| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 5. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 6. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 7. |
- Jones, Gregory T., et al.
(författare)
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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- 2017
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Ingår i: Circulation Research. - 0009-7330 .- 1524-4571. ; 120:2, s. 341-
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
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| 8. |
- Swed, S., et al.
(författare)
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Monkeypox in Syria : Highlighting an awareness issue
- 2023
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Ingår i: IJID Regions. - : Elsevier BV. - 2772-7076. ; 7, s. 271-276
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Tidskriftsartikel (refereegranskat)abstract
- Background: The World Health Organization (WHO) verified 780 cases of monkeypox across 27 countries between 13 May 2022 and 2 June 2022. The aim of our study was to assess the level of awareness of human monkeypox virus among Syrian medical students, general practitioners, medical residents, and specialists. Methods: A cross-sectional online survey was performed in Syria between May 2 and September 8, 2022. The survey consisted of 53 questions within the following three categories: demographic information, work-related details, and monkeypox knowledge. Results: In total, 1257 Syrian healthcare workers and medical students were enrolled in our study. The animal host and incubation time for monkeypox were correctly identified by just 2.7% and 33.3% of responders, respectively. Sixty percent of the study sample thought that the symptoms of monkeypox and smallpox are identical. No statistically significant associations were found between predictor variables and knowledge regarding monkeypox (p-value > 0.05). Conclusion: Education and awareness regarding monkeypox vaccinations are of paramount importance. It is essential that clinical doctors are adequately aware of this disease, in order to avoid an uncontrolled situation, as experienced with COVID-19.
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| 9. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 10. |
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| 11. |
- Swed, S., et al.
(författare)
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Syrians' awareness of cardiovascular disease risk factors and warning indicators : a descriptive cross-sectional study
- 2023
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Ingår i: Scientific Reports. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The awareness of cardiovascular diseases (CVDs) contributes to the complications and fatality rates from these diseases among individuals; however, no previous study in Syria was conducted on this topic; thus, this study aims to assess Syrians' awareness of CVDs warning symptoms and risk factors. This online cross-sectional study was performed in Syria between the 1st and 25th of August 2022. The inclusion criteria for the sample were citizens of Syria over 18 who currently reside in Syria. The questionnaire included open- and closed-ended questions to assess the awareness of CVDs. A total of 1201 participants enrolled in the study with a response rate of 97.2%; more than half of the participants (61.4%) were aged 18–24. The most recognizable risk factors and warning signs when asking close-ended and open-ended questions were smoking (95.2%, 37.1%) and chest pain (87.8%, 24.8%), respectively. Overall knowledge scores for risk factors and warning signs were (61.5%). Regarding knowledge score of CVDs risk factors and warning signs, participants aged 45–54 scored higher than other age groups, and respondents with a university education level had a higher score than other educational levels (15.7 ± 0.3), (14.5 ± 0.1), respectively. Participants aged 45–54 have a higher probability of good knowledge of CVDs risk factors and warning signs than participants aged 18–24 (OR = 4.8, P value < 0.001), while participants living in the countryside were less likely to have good knowledge of CVDs risk factors and warning signs than city residents (OR = 0.6, P value < 0.05). According to our results, there is inadequate knowledge of the risk factors and warning signs of CVDs. Consequently, there is a greater need to raise CVD awareness and learning initiatives on the disease's risk factors and symptoms.
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| 14. |
- Shehata, Awad A., et al.
(författare)
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Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry
- 2022
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Ingår i: Microorganisms. - : MDPI AG. - 2076-2607. ; 10:2
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Forskningsöversikt (refereegranskat)abstract
- The gut microbiota has been designated as a hidden metabolic 'organ' because of its enormous impact on host metabolism, physiology, nutrition, and immune function. The connection between the intestinal microbiota and their respective host animals is dynamic and, in general, mutually beneficial. This complicated interaction is seen as a determinant of health and disease; thus, intestinal dysbiosis is linked with several metabolic diseases. Therefore, tractable strategies targeting the regulation of intestinal microbiota can control several diseases that are closely related to inflammatory and metabolic disorders. As a result, animal health and performance are improved. One of these strategies is related to dietary supplementation with prebiotics, probiotics, and phytogenic substances. These supplements exert their effects indirectly through manipulation of gut microbiota quality and improvement in intestinal epithelial barrier. Several phytogenic substances, such as berberine, resveratrol, curcumin, carvacrol, thymol, isoflavones and hydrolyzed fibers, have been identified as potential supplements that may also act as welcome means to reduce the usage of antibiotics in feedstock, including poultry farming, through manipulation of the gut microbiome. In addition, these compounds may improve the integrity of tight junctions by controlling tight junction-related proteins and inflammatory signaling pathways in the host animals. In this review, we discuss the role of probiotics, prebiotics, and phytogenic substances in optimizing gut function in poultry.
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| 15. |
- Swed, S., et al.
(författare)
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NHANES cross sectional study of aspirin and fractures in the elderly
- 2023
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017–2020 and 2013–2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08–1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81–1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden.
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| 16. |
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| 17. |
- Fredriksson, Anna M K, 1979, et al.
(författare)
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Exploring contextual variables of tactical planning within the construction industry
- 2017
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Ingår i: 24th EurOMA conference, July 3-5, Edinburgh, Scotland..
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Konferensbidrag (refereegranskat)abstract
- The purpose is to explore what context dependencies within the planning environment of the construction industry that need to be considered designing tactical planning processes. The preliminary result using a Delphi study including architects, clients, contractors, researchers, and suppliers indicates that the top five most important context dependencies are: Several kinds of stakeholders, Several planning phases, Lack of standardisation in planning, Low information sharing, and Opportunistic behaviour. Based on the patterns between the different expert groups two propositions are developed, indicating lack of shared understanding of planning between different stakeholders in construction and a project focus when thinking of planning.
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| 18. |
- Ghoran, Salar Hafez, et al.
(författare)
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Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta. : Cytotoxicity, molecular docking, and chemotaxonomic significance
- 2023
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Ingår i: Journal of Molecular Structure. - : Elsevier. - 0022-2860 .- 1872-8014. ; 1273
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Tidskriftsartikel (refereegranskat)abstract
- Phytochemical investigation of the chloroform extract of Scilla bisotunensis Speta. bulbs led to the isolation and structure elucidation of six sappinane-4-one ( 1-4, 7, 9 ) and three 3,9-dehydrosappinan-4-one ( 5, 6, 8 ) homoisoflavonoids. The structures of compounds 1 -9 were established based on extensive NMR, ESIMS, UV, and ECD spectra, and also by comparison with the previously reported spectroscopic data. The in vitro cytotoxicity of sappanin-type homoisoflavonoids 1 -9 was assayed against HT-29 human colorectal cancer cells using sulforhodamine B assay. Compounds 8 and 9 showed higher cytotoxic effects with IC50 of 5.3 and 6.1 mu g/mL, respectively, while compounds 3, 5 , and 7 exhibited moderate activity with IC50 ranging from 25 to 37 mu g/mL. Interestingly, molecular docking studies revealed that compounds 1-9 could be potential sarcoma kinase domain inhibitors with binding energies ranging from -7.37 ( 6 ) to -8.34 ( 9 ) kcal/mol when compared with the native inhibitor, purvalanol A of -7.90 kcal/mol. All homoisoflavonoids, except 1 and 5 are reported for the first time in a member of the Scilla genus, while, to the best of our knowledge this is the first phytochemical and biological study on S. bisotunensis. The plant exhibited good chemotaxonomic relationships to the genus Eucomis L'Her. on the basis of comparing their chemical constituents with those reported in the related plant families.
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| 19. |
- Hafez, H., et al.
(författare)
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A whole life cycle performance-based ECOnomic and ECOlogical assessment framework (ECO2) for concrete sustainability
- 2021
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Ingår i: Journal of Cleaner Production. - : Elsevier Ltd. - 0959-6526 .- 1879-1786. ; 292
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Tidskriftsartikel (refereegranskat)abstract
- Concrete is the primary building material worldwide with a substantial impact on the built environment sustainability. Hence, it is necessary to assess concrete's combined functionality, economic and environmental impact. In this paper, two concrete sustainability assessment frameworks, MARS-SC and CONCRETop, were studied. Building on the identified gaps, a new framework, ECO2 was developed. ECO2 is a multi-criteria decision analysis framework that accounts for carbon sequestration of concrete, impact allocation of raw materials, and the impact from the use and end-of-life phases. Hence, it could be used to optimize the proportions of a concrete mix based on a user-defined sustainability objective. A case study concluded that, due to the whole life cycle scope, the environmental impact calculated through ECO2 is 20% higher than that by MARS-SC and CONCRETop. In case of reinforced concrete, where service life requirements are different, the ranking of the alternatives according to ECO2 will significantly change comparatively.
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| 20. |
- Hautmann, R, et al.
(författare)
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Urinary diversion
- 2006
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Ingår i: Bladder Tumors. ; , s. 239-239
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 21. |
- Hosseinzadeh Delandar, Arash, 1982-, et al.
(författare)
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Three-dimensional dislocation dynamics simulation of plastic deformation in copper single crystal
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Dynamic deformation of single crystal copper at high strain rates ranging from 103 to 105 s-1 is modeled using three dimensional discrete dislocation dynamics method. Numerical uniaxial tensile test is performed on a model crystal along [0 0 1] orientation to examine the resulting macroscopic behavior along with microstructure evolution at high strain rates. Twenty-four straight dislocations of mixed character are randomly distributed inside a model crystal with an edge length of 1 subjected to period boundary conditions. In the simulated single crystal with the considered initial dislocation microstructure, plastic flow demonstrates a significant strain rate dependency at imposed strain rates. Rate sensitivity of flow stress observed at strain rates >> 103 s-1 agrees well with the reported experimental studies on copper single crystal. Furthermore, strain rate considerably affects the microstructure evolution of the sample crystal as a result of influence of strain rate on dislocations generation and interactions. Formation of heterogeneous microstructure is observed at all imposed strain rates. We find that heterogeneity of microstructure escalates as strain rate increases.
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| 22. |
- Masood Hafez Haghighat, Seyed, et al.
(författare)
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Discrete Models : Down to Atoms and Electrons
- 2016
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Ingår i: Handbook of Software Solutions for ICME. - Weinheim, Germany : Wiley-VCH Verlagsgesellschaft. - 9783527339020 ; , s. 385-431
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter reviews some computational methods and software tools available for modeling materials at small scales where the matter exhibits its discrete nature. Discrete models operate on different levels, ranging from the electronic structure and atomistic level to the mesoscopic level at which the discrete objects are molecules or crystal defects rather than the individual atoms. The chapter considers the main methods of atomistic modeling, molecular dynamics (MD) and Monte Carlo (MC), and quantum mechanics (QM) electronic structure methods. It discusses the effective potentials, interatomic interactions, and force fields (FFs), which serve the purpose of passing the physical information between the different levels of modeling. Two atomistic methods are also reviewed. Kinetic MC (KMC) is first introduced as a technique able to link the nanoscale and mesoscale domains but relying heavily on atomistic parameterizations. Then, the powerful MD technique is explained, and some links between both techniques are also hinted.
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| 23. |
- Mokhtar, Ali, et al.
(författare)
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Prediction of Irrigation Water Requirements for Green Beans-Based Machine Learning Algorithm Models in Arid Region
- 2023
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Ingår i: Water resources management. - : Springer. - 0920-4741 .- 1573-1650. ; 37, s. 1557-1580
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Tidskriftsartikel (refereegranskat)abstract
- Water scarcity is the most obstacle faced by irrigation water requirements, likewise, limited available meteorological data to calculate reference evapotranspiration. Consequently, the focal aims of the investigation are to assess the potential of machine learning models in forecasting irrigation water requirements (IWR) of snap beans by evolving multi-scenarios of inputs parameters to figure out the impact of meteorological, crop, and soil parameters on IWR. Six models were applied, support vector regressor (SVR), random forest (RF), deep neural networks (DNN), convolutional neural networks (CNN), long short-term memory (LSTM), and Hybrid CNN-LSTM. Ten variables including maximum and minimum temperature, Relative humidity, wind speed, precipitation, root depth, basal crop coefficient, soil evaporation, a fraction of surface wetted and, exposed and soil wetted fraction were used as the input data for models with their combination, 8 input scenarios were designed. Overall models, the best scenario was scenario 4 (relative humidity, wind speed, basal crop coefficient, soil evaporation), however, the best scenario for DNN and RF model was scenario 7 (root depth, basal crop coefficient, soil evaporation, fraction of surface wetted, exposed and soil wetted fraction). While the weakest one was the group of climatic factors in scenario 6 (maximum temperature, minimum temperature, relative humidity, wind speed, and precipitation). Among the models, the hybrid LTSM & CNN was the most accurate and the SVR model had the lowest estimation accuracy. The outcomes of this research work could set up a modeling strategy that would set in motion the improvement of efforts to identify the shortages in IWR forecasting, which sequentially may support alleviation strategies such as policies for sustainable water use and water resources management. The current approach was promising and has research value for other similar regions.
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