| 1. |
- Castellano, Ginevra, et al.
(författare)
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Towards Empathic Virtual and Robotic Tutors
- 2013
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Ingår i: Lecture Notes in Computer Science. - 0302-9743 .- 1611-3349. ; 7926, s. 733-736
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Tidskriftsartikel (refereegranskat)abstract
- Building on existing work on artificial tutors with human-like capabilities, we describe the EMOTE project approach to harnessing benefits of an artificial embodied tutor in a shared physical space. Embodied in robotic platforms or through virtual agents, EMOTE aims to capture some of the empathic and human elements characterising a traditional teacher. As such, empathy and engagement, abilities key to influencing student learning, are at the core of the EMOTE approach. We present non-verbal and adaptive dialogue challenges for such embodied tutors as a foundation for researchers investigating the potential for empathic tutors that will be accepted by students and teachers.
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| 2. |
- Chasman, Daniel I., et al.
(författare)
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
- 2012
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:24, s. 5329-5343
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Tidskriftsartikel (refereegranskat)abstract
- In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in FBXL20 (P 5.6 10(9)) in meta-analysis of all available data, and additional SNPs at the INHBC, LRP2, PLEKHA1, SLC3A2 and SLC7A6 genes meeting multiple-testing corrected significance for replication and overall P-values of 4.5 10(4)2.2 10(7). Neither the novel PLEKHA1 nor FBXL20 associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. LRP2, encoding the megalin receptor, was identified through connection with the previously known eGFR gene DAB2 and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general.
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| 3. |
- Deshmukh, Amol, et al.
(författare)
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An Empathic Robotic Tutor in a Map Application
- 2015
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Ingår i: Proceedings of the 2015 international conference on autonomous agents & multiagent systems (AAMAS'15). - New York : Association for Computing Machinery (ACM). - 9781450334136 ; , s. 1923-1924
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Konferensbidrag (refereegranskat)abstract
- In this demonstration, we describe a scenario developed in the EMOTE project [2]. The overall goal of the EMOTE project is to develop an empathic robot tutor for 11-13 year old school students in an educational setting. The pedagogical domain we demonstrate here is to assist students in learning and testing their map-reading skills typically learned as part of the geography curriculum in schools. We demonstrate this scenario with a NAO robot interacting with the students whilst performing map-reading tasks in the form of a game on a touch-screen device.
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| 4. |
- Deshmukh, Amol, et al.
(författare)
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How expressiveness of a robotic tutor is perceived by children in a learning environment
- 2016
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Ingår i: Proc. 11th ACM/IEEE International Conference on Human Robot Interaction. - Piscataway, NJ : IEEE Press. - 9781467383707 ; , s. 423-424
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Konferensbidrag (refereegranskat)abstract
- We present a study investigating the expressiveness of two different types of robots in a tutoring task. The robots used were i) the EMYS robot, with facial expression capabilities, and ii) the NAO robot, without facial expressions but able to perform expressive gestures. Preliminary results show that the NAO robot was perceived to be more friendly, pleasant and empathic than the EMYS robot as a tutor in a learning environment.
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| 5. |
- Hall, Lynne, et al.
(författare)
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Map reading with an empathic robot tutor
- 2016
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Ingår i: ACMIEEE International Conference on Human-Robot Interaction. - Piscataway, NJ : IEEE. - 2167-2121. - 9781467383707
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Konferensbidrag (refereegranskat)
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| 6. |
- Jones, Aidan, et al.
(författare)
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Empathic Robotic Tutors for Personalised Learning: A Multidisciplinary Approach
- 2015
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Ingår i: Social Robotics: Proceedings of the 7th International Conference, ICSR 2015, Paris, France, October 26-30, 2015. - Cham : Springer International Publishing. ; , s. 285-295, s. 285-295
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Konferensbidrag (refereegranskat)abstract
- Within any learning process, the formation of a socio-emotional relationship between learner and teacher is paramount to facilitating a good learning experience. The ability to form this relationship may come naturally to an attentive teacher; but how do we endow an unemotional robot with this ability? In this paper, we extend upon insights from the literature to include tools from user-centered design (UCD) and analyses of human-human interaction (HHI) as the basis of a multidisciplinary approach in the development of an empathic robotic tutor. We discuss the lessons learned in respect to design principles with the aim of personalised learning with empathic robotic tutors.
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| 7. |
- Joshi, Peter K, et al.
(författare)
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Directional dominance on stature and cognition in diverse human populations
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 523:7561, s. 459-462
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Tidskriftsartikel (refereegranskat)abstract
- Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
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| 8. |
- Meena, Raveesh, 1981-
(författare)
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Data-driven Methods for Spoken Dialogue Systems : Applications in Language Understanding, Turn-taking, Error Detection, and Knowledge Acquisition
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Spoken dialogue systems are application interfaces that enable humans to interact with computers using spoken natural language. A major challenge for these systems is dealing with the ubiquity of variability—in user behavior, in the performance of the various speech and language processing sub-components, and in the dynamics of the task domain. However, as the predominant methodology for dialogue system development is to handcraft the sub-components, these systems typically lack robustness in user interactions. Data-driven methods, on the other hand, have been shown to offer robustness to variability in various domains of computer science and are increasingly being used in dialogue systems research. This thesis makes four novel contributions to the data-driven methods for spoken dialogue system development. First, a method for interpreting the meaning contained in spoken utterances is presented. Second, an approach for determining when in a user’s speech it is appropriate for the system to give a response is presented. Third, an approach for error detection and analysis in dialogue system interactions is reported. Finally, an implicitly supervised learning approach for knowledge acquisition through the interactive setting of spoken dialogue is presented. The general approach taken in this thesis is to model dialogue system tasks as a classification problem and investigate features (e.g., lexical, syntactic, semantic, prosodic, and contextual) to train various classifiers on interaction data. The central hypothesis of this thesis is that the models for the aforementioned dialogue system tasks trained using the features proposed here perform better than their corresponding baseline models. The empirical validity of this claim has been assessed through both quantitative and qualitative evaluations, using both objective and subjective measures.
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| 9. |
- Parsa, Afshin, et al.
(författare)
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Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
- 2013
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Ingår i: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 24:12, s. 2105-2117
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Tidskriftsartikel (refereegranskat)abstract
- Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at LRP2, rs1050700 at TSC1, rs249942 at PALB2, and rs9827843 at ROBO2) did not achieve significance in a stage 2 meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research.
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| 10. |
- Pattaro, Cristian, et al.
(författare)
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Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
- 2012
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 8:3, s. e1002584-
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
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| 11. |
- Winfield, Alan F. T., et al.
(författare)
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IEEE P7001 : A Proposed Standard on Transparency
- 2021
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Ingår i: Frontiers in Robotics and AI. - : Frontiers Media S.A.. - 2296-9144. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes IEEE P7001, a new draft standard on transparency of autonomous systems1. In the paper, we outline the development and structure of the draft standard. We present the rationale for transparency as a measurable, testable property. We outline five stakeholder groups: users, the general public and bystanders, safety certification agencies, incident/accident investigators and lawyers/expert witnesses, and explain the thinking behind the normative definitions of “levels” of transparency for each stakeholder group in P7001. The paper illustrates the application of P7001 through worked examples of both specification and assessment of fictional autonomous systems.
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