| 1. |
- Jin, Bao, et al.
(författare)
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Phase transition structural superlubricity
- 2024
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Ingår i: Matter. - : Cell Press. - 2590-2393 .- 2590-2385.
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Tidskriftsartikel (refereegranskat)abstract
- Structural superlubricity refers to a state with almost vanishing friction and wear between crystalline surfaces in incommensurate configurations. However, thus far, this phenomenon has been observed only at solid-solid interfaces. Here, we constructed an in situ heterojunction between a crystalline boundary tribofilm and a pressure-induced solid-phase 1–dodecanol molecular layer, achieving structural superlubricity in a liquid-solid interface. This novel superlubricity state, termed phase transition structural superlubricity (PTSS), is induced by incommensurate slip at the in situ heterojunction. Atomic force microscopy experiments and molecular dynamics simulations demonstrated that the friction of in situ heterojunction exhibits a periodicity of 180°. Notably, the PTSS arises when the molecular axis of 1–dodecanol is oriented 90° to the direction of friction. These findings provide a novel design strategy for structural superlubricity and bridge the gap between liquid and solid superlubricity, shedding substantial light upon achieving structural superlubricity across a broad range of environments.
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| 2. |
- Chen, Guangyan, et al.
(författare)
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Engineering Active-Site-Induced Homogeneous Growth of Polydopamine Nanocontainers on Loading-Enhanced Ultrathin Graphene for Smart Self-Healing Anticorrosion Coatings
- 2023
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 15:19, s. 23679-23689
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Tidskriftsartikel (refereegranskat)abstract
- Engineering nanocontainers with encapsulated inhibitors onto graphene has been an emerging technology for developing self-healing anticorrosion coatings. However, the loading contents of inhibitors are commonly limited by inhomogeneous nanostructures of graphene platforms. Here, we propose an activation-induced ultrathin graphene platform (UG-BP) with the homogeneous growth of polydopamine (PDA) nanocontainers encapsulated with benzotriazole (BTA). Ultrathin graphene prepared by catalytic exfoliation and etching activation provides an ideal platform with an ultrahigh specific surface area (1646.8 m2/g) and homogeneous active sites for the growth of PDA nanocontainers, which achieves a high loading content of inhibitors (40 wt %). The obtained UG-BP platform exhibits pH-sensitive corrosion inhibition effects due to its charged groups. The epoxy/UG-BP coating possesses integrated properties of enhanced mechanical properties (>94%), efficient pH-sensitive self-healing behaviors (98.5% healing efficiency over 7 days), and excellent anticorrosion performance (4.21 × 109 Ω·cm2 over 60 days), which stands out from previous related works. Moreover, the interfacial anticorrosion mechanism of UG-BP is revealed in detail, which can inhibit the oxidation of Fe2+ and promote the passivation of corrosion products by a dehydration process. This work provides a universal activation-induced strategy for developing loading-enhanced and tailor-made graphene platforms in extended smart systems and demonstrates a promising smart self-healing coating for advanced anticorrosion applications.
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| 3. |
- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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| 4. |
- Orentas, Rimas J, et al.
(författare)
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Bioinformatic description of immunotherapy targets for pediatric T-cell leukemia and the impact of normal gene sets used for comparison
- 2014
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Pediatric lymphoid leukemia has the highest cure rate of all pediatric malignancies, yet due to its prevalence, still accounts for the majority of childhood cancer deaths and requires long-term highly toxic therapy. The ability to target B-cell ALL with immunoglobulin-like binders, whether anti-CD22 antibody or anti-CD19 CAR-Ts, has impacted treatment options for some patients. The development of new ways to target B-cell antigens continues at rapid pace. T-cell ALL accounts for up to 20% of childhood leukemia but has yet to see a set of high-value immunotherapeutic targets identified. To find new targets for T-ALL immunotherapy, we employed a bioinformatic comparison to broad normal tissue arrays, hematopoietic stem cells (HSC), and mature lymphocytes, then filtered the results for transcripts encoding plasma membrane proteins. T-ALL bears a core T-cell signature and transcripts encoding TCR/CD3 components and canonical markers of T-cell development predominate, especially when comparison was made to normal tissue or HSC. However, when comparison to mature lymphocytes was also undertaken, we identified two antigens that may drive, or be associated with leukemogenesis; TALLA-1 and hedgehog interacting protein. In addition, TCR subfamilies, CD1, activation and adhesion markers, membrane-organizing molecules, and receptors linked to metabolism and inflammation were also identified. Of these, only CD52, CD37, and CD98 are currently being targeted clinically. This work provides a set of targets to be considered for future development of immunotherapies for T-ALL.
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