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| 2. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 11. |
- Angelini, P., et al.
(författare)
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On the area requirements of Euclidean minimum spanning trees
- 2014
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Ingår i: Computational geometry. - : Elsevier. - 0925-7721 .- 1879-081X. ; 47:2, s. 200-213
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Tidskriftsartikel (refereegranskat)abstract
- In their seminal paper on Euclidean minimum spanning trees, Monma and Suri (1992) proved that any tree of maximum degree 5 admits a planar embedding as a Euclidean minimum spanning tree. Their algorithm constructs embeddings with exponential area; however, the authors conjectured that there exist n-vertex trees of maximum degree 5 that require c(n) x c(n) area to be embedded as Euclidean minimum spanning trees, for some constant c > 1. In this paper, we prove the first exponential lower bound on the area requirements for embedding trees as Euclidean minimum spanning trees.
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| 12. |
- Angelini, P., et al.
(författare)
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On the area requirements of Euclidean minimum spanning trees
- 2011
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Ingår i: Algorithms and Data Structures. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642222993 ; , s. 25-36
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Konferensbidrag (refereegranskat)abstract
- In their seminal paper on Euclidean minimum spanning trees [Discrete & Computational Geometry, 1992], Monma and Suri proved that any tree of maximum degree 5 admits a planar embedding as a Euclidean minimum spanning tree. Their algorithm constructs embeddings with exponential area; however, the authors conjectured that c(n) x c(n) area is sometimes required to embed an n-vertex tree of maximum degree 5 as a Euclidean minimum spanning tree, for some constant c > 1. In this paper, we prove the first exponential lower bound on the area requirements for embedding trees as Euclidean minimum spanning trees.
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| 14. |
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| 15. |
- Rughetti, Aurelia, et al.
(författare)
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Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells
- 2005
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Ingår i: J Immunol. ; 174:12, s. 7764-7772
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Tidskriftsartikel (refereegranskat)abstract
- Tumors exploit several strategies to evade immune recognition, including the production of a large number of immunosuppressive factors, which leads to reduced numbers and impaired functions of dendritic cells (DCs) in the vicinity of tumors. We have investigated whether a mucin released by tumor cells could be involved in causing these immunomodulating effects on DCs. We used a recombinant purified form of the MUC1 glycoprotein, an epithelial associated mucin that is overexpressed, aberrantly glycosylated, and shed during cancer transformation. The O-glycosylation profile of the recombinant MUC1 glycoprotein (ST-MUC1) resembled that expressed by epithelial tumors in vivo, consisting of large numbers of sialylated core 1 (sialyl-T, ST) oligosaccharides. When cultured in the presence of ST-MUC1, human monocyte-derived DCs displayed a modified phenotype with decreased expression of costimulatory molecules (CD86, CD40), Ag-presenting molecules (DR and CD1d), and differentiation markers (CD83). In contrast, markers associated with an immature phenotype, CD1a and CD206 (mannose receptor), were increased. This effect was already evident at day 4 of DC culture and was dose dependent. The modified phenotype of DCs corresponded to an altered balance in IL-12/IL-10 cytokine production, with DC expressing an IL-10highIL-12low phenotype after exposure to ST-MUC1. These DCs were defective in their ability to induce immune responses in both allogeneic and autologous settings, as detected in proliferation and ELISPOT assays. The altered DC differentiation and Ag presentation function induced by the soluble sialylated tumor-associated mucin may represent a mechanism by which epithelial tumors can escape immunosurveillance.
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| 16. |
- Simon, C, et al.
(författare)
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Incorporating molecular evolution into phylogenetic analysis, and a new compilation of conserved polymerase chain reaction primers for animal mitochondrial DNA
- 2006
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Ingår i: ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS. - : Annual Reviews. - 1543-592X .- 1545-2069. ; 37, s. 545-579
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- DNA data has been widely used in animal phylogenetic studies over the past 15 years. Here we review how these studies have used advances in knowledge of molecular evolutionary processes to create more realistic models of evolution, evaluate the information content of data, test phylogenetic hypotheses, attach time to phylogenies, and understand the relative usefulness of mitochondrial and nuclear genes. We also provide a new compilation of conserved polymerase chain reaction (PCR) primers for mitochondrial genes that complements our earlier compilation.
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