| 1. |
- Edlund, Ann-Catrine, 1959-, et al.
(författare)
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Basttulijani och Janosa Eva. Personnamn och identifikation i Kågeträskdagboken 1891–1901
- 2020
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Ingår i: Namn i skrift. Names in Writing. - Göteborg : Meijerbergs institut för etymologisk forskning. - 9789172760981 - 9789187850035 ; , s. 37-59
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Konferensbidrag (refereegranskat)abstract
- In this paper we explore the relationship between unofficial personal names and socialidentification in a peasant diary from Kågeträsk in the county of Västerbotten, datingfrom 1891–1901. From a total of 208 unique personal names we have extracted 169 unofficial personal names. Three categories of unofficial names have thereby been identified and closely analysed. The social aspects that are highlighted in the name formation are gender, place and kinship. The most extensive category consists of names where the kinship relation to the father is indicated: Adams Oskar and Nickes Tilda (60 names). The second category consists of unofficial names formed in relation to place-names: Bastulid-Johan and Strand-Alma (44 names). The third category consistsof personal names for married women given in relation to the name of her husband:Roberts Greta (17 names). The analysis shows that gender is a particularly salient social aspect in all three categories. The most part of the unofficial names used in the diary are men’s names, either their own unofficial name or the name of theirson, daughter or wife. The kinship relations that are indicated by the unofficial names hereby departs from the man in the household, whereas the kinship relations to the woman in the household are unmarked and therefore invisible in the personal naming. The social identification that is indicated by the personal names may also position women and men in different social domains. Both men and women may be identified by their kinship relation to their father and their belonging to a certain place. But while men tend to be identified as sons belonging to the village, women tend to be identified both as servants, daughters, wives or daughters-in-law belonging to the particular farm.
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| 2. |
- Edlund, Ann-Catrine, 1959-, et al.
(författare)
-
Kågeträskdagboken : En västerbottnisk dagbok 1891–1901 med kommentarer. Volym 2.
- 2022
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Kågeträskdagboken är tillkommen mellan 1891 och 1901. Den är skriven av systrarna Greta Dahlqvist (1859–1947) och Lovisa Dahlqvist (1862–1938), som bodde på Anten-Ors gård i Kågeträsk i norra Västerbotten. I dagboken får vi en inblick i det dagliga livet på gården: här redovisas i detaljer husfolkets utomhusarbete under vår, sommar och höst samt kvinnornas inomhusarbete under vinterhalvåret med vävning, stickning och andra aktiviteter. Det sociala livet i byn har en framträdande plats i dagboken, och uppgifter om nattfrierier, giftermål, födslar och död finns noggrant dokumenterade. Själva dagboksutgåvan består av två volymer. I den första får man en omfattande presentation av dagbokens historiska och sociala sammanhang, och där finns också person-, ortnamns- och ordregister samt en käll- och litteraturförteckning. I denna andra volym återfinns hela dagboken med tolkning och omfattande språkliga och innehållsliga kommentarer. En tredje volym behandlar de vis- och gåtböcker som sammanställdes på Anten-Ors gård under samma tid.I den tryckta boken presenteras en dagbokssida på varje uppslag. På den högra sidan återfinns renskriften, på den vänstra sidan översättningen/tolkningen. I pdf:en presenteras dagboken istället sida för sida, vilket innebär att det inte är möjligt att läsa renskrift och översättning intill varandra.
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| 3. |
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Kågeträskdagboken, volym 2 : En västerbottnisk dagbok 1891–1901 med kommentarer
- 2022. - 1
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Kågeträskdagboken är tillkommen mellan 1891 och 1901 på Anten-Ors gård i norra Västerbotten och är skriven av de två systrarna Greta Dahlqvist (1859– 1947) och Lovisa Dahlqvist (1862–1938). I föreliggande volym återger vi hela dagboken med tolkning och kommentarer. I Kågeträskdagbokens volym I ges en fördjupad presentation av det historiska och sociala sammanhang där Kågeträskdagboken tillkom. Där finns också tre register: Personregister, Ort- namnsregister och Ordregister. Käll- och litteraturförteckning för källor och litteratur som åberopas i fotnoterna i volym II återfinns också i volym I. Gretas och Lovisas förstaspråk var Skelleftemålet. Talad rikssvenska hade de mött som uppläsningsspråk i mer officiella sammanhang, och i skolan lärde de sig skriva svenska. Dagbokstexten utmärker sig av starka dialektala inslag samtidigt som det är uppenbart att de båda skribenterna haft starka ambitio- ner att följa normen för det svenska riksspråket. Detta gör dagboken till ett intressant forskningsobjekt inom skriftbruksforskning som är ett tvärveten- skapligt område. För att det ska vara möjligt för nutida läsare att ta del av såväl originaltex- ten som dagbokens innehåll har vi valt att återge en noggrann transkription av dagboksanteckningarna tillsammans med en tolkning. Varje enskild dagboks- sida presenteras på ett uppslag där den radrätt återgivna transkriptionen åter- finns på den högra sidan och tolkningen på den vänstra. I volym I beskriver vi hur vi gått till väga vid redigering av transkriptionen och vilka överväganden som gjorts vid tolkningen I dagboksutgåvan återfinns två typer av numrering, dels en löpande num- rering, dels en särskild numrering av dagbokssidorna; se även innehållsförteck- ningen. Dagbokshandskriften består av tre anteckningsböcker och en stor mängd lösa blad. Numreringen av dagbokssidorna utgår från de fem sviter av anteckningar som vi upprättat: i exempelvis numreringen 4:2 anger siffran 4 dagbokssvitens nummer, medan siffran 2 säger att det är sidan 2 i denna svit. Vart och ett av dagboksåren inleds med en vinjett som kort sammanfattar några av de händelser som redovisas i anteckningarna. Intill vinjetten finns en konstbild framställd av bildkonstnär Maria Sundström som gestaltar ett dagboksutdrag. För att kunna förstå dagbokstexten krävs kunskap om dialekten, men även god kunskap om den lokala geografin och om den jordbruks- och hantverkster- minologi som används. Därför har vi utarbetat en omfattande notapparat med ingående kommentarer. Vissa ord och sakförhållanden återkommer naturligt- vis, men för att göra det möjligt för läsaren att direkt hitta en förklaring av textstället upprepas samma kommentar, en del gånger i något förkortat skick. Mängder av dialektala ord förklaras, såsom ”Med slåttanna (slåtanna) avses ’tiden för slåtter av hö’”, där dagbokens återgivning av det aktuella ordet (i detta fall slåtanna) återgivits inom parentes. I noterna kommenteras ock- så ett stort antal kulturhistoriska fenomen, såsom t.ex. njutsminne: ”När man avslutat ett hästköp kunde det beseglas med att man drack njutsminne, dvs. man drack en köpskål.” De människor som omtalas i dagboken presenteras med officiellt namn och födelseår, såsom ”Rånings-Nisch, dvs. Nils Johansson Holmqvist (1845–1907)”. I personregistret i volym I återfinner man utförliga informationer om de aktuella personerna.I fotnoterna finns dessutom hänvisningar till de tre kartor och 13 stamtavlor som inleder volym II. Kartorna är följande: Karta 1. Gårdar i Kågeträsk under sent 1800-tal; Karta 2. Platser i närmiljön; Karta 3. Byar i närmiljön. Många av de människor som omnämns i dagboken är släktingar till husfolket på Anten-Ors gård. För att det ska vara möjligt att se släktskapsrelationerna mellan de olika personerna har vi upprättat stamtavlor för Anten-Ors och de- ras släktingar. De totalt tretton stamtavlorna nämner drygt 300 personer.
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| 4. |
- Steneberg, Pär, et al.
(författare)
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PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
- 2018
-
Ingår i: JCI INSIGHT. - : American Society for Clinical Investigation. - 2379-3708. ; 3:12
-
Tidskriftsartikel (refereegranskat)abstract
- AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and caloric restriction. We here report on the identification of PAN-AMPK activator O304, which - in diet-induced obese mice - increased glucose uptake in skeletal muscle, reduced beta cell stress, and promoted beta cell rest. Accordingly, O304 reduced fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin. T2D is associated with devastating micro-and macrovascular complications, and O304 improved peripheral microvascular perfusion and reduced blood pressure both in animals and T2D patients. Moreover, like exercise, O304 activated AMPK in the heart, increased cardiac glucose uptake, reduced cardiac glycogen levels, and improved left ventricular stroke volume in mice, but it did not increase heart weight in mice or rats. Thus, O304 exhibits a great potential as a novel drug to treat T2D and associated cardiovascular complications.
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| 5. |
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Batch process strategy for analysing metabolic variation controlling the growth process of hybrid aspen
- 2005
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Proceedings (redaktörskap) (populärvet., debatt m.m.)abstract
- High resolution magic angle spinning proton nuclear magnetic resonance spectroscopy, {1}H HR/MAS NMR, and multivariate data analysis using batch processing, BP, was applied for the analysis of two different genotypes of poplar tree (Populus tremula L. x tremuloides Michx.), containing an antisense construct of PttMYB76 and control (wild type). A gene encoding a MYB transcription factor, with unknown function, PttMYB76, was selected from a cambial EST library of poplar tree (Populus tremula L. x remuloides Michx.) for metabonomic characterisation. The PttMYB76 gene is believed to affect different paths of the phenyl propanoid synthetic pathway. This pathway leads to the formation of S- and G-lignin, flavonoids and sinapate esters. Milled poplar samples collected at the internodes of the tree were analysed using {1}H high resolution magic angle spinning NMR spectroscopy. The application of multivariate batch processing of the NMR results revealed a growth-related gradient in the plant internode direction as well as the discrimination between the trees with down regulated PttMYB76 expression and wild type populations. This paper is focused on the potential of a new analytical multivariate approach for analysing time-related plant metabonomic data. The techniques used could, with the aid of suitable model compounds, be of high relevance to the detection and understanding of the different lignification processes within the two types of poplar tree. Additionally, the findings are highlighting the importance of applying robust and organised multivariate data analysis approaches to facilitate modelling and interpretation of complex biological data sets.
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| 6. |
- Buevich, Alexei V, et al.
(författare)
-
NMR studies of calcium-binding to mutant alpha-spectrin EF-hands
- 2004
-
Ingår i: CELLULAR & MOLECULAR BIOLOGY LETTERS. - 1425-8153. ; 9:1, s. 167-86
-
Tidskriftsartikel (refereegranskat)abstract
- The co-operative calcium binding mechanism of the two C-terminal EF-hands of human all-spectrin has been investigated by site-specific mutagenesis and multi-dimensional NMR spectroscopy. To analyse the calcium binding of each EF-hand independently, two mutant structures (E33A and D69S) of wild type alpha-spectrin were prepared. According to NMR analysis both E33A and D69S were properly folded. The unmutated EF-hand in these mutants remained nearly intact and active in calcium binding, whereas the mutated EF-hand lost its affinity for calcium completely. The apparent calcium binding affinity of the E33A mutant was much lower compared to the D39S mutant (similar to2470 muM and similar to240 muM, respectively). When the chemical shift perturbations were followed upon calcium titration, a positive correlation between the D69S mutant and the binding of the first calcium ion to the wild type was revealed. These observations showed that the first EF-hand in spectrin binds the first calcium ion and thereby triggers a conformational change that allows the second calcium ion to bind to the other EF-hand.
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| 7. |
- Edlund, Ann-Catrine, 1959-, et al.
(författare)
-
Språk och kön
- 2007
-
Bok (populärvet., debatt m.m.)
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| 8. |
- Edlund, Karolina, et al.
(författare)
-
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors
- 2012
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:24, s. 9551-9556
-
Tidskriftsartikel (refereegranskat)abstract
- Cancer mutation databases are expected to play central roles in personalized medicine by providing targets for drug development and biomarkers to tailor treatments to each patient. The accuracy of reported mutations is a critical issue that is commonly overlooked, which leads to mutation databases that include a sizable number of spurious mutations, either sequencing errors or passenger mutations. Here we report an analysis of the latest version of the TP53 mutation database, including 34,453 mutations. By using several data-driven methods on multiple independent quality criteria, we obtained a quality score for each report contributing to the database. This score can now be used to filter for high-confidence mutations and reports within the database. Sequencing the entire TP53 gene from various types of cancer using next-generation sequencing with ultradeep coverage validated our approach for curation. In summary, 9.7% of all collected studies, mostly comprising numerous tumors with multiple infrequent TP53 mutations, should be excluded when analyzing TP53 mutations. Thus, by combining statistical and experimental analyses, we provide a curated mutation database for TP53 mutations and a framework for mutation database analysis.
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| 9. |
- Edlund, Ulf, 1957-, et al.
(författare)
-
A composite ply failure model based on continuum damage mechanics
- 2004
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Ingår i: Composite structures. - : Elsevier BV. - 0263-8223 .- 1879-1085. ; 65:3-4, s. 347-355
-
Tidskriftsartikel (refereegranskat)abstract
- A material model including the failure behaviour is derived for a thin unidirectional (UD) composite ply. The model is derived within a thermodynamic framework and the failure behaviour is modelled using continuum damage mechanics. The following features describe the model: (i) The ply is assumed to be in a plane state of stress. (ii) Three damage variables associated with the stress in the fibre-, transverse and shear directions, respectively, are used. (iii) The plastic behaviour of the matrix material is modelled. (iv) The difference in the material response in tensile and compressive loading is modelled. (v) Rate dependent behavior of plasticity and damage (i.e. strength) is modelled.
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| 10. |
- Edlund, Ulf, et al.
(författare)
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A model of an adhesively bonded joint with elastic-plastic adherends and a softening adhesive
- 2009
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Ingår i: Computer Methods in Applied Mechanics and Engineering. - : Elsevier BV. - 0045-7825 .- 1879-2138. ; 198:5-8, s. 740-752
-
Tidskriftsartikel (refereegranskat)abstract
- This paper deals with the generalization of a model of an adhesively bonded joint with the aim to allow elastic-plastic adherends. In the model of the joint that we extend, the thinness of the bodies and the low Youngs modulus of the adhesive were used to obtain a simplified model where the parts are described as material surfaces. We formulate an elastic-plastic material model with isotropic hardening expressed in the generalized stress and strain measures used for the surface description of the joint. The finite element formulation and the numerical treatment of the constitutive law are discussed. Numerical results showing the accuracy of the proposed treatment of the adherends are presented. Two failure load computations, using a softening material model for the adhesive, are presented and compared with experiments. The results show the importance of taking into account potential plastic deformations in the adherends in failure load computations.
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| 11. |
- Edlund, Ulf, 1945-
(författare)
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Studier av 2-cykloaminoindener speciellt med hänsyn till prototropa omlagringar
- 1974
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is a short review of six papers (Papers 1-6,page 5) concerning studies of enamines from 2-indanones. The unusually stable 2-(N-pyrrolidyl)indene has been studied (Paper 2 ). As a base catalyst this enamine rearranges 1-methylindene to 3-methylindene with a lower rate constant compared with triethylamine. During this 1, 3-prototropic rearrangement no hydrogen exchange was observed (Paper 1).Special attention has been drawn to 1,3-rearrangements ofalkyl-substituted enamines of 2-indanone. From 1-methyl-2-indanone, which was most conveniently prepared by oxidation of the corresponding indene, a series of enamines has been prepared with varying amine components. A study of the kinetic control of the formation of these enamines showed that the less substituted double-bond isomer was formed more rapidly than the other form. Furthermore, the nature of the amine group has a significant influence on the composition of the equilibrium mixture observed, but the isomeric ratios obtained were unexpected in the light of earlier investigations of enamines from 2-methylcyclohexanone (Paper l).A 13C NMR study of these 2-cycloaminoindenes showed that introduction of a 1-methyl substituent caused a decrease in overlap but the magnitude of this perturbation was almost independent of the variation of the amine component. Furthermore, when using pyrrolidineor hexamethyleneimine as amine parts this decrease in overlap was of a comparable magnitude with the diminished conjugation noted in the 3-methyl isomers. However, when piperidine or morpholine was used the decreased delocalization was more pronounced in the 3-methyl tautomers compared with the 1-methyl analogues (Paper6).One isomer, 1-methyl-2-(N-piperidyl)indene, has been shown to undergo base- as well as acid-catalyzed 1,3-tautomerizations in pyridine solvent. The isomerization rates using 1,4-diazabicyclo-(2.2.2.)octane or quinuclidine as base catalysts were considerably slower than the rate of the acid-catalyzed reaction or the base-catalyzed rearrangement rates involving alkyl-substituted indenes as substrates. This retarding effect, caused by the amine group, is in agreement with differences in pKA values obtained via simple Hückel calculation (Paper 4).The reaction between pyrrolidine and 1-(2-indanylidene)indan--2-one has been investigated. Two possible mechanisms were suggested for the formation of products consisting of a linear dienamine and an indenyl-substituted enamine (9:1). In the main product, isolated by recrystallization, the indenyl substituent was shown to be twisted out of conjugation. This dienamine also underwent acid-catalyzed isomerization to form the enamine product (Paper 3).Convenient syntheses of the pharmacologically interesting N-substituted 2-aminoindanes have also been described. The perchlorate salts of the enamines were treated with sodium borohydride in methanol to afford the desired products (Paper 5).
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| 12. |
- Ekbäck, Gustav, et al.
(författare)
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The Effects of Platelet Rish Plasmapheresis in Total Hip Replacement Surgery on Platelet Activation Studied by Flow Cytometry
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Autologous platelet rich plasma (PRP) harvest with autotransfusion devices has been used for ten years in cardiac surgery and recently in orthopedics. Its influence on the outcome of surgery is still controversial, in part because of methodological difficulties in studying platelet function during surgery.Methods: Twenty patients undergoing primary total hip replacement (THR) were studied. Ten patients underwent an immediately preoperative platelet apheresis forming concentrated platelet rich plasma (c-PRP). Ten patients not undergoing apheresis were allocated to a control group. Platelet activation was evaluated as the population expressing P-Selektin on the surface of platelets in the c-PRP and in blood samples collected pre-, per- and postoperatively. The method used was flow cytometry.Results and Conclusions: There is a minor population of activated platelets circulating in the patient's blood with a highly significant difference between patients (p=0.005) with a range of 1-23 % in peroperative activation. PRP harvest did not significantly alter platelet activity. The platelet apheresis procedure did not inhibit platelet function in the c-PRP as judged by a high proportion of platelets that could be activated in ADP stimulation experiments (mean value±SD 86%±7.5%).The total number of platelets that could be activated in the c-PRP estimated as % ADP activated platelets x % sampled platelets in the c-PRP (total platelet yield), was non significantly correlated (r=-0.59, p<0.l) with postoperative bleeding, indicating a possible hemostatic effect of these platelets.
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| 13. |
- Ekbäck, Gustav, et al.
(författare)
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Tranexamic Acid Reduces Blood Loss in Total Hip Replacement Surgery
- 2000
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Ingår i: Anesthesia and Analgesia. - 0003-2999 .- 1526-7598. ; 91:5, s. 1124-1130
-
Tidskriftsartikel (refereegranskat)abstract
- Intraoperatively administered, tranexamic acid (TA) does not reduce bleeding in total hip replacement (THR). Therefore, its prophylactic use was attempted in the present study because this has been shown to be more effective in cardiac surgery. We investigated 40 patients undergoing THR in a prospective, randomized, double-blinded study. Twenty patients received TA given in two bolus doses of 10 mg/kg each, the first just before surgical incision and the second 3 h later. In addition, a continuous infusion of TA, 1.0 mg · kg−1 · h−1 for 10 h, was given after the first bolus dose. The remaining 20 patients formed a control group. Both groups used preoperative autologous blood donation and intraoperative autotransfusion. Intraoperative bleeding was significantly less (P = 0.001) in the TA group compared with the control group (630 ± 220 mL vs 850 ± 260 mL). Postoperative drainage bleeding was correspondingly less (P = 0.001) (520 ± 280 vs 920 ± 410 mL). Up to 10 h postoperatively, plasma D-dimer concentration was halved in the TA group compared with the control group. One patient in each group had an ultrasound-verified late deep vein thrombosis. In conclusion, we found TA, administrated before surgical incision, to be efficient in reducing bleeding during THR.
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| 14. |
- Ekman-Ordeberg, G, et al.
(författare)
-
Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro
- 2009
-
Ingår i: Acta Obstet Gynecol Scand. - : Wiley. ; 88:9, s. 984-989
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. DESIGN: Experimental in vitro study. SETTING: Lund University and Karolinska Institute, Sweden. METHODS: The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. MAIN OUTCOME MEASURES: Mean force and number of contractions in uterine smooth muscle strips and interleukin-8 (IL-8) secretion in cervical fibroblasts. RESULTS: Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. CONCLUSIONS: A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Elg Christoffersson, Kristina, et al.
(författare)
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Reactivity of dissolving pulp: characterisation using chemical properties, NMR spectroscopy and multivariate data analysis
- 2002
-
Ingår i: Cellulose. ; 9:2, s. 159-70
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Tidskriftsartikel (refereegranskat)abstract
- The reactivity of dissolving pulp was experimentally determined in termsof residual cellulose in viscose. The correlations between 11 chemicalproperties of pulp and filter values and residual cellulose contents of viscosewere then investigated by multivariate data analysis. Both the viscose filtervalue and the residual cellulose were well modelled from the 11 propertiesby partial least squares regression. The results show that pulps with highacetone extractable fractions, high magnesium contents, low alkali resistanceand low viscosity, gave low viscose filter values and low residual cellulosecontents. Pulps with low residual cellulose contents also had low carboxylgroupcontents and low polydispersity. The results are interpreted as that in pulpwith high reactivity, the hemicellulose content is low and that the cellulosechains are shorter and more soluble in alkali. An explanation of the positiveeffect from the high extractive content is that the extractives facilitate thediffusion of carbon disulfide. A principal component analysis of CP/MAS13C-NMR spectral data of six pulp samples showed that differences inreactivity between the pulps could be explained by variations in the hydrogenbonds in the cellulose and/or changes in the glucosidic bonds. In a separatestudy electron beam processing enhanced the reactivity, i.e. lowered theresidual cellulose content, of the investigated pulps. The magnitude of theelectron dose, within the tested range (5.4–23.7 kGy), didnotseem to be important, but the reactivity within pulp sheets tended to be ratherinhomogeneous.
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| 19. |
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| 20. |
- Fahlgren, Anna, et al.
(författare)
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Direct ex vivo measurement of the fluid permeability of loose scar tissue
- 2012
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Ingår i: Acta of Bioengineering and Biomechanics. - Wroclaw, Poland : Wroclaw University of Technology. - 1509-409X. ; 14:2, s. 47-51
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Tidskriftsartikel (refereegranskat)abstract
- Fluid flow is important in many biomechanical models, but there is a lack of experimental data that quantifies soft tissue permeability. We measured the tissue permeability in fibrous soft tissue, using a novel technique to obtain specimens by allowing soft tissue to grow into coralline hydroxyapatite scaffoldings implanted between the abdominal muscle layers of rats.
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| 21. |
- Fahlgren, Anna, et al.
(författare)
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Fluid pressure and flow as a cause of bone resorption
- 2010
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Ingår i: Acta Orthopaedica. - : Taylor & Francis. - 1745-3674 .- 1745-3682. ; 81:4, s. 508-516
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Tidskriftsartikel (refereegranskat)abstract
- Background Unstable implants in bone become surrounded by an osteolytic zone. This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability. Method To understand the roles of pressure and flow, we describe the 3-dimensional distribution of osteolytic lesions in response to fluid pressure and flow in a previously reported rat model of aseptic loosening. 50 rats had a piston inserted in the proximal tibia, designed to produce 20 local spikes in fluid pressure of a clinically relevant magnitude (700 mmHg) twice a day. The spikes lasted for about 0.3 seconds. After 2 weeks, the pressure was measured in vivo, and the osteolytic lesions induced were studied using micro-CT scans. Results Most bone resorption occurred at pre-existing cavities within the bone in the periphery around the pressurized region, and not under the piston. This region is likely to have a higher fluid flow and less pressure than the area just beneath the piston. The velocity of fluid flow was estimated to be very high (roughly 20 mm/s). Interpretation The localization of the resorptive lesions suggests that high-velocity fluid flow is important for bone resorption induced by instability.
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| 22. |
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| 23. |
- Gromov, SP, et al.
(författare)
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Novel supramolecular charge-transfer systems based on bis(18-crown-6)stilbene and viologen analogues bearing two ammonioalkyl groups
- 2005
-
Ingår i: NEW JOURNAL OF CHEMISTRY. - : Royal Society of Chemistry (RSC). - 1144-0546 .- 1369-9261. ; 29:7, s. 881-94
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Tidskriftsartikel (refereegranskat)abstract
- A series of new viologen analogues bearing two ammonioalkyl groups (2-4) were synthesized in order to study their complexation with bis(18-crown-6)stilbene (1b). Electronic spectroscopy and H-1 NMR measurements show that in acetonitrile, bis( crown) stilbene 1b forms highly stable 1 : 1 and 2 : 1 charge-transfer (CT) complexes with pi-acceptors 2-4 owing to host-guest bonding. The influence of geometric and electronic factors on the complex formation constants are discussed. The structures of the supramolecular CT complexes are analyzed on the basis of H-1 and C-13 NMR data obtained in solution and in the solid state. X-Ray diffraction data for 1b and for model tetramethoxystilbene are also reported.
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| 24. |
- Gromov, Sergey P, et al.
(författare)
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Novel Photoswitchable Receptors: Synthesis and Cation-Induced Self-Assembly into Dimeric Complexes Leading to Stereospecific [2+2]-Photocycloaddition of Styryl Dyes Containing a 15-Crown-5 Ether Unit
- 2003
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Ingår i: The Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 68:16, s. 6115-25
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Tidskriftsartikel (refereegranskat)abstract
- Styryl dyes 4a-e containing a 15-crown-5 ether unit and a quinoline residue with a sulfonatoalkyl or sulfonatobenzyl N-substituent were synthesized. The relationship between the photochemical behavior of these dyes and their aggregates derived from complexation with Mg2+ in MeCN was studied using 1H NMR and absorption spectroscopy. The E-isomers of 4a-e were shown to form highly stable dimeric (2:2) complexes with Mg2+. Upon irradiation with visible light, the dimeric complexes undergo two competing photoreactions, viz., geometric E Z isomerization, resulting in an anion-capped 1:1 complex of the Z-isomer with Mg2+ and stereospecific syn-head-to-tail [2+2]-cycloaddition, affording a single isomer of bis-crown-containing cyclobutane. The N-substituent in the dye has a dramatic effect on the photochemical behavior of the dimeric complex. Molecular dynamics and semiempirical quantum-chemical calculations were carried out to interpret the observed photocycloaddition in the dimer. Conformational equilibria for the dimer of (E)-4b were analyzed using 1H NMR spectroscopy.
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| 25. |
- Gromov, S P, et al.
(författare)
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Self-assembly of a (benzothiazolyl)ethenylbenzocrown ether into a sandwich complex and stereoselective [2+2] photocycloaddition
- 2005
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Ingår i: RUSSIAN CHEMICAL BULLETIN. - : Springer Science and Business Media LLC. - 1066-5285 .- 1573-9171. ; 54:7, s. 1569-79
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Tidskriftsartikel (refereegranskat)abstract
- In the presence of Ba2+ ions, (benzothiazolyl)ethenylbenzocrown ether forms the stable sandwich complex 2L center dot Ba2+ with an unusual structure, in which the benzothiazole fragments are arranged one above the other. Irradiation of the sandwich complex with visible light induces stereoselective [2+2] cycloaddition giving rise to two "head-to-head" isomers of biscrown-cyclobutane. The addition of dibasic dicarboxylic acids that additionally stabilize the sandwich complex in a favorable conformation affects the isomer ratio of the cyclobutanes formed. The conformational equilibria for the sandwich complex and cyclobutanes were studied by H-1 N MR spectroscopy.
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