| 1. |
- Eliasson, Ann-Christin, 1950-, et al.
(författare)
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The effectiveness of Baby-CIMT in infants younger than 12 months with clinical signs of unilateral-cerebral palsy : an explorative study with randomized design
- 2018
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Ingår i: Research in Developmental Disabilities. - : Elsevier. - 0891-4222 .- 1873-3379. ; 72, s. 191-201
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To explore the effectiveness of baby-CIMT (constraint-induced movement therapy) and baby-massage for improving the manual ability of infants younger than 12 months with unilateral cerebral palsy (CP).METHOD: Infants eligible for inclusion were 3-8 months old with asymmetric hand function and at high risk of developing unilateral CP. Thirty-seven infants were assigned randomly to receive baby-CIMT or baby-massage. At one year of age 31 children were diagnosed with unilateral CP, 18 (8 boys, 6.1±1.7months) of these had received baby-CIMT and 13 (8 boys, 5.0±1.6months) baby-massage. There were two 6-week training periods separated by a 6-week pause. The Hand Assessment for Infants (HAI), Assisting Hand Assessment (AHA), the Parenting Sense of Competence Scale (PSCS) and a questionnaire concerning feasibility were applied.RESULTS: There was improvement in the "Affected hand score" of HAI from median 10 (6;13 IQR) to 13 (7;17 IQR) raw score in the baby-CIMT group and from 5 (4;11 IQR) to 6 (3;12 IQR) for baby-massage with a significant between group difference (p=0.041). At 18-month of age, the median AHA score were 51 (38;72 IQR) after baby-CIMT (n=18) compared to 24 (19;43 IQR) baby-massage (n=9). The PSCS revealed an enhanced sense of competence of being a parent among fathers in the baby-CIMT group compared to fathers in the baby-massage (p=0.002). Parents considered both interventions to be feasible.CONCLUSION: Baby-CIMT appears to improve the unimanual ability of young children with unilateral CP more than massage.
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| 2. |
- Islam, Mominul, et al.
(författare)
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Is outcome of constraint-induced movement therapy in unilateral cerebral palsy dependent on corticomotor projection pattern and brain lesion characteristics?
- 2014
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Ingår i: Developmental Medicine & Child Neurology. - : Mac Keith Press. - 0012-1622 .- 1469-8749. ; 56:3, s. 252-258
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The aim of the study was to explore individual variations in outcome of hand function after constraint-induced movement therapy (CIMT) in relation to the organization of corticomotor projection and brain lesion characteristics in participants with unilateral cerebral palsy (CP).METHOD: Sixteen participants (eight males, eight females; mean age 13 y, [SD 2 y] range 10-16 y) with unilateral CP (nine right-sided; Manual Ability Classification System [MACS] level I, n=1; level II, n=15) who participated in a 2-week CIMT day camp (63 h) were included in the study. Various aspects of hand function were measured by the Jebsen-Taylor Hand Function Test (JTHFT), the Assisting Hand Assessment (AHA), and the Melbourne Assessment, both before and after the day camp. Transcranial magnetic stimulation was used to explore the corticomotor organization, and brain lesion characteristics were described by visual assessment of conventional structural magnetic resonance images.RESULTS: At a group level, the training was associated with significant improvements in JTHFT (p=0.003) and AHA (p=0.046), but not in Melbourne Assessment scores. Improvements were found in all types of corticomotor projection patterns, i.e. contralateral, mixed, and ipsilateral. There was no relationship between functional improvement and brain lesion characteristics.INTERPRETATION: Individuals with CP experience improved motor outcomes after CIMT, independent of corticomotor projection pattern and lesion characteristics.
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| 3. |
- Novak, Iona, et al.
(författare)
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Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy : Advances in Diagnosis and Treatment
- 2017
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Ingår i: JAMA pediatrics. - : American Medical Association. - 2168-6203 .- 2168-6211. ; 171:9, s. 897-907
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Forskningsöversikt (refereegranskat)abstract
- Importance: Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age.Objectives: To systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function.Evidence Review: This study systematically searched the literature about early diagnosis of cerebral palsy in MEDLINE (1956-2016), EMBASE (1980-2016), CINAHL (1983-2016), and the Cochrane Library (1988-2016) and by hand searching. Search terms included cerebral palsy, diagnosis, detection, prediction, identification, predictive validity, accuracy, sensitivity, and specificity. The study included systematic reviews with or without meta-analyses, criteria of diagnostic accuracy, and evidence-based clinical guidelines. Findings are reported according to the PRISMA statement, and recommendations are reported according to the Appraisal of Guidelines, Research and Evaluation (AGREE) II instrument.Findings: Six systematic reviews and 2 evidence-based clinical guidelines met inclusion criteria. All included articles had high methodological Quality Assessment of Diagnostic Accuracy Studies (QUADAS) ratings. In infants, clinical signs and symptoms of cerebral palsy emerge and evolve before age 2 years; therefore, a combination of standardized tools should be used to predict risk in conjunction with clinical history. Before 5 months' corrected age, the most predictive tools for detecting risk are term-age magnetic resonance imaging (86%-89% sensitivity), the Prechtl Qualitative Assessment of General Movements (98% sensitivity), and the Hammersmith Infant Neurological Examination (90% sensitivity). After 5 months' corrected age, the most predictive tools for detecting risk are magnetic resonance imaging (86%-89% sensitivity) (where safe and feasible), the Hammersmith Infant Neurological Examination (90% sensitivity), and the Developmental Assessment of Young Children (83% C index). Topography and severity of cerebral palsy are more difficult to ascertain in infancy, and magnetic resonance imaging and the Hammersmith Infant Neurological Examination may be helpful in assisting clinical decisions. In high-income countries, 2 in 3 individuals with cerebral palsy will walk, 3 in 4 will talk, and 1 in 2 will have normal intelligence.Conclusions and Relevance: Early diagnosis begins with a medical history and involves using neuroimaging, standardized neurological, and standardized motor assessments that indicate congruent abnormal findings indicative of cerebral palsy. Clinicians should understand the importance of prompt referral to diagnostic-specific early intervention to optimize infant motor and cognitive plasticity, prevent secondary complications, and enhance caregiver well-being.
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| 4. |
- Abdellaoui, G., et al.
(författare)
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Science and mission status of EUSO-SPB2
- 2022
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Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The Extreme Universe Space Observatory on a Super Pressure Balloon II (EUSO-SPB2) is a second generation stratospheric balloon instrument for the detection of Ultra High Energy Cosmic Rays (UHECRs, E > 1 EeV) via the fluorescence technique and of Very High Energy (VHE, E > 10 PeV) neutrinos via Cherenkov emission. EUSO-SPB2 is a pathfinder mission for instruments like the proposed Probe Of Extreme Multi-Messenger Astrophysics (POEMMA). The purpose of such a space-based observatory is to measure UHECRs and UHE neutrinos with high statistics and uniform exposure. EUSO-SPB2 is designed with two Schmidt telescopes, each optimized for their respective observational goals. The Fluorescence Telescope looks at the nadir to measure the fluorescence emission from UHECR-induced extensive air shower (EAS), while the Cherenkov Telescope is optimized for fast signals (∼10 ns) and points near the Earth's limb. This allows for the measurement of Cherenkov light from EAS caused by Earth skimming VHE neutrinos if pointed slightly below the limb or from UHECRs if observing slightly above. The expected launch date of EUSO-SPB2 is Spring 2023 from Wanaka, NZ with target duration of up to 100 days. Such a flight would provide thousands of VHECR Cherenkov signals in addition to tens of UHECR fluorescence tracks. Neither of these kinds of events have been observed from either orbital or suborbital altitudes before, making EUSO-SPB2 crucial to move forward towards a space-based instrument. It will also enhance the understanding of potential background signals for both detection techniques. This contribution will provide a short overview of the detector and the current status of the mission as well as its scientific goals.
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| 5. |
- Bagheri, Mahdi, et al.
(författare)
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Overview of Cherenkov Telescope on-board EUSO-SPB2 for the Detection of Very-High-Energy Neutrinos
- 2022
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- We present the status of the development of a Cherenkov telescope to be flown on a long-duration balloon flight, the Extreme Universe Space Observatory Super Pressure Balloon 2 (EUSO-SPB2). EUSO-SPB2 is an approved NASA balloon mission that is planned to fly in 2023 and is a precursor of the Probe of Extreme Multi-Messenger Astrophysics (POEMMA), a candidate for an Astrophysics probe-class mission. The purpose of the Cherenkov telescope on-board EUSOSPB2 is to classify known and unknown sources of backgrounds for future space-based neutrino detectors. Furthermore, we will use the Earth-skimming technique to search for Very-High-Energy (VHE) tau neutrinos below the limb (E > 10 PeV) and observe air showers from cosmic rays above the limb. The 0.785 m2 Cherenkov telescope is equipped with a 512-pixel SiPM camera covering a 12.8° x 6.4° (Horizontal × Vertical) field of view. The camera signals are digitized with a 100 MS/s readout system. In this paper, we discuss the status of the telescope development, the camera integration, and simulation studies of the camera response.
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| 6. |
- Battisti, M., et al.
(författare)
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Overview of the Mini-EUSO μs trigger logic performance
- 2022
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Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- Mini-EUSO is the first detector of the JEM-EUSO program deployed on the ISS. It is a wide field of view telescope currently operating from a nadir-facing UV-transparent window on the ISS. It is based on an array of MAPMTs working in photon counting mode with a 2.5 μs time resolution. Among the different scientific objectives it searches for light signals with time duration compatible to those expected from Extensive Air Showers (EAS) generated by EECRs interacting in the atmosphere. Although the energy threshold for cosmic ray showers is above E > 1021eV, due the constraints given by the size of the UV-transparent window, the dedicated trigger logic has been capable of the detection of other interesting classes of events, like elves and ground flashers. An overview of the general performance of the trigger system is provided, with a particular focus on the identification of classes of events responsible for the triggers.
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| 7. |
- Berntsson, K., et al.
(författare)
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Patient safety when receiving telephone advice in primary care – a Swedish qualitative interview study
- 2022
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Ingår i: BMC Nursing. - : BioMed Central. - 1472-6955. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: A lack of patient safety is a significant global public health challenge and is one of the leading causes of death and disability, entailing significant financial and economic costs. However, patient safety can be improved and patients can avoid being harmed if more knowledge could be gained about what it is that impacts patient safety. Patient safety when receiving telephone advice is an important issue given the increase in digitalization in healthcare services. Aim: The aim of this study was to explore district nurses’ (“telenurses”) experiences and perceptions of patient safety when providing health advice over the phone. Methods: Data collection was performed using semi-structured interviews and analyzed using qualitative content analysis. The participants (n = 12) were telnurses in primary care. Results: The theme “Being able to make the right decision” was formed based on two categories: “Communication” and “Assessment”. Through effective communication with the right conditions to make an assessment, the correct decision can be made when a patient calls, and the district nurse feels that their telephone advice is safe for the patient. Conclusions: Patient safety can be challenged when receiving telephone advice, particularly when they feel stressed due to organizational factors. There is a need to shift from the individual to the organization. Further, while computerized knowledge support generally results in safe decisions, there may also be problems. Hence, it is imperative to develop computerized knowledge support as a part of improved patient safety in telephone advice.
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| 8. |
- Casolino, M., et al.
(författare)
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The Mini-EUSO telescope on board the International Space Station : Launch and first results
- 2022
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Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- Mini-EUSO is a telescope launched on board the International Space Station in 2019 and currently located in the Russian section of the station. Main scientific objectives of the mission are the search for nuclearites and Strange Quark Matter, the study of atmospheric phenomena such as Transient Luminous Events, meteors and meteoroids, the observation of sea bioluminescence and of artificial satellites and man-made space debris. It is also capable of observing Extensive Air Showers generated by Ultra-High Energy Cosmic Rays with an energy above 1021 eV and detect artificial showers generated with lasers from the ground. Mini-EUSO can map the night-time Earth in the UV range (290 - 430 nm), with a spatial resolution of about 6.3 km and a temporal resolution of 2.5 μs, observing our planet through a nadir-facing UV-transparent window in the Russian Zvezda module. The instrument, launched on 2019/08/22 from the Baikonur cosmodrome, is based on an optical system employing two Fresnel lenses and a focal surface composed of 36 Multi-Anode Photomultiplier tubes, 64 channels each, for a total of 2304 channels with single photon counting sensitivity and an overall field of view of 44◦. Mini-EUSO also contains two ancillary cameras to complement measurements in the near infrared and visible ranges. In this paper we describe the detector and present the various phenomena observed in the first year of operation.
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| 9. |
- Danielsson, Erna, et al.
(författare)
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Samverkan i praktiken
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport har varit att studera den samverkan som sker på en skadeplats där flera räddningsorganisationer och enskilda frivilliga är inblandade i räddningsarbetet. Men rapporten omfattar även den samverkan som sker i händelsens periferi, inom och mellan organisationernas staber, samt samverkan med frivilligorganisationer verksamma vid kriser och olyckor. Resultatet visar att omvandlingen av en olycksplats till en skadeplats påbörjas då en spontanfrivillig uppmärksammar en olycka och ringer till SOS Alarm. När räddningsorganisationerna kommer till skadeplatsen skapas en organisation för att ta hand om händelsen. I denna miljö möts spontanfrivilliga och räddningspersonal. Spontanfrivilliga kan i detta möte fylla två viktiga funktioner, för det första som informationskälla, dvs. i definitionen av en första lägesbild och i egenskap av vittnen. För det andra kan de få en funktion som medhjälpare, t.ex. påbörja lättare sjukvårdsinsatser eller dirigera trafik. Men genom att händelsen omgärdas av ett organisatoriskt sammanhang sätts gränser t.ex. för vad som betraktas som en legitim aktör. Ofta inkluderas spontanfrivilliga så tillvida att de blir geografiskt inkluderade, men de blir lika ofta symboliskt exkluderade. Räddningspersonalens avståndstagande gör att spontanfrivilliga känner sig obekväma i situationen och lämnar skadeplatsen i ett tidigt skede. Liksom skadeplatsen utgör räddningsstaben både en organisatorisk konstruktion och en institutionell miljö. Det som är särskilt utmärkande för staber är deras behov av lägesbilder. Till skillnad mot arbetet på skadeplatsen som börjar i kaos, börjar staben med ett ”tomt” rum som ska fyllas av händelsen, där lägesbilderna som förmedlas från skadeplatsen utgör grunden för stabens arbete. Etableringen av frivilligorganisationer följer till dels andra rutiner. Det som utmärker dessa organisationer är deras elasticitet, dvs. tillkomsten av frivilliga i händelse av en kris. Den verksamhet som vissa frivilligorganisationer bedriver är till dels lika dem som de bedriver i vardagen. Frivilligorganisationerna är inte verksamma på skadeplatsen och de aktiveras senare under händelsen och verksamheten kan pågå under lång tid efteråt. Om arbetet på skadeplatsen kännetecknas av en räddningspraktik, så kännetecknas de frivilligorganisationer som ingår i studien av en omhändertagandepraktik. Sammanfattningsvis framkommer att samverkan etableras i vardagen och att det finns en tendens att överbetona samverkan; samverkan är inte alltid viktig. Svårigheter att samverka kan bero på kunskapsbrister, att gränser försvårar samverkan där vissa inkluderas och andra exkluderas, samt att en strävan efter en gemensam lägesbild inte alltid är en rimlig utgångspunkt vid samverkan.
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| 10. |
- Demarin, Eva-Lena, et al.
(författare)
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Samhällsvetenskapliga perspektiv på risk och kris : Uppfattning, kommunikation och organisation.
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Forskargruppen KRIHS, Kris och risk i det heterogena samhället, har fått uppdraget att skriva en kunskapsöversikt inom ramen för MSB:s verksamhetsområden skydd mot olyckor, krishantering och civil beredskap. Uppdraget har gjorts i samarbete med Eva-Lena Demarin som stått för stora delar av sammanställningen av tidigare forskning samt delar av övriga avsnitt. Undertecknad ansvarar för översiktens vetenskapliga kvalitet. Kunskapsöversikten är dock ett resultat av forskargruppens gemensamma ansträngningar. Tillsammans med Eva-Lena har gruppen träffats vid fem tillfällen varav vid ett seminarium där texten diskuterats och reviderats. De som varit med och diskuterat, samlat in material och/eller skrivit delar av översikten är förutom ovan nämnda, Erna Danielsson, Sara Ekholm, Linda Eliasson, Roine Johansson, Jörgen Sparf, Erika Wall och Susanna Öhman.Då både tiden och utrymmet har varit begränsat gör vi inga anspråk på att kunskapsöversikten är heltäckande. Den ska snarare ses som en ganska grovkorning bild av de senaste tio årens risk- och krisforskning rörande uppfattningar, kommunikation och organisation. Det huvudsakliga bidraget är att översikten identifierar vissa områden där kunskapsuppbyggnad behövs. På så sätt kan översikten ses som en karta där vissa kompassriktningar markerats utifrån vilka MSB kan välja vilka som passar myndighetens framtida verksamhet.
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| 11. |
- Diesing, R., et al.
(författare)
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UCIRC2: EUSO-SPB2’s Infrared Cloud Monitor
- 2022
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Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The second generation of the Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB2) is a balloon instrument for the detection of ultra high energy cosmic rays (UHECRs) with energies above 1 EeV and very high energy neutrinos with energies above 10 PeV. EUSOSPB2 consists of two telescopes: a fluorescence telescope pointed downward for the detection of UHECRs and a Cherenkov telescope pointed towards the limb for the detection of tau lepton-induced showers produced by up-going tau neutrinos and background signals below the limb. Clouds inside the field of view of these telescopes reduce EUSO-SPB2’s geometric aperture, in particular that of the fluorescence telescope. For this reason, cloud coverage and cloud-top altitude within the field of view of the fluorescence telescope must be monitored throughout data-taking. The University of Chicago Infrared Camera (UCIRC2) will monitor these clouds using two infrared cameras with response centered at wavelengths 10 and 12 microns. By capturing images at wavelengths spanning the cloud thermal emission peak, UCIRC2 will measure cloud color-temperatures and thus cloud-top altitudes. In this contribution, we provide an overview of UCIRC2, including an update on its construction and a discussion of the techniques used to calibrate the instrument.
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| 12. |
- Ek, Linda, et al.
(författare)
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Hand Assessment for Infants : normative reference values
- 2019
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Ingår i: Developmental Medicine & Child Neurology. - : Mac Keith Press. - 0012-1622 .- 1469-8749. ; 61:9, s. 1087-1092
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To create normative reference values for unilateral and bilateral use of the hands, using the Hand Assessment for Infants (HAI), a newly developed criterion-referenced assessment measuring hand use in infants aged 3 months to 12 months at risk of cerebral palsy (CP).METHOD: In total, 489 HAI assessments of typically developing infants (243 females, 246 males), aged 3 months to 10 months (mean 6mo 14d [SD 2mo 5d]), were collected in Italy and Sweden. Normative growth curves based on mean and SDs were created, as well as skill acquisition curves for each test item. Correlation to age and differences between groups based on sex and nationality, as well as differences between the right and the left hand, were investigated.RESULTS: The growth curves showed a steady increase in mean value and a decrease in SD over age. There were no differences between groups based on sex or nationality. There was a negligible mean difference (0.1 raw score) between the right and left hands.INTERPRETATION: HAI normative reference values are now available, which can assist in identifying deviating hand use for each month of age, as well as a side difference between hands in infants at risk of CP.WHAT THIS PAPER ADDS: A Hand Assessment for Infants (HAI) result greater than 2SD below the mean indicates atypical hand use. Skill acquisition curves describe the age at which typically developing infants master the HAI items. Most typically developing infants do not demonstrate asymmetry in hand use.
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| 13. |
- Eliasson, Ann-Christin, 1950-, et al.
(författare)
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Efficacy of baby-CIMT : study protocol for a randomised controlled trial on infants below age 12 months, with clinical signs of unilateral CP
- 2014
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Ingår i: BMC Pediatrics. - : BioMed Central. - 1471-2431. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Infants with unilateral brain lesions are at high risk of developing unilateral cerebral palsy (CP). Given the great plasticity of the young brain, possible interventions for infants at risk of unilateral CP deserve exploration. Constraint-induced movement therapy (CIMT) is known to be effective for older children with unilateral CP but is not systematically used for infants. The development of CIMT for infants (baby-CIMT) is described here, as is the methodology of an RCT comparing the effects on manual ability development of baby-CIMT versus baby-massage. The main hypothesis is that infants receiving baby-CIMT will develop manual ability in the involved hand faster than will infants receiving baby-massage in the first year of life.METHOD AND DESIGN: The study will be a randomised, controlled, prospective parallel-group trial. Invited infants will be to be randomised to either the baby-CIMT or the baby-massage group if they: 1) are at risk of developing unilateral CP due to a known neonatal event affecting the brain or 2) have been referred to Astrid Lindgren Children's Hospital due to asymmetric hand function. The inclusion criteria are age 3-8 months and established asymmetric hand use. Infants in both groups will receive two 6-weeks training periods separated by a 6-week pause, for 12 weeks in total of treatment. The primary outcome measure will be the new Hand Assessment for Infants (HAI) for evaluating manual ability. In addition, the Parenting Sense of Competence scale and Alberta Infant Motor Scale will be used. Clinical neuroimaging will be utilized to characterise the brain lesion type. To compare outcomes between treatment groups generalised linear models will be used.DISCUSSION: The model of early intensive intervention for hand function, baby-CIMT evaluated by the Hand Assessment for Infants (HAI) will have the potential to significantly increase our understanding of how early intervention of upper limb function in infants at risk of developing unilateral CP can be performed and measured.TRIAL REGISTRATION: SFO-V4072/2012, 05/22/2013.
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| 14. |
- Eliasson, Ann-Christin, et al.
(författare)
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Efficacy of the small step program in a randomised controlled trial for infants below age 12 months with clinical signs of CP; a study protocol
- 2016
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Ingår i: BMC Pediatrics. - London : Springer Science and Business Media LLC. - 1471-2431. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- Background: Children with cerebral palsy (CP) have life-long motor disorders, and they are typically subjected to extensive treatment throughout their childhood. Despite this, there is a lack of evidence supporting the effectiveness of early interventions aiming at improving motor function, activity, and participation in daily life. The study will evaluate the effectiveness of the newly developed Small Step Program, which is introduced to children at risk of developing CP during their first year of life. The intervention is based upon theories of early learning-induced brain plasticity and comprises important components of evidence-based intervention approaches used with older children with CP.Method and design: A two-group randomised control trial will be conducted. Invited infants at risk of developing CP due to a neonatal event affecting the brain will be randomised to either the Small Step Program or to usual care. They will be recruited from Astrid Lindgren Children's Hospital at regular check-up and included at age 3-8 months. The Small Step Program was designed to provide individualized, goal directed, and intensive intervention focusing on hand use, mobility, and communication in the child's own home environment and carried out by their parents who have been trained and coached by therapists. The primary endpoint will be approximately 35 weeks after the start of the intervention, and the secondary endpoint will be at 2 years of age. The primary outcome measure will be the Peabody Developmental Motor Scale (second edition). Secondary assessments will measure and describe the children's general and specific development and brain pathology. In addition, the parents' perspective of the program will be evaluated. General linear models will be used to compare outcomes between groups.Discussion: This paper presents the background and rationale for developing the Small-Step Program and the design and protocol of a randomized controlled trial. The aim of the Small Step Program is to influence development by enabling children to function on a higher level than if not treated by the program and to evaluate whether the program will affect parent's ability to cope with stress and anxiety related to having a child at risk of developing CP.
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| 15. |
- Eliasson, Ann-Christin, et al.
(författare)
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Longitudinal development of hand use in children with unilateral spastic cerebral palsy from 18 months to 18 years.
- 2023
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Ingår i: Developmental Medicine & Child Neurology. - : Mac Keith Press. - 0012-1622 .- 1469-8749. ; 65:3, s. 376-384
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To describe the development of the use of the affected hand in bimanual tasks in children with unilateral cerebral palsy (CP) from 18 months to 18 years. Specifically, whether early development can be confirmed in a larger cohort and how development progresses during adolescence.METHOD: In total, 171 participants (95 males, 76 females; mean age 3 years 1 month [SD 3 years 8 months], range 18 months-16 years at inclusion) were classified in Manual Ability Classification System (MACS) levels I (n = 41), II (n = 91), and III (n = 39). Children were assessed repeatedly (median 7, range 2-16 times) with the Assisting Hand Assessment: in total 1197 assessments. Developmental trajectories were estimated using a nonlinear mixed effects model. To further analyse the adolescent period, a linear mixed model was applied.RESULTS: The developmental trajectories were different between participants in MACS levels (MACS I-II, II-III) in both rate (0.019, 95% confidence interval [CI] 0.006-0.031, p = 0.034; 0.025, 95% CI 0.015-0.037, p < 0.001) and limit (19.9, 95% CI 16.6-23.3, p = 0.001; 7.2, 95% CI 3.3-11.2, p < 0.003). The individual variations were large within each level. The developmental trajectories were stable over time for all MACS levels between 7 and 18 years (p > 0.05).INTERPRETATION: Children and adolescents with unilateral CP have considerable development at an early age and a stable ability to use their affected hand in bimanual activities from 7 to 18 years in all MACS levels.
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| 16. |
- Eliasson, Emma T., et al.
(författare)
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Unpacking stigma : Meta-analyses of correlates and moderators of personal stigma in psychosis
- 2021
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Ingår i: Clinical Psychology Review. - : Elsevier. - 0272-7358 .- 1873-7811. ; 89
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Forskningsöversikt (refereegranskat)abstract
- Personal stigma entails perceived, experienced and internalised stigmatisation. Mental Health stigma has been widely researched across a range of countries and a meta-analysis of their associations and moderators in psychosis is timely. Meta-analyses were conducted examining the correlates and moderators of personal stigma in terms of: (1) demographic variables (2) illness related variables (3) symptoms/negative outcomes, and (4) aspects of wellbeing. Associations were obtained from a total of 216 records. Several demographic factors including age, economic status, employment, and rural residence had small associations with aspects of personal stigma (r's = 0.12 to -0.13). Personal stigma aspects were inversely related to medication adherence (r's = -0.20, -0.21), and positively associated with insight and number of hospitalisations (r's = 0.09-0.19). Most symptoms were positively associated with personal stigma (r's = 0.10-0.43), whereas inverse relations with wellbeing variables were identified (r's = -0.13 to -0.54). Moderator effects emerged including that of cultural setting and sex, age and education level, highlighting the role of cultural and demographic factors in shaping personal stigma aspects in psychosis. The present study also highlights the importance of recognizing the negative effect of actual stigma and discrimination experiences; particularly its detrimental impact on self-image and its complex role in shaping the internalisation of societal stigma.
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| 17. |
- Eliasson, Linda, et al.
(författare)
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Capturing ion exchanger-bound infectious pancreatic necrosis virus - design and application for large volume water samples
- 2003
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Ingår i: Journal of Virological Methods. - 1879-0984. ; 110:2, s. 173-178
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Tidskriftsartikel (refereegranskat)abstract
- A method was designed for rapid and reliable demonstration of the presence of infectious pancreatic necrosis virus retrieved from 5 1 water samples. Viruses together with an added carrier protein were adsorbed to a resin of an added anion exchanger. Then the resin was collected rapidly and quantitatively through a specific device which we designed. The resin was transferred to a column from which the viruses were eluted, and subsequently further concentrated by acid precipitation, followed by SDS-polyacrylamide eel electrophoresis and Western blot analysis. Serological results were obtained within 24 h after the water sample was introduced into the laboratory. Proteins were recovered at an efficiency between 70 and 80% and the total concentration factor ranged between 150000 and 250000 times, depending on the requirements and the methods of choice.
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| 18. |
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| 19. |
- Eliasson, Linda
(författare)
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Infectious Pancreatic Necrosis Virus (IPNV) - Structural Studies and Methodology
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Infectious pancreatic necrosis virus (IPNV) is a Birnavirus that infects salmonid fish. The infection is usually mortal for fish under six months of age, while older fish become carriers, usually without any signs of infection, and will spread the virus to other susceptible fish and to their offspring. IPNV is an icosahedral, naked virion and the genome consists of two segments of double-stranded RNA. The virus genome codes for five proteins, three of which are structural components. The virus protein 2 (VP2) is the major protein component of the capsid and it also functions as the virus attachment protein (VAP) of IPNV. In this study we have used three different methods to prove that VP2 is glycosylated: lectin blots, metabolic radiolabelling and gas chromatography-mass spectrometry. We showed that VP2 carries mannose, glucose and galactose. We have further seen a quantitative difference in glycosylation depending on in which cell line the virus has been propagated. During these studies glycosylation of the internal protein VP1, has been shown and this protein is found in the virion both in a free form and as a genome-linked protein. We have also produced and purified recombinant VP2 in its unglycosylated form from bacteria, and isolated and purified authentic, glycosylated VP2 from disintegrated virions. To study the possible significance of virion glycosylation these proteins are to be used in attachment and infectivity competition experiments with infectious viruses in cell cultures. The two variants of VP2 are presently used to produce monospecific antibodies, which will be used in studies on the mechanisms of antibody-mediated neutralization. For infectivity titrations of IPNV an immuno dot blot TCID50 assay, was developed which measures virions and viral proteins in the growth medium of infected cells. The method gives clear cut answers if the cells are virus-infected or not, thus abolishing the need for otherwise subjectively estimated limits. This method was used in a study of different storage conditions for IPNV, and the best storage condition was found to be at -70°C with glycerol as a cryoprotective agent. In the aquaculture industry it can be a problem to detect and identify viruses in the water entering or leaving the rearing facilities. In this study we have developed a method and an apparatus that easy and efficiently will concentrate IPNV from large water volumes by a factor of at the most 250,000 times. Within 24 hrs the viruses will be detected and identified by serological methods.
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| 20. |
- Eliasson, Linda, et al.
(författare)
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Low-pressure measurements of energy depositions in nanometre objects with a single ionisation chamber in a 60 Co beam using the variance-covariance method
- 2024
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Ingår i: Radiation Physics and Chemistry. - : Elsevier BV. - 0969-806X .- 1879-0895. ; 221
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Tidskriftsartikel (refereegranskat)abstract
- Dose -mean lineal energies were measured using the variance-covariance method and commercial ionisation chambers in a therapy level 60 Co field at several different air pressures. The results confirmed the trend from previous studies and the experimental data was extended down to a simulated object diameter of 4.2 nm using a low -noise electrometer. The variance-covariance method was adapted to consecutive charge integrations from a single ionisation chamber and used to correct for signal variations due to pressure drifts in the ion chamber. Monte Carlo simulations using MCNP 6.2 were performed, and the results follow the trend of the experimental values in the nanometric region.
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| 21. |
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| 22. |
- Eliasson, Linda, et al.
(författare)
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Range-shifter effects on the stray field in proton therapy measured with the variance–covariance method
- 2022
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Measurements in the stray radiation field from a proton therapy pencil beam at energies 70 and 146 MeV were performed using microdosimetric tissue- equivalent proportional counters (TEPCs). The detector volumes were filled with a propane-based tissue-equivalent gas at low pressure simulating a mean chord length of 2 mm in tissue. Investigations were performed with and without a beam range shifter, and with different air gaps between the range shifter and a solid water phantom. The absorbed dose, the dose-mean lineal energy, and the dose equivalent were determined for different detector positions using the variance–covariance method. The influence from beam energy, detector- and range-shifter positions on absorbed dose, LET, and dose equivalent were investigated. Monte Carlo simulations of the fluence, detector response, and absorbed dose contribution from different particles were performed with MCNP 6.2. The simulated dose response for protons, neutrons, and photons were compared with, and showed good agreement with, previously published experimental data. The simulations also showed that the TEPC absorbed dose agrees well with the ambient absorbed dose for neutron energies above 20 MeV. The results illustrate that changes in both dose and LET variations in the stray radiation field can be identified from TEPC measurements using the variance–covariance method. The results are in line with the changes seen in the simulated relative dose contributions from different particles associated with different proton energies and range-shifter settings. It is shown that the proton contribution scattered directly from the range shifter dominates in some situations, and although the LET of the radiation is decreased, the ambient dose equivalent is increased up to a factor of 3.
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| 23. |
- Eliasson, Linda
(författare)
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Towards nanodosimetry: therapeutic radiation measurements using the variance method
- 2022
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Understanding how radiation damage occurs in human tissue seems to lie in the knowledge of energy depositions in DNA-size volumes, with diameters typically around a few nanometres. In such small volumes the energy transfers are stochastic and described using distributions of events along a particle track and relevant mean values. Usually, two main quantities are used to describe nanodosimetric characteristics: ionisation clus- ter sizes and lineal energies. The former give a distribution of the number of ionisation events while the latter give the distribution of the energy imparted per mean chord length in the volume of interest. The dose-mean lineal energy is the mean value of the dose-weighted distribution of lineal energy. Both quantities are independent of the deposited dose and depends only on the radiation quality. In the work presented here, dose-mean lineal energies were determined using commercial ion chambers and tissue-equivalent proportional counters containing gas at low pressures, simulating volumes of object sizes in the micro- and nanometre ranges. The variance method was used, where the dose-mean energy imparted during a fixed integration time was measured instead of the energy imparted by each single event. This method is valuable both in high-intensity beams where single-event methods are challenged by e.g. pileup, and in small volumes where the signals from single events are weak and need strong amplifications. To adjust for slow variations in e.g. the radiation beam, gas pressure and applied voltages, the covariance-adjusted variance-covariance method was used and further developed so that only one single detector was required. Paper I describes microdosimetric measurements using tissue-equivalent proportional counters placed in the stray field from a therapeutic proton beam at the Skandion clinic in Uppsala, Sweden. By comparing dose-mean lineal energies with and without the use of a range shifter it could be shown that proton scattering from this range shifter contributed to an increased absorbed dose in some positions. Paper II describes nanodosimetric measurements in a therapy-level 60Co field using commercial ion chambers. Using low-noise electronics, the dose-mean lineal energy down to simulated mean chord lengths of 2.8 nm in unit density in air could be measured. Both papers are steps toward nanodosimetric measurements in therapeutic hadron beams, where the dose-mean lineal energy can give a better understanding and de- scription of radiation quality in radiation therapy.
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| 24. |
- Fridholm, Helena, et al.
(författare)
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Immunogenicity properties of authentic and heterologously synthesized structural protein VP2 of infectious pancreatic necrosis virus.
- 2007
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Ingår i: Viral Immunology. - : Mary Ann Liebert Inc. - 0882-8245 .- 1557-8976. ; 20:4, s. 635-648
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Tidskriftsartikel (refereegranskat)abstract
- The sole coat protein VP2 of infectious pancreatic necrosis virus (IPNV) was isolated and purified from intact virions, propagated in CHSE-214 cells. Likewise was the full-length VP2 protein isolated and purified upon cloning and expression of the corresponding complete gene in E. coli. The two purified proteins of different synthetic origins carrying identical primary structures were utilized in an immunization program using a rabbit model. Sera obtained against both immunogens react equally well with authentic and recombinant VP2 in Western blots and ELISAs. Also, the total net binding forces as determined by avidity index (AI) calculations were high and of similar stature, exceeding 80. An IPNV infection of susceptible and permissive CHSE-214 cells could only be neutralized by IgG preparations obtained from rabbits immunized with authentic VP2. Only such antibodies were able to aggregate and sediment radiolabeled virions in glycerol gradients upon rate zonal centrifugations. The presence of sugar moieties on the authentic protein is suggested to be of pivotal importance in eliciting an immune response capable of preventing infection in cell cultures in vitro.
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| 25. |
- Golzio, Alessio, et al.
(författare)
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A study on UV emission from clouds with Mini-EUSO
- 2022
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Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- Mini-EUSO is the first mission of the JEM-EUSO program located on the International Space Station. One of the main goals of the mission is to provide valuable scientific data in view of future large missions devoted to study Ultra-High Energy Cosmic Rays (UHECRs) from space by exploiting the fluorescence emission generated by Extensive Air Showers (EAS) developing in the atmosphere. A space mission like Mini-EUSO experiences continuous changes in atmospheric conditions, including the cloud presence. The influence of clouds on space-based observation is, therefore, an important topic to investigate as it might alter the instantaneous exposure for EAS detection or deteriorate the quality of the EAS images with consequences on the reconstructed EAS parameters. For this purpose, JEM-EUSO is planning to have an IR camera and a lidar as part of its Atmospheric Monitoring System. At the same time, it would be extremely beneficial if the UV camera itself would be able to detect the presence of clouds, at least in some specific conditions. For this reason, we analyze a few case studies by comparing the pixel count rates from Mini-EUSO during orbits with the cloud cover (as cloud fraction). This quantity is retrieved from the Global Forecast System (GFS) model at different height levels over the Mini-EUSO trajectory. The results of this analysis are reported.
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