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| 2. |
- Obers, Niels A., et al.
(författare)
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Quantum gravity phenomenology at the dawn of the multi-messenger era—A review
- 2022
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Ingår i: Progress in Particle and Nuclear Physics. - : Elsevier BV. - 0146-6410 .- 1873-2224. ; 125
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Forskningsöversikt (refereegranskat)abstract
- The exploration of the universe has recently entered a new era thanks to the multi-messenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 “Quantum gravity phenomenology in the multi-messenger approach”, is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers.
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| 4. |
- Wang, Li-San, et al.
(författare)
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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- 2015
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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| 8. |
- Chung, Sharon A., et al.
(författare)
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Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production
- 2011
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:3, s. e1001323-
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Tidskriftsartikel (refereegranskat)abstract
- Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune disease characterized by autoantibody formation. Previously published genome-wide association studies (GWAS) have investigated SLE as a single phenotype. Therefore, we conducted a GWAS to identify genetic factors associated with anti-dsDNA autoantibody production, a SLE-related autoantibody with diagnostic and clinical importance. Using two independent datasets, over 400,000 single nucleotide polymorphisms (SNPs) were studied in a total of 1,717 SLE cases and 4,813 healthy controls. Anti-dsDNA autoantibody positive (anti-dsDNA +, n = 811) and anti-dsDNA autoantibody negative (anti-dsDNA -, n = 906) SLE cases were compared to healthy controls and to each other to identify SNPs associated specifically with these SLE subtypes. SNPs in the previously identified SLE susceptibility loci STAT4, IRF5, ITGAM, and the major histocompatibility complex were strongly associated with anti-dsDNA + SLE. Far fewer and weaker associations were observed for anti-dsDNA - SLE. For example, rs7574865 in STAT4 had an OR for anti-dsDNA + SLE of 1.77 (95% CI 1.57-1.99, p = 2.0E-20) compared to an OR for anti-dsDNA - SLE of 1.26 (95% CI 1.12-1.41, p = 2.4E-04), with (Pheterogeneity)<0.0005. SNPs in the SLE susceptibility loci BANK1, KIAA1542, and UBE2L3 showed evidence of association with anti-dsDNA + SLE and were not associated with anti-dsDNA - SLE. In conclusion, we identified differential genetic associations with SLE based on anti-dsDNA autoantibody production. Many previously identified SLE susceptibility loci may confer disease risk through their role in autoantibody production and be more accurately described as autoantibody propensity loci. Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE.
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| 10. |
- Demirci, M.F., et al.
(författare)
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Many-to-many feature matching using spherical coding of directed graphs
- 2004
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Ingår i: COMPUTER VISION - ECCV 2004, PT 1. - 3540219846 ; , s. 322-335
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Konferensbidrag (refereegranskat)abstract
- In recent work, we presented a framework for many-to-many matching of multi-scale feature hierarchies, in which features and their relations were captured in a vertex-labeled, edge-weighted directed graph. The algorithm was based on a metric-tree representation of labeled graphs and their metric embedding into normed vector spaces, using the embedding algorithm of Matousek [13]. However, the method was limited by the fact that two graphs to be matched were typically embedded into vector spaces with different dimensionality. Before the embeddings could be matched, a dimensionality reduction technique (PCA) was required, which was both costly and prone to error. In this paper, we introduce a more efficient embedding procedure based on a spherical coding of directed graphs. The advantage of this novel embedding technique is that it prescribes a single vector space into which both graphs are embedded. This reduces the problem of directed graph matching to the problem of geometric point matching, for which efficient many-to-many matching algorithms exist, such as the Earth Mover's Distance. We apply the approach to the problem of multi-scale, view-based object recognition, in which an image is decomposed into a set of blobs and ridges with automatic scale selection.
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| 11. |
- Demirci, M. Fatih, et al.
(författare)
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Object recognition as many-to-many feature matching
- 2006
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Ingår i: International Journal of Computer Vision. - : Springer Science and Business Media LLC. - 0920-5691 .- 1573-1405. ; 69:2, s. 203-222
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Tidskriftsartikel (refereegranskat)abstract
- Object recognition can be formulated as matching image features to model features. When recognition is exemplar-based, feature correspondence is one-to-one. However, segmentation errors, articulation, scale difference, and within-class deformation can yield image and model features which don't match one-to-one but rather many-to-many. Adopting a graph-based representation of a set of features, we present a matching algorithm that establishes many-to-many correspondences between the nodes of two noisy, vertex-labeled weighted graphs. Our approach reduces the problem of many-to-many matching of weighted graphs to that of many-to-many matching of weighted point sets in a normed vector space. This is accomplished by embedding the initial weighted graphs into a normed vector space with low distortion using a novel embedding technique based on a spherical encoding of graph structure. Many-to-many vector correspondences established by the Earth Mover's Distance framework are mapped back into many-to-many correspondences between graph nodes. Empirical evaluation of the algorithm on an extensive set of recognition trials, including a comparison with two competing graph matching approaches, demonstrates both the robustness and efficacy of the overall approach.
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| 13. |
- Hamawandi, Bejan, PhD, et al.
(författare)
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A Comparative Study on the Thermoelectric Properties of Bismuth Chalcogenide Alloys Synthesized through Mechanochemical Alloying and Microwave-Assisted Solution Synthesis Routes
- 2020
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Ingår i: Frontiers in Materials. - : Frontiers Media S.A.. - 2296-8016. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- The way a material is synthesized and processed has an immense effect on its microstructure, which in turn has a big impact on its transport properties. Here, we compare the thermoelectric (TE) properties of n- and p-type Bi2−xSbxTe3 (x: 0 and 1.5) materials synthesized through two different routes, specifically mechanochemical alloying (MA)—as a solid-state synthesis route—and microwave(MW)-assisted polyol synthesis—as a solution synthesis route. Reaction time is significantly reduced in the MW synthesis, leading to significantly lower energy consumption (i.e., higher energy efficiency) per batch than using the MA route. The resultant materials are compared for their crystallinity, phase purity, morphology, and microstructure. Spark plasma sintering was used to prepare pellets, and the resultant consolidates were evaluated for their transport properties. TE properties and microstructure of the specimens were investigated in relation to processing conditions and composition. MA samples formed fused structures (from 200 nm to several micrometers in size) composed of smaller particles. MW-synthesized materials exhibited hexagonal platelet morphology, high crystallinity, and phase purity. They also showed lower thermal conductivity, leading to a higher resultant TE figure-of-merit ZT. TE properties of Bi2−xSbxTe3 samples were studied on sintered cylindrical pellet samples, where the highest ZT values achieved were 1.04 (at 440 K) for MW-Bi2Te3 and 0.76 (at 523 K) for MW-Bi0.5Sb1.5Te3 samples, while MA-Bi2Te3 and MA-Bi0.5Sb1.5Te3 samples showed maximum ZT values of 0.74 (at 460 K) and 0.27 (at 300 K), respectively, as n- and p-type TE materials. The observed trend is much higher ZT values for MW samples, ascribed to their higher degree of texturing and nanostructured grains reducing the thermal conductivity, thus achieving a better overall performance, verifying the prospect to enhance ZT using MW-assisted solution synthesis approach.
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| 14. |
- Hom, Geoffrey, et al.
(författare)
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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
- 2008
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 358:9, s. 900-909
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4are established susceptibility genes; there is strong evidence for the existence of additional risk loci.METHODS: We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples from 1311 case subjects with SLE and 1783 control subjects; all subjects were North Americans of European descent. Genotypes from 1557 additional control subjects were obtained from public data repositories. We measured the association between the SNPs and SLE after applying strict quality-control filters to reduce technical artifacts and to correct for the presence of population stratification. Replication of the top loci was performed in 793 case subjects and 857 control subjects from Sweden.RESULTS: Genetic variation in the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine kinase (BLK) and C8orf13 (chromosome 8p23.1) was associated with disease risk in both the U.S. and Swedish case–control series (rs13277113; odds ratio, 1.39; P=1×10−10) and also with altered levels of messenger RNA in B-cell lines. In addition, variants on chromosome 16p11.22, near the genes encoding integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX), were associated with SLE in the combined sample (rs11574637; odds ratio, 1.33; P=3×10−11).
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| 15. |
- Munke, Anna, et al.
(författare)
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Data Descriptor : Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source
- 2016
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Ingår i: Scientific Data. - : Nature Publishing Group. - 2052-4463. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was chosen as it is a wellcharacterized model system, useful for proof-of-principle experiments, system optimization and algorithm development. RDV, an icosahedral virus of about 70 nm in diameter, was aerosolized and injected into the approximately 0.1 mu m diameter focused hard X-ray beam at the CXI instrument of LCLS. Diffraction patterns from RDV with signal to 5.9 angstrom ngstrom were recorded. The diffraction data are available through the Coherent X-ray Imaging Data Bank (CXIDB) as a resource for algorithm development, the contents of which are described here.
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| 16. |
- Shokoufandeh, All, et al.
(författare)
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The representation and matching of categorical shape
- 2006
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Ingår i: Computer Vision and Image Understanding. - : Elsevier BV. - 1077-3142 .- 1090-235X. ; 103:2, s. 139-154
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Tidskriftsartikel (refereegranskat)abstract
- We present a framework for categorical shape recognition. The coarse shape of an object is captured by a multiscale blob decomposition, representing the compact and elongated parts of an object at appropriate scales. These parts, in turn, map to nodes in a directed acyclic graph, in which edges encode both semantic relations (parent/child) as well as geometric relations. Given two image descriptions, each represented as a directed acyclic graph, we draw on spectral graph theory to derive a new algorithm for computing node correspondence in the presence of noise and occlusion. In computing correspondence, the similarity of two nodes is a function of their topological (graph) contexts.. their geometric (relational) contexts, and their node contents. We demonstrate the approach on the domain of view-based 3-D object recognition.
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