| 1. |
- Mlecnik, B, et al.
(författare)
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Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
- 2023
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 15:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SITC) study evaluated the pre-defined consensus Immunoscore in tumors from 1885 AJCC/UICC-TNM Stage I/II CC patients from Canada/USA (Cohort 1) and Europe/Asia (Cohort 2). METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM). The time to recurrence (TTR) was the primary endpoint. Secondary endpoints were disease-free survival (DFS), overall survival (OS), prognosis in Stage I, Stage II, Stage II-high-risk, and microsatellite-stable (MSS) patients. RESULTS: High-Immunoscore presented with the lowest risk of recurrence in both cohorts. In Stage I/II, recurrence-free rates at 5 years were 78.4% (95%-CI, 74.4–82.6), 88.1% (95%-CI, 85.7–90.4), 93.4% (95%-CI, 91.1–95.8) in low, intermediate and high Immunoscore, respectively (HR (Hi vs. Lo) = 0.27 (95%-CI, 0.18–0.41); p < 0.0001). In Cox multivariable analysis, the association of Immunoscore to outcome was independent (TTR: HR (Hi vs. Lo) = 0.29, (95%-CI, 0.17–0.50); p < 0.0001) of the patient’s gender, T-stage, sidedness, and microsatellite instability-status (MSI). A significant association of Immunoscore with survival was found for Stage II, high-risk Stage II, T4N0 and MSS patients. The Immunoscore also showed significant association with TTR in Stage-I (HR (Hi vs. Lo) = 0.07 (95%-CI, 0.01–0.61); P = 0.016). The Immunoscore had the strongest (69.5%) contribution χ2 for influencing survival. Patients with a high Immunoscore had prolonged TTR in T4N0 tumors even for patients not receiving chemotherapy, and the Immunoscore remained the only significant parameter in multivariable analysis. CONCLUSION: In early CC, low Immunoscore reliably identifies patients at risk of relapse for whom a more intensive surveillance program or adjuvant treatment should be considered.
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| 2. |
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| 3. |
- Duffy, J. E., et al.
(författare)
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Biodiversity mediates top-down control in eelgrass ecosystems: a global comparative-experimental approach
- 2015
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 18:7, s. 696-705
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Tidskriftsartikel (refereegranskat)abstract
- Nutrient pollution and reduced grazing each can stimulate algal blooms as shown by numerous experiments. But because experiments rarely incorporate natural variation in environmental factors and biodiversity, conditions determining the relative strength of bottom-up and top-down forcing remain unresolved. We factorially added nutrients and reduced grazing at 15 sites across the range of the marine foundation species eelgrass (Zostera marina) to quantify how top-down and bottom-up control interact with natural gradients in biodiversity and environmental forcing. Experiments confirmed modest top-down control of algae, whereas fertilisation had no general effect. Unexpectedly, grazer and algal biomass were better predicted by cross-site variation in grazer and eelgrass diversity than by global environmental gradients. Moreover, these large-scale patterns corresponded strikingly with prior small-scale experiments. Our results link global and local evidence that biodiversity and top-down control strongly influence functioning of threatened seagrass ecosystems, and suggest that biodiversity is comparably important to global change stressors.
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| 4. |
- Mlecnik, B, et al.
(författare)
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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
- 2022
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:18
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I–III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75−30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10–4.55) p = 0.0269) of the patient’s gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27−9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35−5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21−5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39−6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
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| 5. |
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| 6. |
- Boström, C., et al.
(författare)
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Distribution, structure and function of Nordic eelgrass (Zostera marina) ecosystems: Implications for coastal management and conservation
- 2014
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Ingår i: Aquatic conservation. - : Wiley. - 1052-7613. ; 24:3, s. 410-434
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Forskningsöversikt (refereegranskat)abstract
- This paper focuses on the marine foundation eelgrass species, Zostera marina, along a gradient from the northern Baltic Sea to the north-east Atlantic. This vast region supports a minimum of 1480km2 eelgrass (maximum >2100km2), which corresponds to more than four times the previously quantified area of eelgrass in Western Europe. Eelgrass meadows in the low salinity Baltic Sea support the highest diversity (4-6 spp.) of angiosperms overall, but eelgrass productivity is low (<2g dw m-2 d-1) and meadows are isolated and genetically impoverished. Higher salinity areas support monospecific meadows, with higher productivity (3-10g dw m-2 d-1) and greater genetic connectivity. The salinity gradient further imposes functional differences in biodiversity and food webs, in particular a decline in number, but increase in biomass of mesograzers in the Baltic. Significant declines in eelgrass depth limits and areal cover are documented, particularly in regions experiencing high human pressure. The failure of eelgrass to re-establish itself in affected areas, despite nutrient reductions and improved water quality, signals complex recovery trajectories and calls for much greater conservation effort to protect existing meadows. The knowledge base for Nordic eelgrass meadows is broad and sufficient to establish monitoring objectives across nine national borders. Nevertheless, ensuring awareness of their vulnerability remains challenging. Given the areal extent of Nordic eelgrass systems and the ecosystem services they provide, it is crucial to further develop incentives for protecting them. © 2014 The Authors.
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| 7. |
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| 8. |
- Al Jebali, Ramsey, et al.
(författare)
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Recent Developments SoNDe High-Flux Detector Project
- 2018
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Ingår i: Recent Developments SoNDe High-Flux Detector Project.
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Konferensbidrag (refereegranskat)abstract
- New high-flux and high-brilliance neutron sources demand a higher count-rate capability in neutron detectors. In order to achieve that goal, the Solid-State Neutron Detector (SoNDe) project is developing a scintillation-based neutron detector. It will be capable of fully exploiting the available flux at small-angle neutron scattering (SANS) instruments at high brilliance sources, such as SKADI at the European Spallation Source (ESS). The read-out of the scintillator is based on a pixelized multi-anode PMT (MaPMT), where each pixel is treated separately. In addition to enabling higher achievable count-rates, one of the design goals was to develop a modular and scalable solution that can also be used in other instruments or even contexts, such as for laboratory setups. This has been achieved by combining the complete read-out electronics along with the MaPMT into modules that can be controlled and read-out individually via a network without additional any infrastructure. An overview of the present state of development and current test results is presented, highlighting the results of previously published project reports.
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| 9. |
- Barboza, F. R., et al.
(författare)
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Geographic variation in fitness-related traits of the bladderwrack Fucus vesiculosus along the Baltic Sea-North Sea salinity gradient
- 2019
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 9:16, s. 9225-9238
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Tidskriftsartikel (refereegranskat)abstract
- In the course of the ongoing global intensification and diversification of human pressures, the study of variation patterns of biological traits along environmental gradients can provide relevant information on the performance of species under shifting conditions. The pronounced salinity gradient, co-occurrence of multiple stressors, and accelerated rates of change make the Baltic Sea and its transition to North Sea a suitable region for this type of study. Focusing on the bladderwrack Fucus vesiculosus, one of the main foundation species on hard-bottoms of the Baltic Sea, we analyzed the phenotypic variation among populations occurring along 2,000km of coasts subjected to salinities from 4 to >30 and a variety of other stressors. Morphological and biochemical traits, including palatability for grazers, were recorded at 20 stations along the Baltic Sea and four stations in the North Sea. We evaluated in a common modeling framework the relative contribution of multiple environmental drivers to the observed trait patterns. Salinity was the main and, in some cases, the only environmental driver of the geographic trait variation in F.vesiculosus. The decrease in salinity from North Sea to Baltic Sea stations was accompanied by a decline in thallus size, photosynthetic pigments, and energy storage compounds, and affected the interaction of the alga with herbivores and epibiota. For some traits, drivers that vary locally such as wave exposure, light availability or nutrient enrichment were also important. The strong genetic population structure in this macroalgae might play a role in the generation and maintenance of phenotypic patterns across geographic scales. In light of our results, the desalination process projected for the Baltic Sea could have detrimental impacts on F.vesiculosus in areas close to its tolerance limit, affecting ecosystem functions such as habitat formation, primary production, and food supply.
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| 10. |
- Barreto, C., et al.
(författare)
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Graphite nanoplatelet/pyromellitic dianhydride melt modified PPC composites: Preparation and characterization
- 2013
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Ingår i: Polymer. - : Elsevier BV. - 0032-3861. ; 54:14, s. 3574-3585
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Tidskriftsartikel (refereegranskat)abstract
- The properties of composites prepared by melt compounding from graphite nanoplatelets (GNP) and pyromellitic anhydride modified poly(propylene carbonate) (PPC) were investigated. GNPs of different morphologies and acid residue levels were selected. Acid residues in GNP grades were detrimental for PPC in terms of thermal stability, stiffness and conservation of the molecular weight. The exfoliation of graphite nanoparticles was challenging, and morphologies of combined tactoids with thicknesses both on the micro and nano scales were observed. The filler contributed to the thermal stability, and the mechanical reinforcement was observed from approximately 6 wt% GNP and accompanied by an increase in the glass transition temperature. For a specific GNP grade, at a 15 wt% filler content, the glass transition temperature increased by 10 degrees C and the storage modulus measured at 20 and 30 degrees C increased correspondingly by a factor of ca. 3 and 30, respectively. Solid state NMR spin-spin relaxation time T-2 measurements (Carr-Purcell-Meiboom-Gill pulse sequence) revealed three significantly different components. Using PLS, empirical models were established which enable the prediction of some viscoelastic parameters as a function of filler parameters and the average T-2.
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| 11. |
- Barreto, C., et al.
(författare)
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Multiwall carbon nanotube/PPC composites: Preparation, structural analysis and thermal stability
- 2013
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Ingår i: European Polymer Journal. - : Elsevier BV. - 0014-3057 .- 1873-1945. ; 49:8, s. 2149-2161
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Tidskriftsartikel (refereegranskat)abstract
- The focus of this report concerns the preparation nanocomposites from poly(propylene carbonate) (PPC) and multiwall carbon nanotubes (MWNTs). A solvent route using tetrahydrofuran, ethoxylated non- ionic surfactants combined with sonication was found to be successful in deagglomerating and dispersing the nanotubes. Transmission electron microscopy revealed highly disentangled and dispersed nanotubes and was supported by the qualitative stability evaluations. The morphology and molecular mobility of the prepared nanocomposites (0.5, 3.0 and 5.0 wt% of nanotubes) were characterized by rheology, microscopy, low-field solid-state nuclear magnetic resonance, and electrical conductivity. The networking of nanotubes was highest with a stearyl alcohol ethoxylate surfactant, and was found to improve with the sonication time. Nanotube percolation was established, both rheologically and electrically, from a filler content of approximately 0.5 wt%. A higher tendency toward particle agglomeration was observed at higher MWNT loadings. Only minor changes in the glass transition temperature were measured presumably due to the presence of solvent and surfactant residues. The thermal stability was marginally improved by increasing the loading and dispersion of the nanotubes, and appeared to be modified by solvent and surfactant residues.
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| 12. |
- Bornmalm, Lennart, 1956, et al.
(författare)
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Sverre Varv & Mek. Verkstad, Hisings Kärra. Lustbåtsvarv längs Göta älv.
- 2009
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Ingår i: Fiskebåtarna & Varven – Skeppsbyggarna. (Lennart Bornmalm, Krister Bång, Christine Fredriksen och Curt S. Ohlsson, redaktörer). - Göteborg : Breakwater Publishing. - 9789197769778 ; , s. 244-275
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 13. |
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| 14. |
- Haraldsen, Heidi M. M., et al.
(författare)
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An exploration of reciprocity among teacher and students in female pre-professional ballet education : a shared reality theory perspective
- 2023
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Ingår i: Frontiers in Education. - : Frontiers Media S.A.. - 2504-284X. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to explore perceptions of shared reality in teacher-student partnerships in ballet, and how these perceptions were related to experiences of quality in the relationship and well-being. A longitudinal qualitative study design was adopted, with three female ballet students and their teacher participating in three semi-structured interviews each over an eight-month period. Data were analyzed using a combination of thematic and narrative analysis. Findings indicated that across the teacher-student relationships there were perceptions of a shared reality only on the professional and distanced level and not on a relational and personal level. This was achieved by a common experience of what matters in the world of ballet education as well as students finding their teacher as trustworthy. Furthermore, it appeared that the authoritarian apprenticeship culture in ballet, where the teachers give clear instructions and feedback, and where the student role is to listen and adapt to the teacher's instructions, was a barrier to fully achieving a shared reality on a personal and deeper level. In turn, this influenced the quality of the relationship and the wellbeing of both teacher and students. The present study offers critical reflections on the cultural backdrop of teaching and learning in ballet and highlights the importance of teachers to facilitate a supportive, unconditional, and trustworthy relationship so that they can work together in a more productive manner.
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| 15. |
- Peña, Viviana, et al.
(författare)
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Lithothamnion (Hapalidiales, Rhodophyta) in the changing Arctic and Subarctic : DNA sequencing of type and recent specimens provides a systematics foundation*
- 2021
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Ingår i: European journal of phycology. - : Taylor & Francis. - 0967-0262 .- 1469-4433. ; 56:4, s. 468-493
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Tidskriftsartikel (refereegranskat)abstract
- Coralline red algae in the non-geniculate genera Clathromorphum, Phymatolithon and Lithothamnion are important benthic ecosystem engineers in the photic zone of the Arctic and Subarctic. In these regions, the systematics and biogeography of Clathromorphum and Phymatolithon have mostly been resolved whereas Lithothamnion has not, until now. Seventy-three specific and infraspecific names were given to Arctic and Subarctic Lithothamnion specimens in the late 19th and early 20th century by Frans R. Kjellman and Mikael H. Foslie. DNA sequences from 36 type specimens, five historical specimens, and an extensive sampling of recent collections resulted in the recognition of four Arctic and Subarctic Lithothamnion species, L. glaciale, L. lemoineae, L. soriferum and L. tophiforme. Three genes were sequenced, two plastid-encoded, rbcL and psbA, and the mitochondrial encoded COI-5P; rbcL and COI-5P segregated L. glaciale from L. tophiforme but psbA did not. Partial rbcL sequences obtained from type collections enabled us to correctly apply the earliest available names and to correctly place the remainder in synonymy. We were unable to sequence another 22 type specimens, but all of these are more recent names than those that are now applied. It is difficult to identify these species solely on morpho-anatomy as they can all occur as encrusting corallines or as maerl (rhodoliths). We demonstrate the importance of sequencing historical type specimens by showing that the recently proposed North-east Atlantic L. erinaceum is a synonym of one of the earliest published Arctic species of Lithothamnion, L. soriferum, itself incorrectly placed in synonymy under L. tophiforme based on morpho-anatomy. Based on sequenced specimens, we update the distributions and ecology of these species.
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| 16. |
- Ramirez-Llodra, E., et al.
(författare)
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A snap shot of the short-term response of crustaceans to macrophyte detritus in the deep Oslofjord
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- A test deployment of a time-lapse camera lander in the deep Oslofjord (431 m) was used to obtain initial information on the response of benthic fauna to macroalgal debris. Three macroalgal species were used on the lander baited plate: Fucus serratus, Saccharina latissima and Laminaria hyperborea and observed during 41.5 hours. The deep-water shrimp Pandalus borealis were attracted to the macroalgae rapidly (3 min after the lander reached the seafloor), followed by amphipods. Shrimp abundances were significantly higher in areas covered by macroalgae compared to the adjacent seafloor and the number of shrimp visiting the macroalgae increased with time. Amphipods arrived 13 hours later and were observed mainly on decaying L. hyperborea. The abundance of amphipods on L. hyperborea increased rapidly, reaching a peak at 31 h after deployment. These initial observations suggest that debris from kelp forests and other macroalgal beds may play an important role in fuelling deep benthic communities in the outer Oslofjord and, potentially, enhance secondary production of commercial species such as P. borealis.
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