| 1. |
- Aad, G., et al.
(författare)
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Integrated and differential fiducial cross-section measurements for the vector boson fusion production of the Higgs boson in the H → WW* → eνμν decay channel at 13 TeV with the ATLAS detector
- 2023
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 108:7
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Tidskriftsartikel (refereegranskat)abstract
- The vector-boson production cross section for the Higgs boson decay in the H→WW*→eνμν channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at √s=13 TeV center-of-mass energy, corresponding to an integrated luminosity of 139 fb−1. The different flavor final state is studied by selecting an electron and a muon originating from a pair of W bosons and compatible with the Higgs boson decay. The data are corrected for the effects of detector inefficiency and resolution, and the measurements are compared with different state-of-the-art theoretical predictions. The differential cross sections are used to constrain anomalous interactions described by dimension-six operators in an effective field theory.
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| 2. |
- Aad, G., et al.
(författare)
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Measurement of the Sensitivity of Two-Particle Correlations in pp Collisions to the Presence of Hard Scatterings
- 2023
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 131:16
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Tidskriftsartikel (refereegranskat)abstract
- A key open question in the study of multiparticle production in high-energy pp collisions is the relationship between the “ridge”—i.e., the observed azimuthal correlations between particles in the underlying event that extend over all rapidities—and hard or semihard scattering processes. In particular, it is not known whether jets or their soft fragments are correlated with particles in the underlying event. To address this question, two-particle correlations are measured in pp collisions at √s=13 TeV using data collected by the ATLAS experiment at the LHC, with an integrated luminosity of 15.8 pb−1, in two different configurations. In the first case, charged particles associated with jets are excluded from the correlation analysis, while in the second case, correlations are measured between particles within jets and charged particles from the underlying event. Second-order flow coefficients, v2, are presented as a function of event multiplicity and transverse momentum. These measurements show that excluding particles associated with jets does not affect the measured correlations. Moreover, particles associated with jets do not exhibit any significant azimuthal correlations with the underlying event, ruling out hard processes contributing to the ridge.
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| 3. |
- Aad, G., et al.
(författare)
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Observation of Single-Top-Quark Production in Association with a Photon Using the ATLAS Detector
- 2023
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Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 131:18
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Tidskriftsartikel (refereegranskat)abstract
- This Letter reports the observation of single top quarks produced together with a photon, which directly probes the electroweak coupling of the top quark. The analysis uses 139 fb−1 of 13 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider. Requiring a photon with transverse momentum larger than 20 GeV and within the detector acceptance, the fiducial cross section is measured to be 688±23(stat) , to be compared with the standard model prediction of at next-to-leading order in QCD.
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| 4. |
- Aad, G, et al.
(författare)
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Electron and photon energy calibration with the ATLAS detector using LHC Run 2 data
- 2024
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Ingår i: Journal of Instrumentation. - : Institute of Physics. - 1748-0221. ; 19:2
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the electron and photon energy calibration obtained with the ATLAS detector using 140 fb−1 of LHC proton-proton collision data recorded at √s = 13 TeV between 2015 and 2018. Methods for the measurement of electron and photon energies are outlined, along with the current knowledge of the passive material in front of the ATLAS electromagnetic calorimeter. The energy calibration steps are discussed in detail, with emphasis on the improvements introduced in this paper. The absolute energy scale is set using a large sample of Z-boson decays into electron-positron pairs, and its residual dependence on the electron energy is used for the first time to further constrain systematic uncertainties. The achieved calibration uncertainties are typically 0.05% for electrons from resonant Z-boson decays, 0.4% at ET ∼ 10 GeV, and 0.3% at ET ∼ 1 TeV; for photons at ET ∼ 60 GeV, they are 0.2% on average. This is more than twice as precise as the previous calibration. The new energy calibration is validated using J/ → ee and radiative Z-boson decays. © 2024 Institute of Physics. All rights reserved.
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| 5. |
- Aad, G, et al.
(författare)
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Measurement of Suppression of Large-Radius Jets and Its Dependence on Substructure in Pb+Pb Collisions at √sNN=5.02 TeV with the ATLAS Detector
- 2023
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Ingår i: Physical Review Letters. - 1079-7114. ; 131:17
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Tidskriftsartikel (refereegranskat)abstract
- This letter presents a measurement of the nuclear modification factor of large-radius jets in Formula Presented Formula Presented collisions by the ATLAS experiment. The measurement is performed using Formula Presented and Formula Presented of Formula Presented and Formula Presented data, respectively. The large-radius jets are reconstructed with the anti-Formula Presented algorithm using a radius parameter of Formula Presented, by reclustering anti-Formula Presented Formula Presented jets, and are measured over the transverse momentum (Formula Presented) kinematic range of Formula Presented and absolute pseudorapidity Formula Presented. The large-radius jet constituents are further reclustered using the Formula Presented algorithm in order to obtain the splitting parameters, Formula Presented and Formula Presented, which characterize the transverse momentum scale and angular separation for the hardest splitting in the jet, respectively. The nuclear modification factor, Formula Presented, obtained by comparing the Formula Presented jet yields to those in Formula Presented collisions, is measured as a function of jet transverse momentum (Formula Presented) and Formula Presented or Formula Presented. A significant difference in the quenching of large-radius jets having single subjet and those with more complex substructure is observed. Systematic comparison of jet suppression in terms of Formula Presented for different jet definitions is also provided. Presented results support the hypothesis that jets with hard internal splittings lose more energy through quenching and provide a new perspective for understanding the role of jet structure in jet suppression. © 2023 CERN, for the ATLAS Collaboration.
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| 6. |
- Aad, G., et al.
(författare)
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Study of High-Transverse-Momentum Higgs Boson Production in Association with a Vector Boson in the qqbb Final State with the ATLAS Detector
- 2024
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Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 132:13
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Tidskriftsartikel (refereegranskat)abstract
- This Letter presents the first study of Higgs boson production in association with a vector boson (V ¼ W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at √s = 13 TeV and corresponding to an integrated luminosity of 137 fb−1. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb̄. Dominant backgrounds from multijet production are determined directly from the data, and a likelihood fit to the jet mass distribution of Higgs boson candidates is used to extract the number of signal events. The VH production cross section is measured inclusively and differentially in several ranges of Higgs boson transverse momentum: 250–450, 450–650, and greater than 650 GeV. The inclusive signal yield relative to the standard model expectation is observed to be μ = 1.4+1.0−0.9 and the corresponding cross section is 3.1 ± 1.3(stat)+1.8−1.4(syst) pb. © 2024 CERN, for the ATLAS Collaboration.
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| 7. |
- Berg, Carlo, et al.
(författare)
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Dissection of Microbial Community Functions during a Cyanobacterial Bloom in the Baltic Sea via Metatranscriptomics
- 2018
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Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745.
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Tidskriftsartikel (refereegranskat)abstract
- Marine and brackish surface waters are highly dynamic habitats that undergo repeated seasonal variations in microbial community composition and function throughout time. While succession of the various microbial groups has been well investigated, little is known about the underlying gene-expression of the microbial community. We investigated microbial interactions via metatranscriptomics over a spring to fall seasonal cycle in the brackish Baltic Sea surface waters, a temperate brackish water ecosystem periodically promoting massive cyanobacterial blooms, which have implications for primary production, nutrient cycling, and expansion of hypoxic zones. Network analysis of the gene expression of all microbes from 0.22 to 200 mu m in size and of the major taxonomic groups dissected the seasonal cycle into four components that comprised genes peaking during different periods of the bloom. Photoautotrophic nitrogen-fixing Cyanobacteria displayed the highest connectivity among the microbes, in contrast to chemoautotrophic ammonia-oxidizing Thaumarchaeota, while heterotrophs dominated connectivity among pre- and post-bloom peaking genes. The network was also composed of distinct functional connectivities, with an early season balance between carbon metabolism and ATP synthesis shifting to a dominance of ATP synthesis during the bloom, while carbon degradation, specifically through the glyoxylate shunt, characterized the post-bloom period, driven by Alphaproteobacteria as well as by Gammaproteobacteria of the SAR86 and SAR92 clusters. Our study stresses the exceptionally strong biotic driving force executed by cyanobacterial blooms on associated microbial communities in the Baltic Sea and highlights the impact cyanobacterial blooms have on functional microbial community composition.
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| 8. |
- Dupont, Chris L., et al.
(författare)
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Functional Tradeoffs Underpin Salinity-Driven Divergence in Microbial Community Composition
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2, s. e89549-
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Tidskriftsartikel (refereegranskat)abstract
- Bacterial community composition and functional potential change subtly across gradients in the surface ocean. In contrast, while there are significant phylogenetic divergences between communities from freshwater and marine habitats, the underlying mechanisms to this phylogenetic structuring yet remain unknown. We hypothesized that the functional potential of natural bacterial communities is linked to this striking divide between microbiomes. To test this hypothesis, metagenomic sequencing of microbial communities along a 1,800 km transect in the Baltic Sea area, encompassing a continuous natural salinity gradient from limnic to fully marine conditions, was explored. Multivariate statistical analyses showed that salinity is the main determinant of dramatic changes in microbial community composition, but also of large scale changes in core metabolic functions of bacteria. Strikingly, genetically and metabolically different pathways for key metabolic processes, such as respiration, biosynthesis of quinones and isoprenoids, glycolysis and osmolyte transport, were differentially abundant at high and low salinities. These shifts in functional capacities were observed at multiple taxonomic levels and within dominant bacterial phyla, while bacteria, such as SAR11, were able to adapt to the entire salinity gradient. We propose that the large differences in central metabolism required at high and low salinities dictate the striking divide between freshwater and marine microbiomes, and that the ability to inhabit different salinity regimes evolved early during bacterial phylogenetic differentiation. These findings significantly advance our understanding of microbial distributions and stress the need to incorporate salinity in future climate change models that predict increased levels of precipitation and a reduction in salinity.
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| 9. |
- Ekman, Alexander
(författare)
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Searches for New Physics Using Innovative Data Acquisition, Analysis, and Compression Techniques
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The high event rate delivered by the Large Hadron Collider (LHC) provides experiments with opportunities for new discoveries as well as challenges related to the large amounts of data recorded. Overcoming this requires innovative techniques in the three topics of this thesis: Data acquisition, data analysis, and data compression.In the data taking period of 2015-2018, the ATLAS experiment received 10-70 simultaneous proton-proton collision events every 25 ns. At these high event rates, the experiment relies on trigger methods which only process the interesting collision events and keep detector readout and data storage within bandwidth constraints. The Trigger Level Analysis (TLA) presented in this thesis circumvents these bandwidth constraints by using the smaller event objects reconstructed at the trigger level as input to the analysis. The trigger level objects require custom calibration schemes, one of these was developed as part of this thesis to be used in the current and next iterations of the analysis.The LHC is scheduled to be upgraded to the High Luminosity LHC (HL-LHC) and deliver 200 simultaneous proton-proton collision events. To provide the necessary resolution, readout speed, and radiation hardness, the ATLAS Inner Detector will be upgraded to the new fully silicon-based Inner Tracker (ITk). This thesis presents the work performed in developing, manufacturing, and delivering an automated quality control system for the new detector modules. Quality testing of the detector modules using this system is currently ongoing at multiple international institutes.The large amount of simultaneous events provided by the HL-LHC will also be challenging for data storage, where the amount of ATLAS generated data is projected to be 5 times larger than the storage resources. As the data are already highly compressed using lossless methods, the work in this thesis presents proof-of-principle studies using machine learning-based methods to derive lossy compression algorithms tailored to a variety of datasets. The tool developed for this purpose is made available as an open-source project called "Baler".
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| 10. |
- Franzén, Erika, et al.
(författare)
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The EXPANd trial : effects of exercise and exploring neuroplastic changes in people with Parkinson's disease
- 2019
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Ingår i: BMC Neurology. - : Springer Science and Business Media LLC. - 1471-2377. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Parkinson's disease (PD) affects many physiological systems essential for balance control. Recent studies suggest that intensive and cognitively demanding physical exercise programs are capable of inducing plastic brain changes in PD. We have developed a highly challenging balance training (the HiBalance) program that emphasizes critical aspects of balance control through progressively introducing more challenging exercises which incorporates dual-tasking. Earlier studies have shown it to be effective in improving balance, gait and dual-tasking. The study design has thereafter been adjusted to link intervention-induced behavioral changes to brain morphology and function. Specifically, in this randomized controlled trial, we will determine the effects of the HiBalance program on balance, gait and cognition and relate this to task-evoked functional MRI (fMRI), as well as brain-derived neurotrophic factor (BDNF) in participants with mild-moderate PD.Methods: One hundred participants with idiopathic PD, Hoehn & Yahr stage 2 or 3, >= 60 years of age, >= 21 on Montreal Cognitive Assessment will be recruited in successive waves and randomized into either the HiBalance program or to an active control group (the HiCommunication program, targeting speech and communication). Both interventions will be performed in small groups, twice a week with 1 h sessions for 10 weeks. In addition, a 1 h, once a week, home exercise program will also be performed. A double-blinded design will be used. At the pre- and post-assessments, participants will be assessed on balance (main outcome), gait, cognitive functions, physical activity, voice/speech function, BDNF in serum and fMRI (3 T Philips) during performance of motor-cognitive tasks.Discussion: Since there is currently no cure for PD, findings of neuroplastic brain changes in response to exercise would revolutionize the way we treat PD, and, in turn, provide new hope to patients for a life with better health, greater independence and improved quality of life.
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| 11. |
- Freidle, Malin, et al.
(författare)
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Measuring implicit sequence learning and dual task ability in mild to moderate Parkinson's disease: A feasibility study
- 2021
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:5
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the feasibility aspects of two choice reaction time tasks designed to assess implicit sequence learning and dual task ability in individuals with mild to moderate Parkinson's disease in comparison to healthy individuals. Twelve individuals with mild to moderate Parkinson's disease and 12 healthy individuals, all . 60 years of age, were included. A serial reaction time task was used as a measure of implicit sequence learning and a similar task but with the addition of a simple counting task, was used as a measure of dual task ability. We have present thorough descriptive statistics of the data but we have refrained from any inferential statistics due to the small sample size. All participants understood the task instructions and the difficulty level of both tasks was deemed acceptable. There were indications of task fatigue that demand careful choices for how best to analyse the data from such tasks in future trials. Ceiling effects were present in several accuracy outcomes, but not in the reaction time outcomes. Overall, we found both tasks to be feasible to use in samples of individuals with mild to moderate Parkinson's disease and healthy older individuals.
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| 12. |
- Mullier, Geoffrey A., et al.
(författare)
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Measurement of the Higgs boson mass with H →†’ γγ decays in 140 fb-1 of √ˆšs=13 TeV pp collisions with the ATLAS detector
- 2023
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 847
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Tidskriftsartikel (refereegranskat)abstract
- The mass of the Higgs boson is measured in the H -> γγ decay channel, exploiting the high resolution of the invariant mass of photon pairs reconstructed from the decays of Higgs bosons produced in proton-proton collisions at a centre-of-mass energy √s = 13 TeV. The dataset was collected between 2015 and 2018 by the ATLAS detector at the Large Hadron Collider, and corresponds to an integrated luminosity of 140 fb-1. The measured value of the Higgs boson mass is 125.17 ± 0.11 (stat.) ± 0.09 (syst.) GeV and is based on an improved energy scale calibration for photons, whose impact on the measurement is about four times smaller than in the previous publication. A combination with the corresponding measurement using 7 and 8 TeV pp collision ATLAS data results in a Higgs boson mass measurement of 125.22 ± 0.11 (stat.) ± 0.09 (syst.) GeV. With an uncertainty of 1.1 per mille, this is currently the most precise measurement of the mass of the Higgs boson from a single decay channel.
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| 13. |
- Mullier, Geoffrey A., et al.
(författare)
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Measurements of the suppression and correlations of dijets in Xe+Xe collisions at √SNN=5.44 TeV
- 2023
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 108:2
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the suppression and correlations of dijets is performed using 3 μb-1 of Xe+Xe data at √sNN = 5.44 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Dijets with jets reconstructed using the R = 0.4 anti-kt algorithm are measured differentially in jet pT over the range of 32 to 398 GeV and the centrality of the collisions. Significant dijet momentum imbalance is found in the most central Xe+Xe collisions, which decreases in more peripheral collisions. Results from the measurement of per-pair normalized and absolutely normalized dijet p(T) balance are compared with previous Pb+Pb measurements at √sNN = 5.02 TeV. The differences between the dijet suppression in Xe+Xe and Pb+Pb are further quantified by the ratio of pair nuclear-modification factors. The results are found to be consistent with those measured in Pb+Pb data when compared in classes of the same event activity and when taking into account the difference between the center-of-mass energies of the initial parton scattering process in Xe+Xe and Pb+Pb collisions. These results should provide input for a better understanding of the role of energy density, system size, path length, and fluctuations in the parton energy loss.
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| 14. |
- Mullier, Geoffrey A., et al.
(författare)
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Search for lepton-flavour violation in high-mass dilepton final states using 139 fb-1 of pp collisions at √ˆšs=13 TeV with the ATLAS detector
- 2023
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479.
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Tidskriftsartikel (refereegranskat)abstract
- A search is performed for a heavy particle decaying into different-flavour, dilepton final states, using 139 fb-1 of proton-proton collision data at √s = 13TeV collected in 2015-2018 by the ATLAS detector at the Large Hadron Collider. Final states with electrons, muons and hadronically decaying tau leptons are considered (eμ, eτ or μτ). No significant excess over the Standard Model predictions is observed. Upper limits on the production cross-section are set as a function of the mass of a Z' boson, a supersymmetric τ-sneutrino, and a quantum black-hole. The observed 95% CL lower mass limits obtained on a typical benchmark model Z' boson are 5.0TeV (eμ), 4.0TeV (eτ), and 3.9TeV (μτ), respectively.
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| 15. |
- Mullier, Geoffrey A., et al.
(författare)
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Search for the decay of the Higgs boson to a Z boson and a light pseudoscalar particle decaying to two photons
- 2024
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 850
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Tidskriftsartikel (refereegranskat)abstract
- A search for the decay of the Higgs boson to a ? boson and a light, pseudoscalar particle, ?, decaying respectively to two leptons and to two photons is reported. The search uses the full LHC Run 2 proton–proton collision data at √? = 13 TeV, corresponding to 139 fb−1 collected by the ATLAS detector. This is one of the first searches for this specific decay mode of the Higgs boson, and it probes unexplored parameter space in models with axion-likeparticles (ALPs) and extended scalar sectors. The mass of the ? particle is assumed to be in the range 0.1–33 GeV. The data are analysed in two categories: a merged category where the photons from the ? decay are reconstructedin the ATLAS calorimeter as a single cluster, and a resolved category in which two separate photons are detected. The main background processes are from Standard Model ? boson production in association with photons orjets. The data are in agreement with the background predictions, and upper limits on the branching ratio of the Higgs boson decay to ?? times the branching ratio ? → ?? are derived at the 95% confidence level and theyrange from 0.08% to 2% depending on the mass of the ? particle. The results are also interpreted in the contextof ALP models.
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| 16. |
- Nilsson, Håkan, 1967-
(författare)
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Utvecklingsförmåga : En relationell process mellan ledning och arbetarkollektiv
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focal point of this thesis is an interest in workplace development and how the relationship between managers and workers affects an organization’s ability to develop its way of working. The aim of the study is to contribute to debates on workplace development away from Tayloristic principles based on a strict division of labour and to investigate how to manage the well-documented consequences of such principles, low productivity and lack of engagement from employees. The aim is also to discuss how workplace relations founded on such principles can be changed and to elaborate on the benefits from such a change.In order to do so two lines of inquiry have guided the research process and formulation of research questions. The first examines how the relationship between managers and workers affects the organization’s ability to undertake organizational development. The second focuses on how the relationship between managers and workers can be configured to support organizational development.To find answers to these lines of inquiry an action research project was initiated in the same organization where the author has been working for more than twenty years: the research is conducted on his own practice as a change agent. In his job as an in-house trainer he met members of a part of the organization where the employees described their history as a quite dysfunctional workplace, yet at the same time they claimed it is “much better now”. The story caught the author’s interest which led to an agreement that an insider action research project was conducted in that part of the organization.For one year the author participated in the organization with a twofold purpose: first, to find answers to the research questions and second to support the organization in its ongoing challenges. Through dialogue and interviews, at both individual and group levels, a historical story of the workplace and its functioning “a long time ago” was built up. An informal system was identified whereby workers strove to secure what the thesis calls a “workless salary”, that is, to do as little as possible and still get full pay. This situation was later compared to the situation that emerged during the time of the intervention. The latter was a very different situation with high productivity and high levels of job satisfaction. The differences between the two work situations over time were obvious. This prompted the next part of the study, namely an investigation into how the development work had been achieved.The study concerns multiple levels and disciplines, which is common in action research. The result shows that workers’ ability to influence their own work situation along with growing arenas for discussions of work experience made the development possible and that a reflexive dialogue combined with a practice-oriented relational leadership can influence ways of working in practice that are conducive to workplace development. These four factors are presented in the thesis as constituting a platform for the workplace to develop better ways of working.Organizational change, Organizational development, Workplace science, Action research
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| 17. |
- Rao, Shuan, et al.
(författare)
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RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
- 2017
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Ingår i: Genes & Development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 31:20, s. 2099-2112
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Tidskriftsartikel (refereegranskat)abstract
- Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas(G12D) in mouse lung epithelial cells markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis in human and murine lung cancer cells and promotes expansion of lung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration. Our data also indicate survival differences in KRas(G12D)-driven lung cancer between male and female mice, and we show that female sex hormones can promote lung cancer progression via the RANK pathway. These data uncover a direct role for RANK in lung cancer and may explain why female sex hormones accelerate lung cancer development. Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer.
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| 18. |
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| 19. |
- Thompson, Paul M., et al.
(författare)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 20. |
- Zamora, Juan Carlos, et al.
(författare)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Tidskriftsartikel (refereegranskat)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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