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- Gardumi, Francesco, et al.
(author)
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Carrying out a multi-model integrated assessment of European energy transition pathways : Challenges and benefits
- 2022
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In: Energy. - : Elsevier BV. - 0360-5442 .- 1873-6785. ; 258, s. 124329-124329
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Journal article (peer-reviewed)abstract
- With the publication of the European Green Deal, the European Union has committed to reaching carbon neutrality by 2050. The envisaged reductions of direct greenhouse gases emissions are seen as technically feasible, but if a wrong path is pursued, significant unintended impacts across borders, sectors, societies and ecosystems may follow. Without the insights gained from an impact assessment framework reaching beyond the techno-economic perspective, the pursuit of direct emission reductions may lead to counterproductive outcomes in the long run. We discuss the opportunities and challenges related to the creation and use of an integrated assessment framework built to inform the European Commission on the path to decarbonisation. The framework is peculiar in that it goes beyond existing ones in its scope, depth and cross-scale coverage, by use of numerous specialised models and case studies. We find challenges of consistency that can be overcome by linking modelling tools iteratively in some cases, harmonising modelling assumptions in others, comparing model outputs in others. We find the highest added value of the framework in additional insights it provides on the technical feasibility of decarbonisation pathways, on vulnerability aspects and on unintended environmental and health impacts on national and sub-national scale.
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- Hultborn, Ragnar, 1946, et al.
(author)
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Efficacy of pamidronate in breast cancer with bone metastases: a randomized, double-blind placebo-controlled multicenter study
- 1999
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In: Anticancer Res. - 0250-7005. ; 19:4C, s. 3383-92
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Journal article (peer-reviewed)abstract
- PURPOSE: To evaluate the efficacy of pamidronate 60 mg i.v. q 4 weeks in women with advanced breast cancer with skeletal metastases. PATIENTS AND METHODS: 404 woman with skeletal metastases from breast cancer in Sweden and Norway were included in a randomized, placebo-controlled, multicenter study. Except for the study medication, other palliative treatment was chosen at the discretion of the physician. Skeletal related events, i.e. increased pain, treatment of hypercalcemia, pathologic fractures of long bones or pelvis, paralyses due to vertebral compression, palliative radiotherapy for skeletal metastases, surgery on bone and change of antitumor therapy were recorded every third month as well as a self-estimated pain-score using visual Analog Scales and analgesic consumption. RESULTS: There was a significantly increased time to progression of pain (p < 0.01), to hypercalcemic events (p < 0.05) as well as for the cumulative number of skeletal related events (p < 0.01) in favor for the pamidronate group. No statistically significant reduction of pathologic fractures of long bones or pelvis, or pareses due to vertebral compression occurred. No statistically significant differences were found for the need of radiotherapy and surgery on bone. The pamidronate group faired better regarding performance status (p < 0.05). There was a statistically not significant lower consumption of opioid analgesics in the pamidronate group (p = 0.14). CONCLUSION: Pamidronate 60 mg i.v. q 4 weeks reduces skeletal events and improves the quality of life in women with bone metastases from breast cancer.
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- Shivakumar, Abhishek, et al.
(author)
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Drivers of renewable energy deployment in the EU : An analysis of past trends and projections
- 2019
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In: Energy Strategy Reviews. - : Elsevier. - 2211-467X .- 2211-4688. ; 26
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Journal article (peer-reviewed)abstract
- Energy policy in the European Union (EU) is driven by the objective to transition to an affordable, reliable, and low carbon energy system. To achieve this objective, the EU has explicitly stated targets for greenhouse reduction, shares of renewable energy sources (RES), and energy efficiency improvements for 2020 and 2030. In this paper, we focus on the drivers, barriers and enablers to achieving the EU's RES targets (20% by 2020 and 27% by 2030). Effective energy policies play a key role in the deployment of RES technologies. In order to design effective policies, a clear understanding of past trends and projections for future deployment is required. In this paper, we first analyse the past deployment of RES technologies for electricity supply (RES-E) in selected EU Member States. This highlights the key drivers, barriers, and enablers for deployment of RES in the past. In a second step, we conduct a meta-analysis of projections for RES-E shares from multiple well-established studies. Such an analysis will help in supporting the design of more effective energy policies and successfully achieving the EU's energy targets.
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