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| 2. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 8. |
- Kozak Ljunggren, Monika, et al.
(författare)
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Effect of Surgical Technique on Corneal Implant Performance.
- 2014
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Ingår i: Translational Vision Science & Technology. - : Association for Research in Vision and Ophthalmology (ARVO). - 2164-2591. ; 3:2
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Our aim was to determine the effect of a surgical technique on biomaterial implant performance, specifically graft retention.METHODS: Twelve mini pigs were implanted with cell-free, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) cross-linked recombinant human collagen type III (RHCIII) hydrogels as substitutes for donor corneal allografts using overlying sutures with or without human amniotic membrane (HAM) versus interrupted sutures with HAM. The effects of the retention method were compared as well as the effects of collagen concentration (13.7% to 15% RHCIII).RESULTS: All implanted corneas showed initial haze that cleared with time, resulting in corneas with optical clarity matching those of untreated controls. Biochemical analysis showed that by 12 months post operation, the initial RHCIII implants had been completely remodeled, as type I collagen, was the major collagenous protein detected, whereas no RHCIII could be detected. Histological analysis showed all implanted corneas exhibited regeneration of epithelial and stromal layers as well as nerves, along with touch sensitivity and tear production. Most neovascularization was seen in corneas stabilized by interrupted sutures.CONCLUSIONS: This showed that the surgical technique used does have a significant effect on the overall performance of corneal implants, overlying sutures caused less vascularization than interrupted sutures.TRANSLATIONAL RELEVANCE: Understanding the significance of the suturing technique can aid the selection of the most appropriate procedure when implanting artificial corneal substitutes. The same degree of regeneration, despite a higher collagen content indicates that future material development can progress toward stronger, more resistant implants.
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| 9. |
- Liu, Wei, et al.
(författare)
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Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea : the Connexin26/30 proteins are separately expressed in man
- 2016
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Ingår i: Cell and Tissue Research. - : Springer. - 0302-766X .- 1432-0878. ; , s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Globally 360 million people have disabling hearing loss and, of these, 32 million are children. Human hearing relies on 15,000 hair cells that transduce mechanical vibrations to electrical signals in the auditory nerve. The process is powered by the endo-cochlear potential, which is produced by a vascularized epithelium that actively transports ions in conjunction with a gap junction (GJ) system. This “battery” is located “off-site” in the lateral wall of the cochlea. The GJ syncytium contains the GJ protein genes beta 2 (GJB2/connexin26 (Cx26)) and 6 (GJB6/connexin30 (Cx30)), which are commonly involved in hereditary deafness. Because the molecular arrangement of these proteins is obscure, we analyze GJ protein expression (Cx26/30) in human cochleae by using super-resolution structured illumination microscopy. At this resolution, the Cx26 and Cx30 proteins were visible as separate plaques, rather than being co-localized in heterotypic channels, as previously suggested. The Cx26 and Cx30 proteins thus seem not to be co-expressed but to form closely associated assemblies of GJ plaques. These results could assist in the development of strategies to treat genetic hearing loss in the future.
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| 10. |
- Shao, Z., et al.
(författare)
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Cytochrome P450 2C8 omega 3-Long-Chain Polyunsaturated Fatty Acid Metabolites Increase Mouse Retinal Pathologic Neovascularization-Brief Report
- 2014
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - : Ovid Technologies (Wolters Kluwer Health). - 1079-5642 .- 1524-4636. ; 34:3, s. 581-586
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Tidskriftsartikel (refereegranskat)abstract
- Objective Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary 3-long-chain polyunsaturated fatty acids (3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs, producing bioactive epoxides, which are inactivated by soluble epoxide hydrolase (sEH) to transdihydrodiols. The effect of these enzymes and their metabolites on neovascularization is unknown. Approach and Results The mouse model of oxygen-induced retinopathy was used to investigate retinal neovascularization. We found that CYP2C (localized in wild-type monocytes/macrophages) is upregulated in oxygen-induced retinopathy, whereas sEH is suppressed, resulting in an increased retinal epoxide:diol ratio. With a 3LCPUFA-enriched diet, retinal neovascularization increases in Tie2-driven human-CYP2C8-overexpressing mice (Tie2-CYP2C8-Tg), associated with increased plasma 19,20-epoxydocosapentaenoic acid and retinal epoxide:diol ratio. 19,20-Epoxydocosapentaenoic acids and the epoxide:diol ratio are decreased with overexpression of sEH (Tie2-sEH-Tg). Overexpression of CYP2C8 or sEH in mice does not change normal retinal vascular development compared with their wild-type littermate controls. The proangiogenic role in retina of CYP2C8 with both 3LCPUFA and 6LCPUFA and antiangiogenic role of sEH in 3LCPUFA metabolism were corroborated in aortic ring assays. Conclusions Our results suggest that CYP2C 3LCPUFA metabolites promote retinal pathological angiogenesis. CYP2C8 is part of a novel lipid metabolic pathway influencing retinal neovascularization.
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| 11. |
- Amizhtan, S. K., et al.
(författare)
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Experimental Study and ANN Analysis of Rheological Behavior of Mineral Oil-Based SiO2 Nanofluids
- 2022
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Ingår i: IEEE transactions on dielectrics and electrical insulation. - : Institute of Electrical and Electronics Engineers (IEEE). - 1070-9878 .- 1558-4135. ; 29:3, s. 956-964
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Tidskriftsartikel (refereegranskat)abstract
- This work reports an experimental and theoretical analysis of the rheological properties of mineral oil-based SiO2 nanofluid for their potential applications in transformer insulation. The flow electrification mechanism on the nanofluids with different surfactants such as cetyl trimethyl ammonium bromide (CTAB), oleic acid, and Span 80 is studied using a spinning disk technique. The results show a higher streaming current for the nanofluids with CTAB as a surfactant compared to oleic acid and Span 80. The rheological behavior of nanofluids is explored with the double gap concentric cylinder geometry. The variation of shear stress with shear rate follows a power law relationship along with a yield stress observed for all the nanofluids. A transition is seen from storage modulus to dominant loss modulus for the nanofluids during the frequency sweep analysis, whereas no transition is observed in the case of mineral oil. In addition, regression analysis using artificial neural network (ANN) algorithms are performed on the experimentally measured viscosity of the nanofluids in order to estimate theoretical parameters and provide insights into the streaming current formation. The desirable rheological characteristics of nanofluids are identified for achieving enhanced insulation performance in transformers.
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| 12. |
- Amizhtan, S. K., et al.
(författare)
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Impact of Magnetic Field on Corona Discharge Behavior of Mineral Oil Under AC Voltage
- 2022
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Ingår i: IEEE transactions on dielectrics and electrical insulation. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1070-9878 .- 1558-4135. ; 29:4, s. 1417-1424
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Tidskriftsartikel (refereegranskat)abstract
- This article reports an experimental investigation of the impact of magnetic field on corona discharge activity in mineral oil, using both ultrahigh-frequency (UHF) and fluorescence techniques under ac voltage. The results show that corona inception voltage (CIV) increased under ac voltage with varying harmonic frequencies without considering any phase shift and reduced marginally under magnetic field. In addition, the impact of the magnetic field shifted the dominating frequency of the UHF signal (0.9 GHz) obtained under ac voltage toward lower frequencies (0.3 and 0.6 GHz). Under high magnetic fields, the parameters such as rise time, fall time, and pulsewidth of the fluorescence signal increased in its magnitude compared to its effect without a magnetic field. Also, using both the UHF sensor and the fluorescence sensor, there was no clear difference in the phase-resolved partial discharge (PRPD) pattern caused by corona discharge (with and without magnetic field). Furthermore, the number of discharges is observed to be high under the impact of harmonic ac voltages with third- and seventh-order containing total harmonic distortions (THDs) of 4% and 40%.
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| 13. |
- Amizhtan, S. K., et al.
(författare)
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Impact of Surfactants on the Electrical and Rheological Aspects of Silica Based Synthetic Ester Nanofluids
- 2022
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Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536. ; 10, s. 18192-18200
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Tidskriftsartikel (refereegranskat)abstract
- This study reports experimental investigations of the effects of different surfactants (CTAB, Oleic acid and Span 80) on silica based synthetic ester nanofluids. The positive and negative potential observed for the ionic (CTAB) and non-ionic surfactant (Span 80) from zeta potential analysis indicates an improved stability. The optimization of nanofillers and surfactants is performed considering the corona inception voltage measured using ultra high frequency (UHF) technique and fluorescent fiber. Rheological analysis shows no significant variation of properties with shear rate, implying Newtonian behavior even with the addition of surfactant. In addition, the permittivity of the nanofluid is not much affected by adding surfactant but a marginal variation is noticed in the loss tangent with the effect of temperature. The fluorescence spectroscopy shows no change in the emission wavelength with the addition of silica nanofiller and surfactants. Flow electrification studies indicate an increase in the streaming current with the rotation speed and temperature, with a higher current magnitude observed in the case of nanofluids.
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| 14. |
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| 15. |
- Doddapaneni, Venkatesh, et al.
(författare)
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Spectroscopic investigations of the ablated species from the polymers exposed to electric arcs in air
- 2015
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Ingår i: 2015 3rd International Conference on Electric Power Equipment - Switching Technology, ICEPE-ST 2015. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467374149 ; , s. 337-340
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Konferensbidrag (refereegranskat)abstract
- Polymeric walls have been widely used in the last decades to improve the arc interruption process in electrical switching applications. This improvement is achieved by the evaporation (ablation) of the polymeric walls due to the highly energetic radiation generated by the electrical arcs. This experimental study deals with polymeric walls that are exposed to the electrical arcs generated between a 5 mm air gap with prospective current of 1.4 kA. In this paper, two different techniques are discussed aiming at the identification of the dominant ablated species produced during the arc interruption process, namely Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric analysis coupled with Fourier transform infrared analysis of evolved gases (EGA). In addition, the morphological and chemical changes on the surface of the exposed polymeric walls are analyzed by microscopical techniques.
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| 16. |
- Edin, Benoni B, et al.
(författare)
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Classification of human muscle stretch receptor afferents : a Bayesian approach.
- 1990
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Ingår i: Journal of Neurophysiology. - 0022-3077 .- 1522-1598. ; 63:6, s. 1314-1322
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Tidskriftsartikel (refereegranskat)abstract
- 1. A sample of 124 human muscle afferents originating from the finger extensor muscles were recorded from the radial nerve in the upper arm. A method is described to formalize the classification of units in muscle spindle primary and secondary afferents and Golgi tendon organ afferents on the basis of a few, nonrigorous assumptions. The classification was based on experimental data that largely have been described in a series of previous papers, although some additional data were collected in the present study. 2. The units were subjected to five tests providing identification data: twitch contraction test, ramp-and-hold stretch, small-amplitude sinusoidal stretches superimposed on ramp stretch, stretch sensitization, and isometric contraction/relaxation. From these five tests the following eight response features were extracted: response to maximal isometric twitch contractions, type of stretch sensitization, correlation between discharge rate and contractile force, response to sudden isometric relaxation, presence or absence of an initial burst, deceleration response, prompt silencing at slow muscle shortening, and driving by small-amplitude sinusoidal stretches. 3. A Bayesian decision procedure was adopted to classify the units on the basis of the eight discriminators. As a first step, units were provisionally classified into muscle spindle primary and secondary afferents, and Golgi tendon organ afferents, by intuitively weighting their responses to the identification tests. Prior probabilities were estimated on the basis of the provisional classification. The eight response features were analyzed and tabulated for all afferents, and the likelihood functions of the tests were directly calculated on the basis of these data.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 17. |
- Edin, Benoni B, et al.
(författare)
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Dynamic response of human muscle spindle afferents to stretch.
- 1990
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Ingår i: Journal of Neurophysiology. - 0022-3077 .- 1522-1598. ; 63:6, s. 1297-1306
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Tidskriftsartikel (refereegranskat)abstract
- 1. One hundred and twenty-four muscle afferents from the finger extensor muscles were recorded from the radial nerve in human subjects. 2. The afferents were provisionally classified as muscle spindle primary (78/124) and secondary afferents (25/124), and Golgi tendon organ afferents (21/124), on the basis of their response to 1) maximal twitch contractions, 2) 20- and 50-Hz sinusoids superimposed on ramp-and-hold stretches, 3) stretch sensitization, and 4) isometric contractions and sudden relaxations. 3. Ramp-and-hold stretches at two velocities, 10 and 50 degrees/s, were applied to the appropriate metacarpophalangeal (MCP) joint while the parent muscle remained relaxed. For each unit three discrete parameters were assessed: the presence or absence of 1) an initial burst at the commencement of the ramp stretch, 2) a deceleration response at the beginning of the hold phase, and 3) a prompt silencing at muscle shortening. In addition, two kinds of dynamic indexes were calculated for 79 of the muscle spindle afferents. 4. Most spindle afferents responded readily to stretch, whereas the Golgi tendon organ afferents produced very poor stretch responses. All of them lacked a static response, whereas the dynamic response, when present at all, consisted of only a few impulses. 5. The dynamic index was higher for spindle primaries than for secondaries, and this difference was statistically significant although the distribution was unimodal for spindle afferents as a group. Hence, this parameter was a poor discriminator. 6. Initial bursts, deceleration responses, and silences during imposed shortening were more common in spindle primaries than in secondaries. The differences were significant in all these respects. 7. The three discrete parameters were statistically pairwise independent for the spindle afferents, justifying the combination of the three into a useful battery for discrimination between primary and secondary spindle afferents and the use of this battery as a partial data base for a probability approach towards a solid classification of human muscle afferents.
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| 18. |
- Edin, Benoni B, et al.
(författare)
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Muscle afferent responses to isometric contractions and relaxations in humans.
- 1990
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Ingår i: Journal of Neurophysiology. - 0022-3077 .- 1522-1598. ; 63:6, s. 1307-1313
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Tidskriftsartikel (refereegranskat)abstract
- 1. One hundred and two single afferents from the finger extensor muscles of humans were studied with the microneurography technique. 2. The afferents were provisionally classified as primary muscle spindle afferents (62/102), secondary spindle afferents (22), and Golgi tendon organ afferents (18) on the basis of their responses to four tests: 1) ramp-and-hold stretch, 2) 20- and 50-Hz small-amplitude sinusoidal stretch superimposed on ramp-and-hold stretch, 3) maximal isometric twitch contraction, and 4) stretch sensitization. 3. The response profiles of the three unit types were analyzed during slowly rising isometric contraction terminating with an abrupt relaxation. About 75% (61/84) of all muscle spindle afferents increased their discharge during isometric contraction, whereas the discharge was reduced for the remaining afferents. All Golgi tendon organs increased their discharge during the contraction. 4. The level of extrafusal contraction at which a spindle afferent increased its discharge rate often varied from trial to trial, speaking against a fixed fusimotor recruitment level of the individual spindle ending. 5. In 70% of the spindle afferents, a distinct burst of impulses appeared when the subject rapidly relaxed after the isometric contraction. The burst was more common and usually much more prominent with primary than secondary afferents, often reaching instantaneous discharge rates well above 100 Hz. 6. Whereas all Golgi tendon organ afferents displayed an increased discharge during the contraction phase, only one of them exhibited a rate acceleration close to the relaxation phase. However, this response could clearly be identified as being of different nature than the spindle bursts.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 19. |
- Edin, Benoni B, et al.
(författare)
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Single unit retrieval in microneurography : a microprocessor-based device controlled by an operator.
- 1988
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Ingår i: Journal of Neuroscience Methods. - 0165-0270 .- 1872-678X. ; 24:2, s. 137-144
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Tidskriftsartikel (refereegranskat)abstract
- A microprocessor-based device was constructed to retrieve single unit activity from nerve recordings contaminated by other units and EMG activity. The microneurographic signal is sampled at 10 kHz and an algorithm applied to identify impulses from a single nerve fibre. On line, a TTL pulse is delivered when an event, i.e. a provisional nerve impulse, is selected. The wave form and clock time of events are stored. Moreover, the latest selected event and the actual selection criteria are continuously displayed on a standard oscilloscope. Off line, the wave form and clock time of events as well as an instantaneous frequency plot can be displayed on the oscilloscope. The final selection of events is done with a combination of a second algorithm, which essentially is a wave form comparator, and a manual check. The device is controlled either by hardware, with knobs on the front panel, or by software through a data bus connected to a microcomputer. Clock times and wave forms of the events, which are stored in the microprocessor memory, may also be presented on the data bus for later off-line analysis and coordination with other related signals collected during the experiment, e.g. transducer and electromyography records, whether these were stored on analog or digital tape or computer disc. Compared to other available techniques, the device has a superior discriminative power when electromyographic artefacts are present.
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| 20. |
- Edin, Benoni B, et al.
(författare)
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Stretch sensitization of human muscle spindles.
- 1988
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Ingår i: Journal of Physiology. - 0022-3751 .- 1469-7793. ; 400, s. 101-11
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Tidskriftsartikel (refereegranskat)abstract
- 1. Sixty-seven afferents from the finger extensor muscles were consecutively recorded by microneurography. 2. The units were classified as primary or secondary muscle spindle afferents or Golgi tendon organ afferents on the basis of their responses to ramp-and-hold stretches, sinusoidals superimposed on ramp-and-hold stretches, maximal twitch contractions and isometric contractions and relaxations. 3. The muscle was repeatedly stretched and then either kept short or long for a few seconds followed by a slow ramp stretch. The responses of the muscle afferents to the slow stretch were compared under the two conditions. 4. Thirty out of thirty-eight units classified as primary spindle afferents and four out of eleven units classified as secondary afferents showed an enhanced response to the slow ramp when the muscle had been kept short compared to the response when the muscle had been kept long. 5. None of the eighteen Golgi tendon organ afferents showed any difference in this respect. 6. It is concluded that stretch sensitization does occur in human muscle spindles and, when present, constitutes firm evidence of the afferent originating from a muscle spindle rather than a Golgi tendon organ. In addition, due to differences in the response characteristics of primaries and secondaries, the test may aid in separating muscle spindle primary afferents from secondary afferents.
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| 21. |
- Edin, Benoni B, et al.
(författare)
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Twitch contraction for identification of human muscle afferents.
- 1987
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772 .- 1365-201X. ; 131:1, s. 129-138
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Tidskriftsartikel (refereegranskat)abstract
- A classical test to differentiate between Golgi tendon organs and muscle spindles is the twitch contraction elicited by electrical stimulation. The possibility of producing maximal twitches in the finger extensor muscles using surface stimulation over the muscle belly was investigated as well as the feasibility of the test in microneurography experiments. Electrical stimuli were applied either over the muscle in the forearm or the radial nerve in the upper arm, while the resulting torque output at single metacarpophalangeal joints was measured. The relationship between current intensity and maximal contraction force was determined and stimulus response plots were constructed over a large range of current intensities. Stimulation of the radial nerve always yielded plots with a steep and monotonous rising limb up to a plateau. It was concluded that the plateau represented maximal twitch contractions. With transcutaneous stimulation over the muscle belly, the stimulus response plots were usually more complex. However, this could be explained by force transmission through the intertendinous connections on the dorsum of the hand and by antagonist activation. It was concluded that maximal twitch contractions can readily be elicited in the human extensor digitorum muscle with nonpainful transcutaneous electrical stimulations. Moreover, maximal twitches are compatible with single unit recording from muscle afferents in microneurography experiments.
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| 22. |
- Edin Grimheden, Martin, 1971-, et al.
(författare)
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Guest Editors Introduction: Special Issue on Education for Cyber-Physical Systems
- 2020
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Ingår i: IEEE design & test. - : Institute of Electrical and Electronics Engineers (IEEE). - 2168-2356 .- 2168-2364. ; 37:6, s. 5-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Cyber-Physical Systems (CPSs) are integrations of physical systems with computations. Their design poses many challenges. For example, CPS design is interdisciplinary by nature, crossing the boundaries of many engineering disciplines. In addition, there is a potential mismatch between the discrete nature of today’s computing systems and typically continuous physical systems, and CPS design has to meet and adhere to many constraints and take many objectives into account. As a result, education for the CPS design is quite challenging. In this context, the special issue on education for CPS aims to provide educators, industrial representatives, and researchers with a view on the needs and share solutions for embedded and CPS education. The special issue addresses questions such as “How can we ensure that students will be able to work in interdisciplinary teams?,” “What skills and capabilities are required by the engineers of tomorrow?,” “How should the corresponding educational programs be formed?,” and “How can effective pedagogic methods be introduced in this domain?”
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| 23. |
- Edin, Kerstin, et al.
(författare)
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Perspectives on intimate relationships among young people in rural South Africa : the logic of risk
- 2016
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Ingår i: Culture, Health and Sexuality. - : Informa UK Limited. - 1369-1058 .- 1464-5351. ; 18:9, s. 1010-1024
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores how young people in rural South Africa understand gender, dating, sexuality and risk-taking in adolescence. The empirical material drawn upon consists of 20 interviews with young men and women (aged 18-19) and reflects normative gender patterns characterised by compulsory heterosexuality and dating as obligatory, and representing key symbols of normality. However, different meanings of heterosexual relationships are articulated in the interviews, for example in the recurring concept of 'passing time', and these meanings show that a relationship can be something arbitrary: a way to reduce boredom and have casual sex. Such a rationale for engaging in a relationship reflects one of several other normative gender patterns, which relate to the trivialisation of dating and sexual risk-taking, and which entail making compromises and legitimising deviations from the 'ideal' life-script and the hope of a better future. However, risks do not exclusively represent something bad, dangerous or immoral, because they are also used as excuses to avoid sex, HIV acquisition and early pregnancy. In conclusion, various interrelated issues can both undermine and/or reinforce risk awareness and subsequent risk behaviour. Recognition of this tension is essential when framing policies to support young people to reduce sexual risk-taking behaviour.
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| 24. |
- Edin-Liljegren, A, et al.
(författare)
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Psychosocial risk factors among Sami in Sweden : a controlled cohort study
- 2006
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Ingår i: Vaartoe.
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Objective: To investigate the occurrence of psychosocial, clinical and behavioural risk factors for cardiovascular diseases (CVD) among reindeer herding and non-reindeer herding Sami. The results on psychosocial risk factors are presented here. Materials and Methods: A cohort of 611 Swedish Sami (276 men and 335 women) was constructed from national population registers and compared with a twice as large control population of non-Sami, matched by age, gender and area of residency. Information on quality of life, social support and Karasek and Theorell`s job-strain indices was obtained from a database containing information from a regional CVD-preventive program. The data was collected from the period of 1990–2001. Results: The Sami people reported lower quality of life and higher demand and intellectual discretion at work than the non-Sami. The Sami women, the reindeer herding as well as the non-reindeer herding, had lower scores on intellectual discretion and social support at work compared with the Sami men. Conclusions: Regarding the psychosocial risk factors investigated here it seems that the Sami women are at higher risk than the Sami men.
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| 25. |
- Edin-Liljegren, A, et al.
(författare)
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Risk factors for cardiovascular diseases among Swedish Sami : a controlled cohort study
- 2004
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Ingår i: International Journal of Circumpolar Health. - 1239-9736 .- 2242-3982. ; 63:Suppl 2, s. 292-297
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the occurrence of clinical, psychosocial and behavioural risk factors for cardiovascular diseases (CVD) among reindeer herding (RS) and non-reindeer herding Sami (NRS). STUDY DESIGN: A retrospective cohort study, comparing risk factors behind CVD between Sami and non-Sami, RS and NRS, and Sami men and women. METHODS: A cohort of 611 Swedish Sami (276 men and 335 women) was constructed from national population registers. A twice as large control cohort of non-Sami was created, matched by age, gender and area of residence. Information on risk factors was obtained from a database containing clinical and psychosocial-behavioural data from a regional CVD preventive programme for the period 1990-2001. RESULTS: The Sami and the non-Sami showed similar risk factor patterns. The main differences were related to working conditions and lifestyle factors of the RS. The RS men had lower blood pressure, were more physically active and had higher job demand and decision latitude. The RS women showed more negative scores on the indices of the job strain model. CONCLUSIONS: Previously reported differences in CVD mortality between Sami and non-Sami, and Sami men and women, can only partly be explained by different exposure to the psychosocial and behaviour risk factors investigated in this study.
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