SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Gustafson Erik A.) "

Sökning: WFRF:(Gustafson Erik A.)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Clark, Andrew G., et al. (författare)
  • Evolution of genes and genomes on the Drosophila phylogeny
  • 2007
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
  • Tidskriftsartikel (refereegranskat)abstract
    • Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
  •  
2.
  • Arnoldussen, Ilse A. C., et al. (författare)
  • Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC study
  • 2019
  • Ingår i: Neurology. - : Wolters Kluwer. - 0028-3878 .- 1526-632X. ; 93:9, s. e864-e878
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Adiposity predictors, body mass index (BMI), waist circumference (WC), and blood leptin and total adiponectin levels were associated with components of cerebral small vessel disease (CSVD) and brain volumetry in 503 adults with CSVD who were ≥50 years of age and enrolled in the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC).METHODS: RUN DMC participants were followed up for 9 years (2006-2015). BMI, WC, brain imaging, and dementia diagnoses were evaluated at baseline and follow-up. Adipokines were measured at baseline. Brain imaging outcomes included CSVD components, white matter hyperintensities, lacunes, microbleeds, gray and white matter, hippocampal, total brain, and intracranial volumes.RESULTS: Cross-sectionally among men at baseline, higher BMI, WC, and leptin were associated with lower gray matter and total brain volumes, and higher BMI and WC were associated with lower hippocampal volume. At follow-up 9 years later, higher BMI was cross-sectionally associated with lower gray matter volume, and an obese WC (>102 cm) was protective for ≥1 lacune or ≥1 microbleed in men. In women, increasing BMI and overweight or obesity (BMI ≥25 kg/m2 or WC >88 cm) were associated with ≥1 lacune. Longitudinally, over 9 years, a baseline obese WC was associated with decreasing hippocampal volume, particularly in men, and increasing white matter hyperintensity volume in women and men.CONCLUSIONS: Anthropometric and metabolic adiposity predictors were differentially associated with CSVD components and brain volumetry outcomes by sex. Higher adiposity is associated with a vascular-neurodegenerative spectrum among adults at risk for vascular forms of cognitive impairment and dementias.
  •  
3.
  •  
4.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (3)
konferensbidrag (1)
Typ av innehåll
refereegranskat (3)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Zhang, Yu (1)
Sirota, Marina (1)
Lindblad-Toh, Kersti ... (1)
Freyhult, Eva, 1979- (1)
Lindblom, A (1)
Nguyen, Thu (1)
visa fler...
Åström, Karl Johan (1)
Johansson, Jan-Erik (1)
Guigo, Roderic (1)
Alexander, Allen (1)
Ljungman, P (1)
Wang, Jun (1)
Kellis, Manolis (1)
Brune, Mats, 1950 (1)
Grabherr, Manfred (1)
Karpen, Gary H. (1)
Pachter, Lior (1)
Mauceli, Evan (1)
Heger, Andreas (1)
Lara, Marcia (1)
Ponting, Chris P. (1)
Venter, J. Craig (1)
Nielsen, Rasmus (1)
Tao, Wei (1)
Ardell, David H. (1)
MacCallum, Iain (1)
Gnerre, Sante (1)
Haerty, Wilfried (1)
Jaffe, David B. (1)
Hultmark, Dan (1)
Wilson, Richard K (1)
McKernan, Kevin (1)
Arnoldussen, Ilse A. ... (1)
Kiliaan, Amanda J. (1)
Gustafson, Deborah R ... (1)
Leijsen, Esther M. C ... (1)
de Leeuw, Frank-Erik (1)
Broliden, K (1)
Kristiansen, Karsten (1)
Evans, Jay D. (1)
Ritchie, Michael G. (1)
Griffiths-Jones, Sam (1)
Vilella, Albert J (1)
Parts, Leopold (1)
Schaeffer, Stephen W ... (1)
Pedersen, Jakob S. (1)
Holmes, Ian (1)
Batzoglou, Serafim (1)
Hinrichs, Angie S. (1)
Fulton, Robert (1)
visa färre...
Lärosäte
Göteborgs universitet (1)
Umeå universitet (1)
Uppsala universitet (1)
Lunds universitet (1)
Högskolan i Skövde (1)
Karolinska Institutet (1)
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
Naturvetenskap (1)
Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy