highest energy SEP events, including those causing Ground Level Enhancements (GLEs). In particular, PAMELA has registered many SEP events during solar cycle 24, offering unique opportunities to address the question of high-energy SEP origin. A preliminary analysis on proton spectra behaviour during this event is presented in this work.
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| 15. |
- Mayorov, A. G., et al.
(författare)
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Antiprotons of galactic cosmic radiation in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 77:5, s. 602-605
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Tidskriftsartikel (refereegranskat)abstract
- A method for antiproton selection against a background of electrons, based on a mathematical model of data classification using variations in interparticle interaction in a calorimeter, and a method for excluding events accompanied by scattering in the inner detectors of a tracking system (which result in errors in the measured trajectory's curvature and charge sign) from analysis are discussed in this paper. Antiproton spectra and antiproton/proton flux ratio at energies of 0.06 to 350 GeV with statistics of events surpassing those in [1] are obtained. The results can be used to create models for the generation and distribution of particles in the Galaxy, and for searching and studying the nature of hypothetical dark matter particles.
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| 16. |
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| 17. |
- Anastasi, A., et al.
(författare)
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Combination of KLOE sigma (e(+) e(-) -> pi(+)pi(-) gamma(gamma)) measurements and determination of a(mu)(pi+pi-) in the energy range 0.10 < s < 0.95 GeV2
- 2018
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :3
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Tidskriftsartikel (refereegranskat)abstract
- The three precision measurements of the cross section sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)) using initial state radiation by the KLOE collaboration provide an important input for the prediction of the hadronic contribution to the anomalous magnetic moment of the muon. These measurements are correlated for both statistical and systematic uncertainties and, therefore, the simultaneous use of these measurements requires covariance matrices that fully describe the correlations. We present the construction of these covariance matrices and use them to determine a combined KLOE measurement for sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)). We find, from this combination, a two-pion contribution to the muon magnetic anomaly in the energy range 0.10 < s < 0.95 GeV2 of a(mu)(pi+pi-) (489.8 +/- 1.7(stat) +/- 4.8(sys)) x 10(-10).
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| 18. |
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| 19. |
- Karelin, A. V., et al.
(författare)
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North-south asymmetry for high-energy cosmic-ray electrons measured with the PAMELA experiment
- 2013
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Ingår i: Journal of Experimental and Theoretical Physics. - 1063-7761 .- 1090-6509. ; 117:2, s. 268-273
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Tidskriftsartikel (refereegranskat)abstract
- The north-south asymmetry for cosmic-ray particles was measured with one instrument of the PAMELA satellite-borne experiment in the period June 2006-May 2009. The analysis has been performed by two independent methods: by comparing the count rates in regions with identical geomagnetic conditions and by comparing the experimental distribution of particle directions with the simulated distribution that would be in the case of an isotropic particle flux. The dependences of the asymmetry on energy release in the PAMELA calorimeter and on time have been constructed. The asymmetry (N (n) - N (s) )/(N (n) + N (s) ) is 0.06 +/- 0.004 at the threshold energy release in the calorimeter and gradually decreases with increasing energy release. The observed effect is shown to be produced by electrons in the energy range 10-100 GeV.
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| 20. |
- Koldobskiy, S. A., et al.
(författare)
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Measurement of galactic cosmic-ray deuteron spectrum in the PAMELA experiment
- 2013
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - : Allerton Press. - 1062-8738. ; 77:5, s. 606-608
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Tidskriftsartikel (refereegranskat)abstract
- This work presents the results of measuring the deuteron spectrum of Galactic cosmic rays (GCRs) with the PAMELA experiment. The PAMELA is an international experiment. Its main objectives are to search for antimatter and measure proton, helium nuclei, electron, and positron spectra over a wide range of energies. In addition, the experimental setup allows the detection of deuterons and the reconstruction of their spectra at low energies. Cosmic ray deuteron spectrum and the deuteron-proton ratio measured in the PAMELA experiment in the energy range of 50-650 MeV/nucleon are presented below.
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| 21. |
- Koldobskiy, S., et al.
(författare)
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Measuring the albedo deuteron flux in the PAMELA satellite experiment
- 2015
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Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 294-297
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Tidskriftsartikel (refereegranskat)abstract
- The results of measuring albedo deuteron fluxes in the vicinity of the Earth are presented. The data were obtained in the PAMELA experiment conducted aboard the Resurs DK-1 artificial Earth satellite. High-precision detectors of the instrument setup allow us to identify albedo deuterons and measure their spectra in the energy interval from 70 to 600 MeV/nucleon at altitudes of 350–600 km for different geomagnetic latitudes.
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| 22. |
- Mayorov, A. G., et al.
(författare)
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Solar modulation of galactic cosmic rays during 2006-2015 based on PAMELA and ARINA data
- 2017
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Ingår i: International Conference On Particle Physics And Astrophysics. - : Institute of Physics Publishing (IOPP).
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Konferensbidrag (refereegranskat)abstract
- Solar modulation of galactic protons with energies from 50 MeV up to dozens of GeV during July '06 - January '16 studied based on a data of the magnetic spectrometer PAMELA and scintillation spectrometer ARINA. This period is interesting because it covers the end of 23(rd) and current 24(th) cycles of solar activity, including the abnormally long transient period and change of the polarity of solar magnetic field.
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| 23. |
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| 24. |
- Adriani, O., et al.
(författare)
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Cosmic-Ray Positron Energy Spectrum Measured by PAMELA
- 2013
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 111:8, s. 081102-
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Tidskriftsartikel (refereegranskat)abstract
- Precision measurements of the positron component in the cosmic radiation provide important information about the propagation of cosmic rays and the nature of particle sources in our Galaxy. The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray positron flux and fraction that extends previously published measurements up to 300 GeV in kinetic energy. The combined measurements of the cosmic-ray positron energy spectrum and fraction provide a unique tool to constrain interpretation models. During the recent solar minimum activity period from July 2006 to December 2009, approximately 24 500 positrons were observed. The results cannot be easily reconciled with purely secondary production, and additional sources of either astrophysical or exotic origin may be required.
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| 25. |
- Adriani, O., et al.
(författare)
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Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
- 2013
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Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
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