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- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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- Backhaus, Thomas, 1967, et al.
(författare)
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Assessing the ecological impact of chemical pollution on aquatic ecosystems requires the systematic exploration and evaluation of four lines of evidence
- 2019
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Ingår i: Environmental Sciences Europe. - : Springer Science and Business Media LLC. - 2190-4707 .- 2190-4715. ; 31:1
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the European Water Framework Directive is to ensure good ecological status for all European surface waters. However, although current monitoring strategies aim to identify the presence and magnitude of ecological impacts, they provide little information on the causes of an ecosystem impairment. In fact, approaches to establish causal links between chemical pollution and impacts on the ecological status of exposed aquatic systems are largely lacking or poorly described and established. This is, however, crucial for developing and implementing appropriately targeted water management strategies. In order to identify the role of chemical pollution on the ecological status of an aquatic ecosystem, we suggest to systematically combine four lines of evidence (LOEs) that provide complementary evidence on the presence and potential ecological impact of complex chemical pollution: (1) component-based methods that allow a predictive mixture risk modeling; (2) effect-based methods; (3) in situ tests; (4) field-derived species inventories. These LOEs differ systematically in their specificity for chemical pollution, data demands, resources required and ecological relevance. They complement each other and, in their combination, allow to assess the contribution of chemical pollution pressure to impacts on ecological structure and function. Data from all LOEs are not always available and the information they provide is not necessarily consistent. We therefore propose a systematic, robust and transparent approach to combine the information available for a given study, in order to ensure that consensual conclusions are drawn from a given dataset. This allows to identify critical data gaps and needs for future testing and/or options for targeted and efficient water management.
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- Schmitz, M., et al.
(författare)
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Demonstration of an aggregated biomarker response approach to assess the impact of point and diffuse contaminant sources in feral fish in a small river case study
- 2022
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 804
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Tidskriftsartikel (refereegranskat)abstract
- The assessment of the exposure of aquatic wildlife to complex environmental mixtures of chemicals originating from both point and diffuse sources and evaluating the potential impact thereof constitutes a significant step towards mitigating toxic pressure and the improvement of ecological status. In the current proof-of-concept study, we demonstrate the potential of a novel Aggregated Biomarker Response (ABR) approach involving a comprehensive set of biomarkers to identify complex exposure and impacts on wild brown trout (Salmo trutta fario). Our scenario used a small lowland river in Germany (Holtemme river in the Elbe river catchment) impacted by two wastewater treatment plants (WWTP) and diffuse agricultural runoff as a case study. The trout were col-lected along a pollution gradient (characterised in a parallel study) in the river. Compared to fish from the refer-ence site upstream of the first WWTP, the trout collected downstream of the WWTPs showed a significant increase in micronucleus formation, phase I and II enzyme activities, and oxidative stress parameters in agree-ment with increasing exposure to various chemicals. By integrating single biomarker responses into an aggre-gated biomarker response, the two WWTPs' contribution to the observed toxicity could be clearly differentiated. The ABR results were supported by chemical analyses and whole transcriptome data, which re-vealed alterations of steroid biosynthesis and associated pathways, including an anti-androgenic effect, as some of the key drivers of the observed toxicity. Overall, this combined approach of in situ biomarker responses complemented with molecular pathway analysis allowed for a comprehensive ecotoxicological assessment of fish along the river. This study provides evidence for specific hazard potentials caused by mixtures of agricultural and WWTP derived chemicals at sublethal concentrations. Using aggregated biomarker responses combined with chemical analyses enabled an evidence-based ranking of sites with different degrees of pollution according to toxic stress and observed effects. (c) 2021 Elsevier B.V. All rights reserved.
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| 6. |
- Deutschmann, Benjamin J. B., et al.
(författare)
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Location-based Initial Access for Wireless Power Transfer with Physically Large Arrays
- 2022
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Ingår i: 2022 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS WORKSHOPS (ICC WORKSHOPS). - : IEEE. - 9781665426718 ; , s. 127-132
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Konferensbidrag (refereegranskat)abstract
- Radio frequency (RF) wireless power transfer (WPT) is a promising technology for 6G use cases. It enables a massive yet sustainable deployment of batteryless energy neutral (EN) devices at an unprecedented scale. Recent research on 6G is exploring high operating frequencies up to the THz spectrum, where antenna arrays with large apertures are capable of forming narrow, "laser-like" beams. At sub-10 GHz frequencies, physically large antenna arrays are considered that are operating in the array near field. Transmitting spherical wavefronts, power can be focused to a focal point rather than a beam, which allows for efficient and radiation-safe WPT. We formulate a multipath channel model comprising specular components and diffuse scattering to find the WPT power budget in a realistic indoor scenario. Specular components can be predicted by means of a geometric model. This is used to transmit power via multiple beams simultaneously, increasing the available power budget and expanding the initial access distance. We show that exploiting this "beam diversity" reduces the required fading margin for the initial access to EN devices.
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| 7. |
- Fascista, Alessio, et al.
(författare)
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Uplink Joint Positioning and Synchronization in Cell-Free Deployments with Radio Stripes
- 2023
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Ingår i: 2023 IEEE International Conference on Communications Workshops: Sustainable Communications for Renaissance, ICC Workshops 2023. ; , s. 1330-1336
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Konferensbidrag (refereegranskat)abstract
- Radio stripes (RSs) is an emerging technology in beyond 5G and 6G wireless networks to support the deployment of cell-free architectures. In this paper, we investigate the potential use of RSs to enable joint positioning and synchronization in the uplink channel at sub-6 GHz bands. The considered scenario consists of a single-antenna user equipment (UE) that communicates with a network of multiple-antenna RSs distributed over a wide area. The UE is assumed to be unsynchronized to the RSs network, while individual RSs are time- and phase-synchronized. We formulate the problem of joint estimation of position, clock offset and phase offset of the UE and derive the corresponding maximum-likelihood (ML) estimator, both with and without exploiting carrier phase information. To gain fundamental insights into the achievable performance, we also conduct a Fisher information analysis and inspect the theoretical lower bounds numerically. Simulation results demonstrate that promising positioning and synchronization performance can be obtained in cell-free architectures supported by RSs, revealing at the same time the benefits of carrier phase exploitation through phase-synchronized RSs.
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