| 1. |
- Heggebo, L. C., et al.
(författare)
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Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH-mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
- 2023
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Ingår i: Bmj Open. - : BMJ. - 2044-6055. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionThe use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from radiation. This is principally beneficial and holds promise of reduced long-term side effects. However, the sparing of seemingly non-cancerous tissue is not necessarily positive for isocitrate dehydrogenase (IDH)-mutated diffuse gliomas grade 2-3, which have a diffuse growth pattern. With their relatively good prognosis, yet incurable nature, therapy needs to be delicately balanced to achieve a maximal survival benefit combined with an optimised quality of life.Methods and analysisPRO-GLIO (PROton versus photon therapy in IDH-mutated diffuse grade 2 and 3 GLIOmas) is an open-label, multicentre, randomised phase III non-inferiority study. 224 patients aged 18-65 years with IDH-mutated diffuse gliomas grade 2-3 from Norway and Sweden will be randomised 1:1 to radiotherapy delivered with protons (experimental arm) or photons (standard arm). First intervention-free survival at 2 years is the primary endpoint. Key secondary endpoints are fatigue and cognitive impairment, both at 2 years. Additional secondary outcomes include several survival measures, health-related quality of life parameters and health economy endpoints.Ethics and disseminationTo implement proton therapy as part of standard of care for patients with IDH-mutated diffuse gliomas grade 2-3, it should be deemed safe. With its randomised controlled design testing proton versus photon therapy, PRO-GLIO will provide important information for this patient population concerning safety, cognition, fatigue and other quality of life parameters. As proton therapy is considerably more costly than its photon counterpart, cost-effectiveness will also be evaluated. PRO-GLIO is approved by ethical committees in Norway (Regional Committee for Medical & Health Research Ethics) and Sweden (The Swedish Ethical Review Authority) and patient inclusion has commenced. Trial results will be published in international peer-reviewed journals, relevant conferences, national and international meetings and expert forums.Trial registration numberClinicalTrials.gov Registry (NCT05190172).
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| 6. |
- Gubanski, S. M., et al.
(författare)
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Performance of biologically contaminated high voltage insulators
- 2006
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Konferensbidrag (refereegranskat)abstract
- Biological growth has been observed on insulators installed all over the world. However, so far, its impact on insulator performance is not well known. This paper summarizes the work published in the field. Based on the gathered experiences, it can be concluded that microbiological growth is unlikely to cause severe degradation of the rubber housings of non-ceramic insulators. Furthermore, it seems that the impact of growth on the insulator performance is rather low. Techniques available for detection and characterisation of growth on insulators are also described and discusses. Among those, laser-induced fluorescence (LIF) spectroscopy has been found to give good results in remote detection of micro-organisms.
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| 12. |
- Abeywickrama, K. G. Nilanga B., et al.
(författare)
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Determination of complex permeability of silicon steel for use in high-frequency modeling of power transformers
- 2008
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Ingår i: IEEE transactions on magnetics. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0018-9464 .- 1941-0069. ; 44:4, s. 438-444
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Tidskriftsartikel (refereegranskat)abstract
- Information about frequency dependence of complex permeability of silicon steel is a vital input parameter in calculations of transformer winding inductance used for modeling. high-frequency behavior (100 Hz-1 MHz). We present two ways of determining small signal complex permeability spectra in frequency domain and compare and discuss the results. The first method is based on an optimization procedure, in which inductance of a winding is measured and calculated by analytical formulas and finite-element modeling. The second method makes use of a single sheet tester. We show that the magnitude of effective permeability of the silicon steel laminations remains significant up to about 100 kHz. We also report on the effect of magnetic viscosity on complex permeability.
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| 14. |
- Bin, Ma, et al.
(författare)
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Dielectric Properties and Resistance to Corona and Ozone of Epoxy Compositions Filled with Micro- and Nano-fillers
- 2009
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Ingår i: Annual Report - Conference on Electrical Insulation and Dielectric Phenomena. ; , s. -380
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Konferensbidrag (refereegranskat)abstract
- This paper describes activities aiming to evaluate and compare the resistance to a prolonged corona and ozone exposure for a range of epoxy based compositions filled with micro- and nano-fillers of silica at different proportions. It has been earlier shown for this system that substitution of 5 wt% of micro-filler by nano-filler slightly improved mechanical properties, yielding an increase in Young's modulus, tensile strength and elongation at break. At the same time, the toughness of the systems decreased with the addition of nano-fillers indicating a poor particle-matrix interaction, which was in accordance with the prior art claiming that this interaction is weaker in case of SiO 2 nano-particles, as for example compared to Al 2O 3 nano-particles. For the exposure to corona and ozone a methodology employing a multiple-needle electrode system was used, as recommended by CIGRE working group WG D1.14. Measurements of surface resistivity, bulk resistivity as well as dielectric response (DR) at broad frequency range (10 -4-10 3 Hz) were performed on new samples of the investigated compositions and after each of two sequences of the corona-ozone treatment, lasting 100hours each. It was found that the long-term corona-ozone exposure had obvious effect on surface resistivity for all the compositions investigated and the contents of the micro- and nano-fillers played a significant role in the observed changes. On the other hand, bulk resisitivity, dielectric permittivity as well as dissipation factor, all being the properties of material bulk, did not exhibit high sensitivity to the exposure.
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| 17. |
- Florkowski, M., et al.
(författare)
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Condition Monitoring and Diagnostics
- 2013
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Ingår i: IEEE Transactions on Dielectrics and Electrical Insulation. - 1558-4135 .- 1070-9878. ; 20:6, s. 1961-1961
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 21. |
- Gubanski, M., et al.
(författare)
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Quality of life in patients with advanced gastric cancer sequentially treated with docetaxel and irinotecan with 5-fluorouracil and folinic acid (leucovin)
- 2014
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Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 31:4, s. 906-
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Tidskriftsartikel (refereegranskat)abstract
- With a median overall survival of only 9-13 months in patients with advanced gastric cancer (GC), the quality of life (QoL) during the palliative treatment remains a key issue. Furthermore, when combinations of two or three drugs are used, the impact on QoL should be carefully evaluated. This was studied within the GATAC trial in patients sequentially treated with docetaxel and irinoteca n with 5-fluorouracil and leucovorin (5-Fu/ Lv). Patients with previously untreated advanced GC were randomly assigned to start with docetaxel 45 mg/m(2) (arm T) or irinotecan 180 mg/m(2) (arm C) with bolus and 44 h infusion of 5-Fu/Lv (D1, q2 weeks). After four courses, there was a prescheduled crossover to the alternative regimen for four additional courses. QoL was measured with the EORTC QLQ-C30 questionnaire at the start of the treatment, at crossover and after completing treatment with both regimens. Eighty-one patients were randomized, and 78 patients started treatment. A total of 191 completed QoL questionnaires were collected. There were no statistically significant differences in QoL scores between the two treatment groups and no changes in mean scores during the 16 weeks of treatment. During the last 8 weeks of treatment, a significantly larger portion of patients with radiological response reported sustained or better QoL scores than those with no radiological response (82 vs. 50 %, p = 0.007). Chemotherapy in advanced GC did not affect QoL average scores. Patients with non-responding tumours reported more often a decline in the global QoL score. The concept of the pre-scheduled switch of chemotherapy regimens prior to progression should be further studied in this disease, as it appears effective, tolerable and not to negatively affect QoL.
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| 22. |
- Gubanski, Stanislaw, 1950, et al.
(författare)
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Ageing of Silicone Rubber Insulators in Coastal and Inland Tropical Environment
- 2010
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Ingår i: IEEE Transactions on Dielectrics and Electrical Insulation. - 1558-4135 .- 1070-9878. ; 17:2, s. 326-333
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents investigations on the performance of 33 kV silicone rubber insulators characterized by different creepage lengths, which aimed to find out whether the insulators could permanently work when electrically stressed beyond the recommended limits in polluted and clean tropical environments. The study was performed under natural field and laboratory conditions. The insulators tested included eight types of silicone rubber composite insulators, one type of hybrid silicone-ceramic insulator and one semi-conducting glazed porcelain insulator, while ordinary porcelain and glass insulators were used as reference. During the field investigation, two sets of the insulators were separately installed and energized in coastal and inland parts of Sri Lanka, being by that exposed to marine and clean tropical environments. Their performances were periodically evaluated by visual inspections and measurements of hydrophobicity class. After five years of field exposure, the insulator performances were evaluated in laboratory by measurements of leakage currents under clean fog conditions and of wet flashover voltage. A third set of the insulators was aged in laboratory for 1000 hours inside a salt fog chamber where the insulators were continuously energized and daily sprayed with salt solution for eight hours and left to rest for remaining 16 hours. This treatment represented conditions similar as those in the field i.e. insulators exposed to salt sprays during monsoons. The insulator performances were investigated by measurements of leakage currents and classifying their patterns into different categories, i.e. capacitive, resistive, non-linear, discharge and strong discharge types, by means of fast Fourier transform and short time Fourier transform analyses. It was found that the long-term field exposure yielded weaker insulator deterioration than the salt fog chamber ageing, which indicated for a possibility to increase the electric stress on silicone rubber insulators to levels higher than the ones used today on glass and porcelain counterparts.
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| 24. |
- Gubanski, S. M., et al.
(författare)
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Performance and diagnostics of biologically contaminated insulators
- 2007
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Ingår i: ICPADM 2006. - : IEEE. - 1424401895 - 9781424401895 ; , s. 23-30
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Konferensbidrag (refereegranskat)abstract
- Biological growth has been observed on insulators installed all over the world. However, so far, its impact on insulator performance is not well known. This paper summarizes a majority of the work published in the field. Based on the gathered experiences, it can be concluded that microbiological growth is unlikely to cause severe degradation of the rubber housings of non-ceramic insulators. Furthermore, it seems that the impact of growth on the insulator performance is rather low. Techniques available for detection and characterisation of growth on insulators are also described and discusses. Among those, laser-induced fluorescence (LIF) spectroscopy has been found to give good results in remote detection of micro-organisms.
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