| 1. |
|
|
| 2. |
- Blennow, Mattias, 1980-, et al.
(författare)
-
Neutrinoless double beta decay in seesaw models
- 2010
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- We study the general phenomenology of neutrinoless double beta decay in seesaw models. In particular, we focus on the dependence of the neutrinoless double beta decay rate on the mass of the extra states introduced to account for the Majorana masses of light neutrinos. For this purpose, we compute the nuclear matrix elements as functions of the mass of the mediating fermions and estimate the associated uncertainties. We then discuss what can be inferred on the seesaw model parameters in the different mass regimes and clarify how the contribution of the light neutrinos should always be taken into account when deriving bounds on the extra parameters. Conversely, the extra states can also have a significant impact, canceling the Standard Model neutrino contribution for masses lighter than the nuclear scale and leading to unobservable neutrinoless double beta decay amplitudes even if neutrinos are Majorana particles. In particular, the decay rate is reduced by at least six orders of magnitude for masses of the extra states below 1MeV in absence of extra contributions. We also discuss how seesaw models could reconcile large rates of neutrinoless double beta decay with more stringent cosmological bounds on neutrino masses.
|
|
| 3. |
- Martín-Santamaría, Sonsoles, et al.
(författare)
-
Symmetric dithiodigalactoside : strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins
- 2011
-
Ingår i: Organic and biomolecular chemistry. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 9:15, s. 5445-5455
-
Tidskriftsartikel (refereegranskat)abstract
- Thioglycosides offer the advantage over O-glycosides to be resistant to hydrolysis. Based on initial evidence of this recognition ability for glycosyldisulfides by screening dynamic combinatorial libraries, we have now systematically studied dithiodigalactoside on a plant toxin (Viscum album agglutinin) and five human lectins (adhesion/growth-regulatory galectins with medical relevance e.g. in tumor progression and spread). Inhibition assays with surface-presented neoglycoprotein and in solution monitored by saturation transfer difference NMR spectroscopy, flanked by epitope mapping, as well as isothermal titration calorimetry revealed binding properties to VAA (K(a): 1560 +/- 20 M (1)). They were reflected by the structural model and the affinity on the level of toxin-exposed cells. In comparison, galectins were considerably less reactive, with intrafamily grading down to very minor reactivity for tandem-repeat-type galectins, as quantitated by radioassays for both domains of galectin-4. Model building indicated contact formation to be restricted to only one galactose moiety, in contrast to thiodigalactoside. The tested glycosyldisulfide exhibits selectivity between the plant toxin and the tested human lectins, and also between these proteins. Therefore, glycosyldisulfides have potential as chemical platform for inhibitor design.
|
|
| 4. |
- Valassi, Andrea, et al.
(författare)
-
Challenges in Monte Carlo Event Generator Software for High-Luminosity LHC
- 2021
-
Ingår i: Computing and Software for Big Science. - : Springer Science and Business Media LLC. - 2510-2044 .- 2510-2036. ; 5:1
-
Tidskriftsartikel (refereegranskat)abstract
- We review the main software and computing challenges for the Monte Carlo physics event generators used by the LHC experiments, in view of the High-Luminosity LHC (HL-LHC) physics programme. This paper has been prepared by the HEP Software Foundation (HSF) Physics Event Generator Working Group as an input to the LHCC review of HL-LHC computing, which has started in May 2020.
|
|
