| 1. |
|
|
| 2. |
|
|
| 3. |
- Ahrentorp, Fredrik, et al.
(författare)
-
Sensitive magnetic biodetection using magnetic multi-core nanoparticles and RCA coils
- 2017
-
Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 427, s. 14-18
-
Tidskriftsartikel (refereegranskat)abstract
- We use functionalized iron oxide magnetic multi-core particles of 100 nm in size (hydrodynamic particle diameter) and AC susceptometry (ACS) methods to measure the binding reactions between the magnetic nanoparticles (MNPs) and bio-analyte products produced from DNA segments using the rolling circle amplification (RCA) method. We use sensitive induction detection techniques in order to measure the ACS response. The DNA is amplified via RCA to generate RCA coils with a specific size that is dependent on the amplification time. After about 75 min of amplification we obtain an average RCA coil diameter of about 1 mu m. We determine a theoretical limit of detection (LOD) in the range of 11 attomole (corresponding to an analyte concentration of 55 fM for a sample volume of 200 mu L) from the ACS dynamic response after the MNPs have bound to the RCA coils and the measured ACS readout noise. We also discuss further possible improvements of the LOD.
|
|
| 4. |
- Anand, Kanwlajeet J. S., et al.
(författare)
-
Assessment of continuous pain in newborns admitted to NICUs in 18 European countries
- 2017
-
Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 106:8, s. 1248-1259
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown.Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission.Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35·0%), and no ventilation (NoV, 20·1%) groups (p<0·001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14·0%, NiV: 10·7%, NoV: 7·6%; p<0·001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0·028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1·60, p<0·001) and NiV groups (OR:1·40, p<0·001).Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns.
|
|
| 5. |
|
|
| 6. |
- Andersson, Mats, 1957, et al.
(författare)
-
Global representation of Segre numbers by Monge–Ampère products
- 2021
-
Ingår i: Mathematische Annalen. - : Springer Science and Business Media LLC. - 0025-5831 .- 1432-1807. ; 380:1-2, s. 349-391
-
Tidskriftsartikel (refereegranskat)abstract
- On a reduced analytic space X we introduce the concept of a generalized cycle, which extends the notion of a formal sum of analytic subspaces to include also a form part. We then consider a suitable equivalence relation and corresponding quotient B(X) that we think of as an analogue of the Chow group and a refinement of de Rham cohomology. This group allows us to study both global and local intersection theoretic properties. We provide many B-analogues of classical intersection theoretic constructions: For an analytic subspace V⊂ X we define a B-Segre class, which is an element of B(X) with support in V. It satisfies a global King formula and, in particular, its multiplicities at each point coincide with the Segre numbers of V. When V is cut out by a section of a vector bundle we interpret this class as a Monge–Ampère-type product. For regular embeddings we construct a B-analogue of the Gysin morphism.
|
|
| 7. |
- Andersson, Mats, 1957, et al.
(författare)
-
Nonproper intersection products and generalized cycles
- 2021
-
Ingår i: European Journal of Mathematics. - : Springer Science and Business Media LLC. - 2199-675X .- 2199-6768. ; 7:4, s. 1337-1381
-
Tidskriftsartikel (refereegranskat)abstract
- We develop intersection theory in terms of the B-group of a reduced analytic space. This group was introduced in a previous work as an analogue of the Chow group; it is generated by currents that are direct images of Chern forms and it contains all usual cycles. However, contrary to Chow classes, the B-classes have well-defined multiplicities at each point. We focus on a B-analogue of the intersection theory based on the Stuckrad-Vogel procedure and the join construction in projective space. Our approach provides global B-classes which satisfy a Bezout theorem and have the expected local intersection numbers. We also introduce B-analogues of more classical constructions of intersections using the Gysin map of the diagonal. These constructions are connected via a B-variant of van Gastel's formulas. Furthermore, we prove that our intersections coincide with the classical ones on cohomology level.
|
|
| 8. |
- Blomberg, Karin, 1970-, et al.
(författare)
-
Quality of life and trust among young people with narcolepsy and their families, after the Pandemrix® vaccination : Protocol for a case-control study
- 2017
-
Ingår i: BMC Pediatrics. - : BioMed Central. - 1471-2431. ; 17:1
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The extensive vaccination programme against swine flu resulted in an increased incidence of narcolepsy among children and adolescents. There is a need to explore if these young persons' experiences have affected their trust in healthcare, their willingness to participate in future prevention programmes, and their contacts with the healthcare system. The overall aim is to identify factors important for the life-situation of children and adolescents with narcolepsy and their families, and factors that correlate with trust in healthcare.METHODS/DESIGN: Data will be collected via questionnaires from all available children with narcolepsy following the vaccination and their families, as well as a control group of children with diabetes and their families. Longitudinal descriptive interviews will also be conducted with a selection of 20-25 children and their families. Techniques from media research will be used for Internet-based data collection and analysis of information relating to narcolepsy from social media.DISCUSSION: This project will use the situation of young persons with narcolepsy after the swine flu vaccination as a case to build a model that can be used in situations where trust in healthcare is essential. This model will be based on findings from the included studies on how trust is influenced by support, quality of life, burden of disease, impact on family, and use of social media. The model developed in this project will be beneficial in future situations where trust in healthcare is essential, such as new pandemic outbreaks but also for "everyday" adherence to health advice.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Engström, Gunnar, et al.
(författare)
-
The Swedish CArdioPulmonary BioImage Study : objectives and design
- 2015
-
Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 278:6, s. 645-659
-
Tidskriftsartikel (refereegranskat)abstract
- Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.
|
|
| 12. |
- Ericsson, Elisabeth, 1959-, et al.
(författare)
-
Experiences of a new self-report instrument for post-operative recovery in children
- 2017
-
Konferensbidrag (refereegranskat)abstract
- The objective was to develop and test an instrument that provides children, also of a younger age, with a quality recovery self-report measure after tonsil surgery.Methods: The development of Postoperative Recovery in Children (PRiC) was influenced by Quality of Recovery-24, for use in adults. It includes 23 items covering different aspects of recovery. PRiC was developed both as a traditional text-based instrument and as a version where each item is illustrated by a photo. It was distributed to 260 children undergoing tonsillotomy or total tonsillectomy in day-surgery, to be answered on post-operative days 1, 4 and 10.Results: In the photo-version, 27% of the children marked the answers on the instrument themselves, compared to 19% in the text-version (n.s.). Parents of 64% of the children in the photo-group reported that their child participated in answering the questions to a very high degree, compared to 58% in the text-group (n.s.). Some parents described that their children were very proud to fill in the instrument and return them by mail. The questions were mainly described as easy to understand and respond to, especially when illustrated with a photo. Some parents highlighted pain issues and asked for specific questions about what pain medication was given at home. One parent asked for the possibility to respond to the instrument online. Conclusion: PRiC can serve as a patient-reported outcome measure for children. PRiC can also provide parents with a tool for communicating with their child about post-operative recovery, especially when using the photo version.
|
|
| 13. |
- Ericsson, Elisabeth, 1959-, et al.
(författare)
-
Self-reported postoperative recovery in children after tonsillectomy compared to tonsillotomy
- 2017
-
Konferensbidrag (refereegranskat)abstract
- Background: Patient-reported outcome measures (PROM) are the golden standard for the planning and follow-up of delivered care, which should also be an axiom for children. The current aims were to describe self-reported postoperative recovery in children after tonsil surgery, and to compare tonsillotomy and tonsillectomy in this aspect.Methods: 238 children (4-12 years) with a history of obstructive problems and/or recurrent tonsillitis were included. 48% were operated with tonsillotomy (TT) and 52% with total tonsillectomy (TE), all in day surgery. Postoperative recovery was assessed on days 1, 4 and 10 using the validated self-rating instrument, Postoperative Recovery in Children (PRiC), which includes 23 items covering different aspects of recovery after tonsil surgery. Results: Daily life activities (sleeping, eating and playing), and physical (e.g., headache, stomach ache, throat ache, otalgia, dizziness, nausea, defecation, urination) and emotional aspects (sadness, frightening dreams) were affected during the recovery period.The TE-girls showed higher scores than the boys in many factors. Children above 6 years of age reported higher values for the physical comfort variables while the younger group showed worse emotional states. Postoperative recovery improved from day 1 to 10 in all surgical groups. The TE-group had lower recovery compared to the TT-group (p < 0.01 – 0.001) in most items.Conclusion: The goal of postoperative management is to minimise or eliminate discomfort, facilitating the recovery process and avoiding complications. Children are able to describe their recovery after tonsil surgery, and thus, PRiC can serve as a PROM to obtain patient-centred data after tonsil surgery.
|
|
| 14. |
- Eriksson, Jenny, 1975-, et al.
(författare)
-
New ways of collecting individual travel information : Evaluation of data collection and recruitment methods
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose of the project is to conduct a demonstration study that shows how two data collection methods that have been developed to collect travel survey data perform in the field, and how they perform compared with traditional TS (i.e., postal questionnaires and/or telephone interviews). The project is also intended to provide a better understanding of the ways in which different recruitment methods of respondents can be used so that future TS can be more cost effective.The two collection methods tested consist of a mobile app and an online questionnaire with a map to assist the respondents to identify travel destinations. Three recruitment methods were used, i.e., recruitment via random sampling, a web panel, and crowdsourcing. The portion of the random sample that received an online questionnaire was divided into two groups. Half the group was given no incentive, while the other half received a gift card worth SEK 100 after answering the questioner. Those who were recruited via a web panel and were to use the mobile app were rewarded in the form of a gift card worth SEK 100 if, at minimum, they made corrections to trips made on one day registered in the mobile app. A nonresponse analysis was performed of the random sample for both the online questionnaire and the mobile app. Cost estimates for each collection method and recruitment method were also performed, as were uncertainty estimates.Overall, the study shows that the mobile app registered significantly more trips per respondent than did the online questionnaire, while the distances travelled were comparable. There are several possible interpretations of this. One is that people who responded to the online questionnaire either forget about and/or combined short trips (particularly trips made for the purposes of leisure or shopping, and using the travel modes walking and car). One presumable explanation for this is that it is easier to confirm/correct the trips that the mobile app suggests than it is to recall and enter all trips in an online questionnaire. Another possible interpretation is that people responding to different data collection methods have different travel patterns. Yet another explanation is connected to technique issues regarding the different data collection methods.
|
|
| 15. |
- Eriksson, Martin, 1970, et al.
(författare)
-
Community-Level Analysis of psbA Gene Sequences and Irgarol Tolerance in Marine Periphyton
- 2009
-
Ingår i: Applied and Environmental Microbiology. - Washington, D.C. : American Society for Microbiology. - 0099-2240 .- 1098-5336. ; 75:4, s. 897-906
-
Tidskriftsartikel (refereegranskat)abstract
- This study analyzes psbA gene sequences, predicted D1 protein sequences, species relative abundance, and pollution-induced community tolerance in marine periphyton communities exposed to the antifouling compound Irgarol 1051. The mechanism of action of Irgarol is the inhibition of photosynthetic electron transport at photosystem II by binding to the D1 protein. The metagenome of the communities was used to produce clone libraries containing fragments of the psbA gene encoding the D1 protein. Community tolerance was quantified with a short-term test for the inhibition of photosynthesis. The communities were established in a continuous flow of natural seawater through microcosms with or without added Irgarol. The selection pressure from Irgarol resulted in an altered species composition and an inducted community tolerance to Irgarol. Moreover, there was a very high diversity in the psbA gene sequences in the periphyton, and the composition of psbA and D1 fragments within the communities was dramatically altered by increased Irgarol exposure. Even though tolerance to this type of compound in land plants often depends on a single amino acid substitution (Ser(264)-> Gly) in the D1 protein, this was not the case for marine periphyton species. Instead, the tolerance mechanism likely involves increased degradation of D1. When we compared sequences from low and high Irgarol exposure, differences in nonconserved amino acids were found only in the so-called PEST region of D1, which is involved in regulating its degradation. Our results suggest that environmental contamination with Irgarol has led to selection for high-turnover D1 proteins in marine periphyton communities at the west coast of Sweden.
|
|
| 16. |
- Eriksson, Mats, 1957-, et al.
(författare)
-
Self-reported postoperative recovery in children after tonsillectomy compared to tonsillotomy
- 2017
-
Ingår i: International Journal of Pediatric Otorhinolaryngology. - : Elsevier. - 0165-5876 .- 1872-8464. ; 96, s. 47-54
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: Tonsil surgery is associated with significant morbidity during recovery. Patient-reported outcome measures (PROM) are the golden standard for the planning and follow-up of delivered care, which should also be an axiom for children. The current aims were to describe self-reported postoperative recovery in children after tonsil surgery, and to compare tonsillotomy and tonsillectomy in this respect.Methods: In total, 238 children (4–12 years old) with a history of obstructive problems and/or recurrent tonsillitis, and undergoing tonsil surgery were included. Forty-eight per cent were operated with partial tonsil resection/tonsillotomy (TT) and 52% with total tonsillectomy (TE), all in day surgery.Postoperative recovery was assessed on days 1, 4 and 10 using the validated self-rating instrument PRiC, Postoperative Recovery in Children. This includes 23 items covering different aspects of recovery after tonsil surgery. A higher score indicates worse status in the respective items.Results: Daily life activities (sleeping, eating and playing), physical symptoms (e.g., headache, stomach ache, sore throat, otalgia, dizziness, nausea, defecation, urination), and emotional aspects (sadness, frightening dreams) were affected during the recovery period.The TE-girls showed higher scores than the boys regarding stomach ache, defecation and dizziness.Children above 6 years of age reported higher values for the physical comfort variables, while the younger group showed worse emotional states.Postoperative recovery improved from day 1–10 in all surgical groups. The TE-group showed lower recovery compared to the TT-group (p < 0.01–0.001) in most items.Conclusion: The goal of postoperative management is to minimize or eliminate discomfort, facilitating the recovery process and avoiding complications. Children are able to describe their recovery, and thus, PRiC seems to be able to serve as a PROM to obtain patient-centered data after tonsil surgery. The recovery process after TT causes less postoperative morbidity and a quicker return to normal activity compared to TE.
|
|
| 17. |
|
|
| 18. |
- Fogelberg, J., et al.
(författare)
-
Kinetic modelling of hydrogen ad/absorption in thin films of hydrogen sensitive field effect devices : Observation of large hydrogen induced dipoles at the Pd/SiO2 interface
- 1995
-
Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 78, s. 988-
-
Tidskriftsartikel (refereegranskat)abstract
- A kinetic modeling of the hydrogen interaction with a Pd‐SiO2‐Si (Pd‐MOS) device is reported. The model is fitted to a number of experimental results, mainly from mass spectrometric desorption measurements. The new results verify an older description of the energetics of hydrogen adsorption states at the Pd/SiO2 interface in the sense that the adsorption may be described by a so‐called Temkin isotherm; however, several new findings have to be incorporated into the model in order to obtain a consistent picture. The initial heat of adsorption at the interface is around 0.8 eV/hydrogen atom. The number of adsorption sites at the interface is considerably smaller than at the surface, 6×1017 m−2 versus 1.5×1019 m−2. Furthermore, the interface hydrogen atoms are strongly polarized. An average value of 2 Debye is obtained. It is the large hydrogen polarization at the Pd/SiO2 interface and not a large concentration of adsorbed hydrogen atoms per se which accounts for the very high sensitivity of a Pd‐MOS device as hydrogen sensor
|
|
| 19. |
- Jaensson, Maria, 1967-, et al.
(författare)
-
Evaluation of postoperative recovery in day surgery patients using a mobile phone application : a multicentre randomized trial
- 2017
-
Ingår i: British Journal of Anaesthesia. - : Oxford University Press. - 0007-0912 .- 1471-6771. ; 119:5, s. 1030-1038
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Many patients undergoing anaesthesia and surgery experience postoperative complications. Our aim was to investigate whether a systematic follow-up smartphone-based assessment, using recovery assessment by phone points (RAPP) compared with standard care, had a positive effect on day surgery patients' postoperative recovery. We also investigated whether there were differences in women and men's recovery and recovery scores.Methods: The study was a single-blind, multicentre randomized controlled trial. A total of 997 patients were randomly allocated to either RAPP or standard care. The Swedish web version of a quality of recovery (SwQoR) questionnaire was used to evaluate the patients' postoperative recovery, either on paper or using an application (RAPP) on postoperative days seven and 14.Results: On postoperative day seven the RAPP group reported significantly better values in seven out of 24 items of the SwQoR: sleeping difficulties; not having a general feeling of wellbeing; having difficulty feeling relaxed/comfortable; and dizziness; headache; pain in the surgical wound; and a swollen surgical wound compared with the control group, implying a good postoperative recovery. Both men and women in the RAPP group reported significantly better values (and, hence good postoperative recovery) compared with the control group in the items sleeping difficulties; not having a general feeling of wellbeing and pain in the surgical wound.Conclusions: Measurement of patient-reported outcomes using a smartphone-based application was associated with decreased discomfort from several postoperative symptoms. Systematic e-assessment can thereby increase patients' quality of recovery and identify key areas for improvement in perioperative care.
|
|
| 20. |
|
|
| 21. |
- Montgomery, Scott, 1961-, et al.
(författare)
-
Sex of older siblings and cognitive function
- 2017
-
Konferensbidrag (refereegranskat)abstract
- Background : Number of older siblings is associated with lower cognitive function, possibly as marker of material disadvantage. Sex differences may signal an influence of inter-sibling interactions.Methods: The study used a national Swedish register-based cohort of men (n=644,603), born between 1970 and 1992 who undertook military conscription assessments in adolescence that included cognitive function measured on a normally-distributed scale of 1-9. Associations with siblings were investigated using linear regression.Results: After adjustment for numbers of younger siblings, year of conscription assessment, age/year of birth, sex, European socioeconomic classification for parents and maternal age at delivery; the regression coefficients (and 95% confidence intervals) for cognitive function are -0.26 (-0.27, -0.25), -0.42 (-0.44, -0.40), and -0.72 (-0.76, -0.67) for one, two and three or more male older siblings, respectively, compared with none; and -0.22 (-0.23, -0.21), -0.39 (-.41, -0.37), -0.62 (-0.67, -0.58) for one two and three or more female older siblings, respectively, compared with none. A larger number of younger siblings is not associated with lower cognitive function in the adjusted model.Conclusions: Family size is associated with cognitive function: older male siblings may have greater implications than females due to their demands on familial resources or through inter-sibling interactions.
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
- Salomonsson, Anette, et al.
(författare)
-
Hydrogen interaction with Pt- and PdMIS devices
- 2005
-
Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 98:1
-
Tidskriftsartikel (refereegranskat)abstract
- Hydrogen-sensitive Pd–SiO2–Si and Pt–SiO2–Si metal–insulator–semiconductor (MIS) devices have been studied in ultrahigh vacuum in the temperature range of 223–523 K. Adsorption/absorption of hydrogen occurs at the metal surface, in the metal bulk, and at the metal–insulator interface. The sensor signal, caused by hydrogen adsorption at the interface, shows a logarithmic dependence on the applied hydrogen pressure. The Pt-MIS device, which is fully functional at atmospheric pressures, is sensitive to changes in hydrogen pressure down to the 10−12-Torr scale. We propose that the interface adsorption follows a so-called Temkin isotherm with an interface heat of adsorption that varies with hydrogen coverage as ΔHi0(1−aθ). The initial heat of adsorption ΔHi0 is determined to 0.78 eV/hydrogen atom. The adsorption potential at the external Pt surface is found to be 0.45 eV/hydrogen atom. These values were obtained by modeling the hydrogen interaction with the MIS devices and fitting the model to a number of experimental results. Also studies of Pd-based devices were performed and compared with Pt. The hydrogen adsorption on the metal surface, previously treated as a first-order process on Pd, is shown to follow a second-order process. Qualitatively the results from the Pd- and Pt-MIS devices agree. Quantitatively there are differences. The hydrogen sensitivity of the Pt-MIS device is only approximately one-third compared to that of the Pd-MIS structure. This agrees with the result that the concentration of available hydrogen adsorption sites at the Pt–SiO2 interface is approximately 7×1017 m−2 whereas the concentrations of sites at the Pd–SiO2 interface is roughly three times larger (2×1018 m−2). An estimate of the size of the dipole moments (0.6–0.7 D) implies that the interface hydrogen atoms are strongly polarized. Differences are also observed in the microstructure of the metal films. Atomic force microscopy results show that the Pd surface reconstructs during H2–O2 exposures, while the Pt surface shows no such change at these temperatures.
|
|
| 25. |
|
|
